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20262 papers

Mixed-model and transcriptome-wide association analyses identify transcription factors and genes associated with colorectal cancer susceptibility.

Zhishan Chen, Wenqiang Song, Qing Li, Chao Li, Wanqing Wen, Jeroen R Huyghe, Philip J Law, Ceres Fernandez-Rozadilla, Maria N Timofeeva, Minta Thomas, Stephanie L Schmit, Vicente Martin, Matthew Devall, Christopher Dampier, Ferran Moratalla-Navarro, Qiuyin Cai, Jifeng Wang, Jiajun Shi, Sun-Seog Kweon, Chizu Tanikawa, Wei-Hua Jia, Xiang Shu, Jirong Long, Jing Gao, Jeongseon Kim, Aesun Shin, Keitaro Matsuo, Sun Ha Jee, Keum Ji Jung, Nan Wang, Dong-Hyun Kim, Jie Ping, Gong Yang, Min-Ho Shin, Zefang Ren, Jae Hwan Oh, Isao Oze, Yoon-Ok Ahn, Yu-Tang Gao, Zhi-Zhong Pan, Yoichiro Kamatani, Luc Van Kaer, Lan Wu, Bingshan Li, Koichi Matsuda, Xiao-Ou Shu, Li Hsu, Malcolm G Dunlop, Stephen B Gruber, Richard Houlston, Ian Tomlinson, Li Li, Ken S Lau, Victor Moreno, Graham Casey, Ulrike Peters, Wei Zheng, Xingyi Guo

Nature communications, 17(1), 1377, Jan 15, 2026, doi: 10.1038/s41467-025-68127-z

Genetic risk impacts stroke mortality and pathogenesis in patients with ischemic stroke: a cohort study of BioBank Japan.

Takashi Shimoyama, Yoichiro Kamatani, Koichi Matsuda, Hiroki Yamaguchi, Kazumi Kimura

Frontiers in neurology, 17, 1664594, 2026, doi: 10.3389/fneur.2026.1664594

20259 papers

Pan-cancer prevalence, risk, and clinical and demographic characteristics of Lynch Syndrome-associated variants in BioBank Japan.

Keijiro Mizukami, Yoshiaki Usui, Yusuke Iwasaki, Kouya Shiraishi, Makoto Hirata, Yoichiro Kamatani, Mikiko Endo, Satoshi Takahashi, Yoshiki Mochizuki, Mitusyo Yamaguchi, Takashi Kohno, Koichi Matsuda, Kokichi Sugano, Teruhiko Yoshida, Hidewaki Nakagawa, Chikashi Terao, Yuriko N Koyanagi, Keitaro Matsuo, Yoshinori Murakami, Amanda B Spurdle, Yukihide Momozawa

Communications medicine, 5(1), 522, Nov 13, 2025, doi: 10.1038/s43856-025-01231-9

Whole-genome sequencing of 3135 individuals representing the genetic diversity of the Japanese population.

Koichiro Higasa, Yoichiro Kamatani, Takahisa Kawaguchi, Shuji Kawaguchi, Saori Sakaue, Ta-Yu Yang, Yukinori Okada, Yukihide Momozawa, Izumi Yamaguchi, Dominic Nelson, Simon Gravel, Yoshinori Murakami, Ryo Yamada, Keitaro Matsuo, Yoshihisa Yamano, Changhoon Kim, Jeong-Sun Seo, Michiaki Kubo, Fumihiko Matsuda

Journal of human genetics, Nov 8, 2025, doi: 10.1038/s10038-025-01430-1

Case-Control Study for 23 Cancer Types With Functional Analysis of CHEK2: Risk Estimation and Clinical Recommendations in East Asia.

Yuri Takehara, Yoshiaki Usui, Lenka Stolařová, Petra Kleiblova, Yusuke Iwasaki, Todd A Johnson, Makoto Hirata, Yoichiro Kamatani, Yoshinori Murakami, Mikiko Endo, Kouya Shiraishi, Takashi Kohno, Kokichi Sugano, Koichi Matsuda, Teruhiko Yoshida, Amanda B Spurdle, Hidewaki Nakagawa, Libor Macurek, Zdenek Kleibl, Yukihide Momozawa

JCO precision oncology, 9, e2400945, Sep, 2025, doi: 10.1200/PO-24-00945

Identification and replication of sex-dimorphic protein quantitative trait loci across multiple ancestries and their associations with diseases

Youngjune Bhak, Vasilis Raptis, Yunye He, Tomoko Nakanishi, Erin Macdonald-Dunlop, Yoji Sagiya, Takayuki Morisaki, Koichi Matsuda, Ho Namkoong, Ryuya Edahiro, Tomomi Takano, Hiroshi Nishihara, Yuya Shirai, Kyuto Sonehara, Hiromu Tanaka, Shuhei Azekawa, Yohei Mikami, Ho Lee, Takanori Hasegawa, Koji Okudela, Daisuke Okuzaki, Daisuke Motooka, Masahiro Kanai, Tatsuhiko Naito, Kenichi Yamamoto, Qingbo S. Wang, Ryunosuke Saiki, Rino Ishihara, Yuta Matsubara, Junko Hamamoto, Hiroyuki Hayashi, Yukihiro Yoshimura, Natsuo Tachikawa, Emmy Yanagita, Takayoshi Hyugaji, Eigo Shimizu, Kotoe Katayama, Yasuhiro Kato, Takayoshi Morita, Kazuhisa Takahashi, Norihiro Harada, Toshio Naito, Makoto Hiki, Yasushi Matsushita, Haruhi Takagi, Ryousuke Aoki, Ai Nakamura, Sonoko Harada, Hitoshi Sasano, Hiroki Kabata, Katsunori Masaki, Hirofumi Kamata, Shinnosuke Ikemura, Shotaro Chubachi, Satoshi Okamori, Hideki Terai, Atsuho Morita, Takanori Asakura, Junichi Sasaki, Hiroshi Morisaki, Yoshifumi Uwamino, Kosaku Nanki, Sho Uchida, Shunsuke Uno, Tomoyasu Nishimura, Takashi Ishiguro, Taisuke Isono, Shun Shibata, Yuma Matsui, Chiaki Hosoda, Kenji Takano, Takashi Nishida, Yoichi Kobayashi, Yotaro Takaku, Noboru Takayanagi, Soichiro Ueda, Ai Tada, Masayoshi Miyawaki, Masaomi Yamamoto, Eriko Yoshida, Reina Hayashi, Tomoki Nagasaka, Sawako Arai, Yutaro Kaneko, Kana Sasaki, Etsuko Tagaya, Masatoshi Kawana, Ken Arimura, Kunihiko Takahashi, Tatsuhiko Anzai, Satoshi Ito, Akifumi Endo, Yuji Uchimura, Yasunari Miyazaki, Takayuki Honda, Tomoya Tateishi, Shuji Tohda, Naoya Ichimura, Kazunari Sonobe, Chihiro Tani Sassa, Jun Nakajima, Yasushi Nakano, Yukiko Nakajima, Ryusuke Anan, Ryosuke Arai, Yuko Kurihara, Yuko Harada, Kazumi Nishio, Tetsuya Ueda, Masanori Azuma, Ryuichi Saito, Toshikatsu Sado, Yoshimune Miyazaki, Ryuichi Sato, Yuki Haruta, Tadao Nagasaki, Yoshinori Yasui, Yoshinori Hasegawa, Yoshikazu Mutoh, Tomoki Kimura, Tomonori Sato, Reoto Takei, Satoshi Hagimoto, Yoichiro Noguchi, Yasuhiko Yamano, Hajime Sasano, Sho Ota, Yasushi Nakamori, Kazuhisa Yoshiya, Fukuki Saito, Tomoyuki Yoshihara, Daiki Wada, Hiromu Iwamura, Syuji Kanayama, Shuhei Maruyama, Takashi Yoshiyama, Ken Ohta, Hiroyuki Kokuto, Hideo Ogata, Yoshiaki Tanaka, Kenichi Arakawa, Masafumi Shimoda, Takeshi Osawa, Hiroki Tateno, Isano Hase, Shuichi Yoshida, Shoji Suzuki, Miki Kawada, Hirohisa Horinouchi, Fumitake Saito, Keiko Mitamura, Masao Hagihara, Junichi Ochi, Tomoyuki Uchida, Rie Baba, Daisuke Arai, Takayuki Ogura, Hidenori Takahashi, Shigehiro Hagiwara, Genta Nagao, Shunichiro Konishi, Ichiro Nakachi, Koji Murakami, Mitsuhiro Yamada, Hisatoshi Sugiura, Hirohito Sano, Shuichiro Matsumoto, Nozomu Kimura, Yoshinao Ono, Hiroaki Baba, Yusuke Suzuki, Sohei Nakayama, Keita Masuzawa, Shinichi Namba, Ken Suzuki, Yoko Naito, Yu-Chen Liu, Ayako Takuwa, Fuminori Sugihara, James B. Wing, Shuhei Sakakibara, Nobuyuki Hizawa, Takayuki Shiroyama, Satoru Miyawaki, Yusuke Kawamura, Akiyoshi Nakayama, Hirotaka Matsuo, Yuichi Maeda, Takuro Nii, Yoshimi Noda, Takayuki Niitsu, Yuichi Adachi, Takatoshi Enomoto, Saori Amiya, Reina Hara, Yuta Yamaguchi, Teruaki Murakami, Tomoki Kuge, Kinnosuke Matsumoto, Yuji Yamamoto, Makoto Yamamoto, Midori Yoneda, Toshihiro Kishikawa, Shuhei Yamada, Shuhei Kawabata, Noriyuki Kijima, Masatoshi Takagaki, Noah Sasa, Yuya Ueno, Motoyuki Suzuki, Norihiko Takemoto, Hirotaka Eguchi, Takahito Fukusumi, Takao Imai, Munehisa Fukushima, Haruhiko Kishima, Hidenori Inohara, Kazunori Tomono, Kazuto Kato, Meiko Takahashi, Fumihiko Matsuda, Haruhiko Hirata, Yoshito Takeda, Hidefumi Koh, Tadashi Manabe, Yohei Funatsu, Fumimaro Ito, Takahiro Fukui, Keisuke Shinozuka, Sumiko Kohashi, Masatoshi Miyazaki, Tomohisa Shoko, Mitsuaki Kojima, Tomohiro Adachi, Motonao Ishikawa, Kenichiro Takahashi, Takashi Inoue, Toshiyuki Hirano, Keigo Kobayashi, Hatsuyo Takaoka, Kazuyoshi Watanabe, Naoki Miyazawa, Yasuhiro Kimura, Reiko Sado, Hideyasu Sugimoto, Akane Kamiya, Naota Kuwahara, Akiko Fujiwara, Tomohiro Matsunaga, Yoko Sato, Takenori Okada, Yoshihiro Hirai, Hidetoshi Kawashima, Atsuya Narita, Kazuki Niwa, Yoshiyuki Sekikawa, Koichi Nishi, Masaru Nishitsuji, Mayuko Tani, Junya Suzuki, Hiroki Nakatsumi, Takashi Ogura, Hideya Kitamura, Eri Hagiwara, Kota Murohashi, Hiroko Okabayashi, Takao Mochimaru, Shigenari Nukaga, Ryosuke Satomi, Yoshitaka Oyamada, Nobuaki Mori, Tomoya Baba, Yasutaka Fukui, Mitsuru Odate, Shuko Mashimo, Yasushi Makino, Kazuma Yagi, Mizuha Hashiguchi, Junko Kagyo, Tetsuya Shiomi, Satoshi Fuke, Hiroshi Saito, Tomoya Tsuchida, Shigeki Fujitani, Mumon Takita, Daiki Morikawa, Toru Yoshida, Takehiro Izumo, Minoru Inomata, Naoyuki Kuse, Nobuyasu Awano, Mari Tone, Akihiro Ito, Yoshihiko Nakamura, Kota Hoshino, Junichi Maruyama, Hiroyasu Ishikura, Tohru Takata, Toshio Odani, Masaru Amishima, Takeshi Hattori, Yasuo Shichinohe, Takashi Kagaya, Toshiyuki Kita, Kazuhide Ohta, Satoru Sakagami, Kiyoshi Koshida, Kentaro Hayashi, Tetsuo Shimizu, Yutaka Kozu, Hisato Hiranuma, Yasuhiro Gon, Namiki Izumi, Kaoru Nagata, Ken Ueda, Reiko Taki, Satoko Hanada, Kodai Kawamura, Kazuya Ichikado, Kenta Nishiyama, Hiroyuki Muranaka, Kazunori Nakamura, Naozumi Hashimoto, Keiko Wakahara, Sakamoto Koji, Norihito Omote, Akira Ando, Nobuhiro Kodama, Yasunari Kaneyama, Shunsuke Maeda, Takashige Kuraki, Takemasa Matsumoto, Koutaro Yokote, Taka-Aki Nakada, Ryuzo Abe, Taku Oshima, Tadanaga Shimada, Masahiro Harada, Takeshi Takahashi, Hiroshi Ono, Toshihiro Sakurai, Takayuki Shibusawa, Yoshifumi Kimizuka, Akihiko Kawana, Tomoya Sano, Chie Watanabe, Ryohei Suematsu, Hisako Sageshima, Ayumi Yoshifuji, Kazuto Ito, Saeko Takahashi, Kota Ishioka, Morio Nakamura, Makoto Masuda, Aya Wakabayashi, Hiroki Watanabe, Suguru Ueda, Masanori Nishikawa, Yusuke Chihara, Mayumi Takeuchi, Keisuke Onoi, Jun Shinozuka, Atsushi Sueyoshi, Yoji Nagasaki, Masaki Okamoto, Sayoko Ishihara, Masatoshi Shimo, Yoshihisa Tokunaga, Yu Kusaka, Takehiko Ohba, Susumu Isogai, Aki Ogawa, Takuya Inoue, Satoru Fukuyama, Yoshihiro Eriguchi, Akiko Yonekawa, Keiko Kan-o, Koichiro Matsumoto, Kensuke Kanaoka, Shoichi Ihara, Kiyoshi Komuta, Yoshiaki Inoue, Shigeru Chiba, Kunihiro Yamagata, Yuji Hiramatsu, Hirayasu Kai, Koichiro Asano, Tsuyoshi Oguma, Yoko Ito, Satoru Hashimoto, Masaki Yamasaki, Yu Kasamatsu, Yuko Komase, Naoya Hida, Takahiro Tsuburai, Baku Oyama, Minoru Takada, Hidenori Kanda, Yuichiro Kitagawa, Tetsuya Fukuta, Takahito Miyake, Shozo Yoshida, Shinji Ogura, Shinji Abe, Yuta Kono, Yuki Togashi, Hiroyuki Takoi, Ryota Kikuchi, Shinichi Ogawa, Tomouki Ogata, Shoichiro Ishihara, Arihiko Kanehiro, Shinji Ozaki, Yasuko Fuchimoto, Sae Wada, Nobukazu Fujimoto, Kei Nishiyama, Mariko Terashima, Satoru Beppu, Kosuke Yoshida, Osamu Narumoto, Hideaki Nagai, Nobuharu Ooshima, Mitsuru Motegi, Akira Umeda, Kazuya Miyagawa, Hisato Shimada, Mayu Endo, Yoshiyuki Ohira, Masafumi Watanabe, Sumito Inoue, Akira Igarashi, Masamichi Sato, Hironori Sagara, Akihiko Tanaka, Shin Ohta, Tomoyuki Kimura, Yoko Shibata, Yoshinori Tanino, Takefumi Nikaido, Hiroyuki Minemura, Yuki Sato, Yuichiro Yamada, Takuya Hashino, Masato Shinoki, Hajime Iwagoe, Hiroshi Takahashi, Kazuhiko Fujii, Hiroto Kishi, Masayuki Kanai, Tomonori Imamura, Tatsuya Yamashita, Masakiyo Yatomi, Toshitaka Maeno, Shinichi Hayashi, Mai Takahashi, Mizuki Kuramochi, Isamu Kamimaki, Yoshiteru Tominaga, Tomoo Ishii, Mitsuyoshi Utsugi, Akihiro Ono, Toru Tanaka, Takeru Kashiwada, Kazue Fujita, Yoshinobu Saito, Masahiro Seike, Hiroko Watanabe, Hiroto Matsuse, Norio Kodaka, Chihiro Nakano, Takeshi Oshio, Takatomo Hirouchi, Shohei Makino, Moritoki Egi, Yosuke Omae, Yasuhito Nannya, Takafumi Ueno, Kazuhiko Katayama, Masumi Ai, Yoshinori Fukui, Atsushi Kumanogoh, Toshiro Sato, Naoki Hasegawa, Katsushi Tokunaga, Makoto Ishii, Ryuji Koike, Yuko Kitagawa, Akinori Kimura, Seiya Imoto, Satoru Miyano, Seishi Ogawa, Takanori Kanai, Koichi Fukunaga, Yukinori Okada, Akinori Kanai, Yutaka Suzuki, Yoshiya Oda, Yoichiro Kamatani, Ho Namkoong, Ryunosuke Saiki, Akinori Kimura, Ryuji Koike, Seishi Ogawa, Satoru Miyano, Seiya Imoto, Takanori Kanai, Koichi Fukunaga, Yukinori Okada, Anders Mälarstig, Albert Tenesa

Scientific Reports, 15(1), Aug 28, 2025, doi: 10.1038/s41598-025-10031-z

Multi-ancestry polygenic risk scores for the prediction of type 2 diabetes and complications in diverse ancestries.

Alicia Huerta-Chagoya, Joohyun Kim, Ravi Mandla, Yingchang Lu, Ken Suzuki, Lauren E Petty, Hong Kiat Ng, Jaewon Choi, Simon Lee, Madhusmita Rout, Kuang Lin, Linda S Adair, Adebowale Adeyemo, Habibul Ahsan, Masato Akiyama, Ping An, Sonia S Anand, Diane M Becker, Alain G Bertoni, Zheng Bian, Lawrence F Bielak, John Blangero, Michael Boehnke, Erwin P Bottinger, Donald W Bowden, Fiona Bragg, Jennifer A Brody, Thomas A Buchanan, Brian E Cade, Jin-Fang Chai, John C Chambers, Giriraj R Chandak, Li-Ching Chang, Kyong-Mi Chang, Miao-Li Chee, Chien-Hsiun Chen, Yuan-Tsong Chen, Zhengming Chen, Yii-Der I Chen, Ji Chen, Guanjie Chen, Shyh-Huei Chen, Wei-Min Chen, Ching-Yu Cheng, Yoon Shin Cho, Hyeok Sun Choi, Lee-Ming Chuang, Miguel Cruz, Mary Cushman, Swapan K Das, Ralph A DeFronzo, H Janaka deSilva, Latchezar Dimitrov, Ayo P Doumatey, Shufa Du, Qing Duan, Ravindranath Duggirala, Leslie S Emery, James C Engert, Daniel S Evans, Michele K Evans, Sarah Finer, Jose C Florez, James S Floyd, Myriam Fornage, Elizabeth G Frankel, Barry I Freedman, Lourdes García-García, Pauline Genter, Hertzel C Gerstein, Mark O Goodarzi, Penny Gordon-Larsen, Mariaelisa Graff, Myron Gross, Yu Guo, Xiuqing Guo, Yang Hai, Craig L Hanis, MGeoffrey Hayes, Momoko Horikoshi, Annie-Green Howard, Sarah Hsu, Willa Hsueh, Wei Huang, Mengna Huang, Yi-Jen Hung, Mi Yeong Hwang, Chii-Min Hwu, Sahoko Ichihara, Michiya Igase, Eli Ipp, Mohammad T Islam, Masato Isono, Hye-Mi Jang, Farzana Jasmine, Jost B Jonas, Yoonjung Y Joo, Edmond Kabagambe, Takashi Kadowaki, Yoichiro Kamatani, Fouad R Kandeel, Sharon L R Kardia, Elizabeth W Karlson, Anuradhani Kasturiratne, Norihiro Kato, Tomohiro Katsuya, Varinderpal Kaur, Takahisa Kawaguchi, Jacob M Keaton, Abel N Kho, Chiea-Chuen Khor, Muhammad Kibriya, Bong-Jo Kim, Woon-Puay Koh, Katsuhiko Kohara, Jaspal S Kooner, Charles Kooperberg, Raymond J Kreienkamp, Amel Lamri, Leslie A Lange, Nanette R Lee, Myung-Shik Lee, Jung-Jin Lee, Donna M Lehman, Liming Li, Yun Li, Victor Jy Lim, Jianjun Liu, Yongmei Liu, Simin Liu, Jirong Long, Tin Louie, Xi Luo, Jun Lv, Julie A Lynch, Shiro Maeda, Anubha Mahajan, Nisa M Maruthur, Fumihiko Matsuda, Mark I McCarthy, Roberta McKean-Cowdin, James B Meigs, Iona Y Millwood, Karen L Mohlke, Ayesha A Motala, Girish N Nadkarni, Jerry L Nadler, Masahiro Nakatochi, Mike A Nalls, Uma Nayak, Aude Nicolas, Kari E North, Darryl Nousome, Yukinori Okada, Ian Pan, James S Pankow, Guillaume Paré, Jaehyun Park, Kyong Soo Park, Esteban J Parra, Sanjay R Patel, Mark A Pereira, Patricia A Peyser, Fraser J Pirie, Michael Preuss, Michael A Province, Bruce M Psaty, Leslie J Raffel, Laura M Raffield, Laura J Rasmussen-Torvik, Susan Redline, Alexander P Reiner, Stephen S Rich, Rebecca Rohde, Kathryn Roll, Rashedeh Roshani, Charles N Rotimi, Charumathi Sabanayagam, Danish Saleheen, Kevin Sandow, Claudia Schurmann, Mohammad Shahriar, Douglas M Shaw, Wayne H-H Sheu, Jinxiu Shi, Xiao-Ou Shu, Megan M Shuey, Moneeza K Siddiqui, Jennifer A Smith, Tamar Sofer, Cassandra N Spracklen, Adrienne M Stilp, Meng Sun, Yasuharu Tabara, E-Shyong Tai, Salman M Tajuddin, Atsushi Takahashi, Fumihiko Takeuchi, Jingyi Tan, Kent D Taylor, Katherine Taylor, Farook Thameem, Lin Tong, Fuu-Jen Tsai, Philip S Tsao, Miriam S Udler, Adan Valladares-Salgado, David A van Heel, Rob M vanDam, Rohit Varma, Maheak Vora, Niels Wacher-Rodarte, Ya-Xing Wang, Ellie Wheeler, Eric A Whitsel, Ananda R Wickremasinghe, Genevieve L Wojcik, Tien Y Wong, Jer-Yuarn Wu, Yong-Bing Xiang, Anny H Xiang, Chittaranjan S Yajnik, Ken Yamamoto, Toshimasa Yamauchi, Lisa R Yanek, Jie Yao, Mitsuhiro Yokota, Canqing Yu, Jian-Min Yuan, Salim Yusuf, Eleftheria Zeggini, Liang Zhang, Weihua Zhang, Wei Zheng, Alan B Zonderman, Carlos A Aguilar-Salinas, Clicerio González-Villalpando, Christopher A Haiman, Young Jin Kim, Soo Heon Kwak, Aaron Leong, Ruth J F Loos, Andres Moreno-Estrada, Andrew P Morris, Lorena Orozco, Jerome I Rotter, Dharambir Sanghera, Teresa Tusie-Luna, Benjamin F Voight, Marijana Vujkovic, Robin G Walters, Tian Ge, Alisa K Manning, Marie Loh, Jennifer E Below, Xueling Sim, Josep M Mercader, Maggie C Y Ng

medRxiv : the preprint server for health sciences, Jul 23, 2025, doi: 10.1101/2025.07.21.25331778

Increased somatic mosaicism in autosomal and X chromosomes for suicide death.

Ikuo Otsuka, Shunsuke Uchiyama, Toshiyuki Shirai, Xiaoxi Liu, Motonori Takahashi, Yoichiro Kamatani, Chikashi Terao, Akitoyo Hishimoto

Molecular psychiatry, 30(3), 881-888, Mar, 2025, doi: 10.1038/s41380-024-02718-y

A variant in HMMR/HMMR-AS1 is associated with serum alanine aminotransferase levels in the Ryukyu population

Noriko Ohyama, Masatoshi Matsunami, Minako Imamura, Akihiro Yoshida, Azeem Javed, Xiaoxi Liu, Ryosuke Kimura, Koichi Matsuda, Takayuki Morisaki, Yukinori Okada, Yoichiro Kamatani, Kaori Muto, Akiko Nagai, Yoji Sagiya, Natsuhiko Kumasaka, Yoichi Furukawa, Yuji Yamanashi, Yoshinori Murakami, Yusuke Nakamura, Wataru Obara, Ken Yamaji, Kazuhisa Takahashi, Satoshi Asai, Yasuo Takahashi, Shinichi Higashiue, Shuzo Kobayashi, Hiroki Yamaguchi, Yasunobu Nagata, Satoshi Wakita, Chikako Nito, Yu-ki Iwasaki, Shigeo Murayama, Kozo Yoshimori, Yoshio Miki, Daisuke Obata, Masahiko Higashiyama, Akihide Masumoto, Yoshinobu Koga, Yukihiro Koretsune, Chikashi Terao, Shiro Maeda

Scientific Reports, 15(1), Feb 22, 2025, doi: 10.1038/s41598-025-90195-w

Mosaic loss of chromosome Y characterises late-onset rheumatoid arthritis and contrasting associations of polygenic risk score based on age at onset

Shunsuke Uchiyama, Yuki Ishikawa, Katsunori Ikari, Suguru Honda, Keiko Hikino, Eiichi Tanaka, Yoichiro Kamatani, Takahisa Gono, Giulio Genovese, Masataka Kuwana, Chikashi Terao

Annals of the Rheumatic Diseases, Feb, 2025, doi: 10.1016/j.ard.2025.01.034

Genomics yields biological and phenotypic insights into bipolar disorder.

Kevin S O'Connell, Maria Koromina, Tracey van der Veen, Toni Boltz, Friederike S David, Jessica Mei Kay Yang, Keng-Han Lin, Xin Wang, Jonathan R I Coleman, Brittany L Mitchell, Caroline C McGrouther, Aaditya V Rangan, Penelope A Lind, Elise Koch, Arvid Harder, Nadine Parker, Jaroslav Bendl, Kristina Adorjan, Esben Agerbo, Diego Albani, Silvia Alemany, Ney Alliey-Rodriguez, Thomas D Als, Till F M Andlauer, Anastasia Antoniou, Helga Ask, Nicholas Bass, Michael Bauer, Eva C Beins, Tim B Bigdeli, Carsten Bøcker Pedersen, Marco P Boks, Sigrid Børte, Rosa Bosch, Murielle Brum, Ben M Brumpton, Nathalie Brunkhorst-Kanaan, Monika Budde, Jonas Bybjerg-Grauholm, William Byerley, Judit Cabana-Domínguez, Murray J Cairns, Bernardo Carpiniello, Miquel Casas, Pablo Cervantes, Chris Chatzinakos, Hsi-Chung Chen, Tereza Clarence, Toni-Kim Clarke, Isabelle Claus, Brandon Coombes, Elizabeth C Corfield, Cristiana Cruceanu, Alfredo Cuellar-Barboza, Piotr M Czerski, Konstantinos Dafnas, Anders M Dale, Nina Dalkner, Franziska Degenhardt, J Raymond DePaulo, Srdjan Djurovic, Ole Kristian Drange, Valentina Escott-Price, Ayman H Fanous, Frederike T Fellendorf, I Nicol Ferrier, Liz Forty, Josef Frank, Oleksandr Frei, Nelson B Freimer, John F Fullard, Julie Garnham, Ian R Gizer, Scott D Gordon, Katherine Gordon-Smith, Tiffany A Greenwood, Jakob Grove, José Guzman-Parra, Tae Hyon Ha, Tim Hahn, Magnus Haraldsson, Martin Hautzinger, Alexandra Havdahl, Urs Heilbronner, Dennis Hellgren, Stefan Herms, Ian B Hickie, Per Hoffmann, Peter A Holmans, Ming-Chyi Huang, Masashi Ikeda, Stéphane Jamain, Jessica S Johnson, Lina Jonsson, Janos L Kalman, Yoichiro Kamatani, James L Kennedy, Euitae Kim, Jaeyoung Kim, Sarah Kittel-Schneider, James A Knowles, Manolis Kogevinas, Thorsten M Kranz, Kristi Krebs, Steven A Kushner, Catharina Lavebratt, Jacob Lawrence, Markus Leber, Heon-Jeong Lee, Calwing Liao, Susanne Lucae, Martin Lundberg, Donald J MacIntyre, Wolfgang Maier, Adam X Maihofer, Dolores Malaspina, Mirko Manchia, Eirini Maratou, Lina Martinsson, Manuel Mattheisen, Nathaniel W McGregor, Melvin G McInnis, James D McKay, Helena Medeiros, Andreas Meyer-Lindenberg, Vincent Millischer, Derek W Morris, Paraskevi Moutsatsou, Thomas W Mühleisen, Claire O'Donovan, Catherine M Olsen, Georgia Panagiotaropoulou, Sergi Papiol, Antonio F Pardiñas, Hye Youn Park, Amy Perry, Andrea Pfennig, Claudia Pisanu, James B Potash, Digby Quested, Mark H Rapaport, Eline J Regeer, John P Rice, Margarita Rivera, Eva C Schulte, Fanny Senner, Alexey Shadrin, Paul D Shilling, Engilbert Sigurdsson, Lisa Sindermann, Lea Sirignano, Dan Siskind, Claire Slaney, Laura G Sloofman, Olav B Smeland, Daniel J Smith, Janet L Sobell, Maria Soler Artigas, Dan J Stein, Frederike Stein, Mei-Hsin Su, Heejong Sung, Beata Świątkowska, Chikashi Terao, Markos Tesfaye, Martin Tesli, Thorgeir E Thorgeirsson, Jackson G Thorp, Claudio Toma, Leonardo Tondo, Paul A Tooney, Shih-Jen Tsai, Evangelia Eirini Tsermpini, Marquis P Vawter, Helmut Vedder, Annabel Vreeker, James T R Walters, Bendik S Winsvold, Stephanie H Witt, Hong-Hee Won, Robert Ye, Allan H Young, Peter P Zandi, Lea Zillich, Rolf Adolfsson, Martin Alda, Lars Alfredsson, Lena Backlund, Bernhard T Baune, Frank Bellivier, Susanne Bengesser, Wade H Berrettini, Joanna M Biernacka, Michael Boehnke, Anders D Børglum, Gerome Breen, Vaughan J Carr, Stanley Catts, Sven Cichon, Aiden Corvin, Nicholas Craddock, Udo Dannlowski, Dimitris Dikeos, Bruno Etain, Panagiotis Ferentinos, Mark Frye, Janice M Fullerton, Micha Gawlik, Elliot S Gershon, Fernando S Goes, Melissa J Green, Maria Grigoroiu-Serbanescu, Joanna Hauser, Frans A Henskens, Jens Hjerling-Leffler, David M Hougaard, Kristian Hveem, Nakao Iwata, Ian Jones, Lisa A Jones, René S Kahn, John R Kelsoe, Tilo Kircher, George Kirov, Po-Hsiu Kuo, Mikael Landén, Marion Leboyer, Qingqin S Li, Jolanta Lissowska, Christine Lochner, Carmel Loughland, Jurjen J Luykx, Nicholas G Martin, Carol A Mathews, Fermin Mayoral, Susan L McElroy, Andrew M McIntosh, Francis J McMahon, Sarah E Medland, Ingrid Melle, Lili Milani, Philip B Mitchell, Gunnar Morken, Ole Mors, Preben Bo Mortensen, Bertram Müller-Myhsok, Richard M Myers, Woojae Myung, Benjamin M Neale, Caroline M Nievergelt, Merete Nordentoft, Markus M Nöthen, John I Nurnberger, Michael C O'Donovan, Ketil J Oedegaard, Tomas Olsson, Michael J Owen, Sara A Paciga, Christos Pantelis, Carlos N Pato, Michele T Pato, George P Patrinos, Joanna M Pawlak, Josep Antoni Ramos-Quiroga, Andreas Reif, Eva Z Reininghaus, Marta Ribasés, Marcella Rietschel, Stephan Ripke, Guy A Rouleau, Panos Roussos, Takeo Saito, Ulrich Schall, Martin Schalling, Peter R Schofield, Thomas G Schulze, Laura J Scott, Rodney J Scott, Alessandro Serretti, Jordan W Smoller, Alessio Squassina, Eli A Stahl, Hreinn Stefansson, Kari Stefansson, Eystein Stordal, Fabian Streit, Patrick F Sullivan, Gustavo Turecki, Arne E Vaaler, Eduard Vieta, John B Vincent, Irwin D Waldman, Cynthia S Weickert, Thomas W Weickert, Thomas Werge, David C Whiteman, John-Anker Zwart, Howard J Edenberg, Andrew McQuillin, Andreas J Forstner, Niamh Mullins, Arianna Di Florio, Roel A Ophoff, Ole A Andreassen

Nature, Jan 22, 2025, doi: 10.1038/s41586-024-08468-9

202420 papers

Population-specific reference panel improves imputation quality for genome-wide association studies conducted on the Japanese population.

Jack Flanagan, Xiaoxi Liu, David Ortega-Reyes, Kohei Tomizuka, Nana Matoba, Masato Akiyama, Masaru Koido, Kazuyoshi Ishigaki, Kyota Ashikawa, Sadaaki Takata, MingYang Shi, Tomomi Aoi, Yukihide Momozawa, Kaoru Ito, Yoshinori Murakami, Koichi Matsuda, Yoichiro Kamatani, Andrew P Morris, Momoko Horikoshi, Chikashi Terao

Communications biology, 7(1), 1665, Dec 19, 2024, doi: 10.1038/s42003-024-07338-4

Cancer and disease profiles for PTEN pathogenic variants in Japanese population.

Yuki Kanazashi, Yoshiaki Usui, Yusuke Iwasaki, Shota Sasagawa, Mikiko Endo, Mitsuyo Yamaguchi, Todd A Johnson, Kazuhiro Maejima, Kouya Shiraishi, Takashi Kohno, Teruhiko Yoshida, Kokichi Sugano, Yoshinori Murakami, Yoichiro Kamatani, Naomichi Matsumoto, Koichi Matsuda, Yukihide Momozawa, Hidewaki Nakagawa

Journal of human genetics, Dec 12, 2024, doi: 10.1038/s10038-024-01311-z

Common and rare genetic variants predisposing females to unexplained recurrent pregnancy loss

Kyuto Sonehara, Yoshitaka Yano, Tatsuhiko Naito, Shinobu Goto, Hiroyuki Yoshihara, Takahiro Otani, Fumiko Ozawa, Tamao Kitaori, Yuji Yamanashi, Yoichi Furukawa, Yukinori Okada, Yoshinori Murakami, Yoichiro Kamatani, Kaori Muto, Akiko Nagai, Yusuke Nakamura, Wataru Obara, Ken Yamaji, Kazuhisa Takahashi, Satoshi Asai, Yasuo Takahashi, Shinichi Higashiue, Shuzo Kobayashi, Hiroki Yamaguchi, Yasunobu Nagata, Satoshi Wakita, Chikako Nito, Yu Ki Iwasaki, Shigeo Murayama, Kozo Yoshimori, Yoshio Miki, Daisuke Obata, Masahiko Higashiyama, Akihide Masumoto, Yoshinobu Koga, Yukihiro Koretsune, Koichi Matsuda, Takashi Nishiyama, Yukinori Okada, Mayumi Sugiura-Ogasawara

Nature Communications, 15(1), Dec, 2024, doi: 10.1038/s41467-024-49993-5

Polygenic risk score and lung adenocarcinoma risk among never-smokers by EGFR mutation status-a brief report.

Batel Blechter, Chao Agnes Hsiung, Xiaoyu Wang, Haoyu Zhang, Wei Jie Seow, Jianxin Shi, Nilanjan Chatterjee, Hee Nam Kim, Maria Pik Wong, Yun-Chul Hong, Jason Yy Wong, Juncheng Dai, H Dean Hosgood, Zhaoming Wang, I-Shou Chang, Jiyeon Choi, Jiucun Wang, Minsun Song, Wei Hu, Wei Zheng, Jin Hee Kim, Baosen Zhou, Demetrius Albanes, Min-Ho Shin, Lap Ping Chung, She-Juan An, Hong Zheng, Yasushi Yatabe, Xu-Chao Zhang, Young Tae Kim, Xiao-Ou Shu, Young-Chul Kim, Roel C H Vermeulen, Bryan A Bassig, Jiang Chang, James Chung Man Ho, Bu-Tian Ji, Michiaki Kubo, Yataro Daigo, Yukihide Momozawa, Yoichiro Kamatani, Takayuki Honda, Hideo Kunitoh, Shun-Ichi Watanabe, Yohei Miyagi, Haruhiko Nakayama, Shingo Matsumoto, Masahiro Tsuboi, Koichi Goto, Zhihua Yin, Atsushi Takahashi, Akiteru Goto, Yoshihiro Minamiya, Kimihiro Shimizu, Kazumi Tanaka, Tangchun Wu, Fusheng Wei, Jian Su, Yeul Hong Kim, In-Jae Oh, Victor Ho Fun Lee, Wu-Chou Su, Yuh-Min Chen, Gee-Chen Chang, Kuan-Yu Chen, Ming-Shyan Huang, Hsien-Chih Lin, Adeline Seow, Jae Yong Park, Sun-Seog Kweon, Chien-Jen Chen, Yu-Tang Gao, Chen Wu, Biyun Qian, Daru Lu, Jianjun Liu, Hyo-Sung Jeon, Chin-Fu Hsiao, Jae Sook Sung, Ying-Huang Tsai, Yoo Jin Jung, Huan Guo, Zhibin Hu, Tzu-Yu Chen, Laurie Burdett, Meredith Yeager, Amy Hutchinson, Sonja I Berndt, Wei Wu, Junwen Wang, Jin Eun Choi, Kyong Hwa Park, Sook Whan Sung, Li Liu, Chang Hyun Kang, Chung-Hsing Chen, Jun Xu, Peng Guan, Wen Tan, Chih-Liang Wang, Alan Dart Loon Sihoe, Ying Chen, Yi Young Choi, Jun Suk Kim, Ho-Il Yoon, Qiuyin Cai, In Kyu Park, Ping Xu, Qincheng He, Chih-Yi Chen, Junjie Wu, Wei-Yen Lim, Kun-Chieh Chen, John K C Chan, Jihua Li, Hongyan Chen, Chong-Jen Yu, Li Jin, Joseph F Fraumeni Jr, Jie Liu, Maria Teresa Landi, Taiki Yamaji, Yang Yang, Belynda Hicks, Kathleen Wyatt, Shengchao A Li, Hongxia Ma, Bao Song, Zhehai Wang, Sensen Cheng, Xuelian Li, Yangwu Ren, Motoki Iwasaki, Junjie Zhu, Gening Jiang, Ke Fei, Guoping Wu, Li-Hsin Chien, Fang-Yu Tsai, Jinming Yu, Victoria L Stevens, Pan-Chyr Yang, Dongxin Lin, Kexin Chen, Yi-Long Wu, Keitaro Matsuo, Nathaniel Rothman, Kouya Shiraishi, Hongbing Shen, Stephen J Chanock, Takashi Kohno, Qing Lan

Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer, Nov 22, 2024, doi: 10.1016/j.jtho.2024.11.019

Genome-wide analysis of heart failure yields insights into disease heterogeneity and enables prognostic prediction in the Japanese population

Nobuyuki Enzan, Kazuo Miyazawa, Satoshi Koyama, Ryo Kurosawa, Hirotaka Ieki, Hiroki Yoshida, Fumie Takechi, Masashi Fukuyama, Ryosuke Osako, Kohei Tomizuka, Xiaoxi Liu, Kouichi Ozaki, Yoshihiro Onouchi, Koichi Matsuda, Yukihide Momozawa, Hiroyuki Aburatani, Yoichiro Kamatani, Takanori Yamaguchi, Akazawa Hiroshi, Koichi Node, Patrick T. Ellinor, Michael G. Levin, Scott M. Damrauer, Benjamin F. Voight, Jacob Joseph, Yan V. Sun, Chikashi Terao, Toshiharu Ninomiya, Issei Komuro, Kaoru Ito

Nov 15, 2024, doi: 10.1101/2024.11.14.24317249

Stratifying Lung Adenocarcinoma Risk with Multi-ancestry Polygenic Risk Scores in East Asian Never-Smokers.

Batel Blechter, Xiaoyu Wang, Jianxin Shi, Kouya Shiraishi, Jiyeon Choi, Keitaro Matsuo, Tzu-Yu Chen, Juncheng Dai, Rayjean J Hung, Kexin Chen, Xiao-Ou Shu, Young Tae Kim, Parichoy Pal Choudhury, Jacob Williams, Maria Teresa Landi, Dongxin Lin, Wei Zheng, Zhihua Yin, Baosen Zhou, Jiucun Wang, Wei Jie Seow, Lei Song, I-Shou Chang, Wei Hu, Li-Hsin Chien, Qiuyin Cai, Yun-Chul Hong, Hee Nam Kim, Yi-Long Wu, Maria Pik Wong, Brian Douglas Richardson, Shilan Li, Tongwu Zhang, Charles Breeze, Zhaoming Wang, Bryan A Bassig, Jin Hee Kim, Demetrius Albanes, Jason Yy Wong, Min-Ho Shin, Lap Ping Chung, Yang Yang, She-Juan An, Hong Zheng, Yasushi Yatabe, Xu-Chao Zhang, Young-Chul Kim, Neil E Caporaso, Jiang Chang, James Chung Man Ho, Michiaki Kubo, Yataro Daigo, Minsun Song, Yukihide Momozawa, Yoichiro Kamatani, Masashi Kobayashi, Kenichi Okubo, Takayuki Honda, H Dean Hosgood, Hideo Kunitoh, Shun-Ichi Watanabe, Yohei Miyagi, Haruhiko Nakayama, Shingo Matsumoto, Hidehito Horinouchi, Masahiro Tsuboi, Ryuji Hamamoto, Koichi Goto, Yuichiro Ohe, Atsushi Takahashi, Akiteru Goto, Yoshihiro Minamiya, Megumi Hara, Yuichiro Nishida, Kenji Takeuchi, Kenji Wakai, Koichi Matsuda, Yoshinori Murakami, Kimihiro Shimizu, Hiroyuki Suzuki, Motonobu Saito, Yoichi Ohtaki, Kazumi Tanaka, Tangchun Wu, Fusheng Wei, Hongji Dai, Mitchell J Machiela, Jian Su, Yeul Hong Kim, In-Jae Oh, Victor Ho Fun Lee, Gee-Chen Chang, Ying-Huang Tsai, Kuan-Yu Che, Ming-Shyan Huang, Wu-Chou Su, Yuh-Min Chen, Adeline Seow, Jae Yong Park, Sun-Seog Kweon, Kun-Chieh Chen, Yu-Tang Gao, Biyun Qian, Chen Wu, Daru Lu, Jianjun Liu, Ann G Schwartz, Richard Houlston, Margaret R Spitz, Ivan P Gorlov, Xifeng Wu, Ping Yang, Stephen Lam, Adonina Tardon, Chu Chen, Stig E Bojesen, Mattias Johansson, Angela Risch, Heike Bickeböller, Bu-Tian Ji, H-Erich Wichmann, David C Christiani, Gadi Rennert, Susanne Arnold, Paul Brennan, James McKay, John K Field, Michael P A Davies, Sanjay S Shete, Loic Le Marchand, Geoffrey Liu, Angeline Andrew, Lambertus A Kiemeney, Shan Zienolddiny-Narui, Kjell Grankvist, Mikael Johansson, Angela Cox, Fiona Taylor, Jian-Min Yuan, Philip Lazarus, Matthew B Schabath, Melinda C Aldrich, Hyo-Sung Jeon, Shih Sheng Jiang, Jae Sook Sung, Chung-Hsing Chen, Chin-Fu Hsiao, Yoo Jin Jung, Huan Guo, Zhibin Hu, Laurie Burdett, Meredith Yeager, Amy Hutchinson, Belynda Hicks, Jia Liu, Bin Zhu, Sonja I Berndt, Wei Wu, Junwen Wang, Yuqing Li, Jin Eun Choi, Kyong Hwa Park, Sook Whan Sung, Li Liu, Chang Hyun Kang, Wen-Chang Wang, Jun Xu, Peng Guan, Wen Tan, Chong-Jen Yu, Gong Yang, Alan Dart Loon Sihoe, Ying Chen, Yi Young Choi, Jun Suk Kim, Ho-Il Yoon, In Kyu Park, Ping Xu, Qincheng He, Chih-Liang Wang, Hsiao-Han Hung, Roel C H Vermeulen, Iona Cheng, Junjie Wu, Wei-Yen Lim, Fang-Yu Tsai, John K C Chan, Jihua Li, Hongyan Chen, Hsien-Chih Lin, Li Jin, Jie Liu, Norie Sawada, Taiki Yamaji, Kathleen Wyatt, Shengchao A Li, Hongxia Ma, Meng Zhu, Zhehai Wang, Sensen Cheng, Xuelian Li, Yangwu Ren, Ann Chao, Motoki Iwasaki, Junjie Zhu, Gening Jiang, Ke Fei, Guoping Wu, Chih-Yi Chen, Chien-Jen Chen, Pan-Chyr Yang, Jinming Yu, Victoria L Stevens, Joseph F Fraumeni, Nilanjan Chatterjee, Olga Y Gorlova, Christopher I Amos, Hongbing Shen, Chao Agnes Hsiung, Stephen J Chanock, Nathaniel Rothman, Takashi Kohno, Qing Lan, Haoyu Zhang

medRxiv : the preprint server for health sciences, Nov 6, 2024, doi: 10.1101/2024.06.26.24309127

Genome-wide association studies for pelvic organ prolapse in the Japanese population

Masatoshi Matsunami, Minako Imamura, Asuka Ashikari, Xiaoxi Liu, Kohei Tomizuka, Keiko Hikino, Kosei Miwa, Katsumi Kadekawa, Tetsuji Suda, Takayuki Morisaki, Yukinori Okada, Yoichiro Kamatani, Kaori Muto, Akiko Nagai, Yoji Sagiya, Natsuhiko Kumasaka, Yoichi Furukawa, Yuji Yamanashi, Yoshinori Murakami, Yusuke Nakamura, Wataru Obara, Ken Yamaji, Kazuhisa Takahash, Satoshi Asai, Yasuo Takahashi, Shinichi Higashiue, Shuzo Kobayashi, Hiroki Yamaguchi, Yasunobu Nagata, Satoshi Wakita, Chikako Nito, Yu-ki Iwasaki, Shigeo Murayama, Kozo Yoshimori, Yoshio Miki, Daisuke Obata, Masahiko Higashiyama, Akihide Masumoto, Yoshinobu Koga, Yukihiro Koretsune, Koichi Matsuda, Minoru Miyazato, Chikashi Terao, Shiro Maeda

Communications Biology, 7(1), Sep 30, 2024, doi: 10.1038/s42003-024-06875-2

Causal relevance of different blood pressure traits on risk of cardiovascular diseases: GWAS and Mendelian randomisation in 100,000 Chinese adults

Alfred Pozarickij, Wei Gan, Kuang Lin, Robert Clarke, Zammy Fairhurst-Hunter, Masaru Koido, Masahiro Kanai, Yukinori Okada, Yoichiro Kamatani, Derrick Bennett, Huaidong Du, Yiping Chen, Ling Yang, Daniel Avery, Yu Guo, Min Yu, Canqing Yu, Dan Schmidt Valle, Jun Lv, Junshi Chen, Richard Peto, Rory Collins, Liming Li, Zhengming Chen, Iona Y. Millwood, Robin G. Walters

Nature Communications, 15(1), Jul 24, 2024, doi: 10.1038/s41467-024-50297-x

Genetic Risk Stratification of Primary Open-Angle Glaucoma in Japanese Individuals.

Masato Akiyama, Gen Tamiya, Kohta Fujiwara, Yukihiro Shiga, Yu Yokoyama, Kazuki Hashimoto, Masataka Sato, Kota Sato, Akira Narita, Sawako Hashimoto, Emi Ueda, Yoshihiko Furuta, Jun Hata, Masahiro Miyake, Hanako O Ikeda, Kenji Suda, Shogo Numa, Yuki Mori, Kazuya Morino, Yusuke Murakami, Sakurako Shimokawa, Shun Nakamura, Nobuyo Yawata, Kimihiko Fujisawa, Satoshi Yamana, Kenichiro Mori, Yasuhiro Ikeda, Kazunori Miyata, Keisuke Mori, Ken Ogino, Yoshito Koyanagi, Yoichiro Kamatani, Toshiharu Ninomiya, Koh-Hei Sonoda, Toru Nakazawa

Ophthalmology, Jul 17, 2024, doi: 10.1016/j.ophtha.2024.05.026

Identification of epistatic SNP combinations in rheumatoid arthritis using LAMPLINK and Japanese cohorts.

Mio Shibata, Aika Terada, Takahisa Kawaguchi, Yoichiro Kamatani, Daigo Okada, Kazuhisa Nagashima, Koichiro Ohmura, Fumihiko Matsuda, Shuji Kawaguchi, Jun Sese, Ryo Yamada

Journal of human genetics, Jul 16, 2024, doi: 10.1038/s10038-024-01269-y

Proteogenomics in cerebrospinal fluid and plasma reveals new biological fingerprint of cerebral small vessel disease

Stephanie Debette, Ilana Caro, Daniel Western, Shinichi Namba, Na Sun, Shuji Kawaguchi, Yunye He, Masashi Fujita, Gennady Roshchupkin, Tim D'Aoust, Marie-Gabrielle Duperron, Murali Sargurupremraj, Ami Tsuchida, Masaru Koido, Marziehsadat Ahmadi, Chengran Yang, Jigyasha Timsina, Laura Ibanez, Koichi Matsuda, Yutaka Suzuki, Yoshiya Oda, Akinori Kanai, Pouria Jandaghi, Hans Markus Munter, Dan Auld, Iana Astafeva, Raquel Puerta, Jerome Rotter, Bruce Psaty, Joshua Bis, Will Longstreth, Thierry Couffinhal, Pablo Garcia-Gonzalez, Vanesa Pytel, Marta Marquié, Amanda Cano, Mercè Boada, Marc Joliot, Mark Lathrop, Quentin Le Grand, Lenore Launer, Joanna Wardlaw, Myriam Heiman, Agustin Ruiz, Paul Matthews, Sudha Seshadri, Myriam Fornage, Hieab Adams, Aniket Mishra, David-Alexandre Trégouët, Yukinori Okada, Manolis Kellis, Philip De Jager, Christophe Tzourio, Yoichiro Kamatani, Fumihiko Matsuda, Carlos Cruchaga

Jul 2, 2024, doi: 10.21203/rs.3.rs-4535534/v1

RNF213 Variants, Vasospastic Angina, and Risk of Fatal Myocardial Infarction.

Keiko Hikino, Satoshi Koyama, Kaoru Ito, Yoshinao Koike, Masaru Koido, Takayoshi Matsumura, Ryo Kurosawa, Kohei Tomizuka, Shuji Ito, Xiaoxi Liu, Yuki Ishikawa, Yukihide Momozawa, Takayuki Morisaki, Yoichiro Kamatani, Taisei Mushiroda, Chikashi Terao

JAMA cardiology, Jun 18, 2024, doi: 10.1001/jamacardio.2024.1483

Body mass index stratification optimizes polygenic prediction of type 2 diabetes in cross-biobank analyses

Takafumi Ojima, Shinichi Namba, Ken Suzuki, Kenichi Yamamoto, Kyuto Sonehara, Akira Narita, Yoichiro Kamatani, Gen Tamiya, Masayuki Yamamoto, Toshimasa Yamauchi, Takashi Kadowaki, Yukinori Okada

Nature Genetics, Jun 11, 2024, doi: 10.1038/s41588-024-01782-y

Genome-Wide Association Study with Three Control Cohorts of Japanese Patients with Esotropia and Exotropia of Comitant Strabismus and Idiopathic Superior Oblique Muscle Palsy

Toshihiko Matsuo, Ichiro Hamasaki, Yoichiro Kamatani, Takahisa Kawaguchi, Izumi Yamaguchi, Fumihiko Matsuda, Akira Saito, Kazuyuki Nakazono, Shigeo Kamitsuji

International Journal of Molecular Sciences, 25(6986), 1-25, Jun, 2024, doi: 10.3390/ijms25136986

Protocol for genome-wide association study of human blood metabolites

Takeshi Iwasaki, Yoichiro Kamatani, Kazuhiro Sonomura, Shuji Kawaguchi, Fumihiko Matsuda

STAR Protocols, 5(2), 103052, Jun, 2024, doi: 10.1016/j.xpro.2024.103052

Genetically proxied HTRA1 protease activity and circulating levels independently predict risk of ischemic stroke and coronary artery disease

Rainer Malik, Nathalie Beaufor, Jiang Li, Koki Tanaka, Marios Georgakis, Yunye He, Masaru Koido, Chikashi Terao, Christopher Anderson, Yoichiro Kamatani, Martin Dichgans

Nature Cardiovascular Research, 3, 701-713, May 20, 2024

Genetic variants for head size share genes and pathways with cancer.

Maria J Knol, Raymond A Poot, Tavia E Evans, Claudia L Satizabal, Aniket Mishra, Muralidharan Sargurupremraj, Sandra van der Auwera, Marie-Gabrielle Duperron, Xueqiu Jian, Isabel C Hostettler, Dianne H K van Dam-Nolen, Sander Lamballais, Mikolaj A Pawlak, Cora E Lewis, Amaia Carrion-Castillo, Theo G M van Erp, Céline S Reinbold, Jean Shin, Markus Scholz, Asta K Håberg, Anders Kämpe, Gloria H Y Li, Reut Avinun, Joshua R Atkins, Fang-Chi Hsu, Alyssa R Amod, Max Lam, Ami Tsuchida, Mariël W A Teunissen, Nil Aygün, Yash Patel, Dan Liang, Alexa S Beiser, Frauke Beyer, Joshua C Bis, Daniel Bos, R Nick Bryan, Robin Bülow, Svenja Caspers, Gwenaëlle Catheline, Charlotte A M Cecil, Shareefa Dalvie, Jean-François Dartigues, Charles DeCarli, Maria Enlund-Cerullo, Judith M Ford, Barbara Franke, Barry I Freedman, Nele Friedrich, Melissa J Green, Simon Haworth, Catherine Helmer, Per Hoffmann, Georg Homuth, M Kamran Ikram, Clifford R Jack Jr, Neda Jahanshad, Christiane Jockwitz, Yoichiro Kamatani, Annchen R Knodt, Shuo Li, Keane Lim, W T Longstreth, Fabio Macciardi, Outi Mäkitie, Bernard Mazoyer, Sarah E Medland, Susumu Miyamoto, Susanne Moebus, Thomas H Mosley, Ryan Muetzel, Thomas W Mühleisen, Manabu Nagata, Soichiro Nakahara, Nicholette D Palmer, Zdenka Pausova, Adrian Preda, Yann Quidé, William R Reay, Gennady V Roshchupkin, Reinhold Schmidt, Pamela J Schreiner, Kazuya Setoh, Chin Yang Shapland, Stephen Sidney, Beate St Pourcain, Jason L Stein, Yasuharu Tabara, Alexander Teumer, Anne Uhlmann, Aad van der Lugt, Meike W Vernooij, David J Werring, B Gwen Windham, A Veronica Witte, Katharina Wittfeld, Qiong Yang, Kazumichi Yoshida, Han G Brunner, Quentin Le Grand, Kang Sim, Dan J Stein, Donald W Bowden, Murray J Cairns, Ahmad R Hariri, Ching-Lung Cheung, Sture Andersson, Arno Villringer, Tomas Paus, Sven Cichon, Vince D Calhoun, Fabrice Crivello, Lenore J Launer, Tonya White, Peter J Koudstaal, Henry Houlden, Myriam Fornage, Fumihiko Matsuda, Hans J Grabe, M Arfan Ikram, Stéphanie Debette, Paul M Thompson, Sudha Seshadri, Hieab H H Adams

Cell reports. Medicine, 101529, May 3, 2024, doi: 10.1016/j.xcrm.2024.101529

Decoding triancestral origins, archaic introgression, and natural selection in the Japanese population by whole-genome sequencing.

Xiaoxi Liu, Satoshi Koyama, Kohei Tomizuka, Sadaaki Takata, Yuki Ishikawa, Shuji Ito, Shunichi Kosugi, Kunihiko Suzuki, Keiko Hikino, Masaru Koido, Yoshinao Koike, Momoko Horikoshi, Takashi Gakuhari, Shiro Ikegawa, Kochi Matsuda, Yukihide Momozawa, Kaoru Ito, Yoichiro Kamatani, Chikashi Terao

Science advances, 10(16), eadi8419, Apr 19, 2024, doi: 10.1126/sciadv.adi8419

Poor accuracy and sustainability of the first‐step FIB4 EASL pathway for stratifying steatotic liver disease risk in the general population

Antonio De Vincentis, Federica Tavaglione, Shinichi Namba, Masahiro Kanai, Yukinori Okada, Yoichiro Kamatani, Samantha Maurotti, Claudio Pedone, Raffaele Antonelli Incalzi, Luca Valenti, Stefano Romeo, Umberto Vespasiani‐Gentilucci

Alimentary Pharmacology & Therapeutics, Mar 18, 2024, doi: 10.1111/apt.17953

X-chromosome and kidney function: evidence from a multi-trait genetic analysis of 908,697 individuals reveals sex-specific and sex-differential findings in genes regulated by androgen response elements

Markus Scholz, Katrin Horn, Janne Pott, Matthias Wuttke, Andreas Kühnapfel, M. Kamal Nasr, Holger Kirsten, Yong Li, Anselm Hoppmann, Mathias Gorski, Sahar Ghasemi, Man Li, Adrienne Tin, Jin-Fang Chai, Massimiliano Cocca, Judy Wang, Teresa Nutile, Masato Akiyama, Bjørn Olav Åsvold, Nisha Bansal, Mary L. Biggs, Thibaud Boutin, Hermann Brenner, Ben Brumpton, Ralph Burkhardt, Jianwen Cai, Archie Campbell, Harry Campbell, John Chalmers, Daniel I. Chasman, Miao Ling Chee, Miao Li Chee, Xu Chen, Ching-Yu Cheng, Renata Cifkova, Martha Daviglus, Graciela Delgado, Katalin Dittrich, Todd L. Edwards, Karlhans Endlich, J. Michael Gaziano, Ayush Giri, Franco Giulianini, Scott D. Gordon, Daniel F. Gudbjartsson, Stein Hallan, Pavel Hamet, Catharina A. Hartman, Caroline Hayward, Iris M. Heid, Jacklyn N. Hellwege, Bernd Holleczek, Hilma Holm, Nina Hutri-Kähönen, Kristian Hveem, Berend Isermann, Jost B. Jonas, Peter K. Joshi, Yoichiro Kamatani, Masahiro Kanai, Mika Kastarinen, Chiea Chuen Khor, Wieland Kiess, Marcus E. Kleber, Antje Körner, Peter Kovacs, Alena Krajcoviechova, Holly Kramer, Bernhard K. Krämer, Mikko Kuokkanen, Mika Kähönen, Leslie A. Lange, James P. Lash, Terho Lehtimäki, Hengtong Li, Bridget M. Lin, Jianjun Liu, Markus Loeffler, Leo-Pekka Lyytikäinen, Patrik K. E. Magnusson, Nicholas G. Martin, Koichi Matsuda, Yuri Milaneschi, Pashupati P. Mishra, Nina Mononen, Grant W. Montgomery, Dennis O. Mook-Kanamori, Josyf C. Mychaleckyj, Winfried März, Matthias Nauck, Kjell Nikus, Ilja M. Nolte, Raymond Noordam, Yukinori Okada, Isleifur Olafsson, Albertine J. Oldehinkel, Brenda W. J. H. Penninx, Markus Perola, Nicola Pirastu, Ozren Polasek, David J. Porteous, Tanja Poulain, Bruce M. Psaty, Ton J. Rabelink, Laura M. Raffield, Olli T. Raitakari, Humaira Rasheed, Dermot F. Reilly, Kenneth M. Rice, Anne Richmond, Paul M. Ridker, Jerome I. Rotter, Igor Rudan, Charumathi Sabanayagam, Veikko Salomaa, Neil Schneiderman, Ben Schöttker, Mario Sims, Harold Snieder, Klaus J. Stark, Kari Stefansson, Hannah Stocker, Michael Stumvoll, Patrick Sulem, Gardar Sveinbjornsson, Per O. Svensson, E-Shyong Tai, Kent D. Taylor, Bamidele O. Tayo, Andrej Teren, Yih-Chung Tham, Joachim Thiery, Chris H. L. Thio, Laurent F. Thomas, Johanne Tremblay, Anke Tönjes, Peter J. van der Most, Veronique Vitart, Uwe Völker, Ya Xing Wang, Chaolong Wang, Wen Bin Wei, John B. Whitfield, Sarah H. Wild, James F. Wilson, Thomas W. Winkler, Tien-Yin Wong, Mark Woodward, Xueling Sim, Audrey Y. Chu, Mary F. Feitosa, Unnur Thorsteinsdottir, Adriana M. Hung, Alexander Teumer, Nora Franceschini, Afshin Parsa, Anna Köttgen, Pascal Schlosser, Cristian Pattaro

Nature Communications, 15(1), Jan 18, 2024, doi: 10.1038/s41467-024-44709-1

202330 papers

Characterizing prostate cancer risk through multi-ancestry genome-wide discovery of 187 novel risk variants

Anqi Wang, Jiayi Shen, Alex A. Rodriguez, Edward J. Saunders, Fei Chen, Rohini Janivara, Burcu F. Darst, Xin Sheng, Yili Xu, Alisha J. Chou, Sara Benlloch, Tokhir Dadaev, Mark N. Brook, Anna Plym, Ali Sahimi, Thomas J. Hoffman, Atushi Takahashi, Koichi Matsuda, Yukihide Momozawa, Masashi Fujita, Triin Laisk, Jéssica Figuerêdo, Kenneth Muir, Shuji Ito, Xiaoxi Liu, Yuji Yamanashi, Yoichi Furukawa, Takayuki Morisaki, Yoshinori Murakami, Kaori Muto, Akiko Nagai, Wataru Obara, Ken Yamaji, Kazuhisa Takahashi, Satoshi Asai, Yasuo Takahashi, Takao Suzuki, Nobuaki Sinozaki, Hiroki Yamaguchi, Shiro Minami, Shigeo Murayama, Kozo Yoshimori, Satoshi Nagayama, Daisuke Obata, Masahiko Higashiyama, Akihide Masumoto, Yukihiro Koretsune, Yuji Uchio, Michiaki Kubo, Yoichiro Kamatani, Artitaya Lophatananon, Peggy Wan, Caroline Andrews, Adriana Lori, Parichoy P. Choudhury, Johanna Schleutker, Teuvo L.J. Tammela, Csilla Sipeky, Anssi Auvinen, Graham G. Giles, Melissa C. Southey, Robert J. MacInnis, Cezary Cybulski, Dominika Wokolorczyk, Jan Lubinski, Christopher T. Rentsch, Kelly Cho, Benjamin H. Mcmahon, David E. Neal, Jenny L. Donovan, Freddie C. Hamdy, Richard M. Martin, Borge G. Nordestgaard, Sune F. Nielsen, Maren Weischer, Stig E. Bojesen, Andreas Røder, Hein V. Stroomberg, Jyotsna Batra, Suzanne Chambers, Lisa Horvath, Judith A. Clements, Wayne Tilly, Gail P. Risbridger, Henrik Gronberg, Markus Aly, Robert Szulkin, Martin Eklund, Tobias Nordstrom, Nora Pashayan, Alison M. Dunning, Maya Ghoussaini, Ruth C. Travis, Tim J. Key, Elio Riboli, Jong Y. Park, Thomas A. Sellers, Hui Yi Lin, Demetrius Albanes, Stephanie Weinstein

Nature Genetics, 55(12), 2065-2074, Dec, 2023, doi: 10.1038/s41588-023-01534-4

Pan-cancer and cross-population genome-wide association studies dissect shared genetic backgrounds underlying carcinogenesis

Go Sato, Yuya Shirai, Shinichi Namba, Ryuya Edahiro, Kyuto Sonehara, Tsuyoshi Hata, Mamoru Uemura, Yuji Yamanashi, Yoichi Furukawa, Takayuki Morisaki, Yoshinori Murakami, Yoichiro Kamatani, Kaori Muto, Akiko Nagai, Wataru Obara, Ken Yamaji, Kazuhisa Takahashi, Satoshi Asai, Yasuo Takahashi, Takao Suzuki, Nobuaki Sinozaki, Hiroki Yamaguchi, Shiro Minami, Shigeo Murayama, Kozo Yoshimori, Satoshi Nagayama, Daisuke Obata, Masahiko Higashiyama, Akihide Masumoto, Yukihiro Koretsune, Koichi Matsuda, Yuichiro Doki, Hidetoshi Eguchi, Yukinori Okada

Nature Communications, 14(1), Dec, 2023, doi: 10.1038/s41467-023-39136-7

East Asian-specific and cross-ancestry genome-wide meta-analyses provide mechanistic insights into peptic ulcer disease

Yunye He, Masaru Koido, Yoichi Sutoh, Mingyang Shi, Yayoi Otsuka-Yamasaki, Hans Markus Munter, Takayuki Morisaki, Akiko Nagai, Yoshinori Murakami, Chizu Tanikawa, Tsuyoshi Hachiya, Koichi Matsuda, Atsushi Shimizu, Yoichiro Kamatani

Nature Genetics, 55(12), 2129-2138, Nov 30, 2023, doi: 10.1038/s41588-023-01569-7

A large-scale microRNA transcriptome-wide association study identifies two susceptibility microRNAs, miR-1307-5p and miR-192-3p, for colorectal cancer risk.

Zhishan Chen, Weiqiang Lin, Qiuyin Cai, Sun-Seog Kweon, Xiao-Ou Shu, Chizu Tanikawa, Wei-Hua Jia, Ying Wang, Xinwan Su, Yuan Yuan, Wanqing Wen, Jeongseon Kim, Aesun Shin, Sun Ha Jee, Keitaro Matsuo, Dong-Hyun Kim, Nan Wang, Jie Ping, Min-Ho Shin, Zefang Ren, Jae Hwan Oh, Isao Oze, Yoon-Ok Ahn, Keum Ji Jung, Yu-Tang Gao, Zhi-Zhong Pan, Yoichiro Kamatani, Weidong Han, Jirong Long, Koichi Matsuda, Wei Zheng, Xingyi Guo

Human molecular genetics, Oct 30, 2023, doi: 10.1093/hmg/ddad185

Identification of telomere maintenance gene variations related to lung adenocarcinoma risk by genome‐wide association and whole genome sequencing analyses

Kouya Shiraishi, Atsushi Takahashi, Yukihide Momozawa, Yataro Daigo, Syuzo Kaneko, Takahisa Kawaguchi, Hideo Kunitoh, Shingo Matsumoto, Hidehito Horinouchi, Akiteru Goto, Takayuki Honda, Kimihiro Shimizu, Masahiro Torasawa, Daisuke Takayanagi, Motonobu Saito, Akira Saito, Yuichiro Ohe, Shun‐ichi Watanabe, Koichi Goto, Masahiro Tsuboi, Katsuya Tsuchihara, Sadaaki Takata, Tomomi Aoi, Atsushi Takano, Masashi Kobayashi, Yohei Miyagi, Kazumi Tanaka, Hiroyuki Suzuki, Daichi Maeda, Takumi Yamaura, Maiko Matsuda, Yoko Shimada, Takaaki Mizuno, Hiromi Sakamoto, Teruhiko Yoshida, Yasushi Goto, Tatsuya Yoshida, Taiki Yamaji, Makoto Sonobe, Shinichi Toyooka, Kazue Yoneda, Katsuhiro Masago, Fumihiro Tanaka, Megumi Hara, Nobuo Fuse, Satoshi S. Nishizuka, Noriko Motoi, Norie Sawada, Yuichiro Nishida, Kazuki Kumada, Kenji Takeuchi, Kozo Tanno, Yasushi Yatabe, Kuniko Sunami, Tomoyuki Hishida, Yasunari Miyazaki, Hidemi Ito, Mitsuhiro Amemiya, Hirohiko Totsuka, Haruhiko Nakayama, Tomoyuki Yokose, Kazuyoshi Ishigaki, Toshiteru Nagashima, Yoichi Ohtaki, Kazuhiro Imai, Ken Takasawa, Yoshihiro Minamiya, Kazuma Kobayashi, Kenichi Okubo, Kenji Wakai, Atsushi Shimizu, Masayuki Yamamoto, Motoki Iwasaki, Koichi Matsuda, Johji Inazawa, Yuichi Shiraishi, Hiroyoshi Nishikawa, Yoshinori Murakami, Michiaki Kubo, Fumihiko Matsuda, Yoichiro Kamatani, Ryuji Hamamoto, Keitaro Matsuo, Takashi Kohno

Cancer Communications, Oct 26, 2023, doi: 10.1002/cac2.12498

Boosting the power of genome-wide association studies within and across ancestries by using polygenic scores

Adrian I. Campos, Shinichi Namba, Shu-Chin Lin, Kisung Nam, Julia Sidorenko, Huanwei Wang, Yoichiro Kamatani, Ling-Hua Wang, Seunggeun Lee, Yen-Feng Lin, Yen-Chen Anne Feng, Yukinori Okada, Peter M. Visscher, Loic Yengo

Nature Genetics, 55(10), 1769-1776, Sep 18, 2023, doi: 10.1038/s41588-023-01500-0

GWAS meta-analysis of over 29,000 people with epilepsy identifies 26 risk loci and subtype-specific genetic architecture

Remi Stevelink, Ciarán Campbell, Siwei Chen, Bassel Abou-Khalil, Oluyomi M. Adesoji, Zaid Afawi, Elisabetta Amadori, Alison Anderson, Joseph Anderson, Danielle M. Andrade, Grazia Annesi, Pauls Auce, Andreja Avbersek, Melanie Bahlo, Mark D. Baker, Ganna Balagura, Simona Balestrini, Carmen Barba, Karen Barboza, Fabrice Bartolomei, Thomas Bast, Larry Baum, Tobias Baumgartner, Betül Baykan, Nerses Bebek, Albert J. Becker, Felicitas Becker, Caitlin A. Bennett, Bianca Berghuis, Samuel F. Berkovic, Ahmad Beydoun, Claudia Bianchini, Francesca Bisulli, Ilan Blatt, Dheeraj R. Bobbili, Ingo Borggraefe, Christian Bosselmann, Vera Braatz, Jonathan P. Bradfield, Knut Brockmann, Lawrence C. Brody, Russell J. Buono, Robyn M. Busch, Hande Caglayan, Ellen Campbell, Laura Canafoglia, Christina Canavati, Gregory D. Cascino, Barbara Castellotti, Claudia B. Catarino, Gianpiero L. Cavalleri, Felecia Cerrato, Francine Chassoux, Stacey S. Cherny, Ching-Lung Cheung, Krishna Chinthapalli, I-Jun Chou, Seo-Kyung Chung, Claire Churchhouse, Peggy O. Clark, Andrew J. Cole, Alastair Compston, Antonietta Coppola, Mahgenn Cosico, Patrick Cossette, John J. Craig, Caroline Cusick, Mark J. Daly, Lea K. Davis, Gerrit-Jan de Haan, Norman Delanty, Chantal Depondt, Philippe Derambure, Orrin Devinsky, Lidia Di Vito, Dennis J. Dlugos, Viola Doccini, Colin P. Doherty, Hany El-Naggar, Christian E. Elger, Colin A. Ellis, Johan G. Eriksson, Annika Faucon, Yen-Chen A. Feng, Lisa Ferguson, Thomas N. Ferraro, Lorenzo Ferri, Martha Feucht, Mark Fitzgerald, Beata Fonferko-Shadrach, Francesco Fortunato, Silvana Franceschetti, Andre Franke, Jacqueline A. French, Elena Freri, Monica Gagliardi, Antonio Gambardella, Eric B. Geller, Tania Giangregorio, Leif Gjerstad, Tracy Glauser, Ethan Goldberg, Alicia Goldman, Tiziana Granata, David A. Greenberg, Renzo Guerrini, Namrata Gupta, Kevin F. Haas, Hakon Hakonarson, Kerstin Hallmann, Emadeldin Hassanin, Manu Hegde, Erin L. Heinzen, Ingo Helbig, Christian Hengsbach, Henrike O. Heyne, Shinichi Hirose, Edouard Hirsch, Helle Hjalgrim, Daniel P. Howrigan, Donald Hucks, Po-Cheng Hung, Michele Iacomino, Lukas L. Imbach, Yushi Inoue, Atsushi Ishii, Jennifer Jamnadas-Khoda, Lara Jehi, Michael R. Johnson, Reetta Kälviäinen, Yoichiro Kamatani, Moien Kanaan, Masahiro Kanai, Anne-Mari Kantanen, Bülent Kara, Symon M. Kariuki, Dalia Kasperavičiūte, Dorothee Kasteleijn-Nolst Trenite, Mitsuhiro Kato, Josua Kegele, Yeşim Kesim, Nathalie Khoueiry-Zgheib, Chontelle King, Heidi E. Kirsch, Karl M. Klein, Gerhard Kluger, Susanne Knake, Robert C. Knowlton, Bobby P. C. Koeleman, Amos D. Korczyn, Andreas Koupparis, Ioanna Kousiappa, Roland Krause, Martin Krenn, Heinz Krestel, Ilona Krey, Wolfram S. Kunz, Mitja I. Kurki, Gerhard Kurlemann, Ruben Kuzniecky, Patrick Kwan, Angelo Labate, Austin Lacey, Dennis Lal, Zied Landoulsi, Yu-Lung Lau, Stephen Lauxmann, Stephanie L. Leech, Anna-Elina Lehesjoki, Johannes R. Lemke, Holger Lerche, Gaetan Lesca, Costin Leu, Naomi Lewin, David Lewis-Smith, Gloria H.-Y. Li, Qingqin S. Li, Laura Licchetta, Kuang-Lin Lin, Dick Lindhout, Tarja Linnankivi, Iscia Lopes-Cendes, Daniel H. Lowenstein, Colin H. T. Lui, Francesca Madia, Sigurdur Magnusson, Anthony G. Marson, Patrick May, Christopher M. McGraw, Davide Mei, James L. Mills, Raffaella Minardi, Nasir Mirza, Rikke S. Møller, Anne M. Molloy, Martino Montomoli, Barbara Mostacci, Lorenzo Muccioli, Hiltrud Muhle, Karen Müller-Schlüter, Imad M. Najm, Wassim Nasreddine, Benjamin M. Neale, Bernd Neubauer, Charles R. J. C. Newton, Markus M. Nöthen, Michael Nothnagel, Peter Nürnberg, Terence J. O’Brien, Yukinori Okada, Elías Ólafsson, Karen L. Oliver, Çiğdem Özkara, Aarno Palotie, Faith Pangilinan, Savvas S. Papacostas, Elena Parrini, Carlos N. Pato, Michele T. Pato, Manuela Pendziwiat, Slavé Petrovski, William O. Pickrell, Rebecca Pinsky, Tommaso Pippucci, Annapurna Poduri, Federica Pondrelli, Rob H. W. Powell, Michael Privitera, Annika Rademacher, Rodney Radtke, Francesca Ragona, Sarah Rau, Mark I. Rees, Brigid M. Regan, Philipp S. Reif, Sylvain Rhelms, Antonella Riva, Felix Rosenow, Philippe Ryvlin, Anni Saarela, Lynette G. Sadleir, Josemir W. Sander, Thomas Sander, Marcello Scala, Theresa Scattergood, Steven C. Schachter, Christoph J. Schankin, Ingrid E. Scheffer, Bettina Schmitz, Susanne Schoch, Susanne Schubert-Bast, Andreas Schulze-Bonhage, Paolo Scudieri, Pak Sham, Beth R. Sheidley, Jerry J. Shih, Graeme J. Sills, Sanjay M. Sisodiya, Michael C. Smith, Philip E. Smith, Anja C. M. Sonsma, Doug Speed, Michael R. Sperling, Hreinn Stefansson, Kári Stefansson, Bernhard J. Steinhoff, Ulrich Stephani, William C. Stewart, Carlotta Stipa, Pasquale Striano, Hans Stroink, Adam Strzelczyk, Rainer Surges, Toshimitsu Suzuki, K. Meng Tan, R. S. Taneja, George A. Tanteles, Erik Taubøll, Liu Lin Thio, G. Neil Thomas, Rhys H. Thomas, Oskari Timonen, Paolo Tinuper, Marian Todaro, Pınar Topaloğlu, Rossana Tozzi, Meng-Han Tsai, Birute Tumiene, Dilsad Turkdogan, Unnur Unnsteinsdóttir, Algirdas Utkus, Priya Vaidiswaran, Luc Valton, Andreas van Baalen, Annalisa Vetro, Eileen P. G. Vining, Frank Visscher, Sophie von Brauchitsch, Randi von Wrede, Ryan G. Wagner, Yvonne G. Weber, Sarah Weckhuysen, Judith Weisenberg, Michael Weller, Peter Widdess-Walsh, Markus Wolff, Stefan Wolking, David Wu, Kazuhiro Yamakawa, Wanling Yang, Zuhal Yapıcı, Emrah Yücesan, Sara Zagaglia, Felix Zahnert, Federico Zara, Wei Zhou, Fritz Zimprich, Gábor Zsurka, Quratulain Zulfiqar Ali

Nature Genetics, Aug 31, 2023, doi: 10.1038/s41588-023-01485-w

Genetic risk score of cerebral infarction in atrial fibrillation genome-wide association study.

Yusuke Ebana, Lian Liu, Kensuke Ihara, Keiko Abe, Chikashi Terao, Yoichiro Kamatani, Tetsuo Sasano, Tetsushi Furukawa

European journal of clinical investigation, e14084, Aug 28, 2023, doi: 10.1111/eci.14084

Androgen receptor binding sites enabling genetic prediction of mortality due to prostate cancer in cancer-free subjects.

Shuji Ito, Xiaoxi Liu, Yuki Ishikawa, David D Conti, Nao Otomo, Zsofia Kote-Jarai, Hiroyuki Suetsugu, Rosalind A Eeles, Yoshinao Koike, Keiko Hikino, Soichiro Yoshino, Kohei Tomizuka, Momoko Horikoshi, Kaoru Ito, Yuji Uchio, Yukihide Momozawa, Michiaki Kubo, Yoichiro Kamatani, Koichi Matsuda, Christopher A Haiman, Shiro Ikegawa, Hidewaki Nakagawa, Chikashi Terao

Nature communications, 14(1), 4863, Aug 23, 2023, doi: 10.1038/s41467-023-39858-8

Hyperfructosemia in sleep disordered breathing: metabolome analysis of Nagahama study.

Yoshinari Nakatsuka, Kimihiko Murase, Kazuhiro Sonomura, Yasuharu Tabara, Tadao Nagasaki, Satoshi Hamada, Takeshi Matsumoto, Takuma Minami, Osamu Kanai, Hirofumi Takeyama, Hironobu Sunadome, Naomi Takahashi, Isuzu Nakamoto, Kiminobu Tanizawa, Tomohiro Handa, Taka-Aki Sato, Naoko Komenami, Tomoko Wakamura, Satoshi Morita, Osamu Takeuchi, Takeo Nakayama, Toyohiro Hirai, Yoichiro Kamatani, Fumihiko Matsuda, Kazuo Chin

Scientific reports, 13(1), 12735, Aug 5, 2023, doi: 10.1038/s41598-023-40002-1

Genome-wide association study identifies risk loci within the major histocompatibility complex region for Hunner-type interstitial cystitis

Yoshiyuki Akiyama, Kyuto Sonehara, Daichi Maeda, Hiroto Katoh, Tatsuhiko Naito, Kenichi Yamamoto, Koichi Matsuda, Yuji Yamanashi, Yoichi Furukawa, Takayuki Morisaki, Yoshinori Murakami, Yoichiro Kamatani, Kaori Muto, Akiko Nagai, Wataru Obara, Ken Yamaji, Kazuhisa Takahashi, Satoshi Asai, Yasuo Takahashi, Takao Suzuki, Nobuaki Sinozaki, Hiroki Yamaguchi, Shiro Minami, Shigeo Murayama, Kozo Yoshimori, Satoshi Nagayama, Daisuke Obata, Masahiko Higashiyama, Akihide Masumoto, Yukihiro Koretsune, Shumpei Ishikawa, Tetsuo Ushiku, Haruki Kume, Yukio Homma, Yukinori Okada

Cell Reports Medicine, 4(7), Jul 18, 2023, doi: 10.1016/j.xcrm.2023.101114

Evidence of causality of low body mass index on risk of adolescent idiopathic scoliosis: a Mendelian randomization study

Nao Otomo, Anas M. Khanshour, Masaru Koido, Kazuki Takeda, Yukihide Momozawa, Michiaki Kubo, Yoichiro Kamatani, John A. Herring, Yoji Ogura, Yohei Takahashi, Shohei Minami, Koki Uno, Noriaki Kawakami, Manabu Ito, Tatsuya Sato, Kei Watanabe, Takashi Kaito, Haruhisa Yanagida, Hiroshi Taneichi, Katsumi Harimaya, Yuki Taniguchi, Hideki Shigematsu, Takahiro Iida, Satoru Demura, Ryo Sugawara, Nobuyuki Fujita, Mitsuru Yagi, Eijiro Okada, Naobumi Hosogane, Katsuki Kono, Masaya Nakamura, Kazuhiro Chiba, Toshiaki Kotani, Tsuyoshi Sakuma, Tsutomu Akazawa, Teppei Suzuki, Kotaro Nishida, Kenichiro Kakutani, Taichi Tsuji, Hideki Sudo, Akira Iwata, Satoshi Inami, Carol A. Wise, Yuta Kochi, Morio Matsumoto, Shiro Ikegawa, Kota Watanabe, Chikashi Terao

Frontiers in Endocrinology, 14, Jun 20, 2023, doi: 10.3389/fendo.2023.1089414

Detection of trait-associated structural variations using short-read sequencing.

Shunichi Kosugi, Yoichiro Kamatani, Katsutoshi Harada, Kohei Tomizuka, Yukihide Momozawa, Takayuki Morisaki, Chikashi Terao

Cell genomics, 3(6), 100328, Jun 14, 2023, doi: 10.1016/j.xgen.2023.100328

Increased PDGFRB and NF-κB signaling caused by highly prevalent somatic mutations in intracranial aneurysms

Yasuyuki Shima, Shota Sasagawa, Nakao Ota, Rieko Oyama, Minoru Tanaka, Mie Kubota-Sakashita, Hirochika Kawakami, Mika Kobayashi, Naoko Takubo, Atsuko Nakanishi Ozeki, Xiaoning Sun, Yeon-Jeong Kim, Yoichiro Kamatani, Koichi Matsuda, Kazuhiro Maejima, Masashi Fujita, Kosumo Noda, Hiroyasu Kamiyama, Rokuya Tanikawa, Motoo Nagane, Junji Shibahara, Toru Tanaka, Yoshiyuki Rikitake, Nobuko Mataga, Satoru Takahashi, Kenjiro Kosaki, Hideyuki Okano, Tomomi Furihata, Ryo Nakaki, Nobuyoshi Akimitsu, Youichiro Wada, Toshihisa Ohtsuka, Hiroki Kurihara, Hiroyuki Kamiguchi, Shigeo Okabe, Masato Nakafuku, Tadafumi Kato, Hidewaki Nakagawa, Nobuhito Saito, Hirofumi Nakatomi

Science Translational Medicine, 15(700), Jun 14, 2023, doi: 10.1126/scitranslmed.abq7721

Improved genetic prediction of the risk of knee osteoarthritis using the risk factor-based polygenic score.

Yugo Morita, Yoichiro Kamatani, Hiromu Ito, Shiro Ikegawa, Takahisa Kawaguchi, Shuji Kawaguchi, Meiko Takahashi, Chikashi Terao, Shuji Ito, Kohei Nishitani, Shinichiro Nakamura, Shinichi Kuriyama, Yasuharu Tabara, Fumihiko Matsuda, Shuichi Matsuda

Arthritis research & therapy, 25(1), 103, Jun 12, 2023, doi: 10.1186/s13075-023-03082-y

Genotype imputation accuracy and the quality metrics of the minor ancestry in multi-ancestry reference panels

Mingyang Shi, Chizu Tanikawa, Hans Markus Munter, Masato Akiyama, Satoshi Koyama, Kohei Tomizuka, Koichi Matsuda, Gregory Mark Lathrop, Chikashi Terao, Masaru Koido, Yoichiro Kamatani

May 30, 2023, doi: 10.1101/2023.05.30.542466

POS0354 IDENTIFICATION OF SOMATIC MUTATIONS IN PATIENTS WITH ANCA-ASSOCIATED VASCULITIS

T. Iwasaki, K. Ohmura, C. Endo, M. Shirakashi, R. Hiwa, H. Tsuji, K. Kitagori, S. Akizuki, R. Nakashima, H. Yoshifuji, A. Morinobu, F. Matsuda, Y. Kamatani

Annals of the Rheumatic Diseases, 82(Suppl 1), 427.2-427, May 30, 2023, doi: 10.1136/annrheumdis-2023-eular.243

Author Correction: The power of genetic diversity in genome-wide association studies of lipids

Sarah E. Graham, Shoa L. Clarke, Kuan-Han H. Wu, Stavroula Kanoni, Greg J. M. Zajac, Shweta Ramdas, Ida Surakka, Ioanna Ntalla, Sailaja Vedantam, Thomas W. Winkler, Adam E. Locke, Eirini Marouli, Mi Yeong Hwang, Sohee Han, Akira Narita, Ananyo Choudhury, Amy R. Bentley, Kenneth Ekoru, Anurag Verma, Bhavi Trivedi, Hilary C. Martin, Karen A. Hunt, Qin Hui, Derek Klarin, Xiang Zhu, Gudmar Thorleifsson, Anna Helgadottir, Daniel F. Gudbjartsson, Hilma Holm, Isleifur Olafsson, Masato Akiyama, Saori Sakaue, Chikashi Terao, Masahiro Kanai, Wei Zhou, Ben M. Brumpton, Humaira Rasheed, Sanni E. Ruotsalainen, Aki S. Havulinna, Yogasudha Veturi, QiPing Feng, Elisabeth A. Rosenthal, Todd Lingren, Jennifer Allen Pacheco, Sarah A. Pendergrass, Jeffrey Haessler, Franco Giulianini, Yuki Bradford, Jason E. Miller, Archie Campbell, Kuang Lin, Iona Y. Millwood, George Hindy, Asif Rasheed, Jessica D. Faul, Wei Zhao, David R. Weir, Constance Turman, Hongyan Huang, Mariaelisa Graff, Anubha Mahajan, Michael R. Brown, Weihua Zhang, Ketian Yu, Ellen M. Schmidt, Anita Pandit, Stefan Gustafsson, Xianyong Yin, Jian’an Luan, Jing-Hua Zhao, Fumihiko Matsuda, Hye-Mi Jang, Kyungheon Yoon, Carolina Medina-Gomez, Achilleas Pitsillides, Jouke Jan Hottenga, Gonneke Willemsen, Andrew R. Wood, Yingji Ji, Zishan Gao, Simon Haworth, Ruth E. Mitchell, Jin Fang Chai, Mette Aadahl, Jie Yao, Ani Manichaikul, Helen R. Warren, Julia Ramirez, Jette Bork-Jensen, Line L. Kårhus, Anuj Goel, Maria Sabater-Lleal, Raymond Noordam, Carlo Sidore, Edoardo Fiorillo, Aaron F. McDaid, Pedro Marques-Vidal, Matthias Wielscher, Stella Trompet, Naveed Sattar, Line T. Møllehave, Betina H. Thuesen, Matthias Munz, Lingyao Zeng, Jianfeng Huang, Bin Yang, Alaitz Poveda, Azra Kurbasic, Claudia Lamina, Lukas Forer, Markus Scholz, Tessel E. Galesloot, Jonathan P. Bradfield, E. Warwick Daw, Joseph M. Zmuda, Jonathan S. Mitchell, Christian Fuchsberger, Henry Christensen, Jennifer A. Brody, Mary F. Feitosa, Mary K. Wojczynski, Michael Preuss, Massimo Mangino, Paraskevi Christofidou, Niek Verweij, Jan W. Benjamins, Jorgen Engmann, Rachel L. Kember, Roderick C. Slieker, Ken Sin Lo, Nuno R. Zilhao, Phuong Le, Marcus E. Kleber, Graciela E. Delgado, Shaofeng Huo, Daisuke D. Ikeda, Hiroyuki Iha, Jian Yang, Jun Liu, Hampton L. Leonard, Jonathan Marten, Börge Schmidt, Marina Arendt, Laura J. Smyth, Marisa Cañadas-Garre, Chaolong Wang, Masahiro Nakatochi, Andrew Wong, Nina Hutri-Kähönen, Xueling Sim, Rui Xia, Alicia Huerta-Chagoya, Juan Carlos Fernandez-Lopez, Valeriya Lyssenko, Meraj Ahmed, Anne U. Jackson, Noha A. Yousri, Marguerite R. Irvin, Christopher Oldmeadow, Han-Na Kim, Seungho Ryu, Paul R. H. J. Timmers, Liubov Arbeeva, Rajkumar Dorajoo, Leslie A. Lange, Xiaoran Chai, Gauri Prasad, Laura Lorés-Motta, Marc Pauper, Jirong Long, Xiaohui Li, Elizabeth Theusch, Fumihiko Takeuchi, Cassandra N. Spracklen, Anu Loukola, Sailalitha Bollepalli, Sophie C. Warner, Ya Xing Wang, Wen B. Wei, Teresa Nutile, Daniela Ruggiero, Yun Ju Sung, Yi-Jen Hung, Shufeng Chen, Fangchao Liu, Jingyun Yang, Katherine A. Kentistou, Mathias Gorski, Marco Brumat, Karina Meidtner, Lawrence F. Bielak, Jennifer A. Smith, Prashantha Hebbar, Aliki-Eleni Farmaki, Edith Hofer, Maoxuan Lin, Chao Xue, Jifeng Zhang, Maria Pina Concas, Simona Vaccargiu, Peter J. van der Most, Niina Pitkänen, Brian E. Cade, Jiwon Lee, Sander W. van der Laan, Kumaraswamy Naidu Chitrala, Stefan Weiss, Martina E. Zimmermann, Jong Young Lee, Hyeok Sun Choi, Maria Nethander, Sandra Freitag-Wolf, Lorraine Southam, Nigel W. Rayner, Carol A. Wang, Shih-Yi Lin, Jun-Sing Wang, Christian Couture, Leo-Pekka Lyytikäinen, Kjell Nikus, Gabriel Cuellar-Partida, Henrik Vestergaard, Bertha Hildalgo, Olga Giannakopoulou, Qiuyin Cai, Morgan O. Obura, Jessica van Setten, Xiaoyin Li, Karen Schwander, Natalie Terzikhan, Jae Hun Shin, Rebecca D. Jackson, Alexander P. Reiner, Lisa Warsinger Martin, Zhengming Chen, Liming Li, Heather M. Highland, Kristin L. Young, Takahisa Kawaguchi, Joachim Thiery, Joshua C. Bis, Girish N. Nadkarni, Lenore J. Launer, Huaixing Li, Mike A. Nalls, Olli T. Raitakari, Sahoko Ichihara, Sarah H. Wild, Christopher P. Nelson, Harry Campbell, Susanne Jäger, Toru Nabika, Fahd Al-Mulla, Harri Niinikoski, Peter S. Braund, Ivana Kolcic, Peter Kovacs, Tota Giardoglou, Tomohiro Katsuya, Konain Fatima Bhatti, Dominique de Kleijn, Gert J. de Borst, Eung Kweon Kim, Hieab H. H. Adams, M. Arfan Ikram, Xiaofeng Zhu, Folkert W. Asselbergs, Adriaan O. Kraaijeveld, Joline W. J. Beulens, Xiao-Ou Shu, Loukianos S. Rallidis, Oluf Pedersen, Torben Hansen, Paul Mitchell, Alex W. Hewitt, Mika Kähönen, Louis Pérusse, Claude Bouchard, Anke Tönjes, Yii-Der Ida Chen, Craig E. Pennell, Trevor A. Mori, Wolfgang Lieb, Andre Franke, Claes Ohlsson, Dan Mellström, Yoon Shin Cho, Hyejin Lee, Jian-Min Yuan, Woon-Puay Koh, Sang Youl Rhee, Jeong-Taek Woo, Iris M. Heid, Klaus J. Stark, Henry Völzke, Georg Homuth, Michele K. Evans, Alan B. Zonderman, Ozren Polasek, Gerard Pasterkamp, Imo E. Hoefer, Susan Redline, Katja Pahkala, Albertine J. Oldehinkel, Harold Snieder, Ginevra Biino, Reinhold Schmidt, Helena Schmidt, Y. Eugene Chen, Stefania Bandinelli, George Dedoussis, Thangavel Alphonse Thanaraj, Sharon L. R. Kardia, Norihiro Kato, Matthias B. Schulze, Giorgia Girotto, Bettina Jung, Carsten A. Böger, Peter K. Joshi, David A. Bennett, Philip L. De Jager, Xiangfeng Lu, Vasiliki Mamakou, Morris Brown, Mark J. Caulfield, Patricia B. Munroe, Xiuqing Guo, Marina Ciullo, Jost B. Jonas, Nilesh J. Samani, Jaakko Kaprio, Päivi Pajukanta, Linda S. Adair, Sonny Augustin Bechayda, H. Janaka de Silva, Ananda R. Wickremasinghe, Ronald M. 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Nature, 618(7965), E19-E20, May 26, 2023, doi: 10.1038/s41586-023-06194-2

Genome-wide association study of lung adenocarcinoma in East Asia and comparison with a European population

Jianxin Shi, Kouya Shiraishi, Jiyeon Choi, Keitaro Matsuo, Tzu-Yu Chen, Juncheng Dai, Rayjean J. Hung, Kexin Chen, Xiao-Ou Shu, Young Tae Kim, Maria Teresa Landi, Dongxin Lin, Wei Zheng, Zhihua Yin, Baosen Zhou, Bao Song, Jiucun Wang, Wei Jie Seow, Lei Song, I-Shou Chang, Wei Hu, Li-Hsin Chien, Qiuyin Cai, Yun-Chul Hong, Hee Nam Kim, Yi-Long Wu, Maria Pik Wong, Brian Douglas Richardson, Karen M. Funderburk, Shilan Li, Tongwu Zhang, Charles Breeze, Zhaoming Wang, Batel Blechter, Bryan A. Bassig, Jin Hee Kim, Demetrius Albanes, Jason Y. Y. Wong, Min-Ho Shin, Lap Ping Chung, Yang Yang, She-Juan An, Hong Zheng, Yasushi Yatabe, Xu-Chao Zhang, Young-Chul Kim, Neil E. Caporaso, Jiang Chang, James Chung Man Ho, Michiaki Kubo, Yataro Daigo, Minsun Song, Yukihide Momozawa, Yoichiro Kamatani, Masashi Kobayashi, Kenichi Okubo, Takayuki Honda, Dean H. Hosgood, Hideo Kunitoh, Harsh Patel, Shun-ichi Watanabe, Yohei Miyagi, Haruhiko Nakayama, Shingo Matsumoto, Hidehito Horinouchi, Masahiro Tsuboi, Ryuji Hamamoto, Koichi Goto, Yuichiro Ohe, Atsushi Takahashi, Akiteru Goto, Yoshihiro Minamiya, Megumi Hara, Yuichiro Nishida, Kenji Takeuchi, Kenji Wakai, Koichi Matsuda, Yoshinori Murakami, Kimihiro Shimizu, Hiroyuki Suzuki, Motonobu Saito, Yoichi Ohtaki, Kazumi Tanaka, Tangchun Wu, Fusheng Wei, Hongji Dai, Mitchell J. Machiela, Jian Su, Yeul Hong Kim, In-Jae Oh, Victor Ho Fun Lee, Gee-Chen Chang, Ying-Huang Tsai, Kuan-Yu Chen, Ming-Shyan Huang, Wu-Chou Su, Yuh-Min Chen, Adeline Seow, Jae Yong Park, Sun-Seog Kweon, Kun-Chieh Chen, Yu-Tang Gao, Biyun Qian, Chen Wu, Daru Lu, Jianjun Liu, Ann G. Schwartz, Richard Houlston, Margaret R. Spitz, Ivan P. Gorlov, Xifeng Wu, Ping Yang, Stephen Lam, Adonina Tardon, Chu Chen, Stig E. Bojesen, Mattias Johansson, Angela Risch, Heike Bickeböller, Bu-Tian Ji, H-Erich Wichmann, David C. Christiani, Gadi Rennert, Susanne Arnold, Paul Brennan, James McKay, John K. Field, Sanjay S. Shete, Loic Le Marchand, Geoffrey Liu, Angeline Andrew, Lambertus A. Kiemeney, Shan Zienolddiny-Narui, Kjell Grankvist, Mikael Johansson, Angela Cox, Fiona Taylor, Jian-Min Yuan, Philip Lazarus, Matthew B. Schabath, Melinda C. Aldrich, Hyo-Sung Jeon, Shih Sheng Jiang, Jae Sook Sung, Chung-Hsing Chen, Chin-Fu Hsiao, Yoo Jin Jung, Huan Guo, Zhibin Hu, Laurie Burdett, Meredith Yeager, Amy Hutchinson, Belynda Hicks, Jia Liu, Bin Zhu, Sonja I. Berndt, Wei Wu, Junwen Wang, Yuqing Li, Jin Eun Choi, Kyong Hwa Park, Sook Whan Sung, Li Liu, Chang Hyun Kang, Wen-Chang Wang, Jun Xu, Peng Guan, Wen Tan, Chong-Jen Yu, Gong Yang, Alan Dart Loon Sihoe, Ying Chen, Yi Young Choi, Jun Suk Kim, Ho-Il Yoon, In Kyu Park, Ping Xu, Qincheng He, Chih-Liang Wang, Hsiao-Han Hung, Roel C. H. Vermeulen, Iona Cheng, Junjie Wu, Wei-Yen Lim, Fang-Yu Tsai, John K. C. Chan, Jihua Li, Hongyan Chen, Hsien-Chih Lin, Li Jin, Jie Liu, Norie Sawada, Taiki Yamaji, Kathleen Wyatt, Shengchao A. Li, Hongxia Ma, Meng Zhu, Zhehai Wang, Sensen Cheng, Xuelian Li, Yangwu Ren, Ann Chao, Motoki Iwasaki, Junjie Zhu, Gening Jiang, Ke Fei, Guoping Wu, Chih-Yi Chen, Chien-Jen Chen, Pan-Chyr Yang, Jinming Yu, Victoria L. Stevens, Joseph F. Fraumeni, Nilanjan Chatterjee, Olga Y. Gorlova, Chao Agnes Hsiung, Christopher I. Amos, Hongbing Shen, Stephen J. Chanock, Nathaniel Rothman, Takashi Kohno, Qing Lan

Nature Communications, 14(1), May 26, 2023, doi: 10.1038/s41467-023-38196-z

Genome‐wide Association Studies Categorized by Class of Antihypertensive Drugs Reveal Complex Pathogenesis of Hypertension with Drug Resistance

Keiko Yamazaki, Chikashi Terao, Atsushi Takahashi, Yoichiro Kamatani, Koichi Matsuda, Satoshi Asai, Yasuo Takahashi

Clinical Pharmacology & Therapeutics, 114(2), 393-403, May 25, 2023, doi: 10.1002/cpt.2934

Mobile element variation contributes to population-specific genome diversification, gene regulation and disease risk.

Shohei Kojima, Satoshi Koyama, Mirei Ka, Yuka Saito, Erica H Parrish, Mikiko Endo, Sadaaki Takata, Misaki Mizukoshi, Keiko Hikino, Atsushi Takeda, Asami F Gelinas, Steven M Heaton, Rie Koide, Anselmo J Kamada, Michiya Noguchi, Michiaki Hamada, Yoichiro Kamatani, Yasuhiro Murakawa, Kazuyoshi Ishigaki, Yukio Nakamura, Kaoru Ito, Chikashi Terao, Yukihide Momozawa, Nicholas F Parrish

Nature genetics, 55(6), 939-951, May 11, 2023, doi: 10.1038/s41588-023-01390-2

The high-dimensional space of human diseases built from diagnosis records and mapped to genetic loci.

Gengjie Jia, Yu Li, Xue Zhong, Kanix Wang, Milton Pividori, Rabab Alomairy, Aniello Esposito, Hatem Ltaief, Chikashi Terao, Masato Akiyama, Koichi Matsuda, David E Keyes, Hae Kyung Im, Takashi Gojobori, Yoichiro Kamatani, Michiaki Kubo, Nancy J Cox, James Evans, Xin Gao, Andrey Rzhetsky

Nature computational science, 3(5), 403-417, May, 2023, doi: 10.1038/s43588-023-00453-y

Helicobacter pylori, Homologous-Recombination Genes, and Gastric Cancer.

Yoshiaki Usui, Yukari Taniyama, Mikiko Endo, Yuriko N Koyanagi, Yumiko Kasugai, Isao Oze, Hidemi Ito, Issei Imoto, Tsutomu Tanaka, Masahiro Tajika, Yasumasa Niwa, Yusuke Iwasaki, Tomomi Aoi, Nozomi Hakozaki, Sadaaki Takata, Kunihiko Suzuki, Chikashi Terao, Masanori Hatakeyama, Makoto Hirata, Kokichi Sugano, Teruhiko Yoshida, Yoichiro Kamatani, Hidewaki Nakagawa, Koichi Matsuda, Yoshinori Murakami, Amanda B Spurdle, Keitaro Matsuo, Yukihide Momozawa

The New England journal of medicine, 388(13), 1181-1190, Mar 30, 2023, doi: 10.1056/NEJMoa2211807

The genetic basis of endometriosis and comorbidity with other pain and inflammatory conditions.

Nilufer Rahmioglu, Sally Mortlock, Marzieh Ghiasi, Peter L Møller, Lilja Stefansdottir, Geneviève Galarneau, Constance Turman, Rebecca Danning, Matthew H Law, Yadav Sapkota, Paraskevi Christofidou, Sini Skarp, Ayush Giri, Karina Banasik, Michal Krassowski, Maarja Lepamets, Błażej Marciniak, Margit Nõukas, Danielle Perro, Eeva Sliz, Marta Sobalska-Kwapis, Gudmar Thorleifsson, Nura F Topbas-Selcuki, Allison Vitonis, David Westergaard, Ragnheidur Arnadottir, Kristoffer S Burgdorf, Archie Campbell, Cecilia S K Cheuk, Caterina Clementi, James Cook, Immaculata De Vivo, Amy DiVasta, O Dorien, Jacqueline F Donoghue, Todd Edwards, Pierre Fontanillas, Jenny N Fung, Reynir T Geirsson, Jane E Girling, Paivi Harkki, Holly R Harris, Martin Healey, Oskari Heikinheimo, Sarah Holdsworth-Carson, Isabel C Hostettler, Henry Houlden, Sahar Houshdaran, Juan C Irwin, Marjo-Riitta Jarvelin, Yoichiro Kamatani, Stephen H Kennedy, Ewa Kepka, Johannes Kettunen, Michiaki Kubo, Bartosz Kulig, Venla Kurra, Hannele Laivuori, Marc R Laufer, Cecilia M Lindgren, Stuart MacGregor, Massimo Mangino, Nicholas G Martin, Charoula Matalliotaki, Michail Matalliotakis, Alison D Murray, Anne Ndungu, Camran Nezhat, Catherine M Olsen, Jessica Opoku-Anane, Sandosh Padmanabhan, Manish Paranjpe, Maire Peters, Grzegorz Polak, David J Porteous, Joseph Rabban, Kathyrn M Rexrode, Hanna Romanowicz, Merli Saare, Liisu Saavalainen, Andrew J Schork, Sushmita Sen, Amy L Shafrir, Anna Siewierska-Górska, Marcin Słomka, Blair H Smith, Beata Smolarz, Tomasz Szaflik, Krzysztof Szyłło, Atsushi Takahashi, Kathryn L Terry, Carla Tomassetti, Susan A Treloar, Arne Vanhie, Katy Vincent, Kim C Vo, David J Werring, Eleftheria Zeggini, Maria I Zervou, Sosuke Adachi, Julie E Buring, Paul M Ridker, Thomas D'Hooghe, George N Goulielmos, Dharani K Hapangama, Caroline Hayward, Andrew W Horne, Siew-Kee Low, Hannu Martikainen, Daniel I Chasman, Peter A W Rogers, Philippa T Saunders, Marina Sirota, Tim Spector, Dominik Strapagiel, Joyce Y Tung, David C Whiteman, Linda C Giudice, Digna R Velez-Edwards, Outi Uimari, Peter Kraft, Andres Salumets, Dale R Nyholt, Reedik Mägi, Kari Stefansson, Christian M Becker, Piraye Yurttas-Beim, Valgerdur Steinthorsdottir, Mette Nyegaard, Stacey A Missmer, Grant W Montgomery, Andrew P Morris, Krina T Zondervan

Nature genetics, 55(3), 423-436, Mar, 2023, doi: 10.1038/s41588-023-01323-z

Genome-wide association study reveals BET1L associated with survival time in the 137,693 Japanese individuals

Masato Akiyama, Saori Sakaue, Atsushi Takahashi, Kazuyoshi Ishigaki, Makoto Hirata, Koichi Matsuda, Yukihide Momozawa, Yukinori Okada, Toshiharu Ninomiya, Masaru Koido, Takayuki Morisaki, Akiko Nagai, Yoji Sagiya, Chikashi Terao, Yoshinori Murakami, Michiaki Kubo, Yoichiro Kamatani

Communications Biology, 6(1), Feb 3, 2023, doi: 10.1038/s42003-023-04491-0

Germ line DDX41 mutations define a unique subtype of myeloid neoplasms.

Hideki Makishima, Ryunosuke Saiki, Yasuhito Nannya, Sophia Korotev, Carmelo Gurnari, June Takeda, Yukihide Momozawa, Steve Best, Pramila Krishnamurthy, Tetsuichi Yoshizato, Yoshiko Atsuta, Yusuke Shiozawa, Yuka Iijima-Yamashita, Kenichi Yoshida, Yuichi Shiraishi, Yasunobu Nagata, Nobuyuki Kakiuchi, Makoto Onizuka, Kenichi Chiba, Hiroko Tanaka, Ayana Kon, Yotaro Ochi, Masahiro M Nakagawa, Rurika Okuda, Takuto Mori, Akinori Yoda, Hidehiro Itonaga, Yasushi Miyazaki, Masashi Sanada, Takayuki Ishikawa, Shigeru Chiba, Hisashi Tsurumi, Senji Kasahara, Carsten Müller-Tidow, Akifumi Takaori-Kondo, Kazuma Ohyashiki, Toru Kiguchi, Fumihiko Matsuda, Joop H Jansen, Chantana Polprasert, Piers Blombery, Yoichiro Kamatani, Satoru Miyano, Luca Malcovati, Torsten Haferlach, Michiaki Kubo, Mario Cazzola, Austin G Kulasekararaj, Lucy A Godley, Jaroslaw P Maciejewski, Seishi Ogawa

Blood, 141(5), 534-549, Feb 2, 2023, doi: 10.1182/blood.2022018221

Cross-ancestry genome-wide analysis of atrial fibrillation unveils disease biology and enables cardioembolic risk prediction.

Kazuo Miyazawa, Kaoru Ito, Masamichi Ito, Zhaonan Zou, Masayuki Kubota, Seitaro Nomura, Hiroshi Matsunaga, Satoshi Koyama, Hirotaka Ieki, Masato Akiyama, Yoshinao Koike, Ryo Kurosawa, Hiroki Yoshida, Kouichi Ozaki, Yoshihiro Onouchi, Atsushi Takahashi, Koichi Matsuda, Yoshinori Murakami, Hiroyuki Aburatani, Michiaki Kubo, Yukihide Momozawa, Chikashi Terao, Shinya Oki, Hiroshi Akazawa, Yoichiro Kamatani, Issei Komuro

Nature genetics, 55(2), 187-197, Jan 19, 2023, doi: 10.1038/s41588-022-01284-9

Genetic Risk Score for Intracranial Aneurysms: Prediction of Subarachnoid Hemorrhage and Role in Clinical Heterogeneity.

Mark K Bakker, Jos P Kanning, Gad Abraham, Amy E Martinsen, Bendik S Winsvold, John-Anker Zwart, Romain Bourcier, Tomonobu Sawada, Masaru Koido, Yoichiro Kamatani, Sandrine Morel, Philippe Amouyel, Stéphanie Debette, Philippe Bijlenga, Takiy Berrandou, Santhi K Ganesh, Nabila Bouatia-Naji, Gregory Jones, Matthew Bown, Gabriel J E Rinkel, Jan H Veldink, Ynte M Ruigrok

Stroke, Jan 19, 2023, doi: 10.1161/STROKEAHA.122.040715

Identification of serum metabolome signatures associated with retinal and renal complications of type 2 diabetes

Yoshihiko Tomofuji, Ken Suzuki, Toshihiro Kishikawa, Nobuhiro Shojima, Jun Hosoe, Kyoko Inagaki, Sunao Matsubayashi, Hisamitsu Ishihara, Hirotaka Watada, Yasushi Ishigaki, Yuji Yamanashi, Yoichi Furukawa, Takayuki Morisaki, Yoichiro Kamatani, Kaori Muto, Akiko Nagai, Wataru Obara, Ken Yamaji, Kazuhisa Takahashi, Satoshi Asai, Yasuo Takahashi, Takao Suzuki, Nobuaki Sinozaki, Hiroki Yamaguchi, Shiro Minami, Shigeo Murayama, Kozo Yoshimori, Satoshi Nagayama, Daisuke Obata, Masahiko Higashiyama, Akihide Masumoto, Yukihiro Koretsune, Hidenori Inohara, Yoshinori Murakami, Koichi Matsuda, Yukinori Okada, Toshimasa Yamauchi, Takashi Kadowaki

Communications Medicine, 3(1), Jan 9, 2023, doi: 10.1038/s43856-022-00231-3

Genetic influences on human blood metabolites in the Japanese population

Takeshi Iwasaki, Yoichiro Kamatani, Kazuhiro Sonomura, Shuji Kawaguchi, Takahisa Kawaguchi, Meiko Takahashi, Koichiro Ohmura, Taka-Aki Sato, Fumihiko Matsuda

iScience, 26(1), 105738, Jan, 2023, doi: 10.1016/j.isci.2022.105738

202241 papers

Predictive Utility of a Coronary Artery Disease Polygenic Risk Score in Primary Prevention.

Nicholas A Marston, James P Pirruccello, Giorgio E M Melloni, Satoshi Koyama, Frederick K Kamanu, Lu-Chen Weng, Carolina Roselli, Yoichiro Kamatani, Issei Komuro, Krishna G Aragam, Adam S Butterworth, Kaoru Ito, Steve A Lubitz, Patrick T Ellinor, Marc S Sabatine, Christian T Ruff

JAMA cardiology, Dec 28, 2022, doi: 10.1001/jamacardio.2022.4466

Implicating genes, pleiotropy, and sexual dimorphism at blood lipid loci through multi-ancestry meta-analysis.

Stavroula Kanoni, Sarah E Graham, Yuxuan Wang, Ida Surakka, Shweta Ramdas, Xiang Zhu, Shoa L Clarke, Konain Fatima Bhatti, Sailaja Vedantam, Thomas W Winkler, Adam E Locke, Eirini Marouli, Greg J M Zajac, Kuan-Han H Wu, Ioanna Ntalla, Qin Hui, Derek Klarin, Austin T Hilliard, Zeyuan Wang, Chao Xue, Gudmar Thorleifsson, Anna Helgadottir, Daniel F Gudbjartsson, Hilma Holm, Isleifur Olafsson, Mi Yeong Hwang, Sohee Han, Masato Akiyama, Saori Sakaue, Chikashi Terao, Masahiro Kanai, Wei Zhou, Ben M Brumpton, Humaira Rasheed, Aki S Havulinna, Yogasudha Veturi, Jennifer Allen Pacheco, Elisabeth A Rosenthal, Todd Lingren, QiPing Feng, Iftikhar J Kullo, Akira Narita, Jun Takayama, Hilary C Martin, Karen A Hunt, Bhavi Trivedi, Jeffrey Haessler, Franco Giulianini, Yuki Bradford, Jason E Miller, Archie Campbell, Kuang Lin, Iona Y Millwood, Asif Rasheed, George Hindy, Jessica D Faul, Wei Zhao, David R Weir, Constance Turman, Hongyan Huang, Mariaelisa Graff, Ananyo Choudhury, Dhriti Sengupta, Anubha 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Yuya Sekine, Yusuke Iwasaki, Nozomi Hakozaki, Mikiko Endo, Yoichiro Kamatani, Koichi Matsuda, Yoshinori Murakami, Takeshi Sano, Shusuke Akamatsu, Takashi Kobayashi, Hidewaki Nakagawa, Kazuyuki Numakura, Shintaro Narita, Tomonori Habuchi, Yukihide Momozawa

Japanese journal of clinical oncology, 52(12), 1441-1445, Dec 5, 2022, doi: 10.1093/jjco/hyac141

Genetic diversity fuels gene discovery for tobacco and alcohol use.

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Nature, 612(7941), 720-724, Dec, 2022, doi: 10.1038/s41586-022-05477-4

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Nature genetics, 54(12), 1803-1815, Dec, 2022, doi: 10.1038/s41588-022-01233-6

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Communications Biology, 5(1), Dec, 2022, doi: 10.1038/s42003-022-03448-z

Genome-Wide Association Study of Age-Related Macular Degeneration Reveals 2 New Loci Implying Shared Genetic Components with Central Serous Chorioretinopathy.

Masato Akiyama, Masahiro Miyake, Yukihide Momozawa, Satoshi Arakawa, Maiko Maruyama-Inoue, Mikiko Endo, Yusuke Iwasaki, Kazuyoshi Ishigaki, Nana Matoba, Yukinori Okada, Miho Yasuda, Yuji Oshima, Shigeo Yoshida, Shin-Ya Nakao, Kazuya Morino, Yuki Mori, Ai Kido, Aki Kato, Tsutomu Yasukawa, Ryo Obata, Yoshimi Nagai, Kanji Takahashi, Kimihiko Fujisawa, Akiko Miki, Makoto Nakamura, Shigeru Honda, Hiroaki Ushida, Tetsuhiro Yasuma, Koji M Nishiguchi, Ryusaburo Mori, Koji Tanaka, Yu Wakatsuki, Kenji Yamashiro, Kazuaki Kadonosono, Chikashi Terao, Tatsuro Ishibashi, Akitaka Tsujikawa, Koh-Hei Sonoda, Michiaki Kubo, Yoichiro Kamatani

Ophthalmology, 130(4), 361-372, Nov 22, 2022, doi: 10.1016/j.ophtha.2022.10.034

Prediction of the cell-type-specific transcription of non-coding RNAs from genome sequences via machine learning

Masaru Koido, Chung-Chau Hon, Satoshi Koyama, Hideya Kawaji, Yasuhiro Murakawa, Kazuyoshi Ishigaki, Kaoru Ito, Jun Sese, Nicholas F. Parrish, Yoichiro Kamatani, Piero Carninci, Chikashi Terao

Nature Biomedical Engineering, Nov 21, 2022, doi: 10.1038/s41551-022-00961-8

Detailed Analysis of the Impact of Clonal Hematopoiesis on the Risk of Severe COVID-19 Infection

Ryunosuke Saiki, Ho Namkoong, Ryuya Edahiro, Kyuto Sonehara, Qingbo S Wang, Takanori Hasegawa, Yukihide Momozawa, Hideki Makishima, Yasuhito Nannya, Nobuyuki Kakiuchi, Chikashi Terao, Yuichi Shiraishi, Kenichi Chiba, Hiroko Tanaka, Koichi Matsuda, Takayuki Morisaki, Yoshinori Murakami, Yoichiro Kamatani, Michiaki Kubo, Akinori Kimura, Seiya Imoto, Satoru Miyano, Takanori Kanai, Koich Fukunaga, Yukinori Okada, Seishi Ogawa

Blood, 140(Supplement 1), 5747-5748, Nov 15, 2022, doi: 10.1182/blood-2022-160436

Multi-ancestry genome-wide association analyses identify novel genetic mechanisms in rheumatoid arthritis.

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Nature genetics, 54(11), 1640-1651, Nov, 2022, doi: 10.1038/s41588-022-01213-w

Genetic footprints of assortative mating in the Japanese population.

Kenichi Yamamoto, Kyuto Sonehara, Shinichi Namba, Takahiro Konuma, Hironori Masuko, Satoru Miyawaki, Yoichiro Kamatani, Nobuyuki Hizawa, Keiichi Ozono, Loic Yengo, Yukinori Okada

Nature human behaviour, Sep 22, 2022, doi: 10.1038/s41562-022-01438-z

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Cancer science, 113(11), 3972-3979, Sep 5, 2022, doi: 10.1111/cas.15522

Inframe insertion and splice site variants in MFGE8 associate with protection against coronary atherosclerosis

Sanni E. Ruotsalainen, Ida Surakka, Nina Mars, Juha Karjalainen, Mitja Kurki, Masahiro Kanai, Kristi Krebs, Sarah Graham, Pashupati P. Mishra, Binisha H. 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Communications Biology, 5(1), Aug 17, 2022, doi: 10.1038/s42003-022-03552-0

A multi-layer functional genomic analysis to understand noncoding genetic variation in lipids.

Shweta Ramdas, Jonathan Judd, Sarah E Graham, Stavroula Kanoni, Yuxuan Wang, Ida Surakka, Brandon Wenz, Shoa L Clarke, Alessandra Chesi, Andrew Wells, Konain Fatima Bhatti, Sailaja Vedantam, Thomas W Winkler, Adam E Locke, Eirini Marouli, Greg J M Zajac, Kuan-Han H Wu, Ioanna Ntalla, Qin Hui, Derek Klarin, Austin T Hilliard, Zeyuan Wang, Chao Xue, Gudmar Thorleifsson, Anna Helgadottir, Daniel F Gudbjartsson, Hilma Holm, Isleifur Olafsson, Mi Yeong Hwang, Sohee Han, Masato Akiyama, Saori Sakaue, Chikashi Terao, Masahiro Kanai, Wei Zhou, Ben M Brumpton, Humaira Rasheed, Aki S Havulinna, Yogasudha Veturi, Jennifer Allen Pacheco, Elisabeth A Rosenthal, Todd Lingren, QiPing Feng, Iftikhar J Kullo, Akira Narita, Jun Takayama, Hilary C Martin, Karen A Hunt, Bhavi Trivedi, Jeffrey Haessler, Franco Giulianini, Yuki Bradford, Jason E Miller, Archie Campbell, Kuang Lin, Iona Y Millwood, Asif Rasheed, George Hindy, Jessica D Faul, Wei Zhao, David R Weir, Constance Turman, Hongyan Huang, Mariaelisa Graff, Ananyo Choudhury, Dhriti Sengupta, Anubha Mahajan, Michael R Brown, Weihua Zhang, Ketian Yu, Ellen M Schmidt, Anita Pandit, Stefan Gustafsson, Xianyong Yin, Jian'an Luan, Jing-Hua Zhao, Fumihiko Matsuda, Hye-Mi Jang, Kyungheon Yoon, Carolina Medina-Gomez, Achilleas Pitsillides, Jouke Jan Hottenga, Andrew R Wood, Yingji Ji, Zishan Gao, Simon Haworth, Ruth E Mitchell, Jin Fang Chai, Mette Aadahl, Anne A Bjerregaard, Jie Yao, Ani Manichaikul, Wen-Jane Lee, Chao Agnes Hsiung, Helen R Warren, Julia Ramirez, Jette Bork-Jensen, Line L Kårhus, Anuj Goel, Maria Sabater-Lleal, Raymond Noordam, Pala Mauro, Floris Matteo, Aaron F McDaid, Pedro Marques-Vidal, Matthias Wielscher, Stella Trompet, Naveed Sattar, Line T Møllehave, Matthias Munz, Lingyao Zeng, Jianfeng Huang, Bin Yang, Alaitz Poveda, Azra Kurbasic, Sebastian Schönherr, Lukas Forer, Markus Scholz, Tessel E Galesloot, Jonathan P Bradfield, Sanni E Ruotsalainen, E Warwick Daw, Joseph M Zmuda, Jonathan S Mitchell, Christian 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American journal of human genetics, 109(8), 1366-1387, Aug 4, 2022, doi: 10.1016/j.ajhg.2022.06.012

Large-scale genome-wide association study of coronary artery disease in genetically diverse populations.

Catherine Tcheandjieu, Xiang Zhu, Austin T Hilliard, Shoa L Clarke, Valerio Napolioni, Shining Ma, Kyung Min Lee, Huaying Fang, Fei Chen, Yingchang Lu, Noah L Tsao, Sridharan Raghavan, Satoshi Koyama, Bryan R Gorman, Marijana Vujkovic, Derek Klarin, Michael G Levin, Nasa Sinnott-Armstrong, Genevieve L Wojcik, Mary E Plomondon, Thomas M Maddox, Stephen W Waldo, Alexander G Bick, Saiju Pyarajan, Jie Huang, Rebecca Song, Yuk-Lam Ho, Steven Buyske, Charles Kooperberg, Jeffrey Haessler, Ruth J F Loos, Ron Do, Marie Verbanck, Kumardeep Chaudhary, Kari E North, Christy L Avery, Mariaelisa Graff, Christopher A Haiman, Loïc Le Marchand, Lynne R Wilkens, Joshua C Bis, Hampton Leonard, Botong Shen, Leslie A Lange, Ayush Giri, Ozan Dikilitas, Iftikhar J Kullo, Ian B Stanaway, Gail P Jarvik, Adam S Gordon, Scott Hebbring, Bahram Namjou, Kenneth M Kaufman, Kaoru Ito, Kazuyoshi Ishigaki, Yoichiro Kamatani, Shefali S Verma, Marylyn D Ritchie, Rachel L Kember, Aris Baras, Luca A Lotta, Sekar Kathiresan, Elizabeth R Hauser, Donald R Miller, Jennifer S Lee, Danish Saleheen, Peter D Reaven, Kelly Cho, J Michael Gaziano, Pradeep Natarajan, Jennifer E Huffman, Benjamin F Voight, Daniel J Rader, Kyong-Mi Chang, Julie A Lynch, Scott M Damrauer, Peter W F Wilson, Hua Tang, Yan V Sun, Philip S Tsao, Christopher J O'Donnell, Themistocles L Assimes

Nature medicine, 28(8), 1679-1692, Aug, 2022, doi: 10.1038/s41591-022-01891-3

Genetic architectures underlie onset age of atopic dermatitis.

Keiko Hikino, Nao Tanaka, Masaru Koido, Kohei Tomizuka, Yoshinao Koike, Shuji Ito, Akari Suzuki, Yukihide Momozawa, Yoichiro Kamatani, Taisei Mushiroda, Chikashi Terao

The Journal of investigative dermatology, 142(12), 3337-3341, Jul 13, 2022, doi: 10.1016/j.jid.2022.06.010

Trans-ancestry meta-analysis improves performance of genetic scores for multiple adiposity-related traits in East Asian populations

Zammy Fairhurst-Hunter, Kuang Lin, Iona Y Millwood, Alfred Pozarickij, Tzu-Ting Chen, Jason M Torres, Jian-an Luan, Christiana Kartsonaki, Wei Gan, Anubha Mahajan, Huaidong Du, Rajani Sohoni, Yu Guo, Sam Sansome, Ling Yang, Canqing Yu, Yiping Chen, Jun Lv, Gibran Hemani, Masaru Koido, Yoichiro Kamatani, Cassandra N Spracklen, Penny Gordon-Larsen, Mine Koprulu, Xiangrui Meng, Karoline Kuchenbaecker, Segun Fatumo, Laxmi Bhatta, Ben Brumpton, Jesus Alegre-Diaz, Pablo Kuri-Morales, Roberto Tapia-Conyer, Sarah E Graham, Cristen J Willer, Matt J Neville, Fredrik Karpe, Mariaelisa Graff, Kari E. North, Ruth J.F. Loos, Christopher A. Haiman, Ulrike Peters, Steve Buskye, Christopher R. Gignoux, Genevieve Wojcik, Yen-Feng Lin, Liming Li, Mark I McCarthy, Zhengming Chen, Michael V Holmes, Robin G Walters

Jul 7, 2022, doi: 10.1101/2022.07.05.22277254

Multi-trait and cross-population genome-wide association studies across autoimmune and allergic diseases identify shared and distinct genetic component

Yuya Shirai, Yoshimitsu Nakanishi, Akari Suzuki, Hachirou Konaka, Rika Nishikawa, Kyuto Sonehara, Shinichi Namba, Hiroaki Tanaka, Tatsuo Masuda, Moto Yaga, Shingo Satoh, Mayuko Izumi, Yumiko Mizuno, Tatsunori Jo, Yuichi Maeda, Takuro Nii, Eri Oguro-Igashira, Takayuki Morisaki, Yoichiro Kamatani, Shingo Nakayamada, Chikako Nishigori, Yoshiya Tanaka, Yoshito Takeda, Kazuhiko Yamamoto, Atsushi Kumanogoh, Yukinori Okada

Annals of the Rheumatic Diseases, 81(9), annrheumdis-2022, Jun 26, 2022, doi: 10.1136/annrheumdis-2022-222460

Different risk genes contribute to clear cell and non-clear cell renal cell carcinoma in 1532 Japanese patients and 5996 controls.

Yuya Sekine, Yusuke Iwasaki, Tomomi Aoi, Mikiko Endo, Makoto Hirata, Yoichiro Kamatani, Koichi Matsuda, Kokichi Sugano, Teruhiko Yoshida, Yoshinori Murakami, Tomohiro Fukui, Shusuke Akamatsu, Osamu Ogawa, Hidewaki Nakagawa, Kazuyuki Numakura, Shintaro Narita, Tomonori Habuchi, Yukihide Momozawa

Human molecular genetics, 31(12), 1962-1969, Jun 22, 2022, doi: 10.1093/hmg/ddab345

Multi‐phenotype analyses of hemostatic traits with cardiovascular events reveal novel genetic associations

Gerard Temprano‐Sagrera, Colleen M. Sitlani, William P. Bone, Miguel Martin‐Bornez, Benjamin F. Voight, Alanna C. Morrison, Scott M. Damrauer, Paul S. de Vries, Nicholas L. Smith, Maria Sabater‐Lleal, Abbas Dehghan, Adam S Heath, Alanna C Morrison, Alex P Reiner, Andrew Johnson, Anne Richmond, Annette Peters, Astrid van Hylckama Vlieg, Barbara McKnight, Bruce M Psaty, Caroline Hayward, Cavin Ward‐Caviness, Christopher O’Donnell, Daniel Chasman, David P Strachan, David A Tregouet, Dennis Mook‐Kanamori, Dipender Gill, Florian Thibord, Folkert W Asselbergs, Frank W.G. 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Zablocki, Jeffrey Whittle, Frank Jacono, Jean Beckham, Salvador Gutierrez, Gretchen Gibson, Kimberly Hammer, Laurence Kaminsky, Gerardo Villareal, Scott Kinlay, Junzhe Xu, Mark Hamner, Roy Mathew, Sujata Bhushan, Pran Iruvanti, Michael Godschalk, Zuhair Ballas, Douglas Ivins, Stephen Mastorides, Jonathan Moorman, Saib Gappy, Jon Klein, Nora Ratcliffe, Hermes Florez, Olaoluwa Okusaga, Maureen Murdoch, Peruvemba Sriram, Shing Shing Yeh, Neeraj Tandon, Darshana Jhala, Samuel Aguayo, David Cohen, Satish Sharma, Suthat Liangpunsakul, Kris Ann Oursler, Mary Whooley, Sunil Ahuja, Joseph Constans, Paul Meyer, Jennifer Greco, Michael Rauchman, Richard Servatius, Melinda Gaddy, Agnes Wallbom, Timothy Morgan, Todd Stapley, Scott Sherman, George Ross, Philip Tsao, Patrick Strollo, Edward Boyko, Laurence Meyer, Samir Gupta, Mostaqul Huq, Joseph Fayad, Adriana Hung, Jack Lichy, Robin Hurley, Brooks Robey, Robert Striker

Biological Psychiatry, 91(3), 313-327, Feb, 2022, doi: 10.1016/j.biopsych.2021.05.029

Trans-ethnic Mendelian-randomization study reveals causal relationships between cardiometabolic factors and chronic kidney disease.

Jie Zheng, Yuemiao Zhang, Humaira Rasheed, Venexia Walker, Yuka Sugawara, Jiachen Li, Yue Leng, Benjamin Elsworth, Robyn E Wootton, Si Fang, Qian Yang, Stephen Burgess, Philip C Haycock, Maria Carolina Borges, Yoonsu Cho, Rebecca Carnegie, Amy Howell, Jamie Robinson, Laurent F Thomas, Ben Michael Brumpton, Kristian Hveem, Stein Hallan, Nora Franceschini, Andrew P Morris, Anna Köttgen, Cristian Pattaro, Matthias Wuttke, Masayuki Yamamoto, Naoki Kashihara, Masato Akiyama, Masahiro Kanai, Koichi Matsuda, Yoichiro Kamatani, Yukinori Okada, Robin Walters, Iona Y Millwood, Zhengming Chen, George Davey Smith, Sean Barbour, Canqing Yu, Bjørn Olav Åsvold, Hong Zhang, Tom R Gaunt

International journal of epidemiology, 50(6), 1995-2010, Jan 6, 2022, doi: 10.1093/ije/dyab203

Stroke genetics informs drug discovery and risk prediction across ancestries

Stéphanie Debette, Aniket Mishra, Rainer Malik, Tsuyoshi Hachiya, Tuuli Jürgenson, Shinichi Namba, Masaru Koido, Quentin Le Grand, Frederick Kamanu, Mingyang Shi, Yunye He, Marios Georgakis, Ilana Caro, Kristi Krebs, Felix Vaura, Naomi Habib, Bendik Winsvold, Yon Ho Jee, Jesper Qvist Thomassen, Vida Abedi, Jara Cárcel-Márquez, Kuang Lin, Marianne Nygaard, Ganesh Chauhan, Hampton Leonard, Chaojie Yang, Ekaterina Yonova-Doing, Maria Knol, Tetsuro Ago, Philippe Amouyel, Christopher Anderson, Nicole Armstrong, Mark Bakker, Traci Bartz, Joshua Bis, Constance Bordes, Sigrid Borte, Anael Cain, Paul Ridker, Zhengming Chen, Michael Chong, John Cole, Rafael de Cid, Matthias Endres, Leslie Ferreira, Natalie Gasca, Vilmundur Gudnason, Jun Hata, Aki Havulinna, Jemma Hopewell, Hyacinth Hyacinth, Michael Inouye, Mina Jacob, Christina  Jeon, Christina Jern, Masahiro Kamouchi, Keith Keene, Takanari Kitazono, Steven Kittner, Takahiro Konuma, Amit Kumar, Paul Lacaze, Lenore Launer, Kaido Lepik, Jiang Li, Liming Li, Ani Manichaikul, Hugh Markus, Nicholas Marston, Thomas Meitinger, Braxton Mitchell, Felipe Montellano, Takayuki Morisaki, Thomas Mosley, Mike Nalls, Børge Nordestgaard, Martin O'Donnell, Yukinori Okada, Guillaume Pare, Annette Peters, Bruce Psaty, Stephen Rich, Jonathan Rosand, Marc Sabatine, Ralph Sacco, Danish Saleheen, Else Charlotte Sandset, Muralidharan Sargurupremraj, Makoto Sasaki, Claudia Satizabal, Carsten Schmidt, Atsushi Shimizu, Nicholas Smith, Daniel Strbian, Yoichi Sutoh, Kozo Tanno, Steffen Tiedt, Nuria Torres-Aguila, David-Alexandre Trégouët, Stella Trompet, Anil Tuladhar, Anne Tybjærg-Hansen, Marion van Vugt, Riina Vibo, Kerri Wiggins, Daniel Woo, Huichun Xu, Qiong Yang, Mark Lathrop, Iona Millwood, Christian Gieger, Toshiharu Ninomiya, Hans Grabe, J Wouter Jukema, Ina Rissanen, Sudha Seshadri, William Longstreth, Daniel Chasman, Joanna Howson, Marguerite Irvin, Hieab Adams, Sylvia Wasssertheil-Smoller, Kaare Christensen, M. Arfan Ikram, Tatjana Rundek, Jerome Rotter, Moeen Riaz, Eleanor Simonsick, Janika Kõrv, Paulo França, Myriam Fornage, Ramin Zand, Kameshwar Prasad, Ruth Frikke-Schmidt, Frank-Erik de Leeuw, Thomas Liman, Karl Georg Haeusler, Ynte Ruigrok, Peter Heuschmann, Keum Jung, John-Anker Zwart, Teemu Niiranen, Christian Ruff, Israel Fernández-Cadenas, Robin Walters, Lili Milani, Yoichiro Kamatani, Martin Dichgans

Jan 4, 2022, doi: 10.21203/rs.3.rs-1175817/v1

日本人を対象としたX染色体ワイドメタ解析による尿酸関連SNP rs3020789の同定

中杤 昌弘, 豊田 優, 中山 昌喜, 河村 優輔, 四ノ宮 成祥, 松尾 洋孝, 金井 仁弘, 菱田 朝陽, 三上 春夫, 松尾 恵太郎, 嶽崎 俊郎, 桃沢 幸秀, 鎌谷 洋一郎, 市原 佐保子, 横田 充弘, 若井 建志, 岡田 随象

日本痛風・尿酸核酸学会総会プログラム・抄録集, 55回, 67, Jan, 2022

Mendelian randomization of genetically independent aging phenotypes identifies LPA and VCAM1 as biological targets for human aging

Paul R. H. J. Timmers, Evgeny S. Tiys, Saori Sakaue, Masato Akiyama, Tuomo T. J. Kiiskinen, Wei Zhou, Shih-Jen Hwang, Chen Yao, Yoichiro Kamatani, Wei Zhou, Joris Deelen, Daniel Levy, Andrea Ganna, Yoichiro Kamatani, Yukinori Okada, Peter K. Joshi, James F. Wilson, Yakov A. Tsepilov

Nature Aging, Jan, 2022, doi: 10.1038/s43587-021-00159-8

202134 papers

Trans-ancestry genome-wide association study identifies novel genetic mechanisms in rheumatoid arthritis

Kazuyoshi Ishigaki, Saori Sakaue, Chikashi Terao, Yang Luo, Kyuto Sonehara, Kensuke Yamaguchi, Tiffany Amariuta, Chun Lai Too, Vincent A Laufer, Ian C Scott, Sebastien Viatte, Meiko Takahashi, Koichiro Ohmura, Akira Murasawa, Motomu Hashimoto, Hiromu Ito, Mohammed Hammoudeh, Samar Al Emadi, Basel K Masri, Hussien Halabi, Humeria Badsha, Imad W Uthman, Xin Wu, Li Lin, Ting Lin, Darren Plant, Anne Barton, Gisela Orozco, Suzanne MM Verstappen, John Bowes, Alexander J MacGregor, Suguru Honda, Masaru Koido, Kohei Tomizuka, Yoichiro Kamatani, Hiroaki Tanaka, Eiichi Tanaka, Akari Suzuki, Yuichi Maeda, Kenichi Yamamoto, Satoru Miyawaki, Gang Xie, Jinyi Zhang, Chris Amos, Ed Keystone, Gertjan Wolbink, Irene van der Horst-Bruinsma, Jing Cui, Katherine P Liao, Robert J Carroll, Hye-Soon Lee, So-Young Bang, Katherine A Siminovitch, Niek de Vries, Lars Alfredsson, Solbritt Rantapää-Dahlqvist, Elizabeth W Karlson, Sang-Cheol Bae, Robert P Kimberly, Jeffrey C Edberg, Xavier Mariette, Tom Huizinga, Philippe Dieudé, Matthias Schneider, Martin Kerick, Joshua C Denny, Koichi Matsuda, Keitaro Matsuo, Tsuneyo Mimori, Fumihiko Matsuda, Keishi Fujio, Yoshiya Tanaka, Atsushi Kumanogoh, Matthew Traylor, Cathryn M Lewis, Stephen Eyre, Huji Xu, Richa Saxena, Thurayya Arayssi, Yuta Kochi, Katsunori Ikari, Masayoshi Harigai, Peter K Gregersen, Kazuhiko Yamamoto, S. Louis Bridges, Leonid Padyukov, Javier Martin, Lars Klareskog, Yukinori Okada, Soumya Raychaudhuri

Dec 5, 2021, doi: 10.1101/2021.12.01.21267132

Model-based assessment of replicability for genome-wide association meta-analysis

Daniel McGuire, Yu Jiang, Mengzhen Liu, J. Dylan Weissenkampen, Scott Eckert, Lina Yang, Fang Chen, Mengzhen Liu, Yu Jiang, Robbee Wedow, Yue Li, David M. Brazel, Fang Chen, Gargi Datta, Jose Davila-Velderrain, Chao Tian, Xiaowei Zhan, H. éléne Choquet, Anna R. Docherty, Jessica D. Faul, Johanna R. Foerster, Lars G. Fritsche, Maiken Elvestad Gabrielsen, Scott D. Gordon, Jeffrey Haessler, Jouke-Jan Hottenga, Hongyan Huang, Seon-Kyeong Jang, Philip R. Jansen, Yueh Ling, Reedik Ma ̈gi, Nana Matoba, George McMahon, Antonella Mulas, Valeria Orru, Teemu Palviainen, Anita Pandit, Gunnar W. Reginsson, Anne Heidi Skogholt, Jennifer A. Smith, Amy E. Taylor, Constance Turman, Gonneke Willemsen, Hannah Young, Kendra A. Young, Gregory J. M. Zajac, Wei Zhao, Wei Zhou, Gyda Bjornsdottir, Jason D. Boardman, Michael Boehnke, Dorret I. Boomsma, Chu Chen, Francesco Cucca, Gareth E. Davies, Charles B. Eaton, Marissa A. Ehringer, Tonu Esko, Edoardo Fiorillo, Nathan A. Gillespie, Daniel F. Gudbjartsson, Toomas Haller, Kathleen Mullan Harris, Andrew C. Heath, John K. Hewitt, Ian B. Hickie, John E. Hokanson, Christian J. Hopfer, David J. Hunter, William G. Iacono, Eric O. Johnson, Yoichiro Kamatani, Sharon L. R. Kardia, Matthew C. Keller, Manolis Kellis, Charles Kooperberg, Peter Kraft, Kenneth S. Krauter, Markku Laakso, Penelope A. Lind, Anu Loukola, Sharon M. Lutz, Pamela A. F. Madden, Nicholas G. Martin, Matt McGue, Matthew B. McQueen, Sarah E. Medland, Andres Metspalu, Karen L. Mohlke, Jonas B. Nielsen, Yukinori Okada, Ulrike Peters, Tinca J. C. Polderman, Danielle Posthuma, Alexander P. Reiner, John P. Rice, Eric Rimm, Richard J. Rose, Valgerdur Runarsdottir, Michael C. Stallings, Alena Stanˇca ́kova, Hreinn Stefansson, Khanh K. Thai, Hilary A. Tindle, Thorarinn Tyrfingsson, Tamara L. Wall, David R. Weir, Constance Weisner, John B. Whitfield, Bendik Slagsvold Winsvold, Jie Yin, Luisa Zuccolo, Laura J. Bierut, Kristian Hveem, James J. Lee, Marcus R. Munafo, Nancy L. Saccone, Cristen J. Willer, Marilyn C. Cornelis, Sean P. David, David Hinds, Eric Jorgenson, Jaakko Kaprio, Jerry A. Stitzel, Kari Stefansson, Thorgeir E. Thorgeirsson, Goncalo Abecasis, Dajiang J. Liu, Scott Vrieze, Arthur Berg, Scott Vrieze, Bibo Jiang, Qunhua Li, Dajiang J. Liu, GWAS and Sequencing Consortium of Alcohol and Nicotine Use (GSCAN)

Nature Communications, 12(1), Dec 1, 2021, doi: 10.1038/s41467-021-21226-z

ゲノムワイド関連解析による病型特異的な痛風関連遺伝子の同定と日本人の適応進化

中山 昌喜, 中杤 昌弘, 河村 優輔, 清水 聖子, 東野 俊英, 清水 徹, 大山 恵子, 大山 博司, 長瀬 満夫, 日高 雄二, 川口 真, 高田 雄三, 高田 龍平, 細谷 龍男, 市田 公美, 四ノ宮 成祥, 松尾 洋孝, 山本 健, 中岡 博史, 菱田 朝陽, 中村 好宏, 中島 宏, 豊田 優, 鎌谷 洋一郎, 久保 充明, 若井 建志, 岡田 随象

痛風と尿酸・核酸, 45(2), 196, Dec, 2021

腎がんの組織型に寄与する遺伝子が異なることを示した大規模ゲノム解析

関根 悠哉, 平田 真, 鎌谷 洋一郎, 松田 浩一, 菅野 康吉, 吉田 輝彦, 村上 善則, 赤松 秀輔, 小川 修, 沼倉 一幸, 羽渕 友則, 中川 英刀, 桃沢 幸秀

日本泌尿器科学会総会, 109回, AOP03-05, Dec, 2021

Genome-Wide Meta-analysis Identifies Genetic Variants Associated With Glycemic Response to Sulfonylureas.

Adem Y Dawed, Sook Wah Yee, Kaixin Zhou, Nienke van Leeuwen, Yanfei Zhang, Moneeza K Siddiqui, Amy Etheridge, Federico Innocenti, Fei Xu, Josephine H Li, Joline W Beulens, Amber A van der Heijden, Roderick C Slieker, Yu-Chuan Chang, Josep M Mercader, Varinderpal Kaur, John S Witte, Ming Ta Michael Lee, Yoichiro Kamatani, Yukihide Momozawa, Michiaki Kubo, Colin N A Palmer, Jose C Florez, Monique M Hedderson, Leen M 't Hart, Kathleen M Giacomini, Ewan R Pearson

Diabetes care, 44(12), 2673-2682, Dec, 2021, doi: 10.2337/dc21-1152

The power of genetic diversity in genome-wide association studies of lipids.

Sarah E Graham, Shoa L Clarke, Kuan-Han H Wu, Stavroula Kanoni, Greg J M Zajac, Shweta Ramdas, Ida Surakka, Ioanna Ntalla, Sailaja Vedantam, Thomas W Winkler, Adam E Locke, Eirini Marouli, Mi Yeong Hwang, Sohee Han, Akira Narita, Ananyo Choudhury, Amy R Bentley, Kenneth Ekoru, Anurag Verma, Bhavi Trivedi, Hilary C Martin, Karen A Hunt, Qin Hui, Derek Klarin, Xiang Zhu, Gudmar Thorleifsson, Anna Helgadottir, Daniel F Gudbjartsson, Hilma Holm, Isleifur Olafsson, Masato Akiyama, Saori Sakaue, Chikashi Terao, Masahiro Kanai, Wei Zhou, Ben M Brumpton, Humaira Rasheed, Sanni E Ruotsalainen, Aki S Havulinna, Yogasudha Veturi, QiPing Feng, Elisabeth A Rosenthal, Todd Lingren, Jennifer Allen Pacheco, Sarah A Pendergrass, Jeffrey Haessler, Franco Giulianini, Yuki Bradford, Jason E Miller, Archie Campbell, Kuang Lin, Iona Y Millwood, George Hindy, Asif Rasheed, Jessica D Faul, Wei Zhao, David R Weir, Constance Turman, Hongyan Huang, Mariaelisa Graff, Anubha Mahajan, Michael R Brown, Weihua Zhang, Ketian Yu, Ellen M Schmidt, Anita Pandit, Stefan Gustafsson, Xianyong Yin, Jian'an Luan, Jing-Hua Zhao, Fumihiko Matsuda, Hye-Mi Jang, Kyungheon Yoon, Carolina Medina-Gomez, Achilleas Pitsillides, Jouke Jan Hottenga, Gonneke Willemsen, Andrew R Wood, Yingji Ji, Zishan Gao, Simon Haworth, Ruth E Mitchell, Jin Fang Chai, Mette Aadahl, Jie Yao, Ani Manichaikul, Helen R Warren, Julia Ramirez, Jette Bork-Jensen, Line L Kårhus, Anuj Goel, Maria Sabater-Lleal, Raymond Noordam, Carlo Sidore, Edoardo Fiorillo, Aaron F McDaid, Pedro Marques-Vidal, Matthias Wielscher, Stella Trompet, Naveed Sattar, Line T Møllehave, Betina H Thuesen, Matthias Munz, Lingyao Zeng, Jianfeng Huang, Bin Yang, Alaitz Poveda, Azra Kurbasic, Claudia Lamina, Lukas Forer, Markus Scholz, Tessel E Galesloot, Jonathan P Bradfield, E Warwick Daw, Joseph M Zmuda, Jonathan S Mitchell, Christian Fuchsberger, Henry Christensen, Jennifer A Brody, Mary F Feitosa, Mary K Wojczynski, Michael Preuss, Massimo Mangino, Paraskevi Christofidou, Niek Verweij, Jan W Benjamins, Jorgen Engmann, Rachel L Kember, Roderick C Slieker, Ken Sin Lo, Nuno R Zilhao, Phuong Le, Marcus E Kleber, Graciela E Delgado, Shaofeng Huo, Daisuke D Ikeda, Hiroyuki Iha, Jian Yang, Jun Liu, Hampton L Leonard, Jonathan Marten, Börge Schmidt, Marina Arendt, Laura J Smyth, Marisa Cañadas-Garre, Chaolong Wang, Masahiro Nakatochi, Andrew Wong, Nina Hutri-Kähönen, Xueling Sim, Rui Xia, Alicia Huerta-Chagoya, Juan Carlos Fernandez-Lopez, Valeriya Lyssenko, Meraj Ahmed, Anne U Jackson, Marguerite R Irvin, Christopher Oldmeadow, Han-Na Kim, Seungho Ryu, Paul R H J Timmers, Liubov Arbeeva, Rajkumar Dorajoo, Leslie A Lange, Xiaoran Chai, Gauri Prasad, Laura Lorés-Motta, Marc Pauper, Jirong Long, Xiaohui Li, Elizabeth Theusch, Fumihiko Takeuchi, Cassandra N Spracklen, Anu Loukola, Sailalitha Bollepalli, Sophie C Warner, Ya Xing Wang, Wen B Wei, Teresa Nutile, Daniela Ruggiero, Yun Ju Sung, Yi-Jen Hung, Shufeng Chen, Fangchao Liu, Jingyun Yang, Katherine A Kentistou, Mathias Gorski, Marco Brumat, Karina Meidtner, Lawrence F Bielak, Jennifer A Smith, Prashantha Hebbar, Aliki-Eleni Farmaki, Edith Hofer, Maoxuan Lin, Chao Xue, Jifeng Zhang, Maria Pina Concas, Simona Vaccargiu, Peter J van der Most, Niina Pitkänen, Brian E Cade, Jiwon Lee, Sander W van der Laan, Kumaraswamy Naidu Chitrala, Stefan Weiss, Martina E Zimmermann, Jong Young Lee, Hyeok Sun Choi, Maria Nethander, Sandra Freitag-Wolf, Lorraine Southam, Nigel W Rayner, Carol A Wang, Shih-Yi Lin, Jun-Sing Wang, Christian Couture, Leo-Pekka Lyytikäinen, Kjell Nikus, Gabriel Cuellar-Partida, Henrik Vestergaard, Bertha Hildalgo, Olga Giannakopoulou, Qiuyin Cai, Morgan O Obura, Jessica van Setten, Xiaoyin Li, Karen Schwander, Natalie Terzikhan, Jae Hun Shin, Rebecca D Jackson, Alexander P Reiner, Lisa Warsinger Martin, Zhengming Chen, Liming Li, Heather M Highland, Kristin L Young, Takahisa Kawaguchi, Joachim Thiery, Joshua C Bis, Girish N Nadkarni, Lenore J Launer, Huaixing 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Nature, 600(7890), 675-679, Dec, 2021, doi: 10.1038/s41586-021-04064-3

Genetic susceptibility to hepatocellular carcinoma in chromosome 22q13.31, findings of a genome-wide association study.

Zhanwei Wang, Anuradha S Budhu, Yi Shen, Linda Lou Wong, Brenda Y Hernandez, Maarit Tiirikainen, Xiaomei Ma, Melinda L Irwin, Lingeng Lu, Hongyu Zhao, Joseph K Lim, Tamar Taddei, Lopa Mishra, Karen Pawlish, Antoinette Stroup, Robert Brown, Mindie H Nguyen, Jill Koshiol, Maria O Hernandez, Marshonna Forgues, Hwai-I Yang, Mei-Hsuan Lee, Yu-Han Huang, Motoki Iwasaki, Atsushi Goto, Shiori Suzuki, Koichi Matsuda, Chizu Tanikawa, Yoichiro Kamatani, Dean Mann, Maria Guarnera, Kirti Shetty, Claire E Thomas, Jian-Min Yuan, Chiea Chuen Khor, Woon-Puay Koh, Harvey Risch, Xin Wei Wang, Herbert Yu

JGH open : an open access journal of gastroenterology and hepatology, 5(12), 1363-1372, Dec, 2021, doi: 10.1002/jgh3.12682

A genome-wide association study identifies a novel candidate locus at the DLGAP1 gene with susceptibility to resistant hypertension in the Japanese population

Yasuo Takahashi, Keiko Yamazaki, Yoichiro Kamatani, Michiaki Kubo, Koichi Matsuda, Satoshi Asai

Scientific Reports, 11(1), 19497, Dec, 2021, doi: 10.1038/s41598-021-98144-z

Leveraging supervised learning for functionally informed fine-mapping of cis-eQTLs identifies an additional 20,913 putative causal eQTLs

Qingbo S. Wang, David R. Kelley, Jacob Ulirsch, Masahiro Kanai, Shuvom Sadhuka, Ran Cui, Carlos Albors, Nathan Cheng, Yukinori Okada, Koichi Matsuda, Yuji Yamanashi, Yoichi Furukawa, Takayuki Morisaki, Yoshinori Murakami, Yoichiro Kamatani, Kaori Muto, Akiko Nagai, Wataru Obara, Ken Yamaji, Kazuhisa Takahashi, Satoshi Asai, Yasuo Takahashi, Takao Suzuki, Nobuaki Sinozaki, Hiroki Yamaguchi, Shiro Minami, Shigeo Murayama, Kozo Yoshimori, Satoshi Nagayama, Daisuke Obata, Masahiko Higashiyama, Akihide Masumoto, Yukihiro Koretsune, Francois Aguet, Kristin G. Ardlie, Daniel G. MacArthur, Hilary K. Finucane

Nature Communications, 12(1), Dec, 2021, doi: 10.1038/s41467-021-23134-8

A deep learning method for HLA imputation and trans-ethnic MHC fine-mapping of type 1 diabetes

Tatsuhiko Naito, Ken Suzuki, Jun Hirata, Yoichiro Kamatani, Koichi Matsuda, Tatsushi Toda, Yukinori Okada

Nature Communications, 12(1), 1639, Dec, 2021, doi: 10.1038/s41467-021-21975-x

Genome-wide meta-analysis identifies 127 open-angle glaucoma loci with consistent effect across ancestries

Puya Gharahkhani, Eric Jorgenson, Pirro Hysi, Anthony P. Khawaja, Sarah Pendergrass, Xikun Han, Jue Sheng Ong, Alex W. Hewitt, Ayellet V. Segrè, John M. Rouhana, Andrew R. Hamel, Robert P. Igo, Helene Choquet, Ayub Qassim, Navya S. Josyula, Jessica N. Cooke Bailey, Pieter W. M. Bonnemaijer, Adriana Iglesias, Owen M. Siggs, Terri L. Young, Veronique Vitart, Alberta A. H. J. Thiadens, Juha Karjalainen, Steffen Uebe, Ronald B. Melles, K. Saidas Nair, Robert Luben, Mark Simcoe, Nishani Amersinghe, Angela J. Cree, Rene Hohn, Alicia Poplawski, Li Jia Chen, Shi-Song Rong, Tin Aung, Eranga Nishanthie Vithana, Gen Tamiya, Yukihiro Shiga, Masayuki Yamamoto, Toru Nakazawa, Hannah Currant, Ewan Birney, Xin Wang, Adam Auton, Michelle K. Lupton, Nicholas G. Martin, Adeyinka Ashaye, Olusola Olawoye, Susan E. Williams, Stephen Akafo, Michele Ramsay, Kazuki Hashimoto, Yoichiro Kamatani, Masato Akiyama, Yukihide Momozawa, Paul J. Foster, Peng T. Khaw, James E. Morgan, Nicholas G. Strouthidis, Peter Kraft, Jae H. Kang, Chi Pui Pang, Francesca Pasutto, Paul Mitchell, Andrew J. Lotery, Aarno Palotie, Cornelia van Duijn, Jonathan L. Haines, Chris Hammond, Louis R. Pasquale, Caroline C. W. Klaver, Michael Hauser, Chiea Chuen Khor, David A. Mackey, Michiaki Kubo, Ching-Yu Cheng, Jamie E. Craig, Stuart MacGregor, Janey L. Wiggs

Nature Communications, 12(1), 1258, Dec, 2021, doi: 10.1038/s41467-020-20851-4

Genetic Contributions to Early and Late Onset Ischemic Stroke

Thomas Jaworek, Huichun Xu, Brady J. Gaynor, John W. Cole, Kristiina Rannikmäe, Tara M. Stanne, Liisa Tomppo, Vida Abedi, Philippe Amouyel, Nicole. D Armstrong, John Attia, Steven Bell, Oscar R. Benavente, Giorgio B. Boncoraglio, Adam Butterworth, Jara Cárcel-Márquez, Zhengming Chen, Michael Chong, Carlos Cruchaga, Mary Cushman, John Danesh, Stephanie Debette, David J. Duggan, Jon Peter Durda, Gunnar Engstrom, Christian Enzinger, Jessica D. Faul, Natalie S. Fecteau, Israel Fernández-Cadenas, Christian Geiger, Anne-Katrin Giese, Raji P. Grewal, Ulrike Grittner, Aki S. Havulinna, Laura Heitsch, Marc C. Hochberg, Elizabeth Holliday, Jie Hu, Andreea Ilinca, Marguerite R. Irvin, Rebecca D. Jackson, Mina A. Jacob, Raquel Rabionet Janssen, Jordi Jimenez-Conde, Julie A. Johnson, Yoichiro Kamatani, Sharon L.R. Kardia, Masaru Koido, Michiaki Kubo, Leslie Lange, Jin-Moo Lee, Robin Lemmens, Christopher Levi, Jiang Li, Liming Li, Kuang Lin, Haley Lopez, Sothear Luke, Jane Maguire, Patrick F. McArdle, Caitrin W. McDonough, James F. Meschia, Tiina Metso, Martina Müller-Nurasyid, Timothy O’Connor, Martin O’Donnell, Leema Reddy Peddareddygari, Joanna Pera, James A. Perry, Annette Peters, Jukka Putaala, Debashree Ray, Kathryn Rexrode, Marta Ribases, Jonathan Rosand, Peter M. Rothwell, Tatjana Rundek, Kathleen A. Ryan, Ralph L. Sacco, Veikko Salomaa, Cristina Sanchez-Mora, Reinhold Schmidt, Pankaj Sharma, Agnieszka Slowik, Jennifer A. Smith, Nicholas L. Smith, Sylvia Wassertheil-Smoller, Martin Soderholm, O. Colin Stine, Daniel Strbian, Cathie LM Sudlow, Turgut Tatlisumak, Chikashi Terao, Vincent Thijs, Nuria P. Torres-Aguila, David-Alexandre Trégouët, Anil Man Tuladhar, Jan H. Veldink, Robin G. Walters, David R. Weir, Daniel Woo, Bradford B. Worrall, Charles C Hong, Owen Ross, Ramin Zand, F-E de Leeuw, Arne G. Lindgren, Guillaume Pare, Christopher D. Anderson, Hugh S. Markus, Christina Jern, Rainer Malik, Martin Dichgans, Braxton D. Mitchell, Steven J. Kittner

Nov 8, 2021, doi: 10.1101/2021.11.06.21265795

Trans-ethnic Mendelian-randomization study reveals causal relationships between cardiometabolic factors and chronic kidney disease.

Jie Zheng, Yuemiao Zhang, Humaira Rasheed, Venexia Walker, Yuka Sugawara, Jiachen Li, Yue Leng, Benjamin Elsworth, Robyn E Wootton, Si Fang, Qian Yang, Stephen Burgess, Philip C Haycock, Maria Carolina Borges, Yoonsu Cho, Rebecca Carnegie, Amy Howell, Jamie Robinson, Laurent F Thomas, Ben Michael Brumpton, Kristian Hveem, Stein Hallan, Nora Franceschini, Andrew P Morris, Anna Köttgen, Cristian Pattaro, Matthias Wuttke, Masayuki Yamamoto, Naoki Kashihara, Masato Akiyama, Masahiro Kanai, Koichi Matsuda, Yoichiro Kamatani, Yukinori Okada, Robin Walters, Iona Y Millwood, Zhengming Chen, George Davey Smith, Sean Barbour, Canqing Yu, Bjørn Olav Åsvold, Hong Zhang, Tom R Gaunt

International journal of epidemiology, Oct 20, 2021, doi: 10.1093/ije/dyab203

A cross-population atlas of genetic associations for 220 human phenotypes

Saori Sakaue, Masahiro Kanai, Yosuke Tanigawa, Juha Karjalainen, Mitja Kurki, Seizo Koshiba, Akira Narita, Takahiro Konuma, Kenichi Yamamoto, Masato Akiyama, Kazuyoshi Ishigaki, Akari Suzuki, Ken Suzuki, Wataru Obara, Ken Yamaji, Kazuhisa Takahashi, Satoshi Asai, Yasuo Takahashi, Takao Suzuki, Nobuaki Shinozaki, Hiroki Yamaguchi, Shiro Minami, Shigeo Murayama, Kozo Yoshimori, Satoshi Nagayama, Daisuke Obata, Masahiko Higashiyama, Akihide Masumoto, Yukihiro Koretsune, Kaoru Ito, Chikashi Terao, Toshimasa Yamauchi, Issei Komuro, Takashi Kadowaki, Gen Tamiya, Masayuki Yamamoto, Yusuke Nakamura, Michiaki Kubo, Yoshinori Murakami, Kazuhiko Yamamoto, Yoichiro Kamatani, Aarno Palotie, Manuel A. Rivas, Mark J. Daly, Koichi Matsuda, Yukinori Okada

Nature Genetics, 53(10), 1415-1424, Oct, 2021, doi: 10.1038/s41588-021-00931-x

Trans-ancestry genome-wide analysis of atrial fibrillation provides new insights into disease biology and enables polygenic prediction of cardioembolic risk

Kazuo Miyazawa, Kaoru Ito, Zhaonan Zou, Hiroshi Matsunaga, Satoshi Koyama, Hirotaka Ieki, Seitaro Nomura, Masato Akiyama, Ryo Kurosawa, Hiroki Yoshida, Kouichi Ozaki, Yoshihiro Onouchi, Atsushi Takahashi, Koichi Matsuda, Yoshinori Murakami, Hiroyuki Aburatani, Michiaki Kubo, Yukihide Momozawa, Chikashi Terao, Shinya Oki, Hiroshi Akazawa, Yoichiro Kamatani, Issei Komuro

Sep 12, 2021, doi: 10.1101/2021.09.06.21263189

「研究利活用のための脳卒中病態解明に資するゲノムデータベースの構築」一次調査結果

三輪 佳織, 鎌谷 洋一郎, 松尾 龍, 高橋 篤, 吉村 壮平, 冨田 努, 鴨打 正浩, 北園 孝成, 豊田 一則, 片岡 大治, 猪原 匡史, 古賀 政利

臨床神経学, 61(Suppl.), S337, Sep, 2021

Polygenic Risk Score of Adolescent Idiopathic Scoliosis for Potential Clinical Use.

Nao Otomo, Hsing-Fang Lu, Masaru Koido, Ikuyo Kou, Kazuki Takeda, Yukihide Momozawa, Michiaki Kubo, Yoichiro Kamatani, Yoji Ogura, Yohei Takahashi, Masahiro Nakajima, Shohei Minami, Koki Uno, Noriaki Kawakami, Manabu Ito, Tatsuya Sato, Kei Watanabe, Takashi Kaito, Haruhisa Yanagida, Hiroshi Taneichi, Katsumi Harimaya, Yuki Taniguchi, Hideki Shigematsu, Takahiro Iida, Satoru Demura, Ryo Sugawara, Nobuyuki Fujita, Mitsuru Yagi, Eijiro Okada, Naobumi Hosogane, Katsuki Kono, Masaya Nakamura, Kazuhiro Chiba, Toshiaki Kotani, Tsuyoshi Sakuma, Tsutomu Akazawa, Teppei Suzuki, Kotaro Nishida, Kenichiro Kakutani, Taichi Tsuji, Hideki Sudo, Akira Iwata, Kazuo Kaneko, Satoshi Inami, Yuta Kochi, Wei-Chiao Chang, Morio Matsumoto, Kota Watanabe, Shiro Ikegawa, Chikashi Terao

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 36(8), 1481-1491, Aug, 2021, doi: 10.1002/jbmr.4324

Combined landscape of single-nucleotide variants and copy number alterations in clonal hematopoiesis.

Ryunosuke Saiki, Yukihide Momozawa, Yasuhito Nannya, Masahiro M Nakagawa, Yotaro Ochi, Tetsuichi Yoshizato, Chikashi Terao, Yutaka Kuroda, Yuichi Shiraishi, Kenichi Chiba, Hiroko Tanaka, Atsushi Niida, Seiya Imoto, Koichi Matsuda, Takayuki Morisaki, Yoshinori Murakami, Yoichiro Kamatani, Shuichi Matsuda, Michiaki Kubo, Satoru Miyano, Hideki Makishima, Seishi Ogawa

Nature medicine, 27(7), 1239-1249, Jul, 2021, doi: 10.1038/s41591-021-01411-9

Eight novel susceptibility loci and putative causal variants in atopic dermatitis.

Nao Tanaka, Masaru Koido, Akari Suzuki, Nao Otomo, Hiroyuki Suetsugu, Yuta Kochi, Kouhei Tomizuka, Yukihide Momozawa, Yoichiro Kamatani, Shiro Ikegawa, Kazuhiko Yamamoto, Chikashi Terao

The Journal of allergy and clinical immunology, 148(5), 1293-1306, Jun 2, 2021, doi: 10.1016/j.jaci.2021.04.019

Hematopoietic mosaic chromosomal alterations increase the risk for diverse types of infection.

Seyedeh M Zekavat, Shu-Hong Lin, Alexander G Bick, Aoxing Liu, Kaavya Paruchuri, Chen Wang, Md Mesbah Uddin, Yixuan Ye, Zhaolong Yu, Xiaoxi Liu, Yoichiro Kamatani, Romit Bhattacharya, James P Pirruccello, Akhil Pampana, Po-Ru Loh, Puja Kohli, Steven A McCarroll, Krzysztof Kiryluk, Benjamin Neale, Iuliana Ionita-Laza, Eric A Engels, Derek W Brown, Jordan W Smoller, Robert Green, Elizabeth W Karlson, Matthew Lebo, Patrick T Ellinor, Scott T Weiss, Mark J Daly, Chikashi Terao, Hongyu Zhao, Benjamin L Ebert, Muredach P Reilly, Andrea Ganna, Mitchell J Machiela, Giulio Genovese, Pradeep Natarajan

Nature medicine, 27(6), 1012-1024, Jun, 2021, doi: 10.1038/s41591-021-01371-0

Genome-wide association study of more than 40,000 bipolar disorder cases provides new insights into the underlying biology.

Niamh Mullins, Andreas J Forstner, Kevin S O'Connell, Brandon Coombes, Jonathan R I Coleman, Zhen Qiao, Thomas D Als, Tim B Bigdeli, Sigrid Børte, Julien Bryois, Alexander W Charney, Ole Kristian Drange, Michael J Gandal, Saskia P Hagenaars, Masashi Ikeda, Nolan Kamitaki, Minsoo Kim, Kristi Krebs, Georgia Panagiotaropoulou, Brian M Schilder, Laura G Sloofman, Stacy Steinberg, Vassily Trubetskoy, Bendik S Winsvold, Hong-Hee Won, Liliya Abramova, Kristina Adorjan, Esben Agerbo, Mariam Al Eissa, Diego Albani, Ney Alliey-Rodriguez, Adebayo Anjorin, Verneri Antilla, Anastasia Antoniou, Swapnil Awasthi, Ji Hyun Baek, Marie Bækvad-Hansen, Nicholas Bass, Michael Bauer, Eva C Beins, Sarah E Bergen, Armin Birner, Carsten Bøcker Pedersen, Erlend Bøen, Marco P Boks, Rosa Bosch, Murielle Brum, Ben M Brumpton, Nathalie Brunkhorst-Kanaan, Monika Budde, Jonas Bybjerg-Grauholm, William Byerley, Murray Cairns, Miquel Casas, Pablo Cervantes, Toni-Kim Clarke, Cristiana Cruceanu, Alfredo Cuellar-Barboza, Julie Cunningham, David Curtis, Piotr M Czerski, Anders M Dale, Nina Dalkner, Friederike S David, Franziska Degenhardt, Srdjan Djurovic, Amanda L Dobbyn, Athanassios Douzenis, Torbjørn Elvsåshagen, Valentina Escott-Price, I Nicol Ferrier, Alessia Fiorentino, Tatiana M Foroud, Liz Forty, Josef Frank, Oleksandr Frei, Nelson B Freimer, Louise Frisén, Katrin Gade, Julie Garnham, Joel Gelernter, Marianne Giørtz Pedersen, Ian R Gizer, Scott D Gordon, Katherine Gordon-Smith, Tiffany A Greenwood, Jakob Grove, José Guzman-Parra, Kyooseob Ha, Magnus Haraldsson, Martin Hautzinger, Urs Heilbronner, Dennis Hellgren, Stefan Herms, Per Hoffmann, Peter A Holmans, Laura Huckins, Stéphane Jamain, Jessica S Johnson, Janos L Kalman, Yoichiro Kamatani, James L Kennedy, Sarah Kittel-Schneider, James A Knowles, Manolis Kogevinas, Maria Koromina, Thorsten M Kranz, Henry R Kranzler, Michiaki Kubo, Ralph Kupka, Steven A Kushner, Catharina Lavebratt, Jacob Lawrence, Markus Leber, Heon-Jeong Lee, Phil H Lee, Shawn E Levy, Catrin Lewis, Calwing Liao, Susanne Lucae, Martin Lundberg, Donald J MacIntyre, Sigurdur H Magnusson, Wolfgang Maier, Adam Maihofer, Dolores Malaspina, Eirini Maratou, Lina Martinsson, Manuel Mattheisen, Steven A McCarroll, Nathaniel W McGregor, Peter McGuffin, James D McKay, Helena Medeiros, Sarah E Medland, Vincent Millischer, Grant W Montgomery, Jennifer L Moran, Derek W Morris, Thomas W Mühleisen, Niamh O'Brien, Claire O'Donovan, Loes M Olde Loohuis, Lilijana Oruc, Sergi Papiol, Antonio F Pardiñas, Amy Perry, Andrea Pfennig, Evgenia Porichi, James B Potash, Digby Quested, Towfique Raj, Mark H Rapaport, J Raymond DePaulo, Eline J Regeer, John P Rice, Fabio Rivas, Margarita Rivera, Julian Roth, Panos Roussos, Douglas M Ruderfer, Cristina Sánchez-Mora, Eva C Schulte, Fanny Senner, Sally Sharp, Paul D Shilling, Engilbert Sigurdsson, Lea Sirignano, Claire Slaney, Olav B Smeland, Daniel J Smith, Janet L Sobell, Christine Søholm Hansen, Maria Soler Artigas, Anne T Spijker, 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Hreinn Stefansson, Kari Stefansson, Eystein Stordal, Fabian Streit, Patrick F Sullivan, Gustavo Turecki, Arne E Vaaler, Eduard Vieta, John B Vincent, Irwin D Waldman, Thomas W Weickert, Thomas Werge, Naomi R Wray, John-Anker Zwart, Joanna M Biernacka, John I Nurnberger, Sven Cichon, Howard J Edenberg, Eli A Stahl, Andrew McQuillin, Arianna Di Florio, Roel A Ophoff, Ole A Andreassen

Nature genetics, 53(6), 817-829, Jun, 2021, doi: 10.1038/s41588-021-00857-4

An X chromosome-wide meta-analysis based on Japanese cohorts revealed that non-autosomal variations are associated with serum urate.

Masahiro Nakatochi, Yu Toyoda, Masahiro Kanai, Akiyoshi Nakayama, Yusuke Kawamura, Asahi Hishida, Haruo Mikami, Keitaro Matsuo, Toshiro Takezaki, Yukihide Momozawa, Yoichiro Kamatani, Sahoko Ichihara, Nariyoshi Shinomiya, Mitsuhiro Yokota, Kenji Wakai, Yukinori Okada, Hirotaka Matsuo

Rheumatology (Oxford, England), 60(9), 4430-4432, May 4, 2021, doi: 10.1093/rheumatology/keab404

Publisher Correction: Clinical use of current polygenic risk scores may exacerbate health disparities (Nature Genetics, (2019), 51, 4, (584-591), 10.1038/s41588-019-0379-x)

Alicia R. Martin, Masahiro Kanai, Yoichiro Kamatani, Yukinori Okada, Benjamin M. Neale, Mark J. Daly

Nature Genetics, 53(5), 763, May 1, 2021, doi: 10.1038/s41588-021-00797-z

Whole genome sequencing of 45 Japanese patients with intellectual disability.

Chihiro Abe-Hatano, Aritoshi Iida, Shunichi Kosugi, Yukihide Momozawa, Chikashi Terao, Keiko Ishikawa, Mariko Okubo, Yasuo Hachiya, Hiroya Nishida, Kazuyuki Nakamura, Rie Miyata, Chie Murakami, Kan Takahashi, Kyoko Hoshino, Haruko Sakamoto, Sayaka Ohta, Masaya Kubota, Eri Takeshita, Akihiko Ishiyama, Eiji Nakagawa, Masayuki Sasaki, Mitsuhiro Kato, Naomichi Matsumoto, Yoichiro Kamatani, Michiaki Kubo, Yoshiyuki Takahashi, Jun Natsume, Ken Inoue, Yu-Ichi Goto

American journal of medical genetics. Part A, 185(5), 1468-1480, May, 2021, doi: 10.1002/ajmg.a.62138

Regional differences in genes and variants causing retinitis pigmentosa in Japan.

Yoshito Koyanagi, Masato Akiyama, Koji M Nishiguchi, Yukihide Momozawa, Yoichiro Kamatani, Sadaaki Takata, Chihiro Inai, Yusuke Iwasaki, Mikako Kumano, Yusuke Murakami, Shiori Komori, Dan Gao, Kentaro Kurata, Katsuhiro Hosono, Shinji Ueno, Yoshihiro Hotta, Akira Murakami, Hiroko Terasaki, Yuko Wada, Toru Nakazawa, Tatsuro Ishibashi, Yasuhiro Ikeda, Michiaki Kubo, Koh-Hei Sonoda

Japanese journal of ophthalmology, 65(3), 338-343, May, 2021, doi: 10.1007/s10384-021-00824-w

Genome‐wide association study of epilepsy in a Japanese population identified an associated region at chromosome 12q24

Toshimitsu Suzuki, Yoshinao Koike, Kyota Ashikawa, Nao Otomo, Atsushi Takahashi, Tomomi Aoi, Naoyuki Kamatani, Yusuke Nakamura, Michiaki Kubo, Yoichiro Kamatani, Yukihide Momozawa, Chikashi Terao, Kazuhiro Yamakawa

Epilepsia, 62(6), 1391-1400, Apr 29, 2021, doi: 10.1111/epi.16911

Genome-wide analysis identifies novel susceptibility loci for myocardial infarction.

Jaana A Hartiala, Yi Han, Qiong Jia, James R Hilser, Pin Huang, Janet Gukasyan, William S Schwartzman, Zhiheng Cai, Subarna Biswas, David-Alexandre Trégouët, Nicholas L Smith, Marcus Seldin, Calvin Pan, Margarete Mehrabian, Aldons J Lusis, Peter Bazeley, Yan V Sun, Chang Liu, Arshed A Quyyumi, Markus Scholz, Joachim Thiery, Graciela E Delgado, Marcus E Kleber, Winfried März, Laurence J Howe, Folkert W Asselbergs, Marion van Vugt, Georgios J Vlachojannis, Riyaz S Patel, Leo-Pekka Lyytikäinen, Mika Kähönen, Terho Lehtimäki, Tuomo V M Nieminen, Pekka Kuukasjärvi, Jari O Laurikka, Xuling Chang, Chew-Kiat Heng, Rong Jiang, William E Kraus, Elizabeth R Hauser, Jane F Ferguson, Muredach P Reilly, Kaoru Ito, Satoshi Koyama, Yoichiro Kamatani, Issei Komuro, Lindsey K Stolze, Casey E Romanoski, Mohammad Daud Khan, Adam W Turner, Clint L Miller, Redouane Aherrahrou, Mete Civelek, Lijiang Ma, Johan L M Björkegren, S Ram Kumar, W H Wilson Tang, Stanley L Hazen, Hooman Allayee

European heart journal, 42(9), 919-933, Mar 1, 2021, doi: 10.1093/eurheartj/ehaa1040

Author Correction: Genome-wide association study of intracranial aneurysms identifies 17 risk loci and genetic overlap with clinical risk factors (Nature Genetics, (2020), 52, 12, (1303-1313), 10.1038/s41588-020-00725-7)

Mark K. Bakker, Rick A. A. van der Spek, Wouter van Rheenen, Sandrine Morel, Romain Bourcier, Isabel C. Hostettler, Varinder S. Alg, Kristel R. van Eijk, Masaru Koido, Masato Akiyama, Chikashi Terao, Koichi Matsuda, Robin G. Walters, Kuang Lin, Liming Li, Iona Y. Millwood, Zhengming Chen, Guy A. Rouleau, Sirui Zhou, Kristiina Rannikmäe, Cathie L. M. Sudlow, Henry Houlden, Leonard H. van den Berg, Christian Dina, Olivier Naggara, Jean-Christophe Gentric, Eimad Shotar, François Eugène, Hubert Desal, Bendik S. Winsvold, Sigrid Børte, Marianne Bakke Johnsen, Ben M. Brumpton, Marie Søfteland Sandvei, Cristen J. Willer, Kristian Hveem, John-Anker Zwart, W. M. Monique Verschuren, Christoph M. Friedrich, Sven Hirsch, Sabine Schilling, Jérôme Dauvillier, Olivier Martin, Zheng Bian, Junshi Chen, Yiping Chen, Robert Clarke, Rory Collins, Yu Guo, Xiao Han, Michael Hill, Depei Liu, Jun Lv, Richard Peto, Sam Sansome, Robin Walters, Xiaoming Yang, Canqing Yu, Stephen Bonner, Daniel Walsh, Diederik Bulters, Neil Kitchen, Martin Brown, Joan Grieve, Martin Dichgans, Gregory T. Jones, Matthew J. Bown, Nerissa U. Ko, Helen Kim, Jonathan R. I. Coleman, Gerome Breen, Jonathan G. Zaroff, Catharina J. M. Klijn, Rainer Malik, Martin Dichgans, Muralidharan Sargurupremraj, Turgut Tatlisumak, Philippe Amouyel, Stéphanie Debette, Gabriel J. E. Rinkel, Bradford B. Worrall, Joanna Pera, Agnieszka Slowik, Emília I. Gaál-Paavola, Mika Niemelä, Juha E. Jääskeläinen, Mikael von Und Zu Fraunberg, Antti Lindgren, Joseph P. Broderick, David J. Werring, Daniel Woo, Richard Redon, Philippe Bijlenga, Yoichiro Kamatani, Jan H. Veldink, Ynte M. Ruigrok, HUNT All-In Stroke

Nature Genetics, 53(2), 254, Feb 1, 2021, doi: 10.1038/s41588-020-00760-4

Impact of sleep-disordered breathing on glucose metabolism among individuals with a family history of diabetes: the Nagahama study.

Takuma Minami, Takeshi Matsumoto, Yasuharu Tabara, David Gozal, Dale Smith, Kimihiko Murase, Kiminobu Tanizawa, Naomi Takahashi, Yoshinari Nakatsuka, Satoshi Hamada, Tomohiro Handa, Hirofumi Takeyama, Toru Oga, Isuzu Nakamoto, Tomoko Wakamura, Naoko Komenami, Kazuya Setoh, Takanobu Tsutsumi, Takahisa Kawaguchi, Yoichiro Kamatani, Yoshimitsu Takahashi, Satoshi Morita, Takeo Nakayama, Toyohiro Hirai, Fumihiko Matsuda, Kazuo Chin

Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine, 17(2), 129-140, Feb 1, 2021, doi: 10.5664/jcsm.8796

Tractor uses local ancestry to enable the inclusion of admixed individuals in GWAS and to boost power

Elizabeth G. Atkinson, Adam X. Maihofer, Masahiro Kanai, Alicia R. Martin, Konrad J. Karczewski, Marcos L. Santoro, Jacob C. Ulirsch, Yoichiro Kamatani, Yukinori Okada, Hilary K. Finucane, Karestan C. Koenen, Caroline M. Nievergelt, Mark J. Daly, Benjamin M. Neale

Nature Genetics, 53(2), 195-204, Feb, 2021, doi: 10.1038/s41588-020-00766-y

Genome-wide SNP data of Izumo and Makurazaki populations support inner-dual structure model for origin of Yamato people.

Timothy Jinam, Yosuke Kawai, Yoichiro Kamatani, Shunro Sonoda, Kanro Makisumi, Hideya Sameshima, Katsushi Tokunaga, Naruya Saitou

Journal of human genetics, Jan 25, 2021, doi: 10.1038/s10038-020-00898-3

Genetic variations in medical research in the past, at present and in the future.

Yoichiro Kamatani, Yusuke Nakamura

Proceedings of the Japan Academy. Series B, Physical and biological sciences, 97(6), 324-335, 2021, doi: 10.2183/pjab.97.018

Two decades after Human Genome Project: do large-genetic studies lead to path of the genomic medicine of complex diseases?

Yoichiro Kamatani, Yukinori Okada

Journal of Human Genetics, 66(1), 1, Jan, 2021, doi: 10.1038/s10038-020-00828-3

Whole genome sequence analyses of eGFR in 23,732 people representing multiple ancestries in the NHLBI trans-omics for precision medicine (TOPMed) consortium.

Bridget M Lin, Kelsey E Grinde, Jennifer A Brody, Charles E Breeze, Laura M Raffield, Josyf C Mychaleckyj, Timothy A Thornton, James A Perry, Leslie J Baier, Lisa de Las Fuentes, Xiuqing Guo, Benjamin D Heavner, Robert L Hanson, Yi-Jen Hung, Huijun Qian, Chao A Hsiung, Shih-Jen Hwang, Margaret R Irvin, Deepti Jain, Tanika N Kelly, Sayuko Kobes, Leslie Lange, James P Lash, Yun Li, Xiaoming Liu, Xuenan Mi, Solomon K Musani, George J Papanicolaou, Afshin Parsa, Alex P Reiner, Shabnam Salimi, Wayne H-H Sheu, Alan R Shuldiner, Kent D Taylor, Albert V Smith, Jennifer A Smith, Adrienne Tin, Dhananjay Vaidya, Robert B Wallace, Kenichi Yamamoto, Saori Sakaue, Koichi Matsuda, Yoichiro Kamatani, Yukihide Momozawa, Lisa R Yanek, Betsi A Young, Wei Zhao, Yukinori Okada, Gonzalo Abecasis, Bruce M Psaty, Donna K Arnett, Eric Boerwinkle, Jianwen Cai, Ida Yii-Der Chen, Adolfo Correa, L Adrienne Cupples, Jiang He, Sharon Lr Kardia, Charles Kooperberg, Rasika A Mathias, Braxton D Mitchell, Deborah A Nickerson, Steve T Turner, Vasan S Ramachandran, Jerome I Rotter, Daniel Levy, Holly J Kramer, Anna Köttgen, Nhlbi Trans-Omics For Precision Medicine TOPMed Consortium, TOPMed Kidney Working Group, Stephen S Rich, Dan-Yu Lin, Sharon R Browning, Nora Franceschini

EBioMedicine, 63, 103157, Jan, 2021, doi: 10.1016/j.ebiom.2020.103157

202037 papers

Population-based Screening for Hereditary Colorectal Cancer Variants in Japan.

Masashi Fujita, Xiaoxi Liu, Yusuke Iwasaki, Chikashi Terao, Keijiro Mizukami, Eiryo Kawakami, Sadaaki Takata, Chihiro Inai, Tomomi Aoi, Misaki Mizukoshi, Kazuhiro Maejima, Makoto Hirata, Yoshinori Murakami, Yoichiro Kamatani, Michiaki Kubo, Kiwamu Akagi, Koichi Matsuda, Hidewaki Nakagawa, Yukihide Momozawa

Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, 20(9), 2132-2141, Dec 11, 2020, doi: 10.1016/j.cgh.2020.12.007

Cerebral small vessel disease genomics and its implications across the lifespan

Muralidharan Sargurupremraj, Hideaki Suzuki, Xueqiu Jian, Chloé Sarnowski, Tavia E. Evans, Joshua C. Bis, Gudny Eiriksdottir, Saori Sakaue, Natalie Terzikhan, Mohamad Habes, Wei Zhao, Nicola J. Armstrong, Edith Hofer, Lisa R. Yanek, Saskia P. Hagenaars, Rajan B. Kumar, Erik B. van den Akker, Rebekah E. McWhirter, Stella Trompet, Aniket Mishra, Yasaman Saba, Claudia L. Satizabal, Gregory Beaudet, Laurent Petit, Ami Tsuchida, Laure Zago, Sabrina Schilling, Sigurdur Sigurdsson, Rebecca F. Gottesman, Cora E. Lewis, Neelum T. Aggarwal, Oscar L. Lopez, Jennifer A. Smith, Maria C. Valdés Hernández, Jeroen van der Grond, Margaret J. Wright, Maria J. Knol, Marcus Dörr, Russell J. Thomson, Constance Bordes, Quentin Le Grand, Marie-Gabrielle Duperron, Albert V. Smith, David S. Knopman, Pamela J. Schreiner, Denis A. Evans, Jerome I. Rotter, Alexa S. Beiser, Susana Muñoz Maniega, Marian Beekman, Julian Trollor, David J. Stott, Meike W. Vernooij, Katharina Wittfeld, Wiro J. Niessen, Aicha Soumaré, Eric Boerwinkle, Stephen Sidney, Stephen T. Turner, Gail Davies, Anbupalam Thalamuthu, Uwe Völker, Mark A. van Buchem, R. Nick Bryan, Josée Dupuis, Mark E. Bastin, David Ames, Alexander Teumer, Philippe Amouyel, John B. Kwok, Robin Bülow, Ian J. Deary, Peter R. Schofield, Henry Brodaty, Jiyang Jiang, Yasuharu Tabara, Kazuya Setoh, Susumu Miyamoto, Kazumichi Yoshida, Manabu Nagata, Yoichiro Kamatani, Fumihiko Matsuda, Bruce M. Psaty, David A. Bennett, Philip L. De Jager, Thomas H. Mosley, Perminder S. Sachdev, Reinhold Schmidt, Helen R. Warren, Evangelos Evangelou, David-Alexandre Trégouët, Mohammad A. Ikram, Wei Wen, Charles DeCarli, Velandai K. Srikanth, J. Wouter Jukema, Eline P. Slagboom, Sharon L. R. Kardia, Yukinori Okada, Bernard Mazoyer, Joanna M. Wardlaw, Paul A. Nyquist, Karen A. Mather, Hans J. Grabe, Helena Schmidt, Cornelia M. Van Duijn, Vilmundur Gudnason, William T. Longstreth, Lenore J. Launer, Mark Lathrop, Sudha Seshadri, Christophe Tzourio, Hieab H. Adams, Paul M. Matthews, Myriam Fornage, Stéphanie Debette

Nature Communications, 11(1), Dec, 2020, doi: 10.1038/s41467-020-19111-2

Genome-wide association study of intracranial aneurysms identifies 17 risk loci and genetic overlap with clinical risk factors.

Mark K Bakker, Rick A A van der Spek, Wouter van Rheenen, Sandrine Morel, Romain Bourcier, Isabel C Hostettler, Varinder S Alg, Kristel R van Eijk, Masaru Koido, Masato Akiyama, Chikashi Terao, Koichi Matsuda, Robin G Walters, Kuang Lin, Liming Li, Iona Y Millwood, Zhengming Chen, Guy A Rouleau, Sirui Zhou, Kristiina Rannikmäe, Cathie L M Sudlow, Henry Houlden, Leonard H van den Berg, Christian Dina, Olivier Naggara, Jean-Christophe Gentric, Eimad Shotar, François Eugène, Hubert Desal, Bendik S Winsvold, Sigrid Børte, Marianne Bakke Johnsen, Ben M Brumpton, Marie Søfteland Sandvei, Cristen J Willer, Kristian Hveem, John-Anker Zwart, W M Monique Verschuren, Christoph M Friedrich, Sven Hirsch, Sabine Schilling, Jérôme Dauvillier, Olivier Martin, Gregory T Jones, Matthew J Bown, Nerissa U Ko, Helen Kim, Jonathan R I Coleman, Gerome Breen, Jonathan G Zaroff, Catharina J M Klijn, Rainer Malik, Martin Dichgans, Muralidharan Sargurupremraj, Turgut Tatlisumak, Philippe Amouyel, Stéphanie Debette, Gabriel J E Rinkel, Bradford B Worrall, Joanna Pera, Agnieszka Slowik, Emília I Gaál-Paavola, Mika Niemelä, Juha E Jääskeläinen, Mikael von Und Zu Fraunberg, Antti Lindgren, Joseph P Broderick, David J Werring, Daniel Woo, Richard Redon, Philippe Bijlenga, Yoichiro Kamatani, Jan H Veldink, Ynte M Ruigrok

Nature genetics, 52(12), 1303-1313, Dec, 2020, doi: 10.1038/s41588-020-00725-7

A Mendelian randomization study identified obesity as a causal risk factor of uterine endometrial cancer in Japanese.

Tatsuo Masuda, Kotaro Ogawa, Yoichiro Kamatani, Yoshinori Murakami, Tadashi Kimura, Yukinori Okada

Cancer science, 111(12), 4646-4651, Dec, 2020, doi: 10.1111/cas.14667

Identification of a novel uterine leiomyoma GWAS locus in a Japanese population

Kensuke Sakai, Chizu Tanikawa, Akira Hirasawa, Tatsuyuki Chiyoda, Wataru Yamagami, Fumio Kataoka, Nobuyuki Susumu, Chikashi Terao, Yoichiro Kamatani, Atsushi Takahashi, Yukihide Momozawa, Makoto Hirata, Michiaki Kubo, Nobuo Fuse, Takako Takai-Igarashi, Atsushi Shimizu, Akimune Fukushima, Aya Kadota, Kokichi Arisawa, Hiroaki Ikezaki, Kenji Wakai, Taiki Yamaji, Norie Sawada, Motoki Iwasaki, Shoichiro Tsugane, Daisuke Aoki, Koichi Matsuda

Scientific Reports, 10(1), Dec, 2020, doi: 10.1038/s41598-020-58066-8

Dimensionality reduction reveals fine-scale structure in the Japanese population with consequences for polygenic risk prediction

Saori Sakaue, Jun Hirata, Masahiro Kanai, Ken Suzuki, Masato Akiyama, Chun Lai Too, Thurayya Arayssi, Mohammed Hammoudeh, Samar Al Emadi, Basel K. Masri, Hussein Halabi, Humeira Badsha, Imad W. Uthman, Richa Saxena, Leonid Padyukov, Makoto Hirata, Koichi Matsuda, Yoshinori Murakami, Yoichiro Kamatani, Yukinori Okada

Nature Communications, 11(1), Dec 1, 2020, doi: 10.1038/s41467-020-15194-z

Genetic and phenotypic landscape of the mitochondrial genome in the Japanese population

Kenichi Yamamoto, Saori Sakaue, Koichi Matsuda, Yoshinori Murakami, Yoichiro Kamatani, Keiichi Ozono, Yukihide Momozawa, Yukinori Okada

Communications Biology, 3(1), Dec 1, 2020, doi: 10.1038/s42003-020-0812-9

Prevalence and Spectrum of Pathogenic Germline Variants in Japanese Patients With Early-Onset Colorectal, Breast, and Prostate Cancer.

Xiaoxi Liu, Sadaaki Takata, Kyota Ashikawa, Tomomi Aoi, Shunichi Kosugi, Chikashi Terao, Nicholas F Parrish, Koichi Matsuda, Hidewaki Nakagawa, Yoichiro Kamatani, Michiaki Kubo, Yukihide Momozawa

JCO precision oncology, 4, 183-191, Nov, 2020, doi: 10.1200/PO.19.00224

Population-specific and trans-ancestry genome-wide analyses identify distinct and shared genetic risk loci for coronary artery disease.

Satoshi Koyama, Kaoru Ito, Chikashi Terao, Masato Akiyama, Momoko Horikoshi, Yukihide Momozawa, Hiroshi Matsunaga, Hirotaka Ieki, Kouichi Ozaki, Yoshihiro Onouchi, Atsushi Takahashi, Seitaro Nomura, Hiroyuki Morita, Hiroshi Akazawa, Changhoon Kim, Jeong-Sun Seo, Koichiro Higasa, Motoki Iwasaki, Taiki Yamaji, Norie Sawada, Shoichiro Tsugane, Teruhide Koyama, Hiroaki Ikezaki, Naoyuki Takashima, Keitaro Tanaka, Kokichi Arisawa, Kiyonori Kuriki, Mariko Naito, Kenji Wakai, Shinichiro Suna, Yasuhiko Sakata, Hiroshi Sato, Masatsugu Hori, Yasushi Sakata, Koichi Matsuda, Yoshinori Murakami, Hiroyuki Aburatani, Michiaki Kubo, Fumihiko Matsuda, Yoichiro Kamatani, Issei Komuro

Nature genetics, 52(11), 1169-1177, Nov, 2020, doi: 10.1038/s41588-020-0705-3

A global atlas of genetic associations of 220 deep phenotypes

Saori Sakaue, Masahiro Kanai, Yosuke Tanigawa, Juha Karjalainen, Mitja Kurki, Seizo Koshiba, Akira Narita, Takahiro Konuma, Kenichi Yamamoto, Masato Akiyama, Kazuyoshi Ishigaki, Akari Suzuki, Ken Suzuki, Wataru Obara, Ken Yamaji, Kazuhisa Takahashi, Satoshi Asai, Yasuo Takahashi, Takao Suzuki, Nobuaki Shinozaki, Hiroki Yamaguchi, Shiro Minami, Shigeo Murayama, Kozo Yoshimori, Satoshi Nagayama, Daisuke Obata, Masahiko Higashiyama, Akihide Masumoto, Yukihiro Koretsune, Kaoru Ito FinnGen, Chikashi Terao, Toshimasa Yamauchi, Issei Komuro, Takashi Kadowaki, Gen Tamiya, Masayuki Yamamoto, Yusuke Nakamura, Michiaki Kubo, Yoshinori Murakami, Kazuhiko Yamamoto, Yoichiro Kamatani, Aarno Palotie, Manuel A. Rivas, Mark J. Daly, Koichi Matsuda, Yukinori Okada

Oct 27, 2020, doi: 10.1101/2020.10.23.20213652

Genetic characterization of pancreatic cancer patients and prediction of carrier status of germline pathogenic variants in cancer-predisposing genes.

Keijiro Mizukami, Yusuke Iwasaki, Eiryo Kawakami, Makoto Hirata, Yoichiro Kamatani, Koichi Matsuda, Mikiko Endo, Kokichi Sugano, Teruhiko Yoshida, Yoshinori Murakami, Hidewaki Nakagawa, Amanda B Spurdle, Yukihide Momozawa

EBioMedicine, 60, 103033, Oct, 2020, doi: 10.1016/j.ebiom.2020.103033

Association of the RPA3-UMAD1 locus with interstitial lung diseases complicated with rheumatoid arthritis in Japanese.

Yuya Shirai, Suguru Honda, Katsunori Ikari, Masahiro Kanai, Yoshito Takeda, Yoichiro Kamatani, Takayuki Morisaki, Eiichi Tanaka, Atsushi Kumanogoh, Masayoshi Harigai, Yukinori Okada

Annals of the rheumatic diseases, 79(10), 1305-1309, Oct, 2020, doi: 10.1136/annrheumdis-2020-217256

A multi-ethnic meta-analysis identifies novel genes, including ACSL5, associated with amyotrophic lateral sclerosis.

Ryoichi Nakamura, Kazuharu Misawa, Genki Tohnai, Masahiro Nakatochi, Sho Furuhashi, Naoki Atsuta, Naoki Hayashi, Daichi Yokoi, Hazuki Watanabe, Hirohisa Watanabe, Masahisa Katsuno, Yuishin Izumi, Kazuaki Kanai, Nobutaka Hattori, Mitsuya Morita, Akira Taniguchi, Osamu Kano, Masaya Oda, Kazumoto Shibuya, Satoshi Kuwabara, Naoki Suzuki, Masashi Aoki, Yasuyuki Ohta, Toru Yamashita, Koji Abe, Rina Hashimoto, Ikuko Aiba, Koichi Okamoto, Kouichi Mizoguchi, Kazuko Hasegawa, Yohei Okada, Tomohiko Ishihara, Osamu Onodera, Kenji Nakashima, Ryuji Kaji, Yoichiro Kamatani, Shiro Ikegawa, Yukihide Momozawa, Michiaki Kubo, Noriko Ishida, Naoko Minegishi, Masao Nagasaki, Gen Sobue

Communications biology, 3(1), 526, Sep 23, 2020, doi: 10.1038/s42003-020-01251-2

Trans-ethnic and Ancestry-Specific Blood-Cell Genetics in 746,667 Individuals from 5 Global Populations

Ming Huei Chen, Laura M. Raffield, Abdou Mousas, Saori Sakaue, Jennifer E. Huffman, Arden Moscati, Bhavi Trivedi, Tao Jiang, Parsa Akbari, Dragana Vuckovic, Erik L. Bao, Xue Zhong, Regina Manansala, Véronique Laplante, Minhui Chen, Ken Sin Lo, Huijun Qian, Caleb A. Lareau, Mélissa Beaudoin, Karen A. Hunt, Masato Akiyama, Traci M. Bartz, Yoav Ben-Shlomo, Andrew Beswick, Jette Bork-Jensen, Erwin P. Bottinger, Jennifer A. Brody, Frank J.A. van Rooij, Kumaraswamynaidu Chitrala, Kelly Cho, Hélène Choquet, Adolfo Correa, John Danesh, Emanuele Di Angelantonio, Niki Dimou, Jingzhong Ding, Paul Elliott, Tõnu Esko, Michele K. Evans, James S. Floyd, Linda Broer, Niels Grarup, Michael H. Guo, Andreas Greinacher, Jeff Haessler, Torben Hansen, Joanna M.M. Howson, Qin Qin Huang, Wei Huang, Eric Jorgenson, Tim Kacprowski, Mika Kähönen, Yoichiro Kamatani, Masahiro Kanai, Savita Karthikeyan, Fotis Koskeridis, Leslie A. Lange, Terho Lehtimäki, Markus M. Lerch, Allan Linneberg, Yongmei Liu, Leo Pekka Lyytikäinen, Ani Manichaikul, Hilary C. Martin, Koichi Matsuda, Karen L. Mohlke, Nina Mononen, Yoshinori Murakami, Girish N. Nadkarni, Matthias Nauck, Kjell Nikus, Willem H. Ouwehand, Nathan Pankratz, Oluf Pedersen, Michael Preuss, Bruce M. Psaty, Olli T. Raitakari, David J. Roberts, Stephen S. Rich, Benjamin A.T. Rodriguez, Jonathan D. Rosen, Jerome I. Rotter, Petra Schubert, Cassandra N. Spracklen, Praveen Surendran, Hua Tang, Jean Claude Tardif, Richard C. Trembath, Mohsen Ghanbari, Uwe Völker, Henry Völzke, Nicholas A. Watkins, Alan B. Zonderman, Peter W.F. Wilson, Yun Li, Adam S. Butterworth, Jean François Gauchat, Charleston W.K. Chiang, Bingshan Li, Ruth J.F. Loos

Cell, 182(5), 1198-1213.e14, Sep 3, 2020, doi: 10.1016/j.cell.2020.06.045

The Polygenic and Monogenic Basis of Blood Traits and Diseases

Dragana Vuckovic, Erik L. Bao, Parsa Akbari, Caleb A. Lareau, Abdou Mousas, Tao Jiang, Ming-Huei Chen, Laura M. Raffield, Manuel Tardaguila, Jennifer E. Huffman, Scott C. Ritchie, Karyn Megy, Hannes Ponstingl, Christopher J. Penkett, Patrick K. Albers, Emilie M. Wigdor, Saori Sakaue, Arden Moscati, Regina Manansala, Ken Sin Lo, Huijun Qian, Masato Akiyama, Traci M. Bartz, Yoav Ben-Shlomo, Andrew Beswick, Jette Bork-Jensen, Erwin P. Bottinger, Jennifer A. Brody, Frank J.A. van Rooij, Kumaraswamy N. Chitrala, Peter W.F. Wilson, Hélène Choquet, John Danesh, Emanuele Di Angelantonio, Niki Dimou, Jingzhong Ding, Paul Elliott, Tõnu Esko, Michele K. Evans, Stephan B. Felix, James S. Floyd, Linda Broer, Niels Grarup, Michael H. Guo, Qi Guo, Andreas Greinacher, Jeff Haessler, Torben Hansen, Joanna M.M. Howson, Wei Huang, Eric Jorgenson, Tim Kacprowski, Mika Kähönen, Yoichiro Kamatani, Masahiro Kanai, Savita Karthikeyan, Fotios Koskeridis, Leslie A. Lange, Terho Lehtimäki, Allan Linneberg, Yongmei Liu, Leo-Pekka Lyytikäinen, Ani Manichaikul, Koichi Matsuda, Karen L. Mohlke, Nina Mononen, Yoshinori Murakami, Girish N. Nadkarni, Kjell Nikus, Nathan Pankratz, Oluf Pedersen, Michael Preuss, Bruce M. Psaty, Olli T. Raitakari, Stephen S. Rich, Benjamin A.T. Rodriguez, Jonathan D. Rosen, Jerome I. Rotter, Petra Schubert, Cassandra N. Spracklen, Praveen Surendran, Hua Tang, Jean-Claude Tardif, Mohsen Ghanbari, Uwe Völker, Henry Völzke, Nicholas A. Watkins, Stefan Weiss, Na Cai, Kousik Kundu, Stephen B. Watt, Klaudia Walter, Alan B. Zonderman, Kelly Cho, Yun Li, Ruth J.F. Loos, Julian C. Knight, Michel Georges, Oliver Stegle, Evangelos Evangelou, Yukinori Okada, David J. Roberts, Michael Inouye, Andrew D. Johnson, Paul L. Auer, William J. Astle, Alexander P. Reiner, Adam S. Butterworth, Willem H. Ouwehand, Guillaume Lettre, Vijay G. Sankaran, Nicole Soranzo

Cell, 182(5), 1214-1231.e11, Sep, 2020, doi: 10.1016/j.cell.2020.08.008

Endogenization and excision of human herpesvirus 6 in human genomes

Xiaoxi Liu, Shunichi Kosugi, Rie Koide, Yoshiki Kawamura, Jumpei Ito, Hiroki Miura, Nana Matoba, Motomichi Matsuzaki, Masashi Fujita, Anselmo Jiro Kamada, Hidewaki Nakagawa, Gen Tamiya, Koichi Matsuda, Yoshinori Murakami, Michiaki Kubo, Amr Aswad, Kei Sato, Yukihide Momozawa, Jun Ohashi, Chikashi Terao, Tetsushi Yoshikawa, Nicholas F. Parrish, Yoichiro Kamatani

PLOS Genetics, 16(8), e1008915, Aug 10, 2020, doi: 10.1371/journal.pgen.1008915

Chromosomal alterations among age-related haematopoietic clones in Japan.

Chikashi Terao, Akari Suzuki, Yukihide Momozawa, Masato Akiyama, Kazuyoshi Ishigaki, Kazuhiko Yamamoto, Koichi Matsuda, Yoshinori Murakami, Steven A McCarroll, Michiaki Kubo, Po-Ru Loh, Yoichiro Kamatani

Nature, 584(7819), 130-135, Aug, 2020, doi: 10.1038/s41586-020-2426-2

Evidence of Polygenic Adaptation in Sardinia at Height-Associated Loci Ascertained from the Biobank Japan.

Minhui Chen, Carlo Sidore, Masato Akiyama, Kazuyoshi Ishigaki, Yoichiro Kamatani, David Schlessinger, Francesco Cucca, Yukinori Okada, Charleston W K Chiang

American journal of human genetics, 107(1), 60-71, Jul 2, 2020, doi: 10.1016/j.ajhg.2020.05.014

LDL receptor gene familyのひとつであるLRP2遺伝子の一塩基多型rs2544390は痛風発症と関連する 日本人男性におけるメタ解析

赤司 藍理, 中山 昌喜, 東野 俊英, 清水 聖子, 河村 優輔, 川口 真, 高尾 幹也, 高田 龍平, 市田 公美, 大山 博司, 四ノ宮 成祥, 松尾 洋孝, 鎌谷 洋一郎, 松尾 道憲, 井本 美咲, 内藤 真理子, 菱田 朝陽

痛風と尿酸・核酸, 44(1), 87, Jul, 2020

LDL receptor gene familyのひとつであるLRP2遺伝子の一塩基多型rs2544390は痛風発症と関連する 日本人男性におけるメタ解析

赤司 藍理, 中山 昌喜, 東野 俊英, 清水 聖子, 河村 優輔, 川口 真, 高尾 幹也, 高田 龍平, 市田 公美, 大山 博司, 四ノ宮 成祥, 松尾 洋孝, 鎌谷 洋一郎, 松尾 道憲, 井本 美咲, 内藤 真理子, 菱田 朝陽

痛風と尿酸・核酸, 44(1), 87, Jul, 2020

Large-scale genome-wide association study in a Japanese population identifies novel susceptibility loci across different diseases.

Kazuyoshi Ishigaki, Masato Akiyama, Masahiro Kanai, Atsushi Takahashi, Eiryo Kawakami, Hiroki Sugishita, Saori Sakaue, Nana Matoba, Siew-Kee Low, Yukinori Okada, Chikashi Terao, Tiffany Amariuta, Steven Gazal, Yuta Kochi, Momoko Horikoshi, Ken Suzuki, Kaoru Ito, Satoshi Koyama, Kouichi Ozaki, Shumpei Niida, Yasushi Sakata, Yasuhiko Sakata, Takashi Kohno, Kouya Shiraishi, Yukihide Momozawa, Makoto Hirata, Koichi Matsuda, Masashi Ikeda, Nakao Iwata, Shiro Ikegawa, Ikuyo Kou, Toshihiro Tanaka, Hidewaki Nakagawa, Akari Suzuki, Tomomitsu Hirota, Mayumi Tamari, Kazuaki Chayama, Daiki Miki, Masaki Mori, Satoshi Nagayama, Yataro Daigo, Yoshio Miki, Toyomasa Katagiri, Osamu Ogawa, Wataru Obara, Hidemi Ito, Teruhiko Yoshida, Issei Imoto, Takashi Takahashi, Chizu Tanikawa, Takao Suzuki, Nobuaki Sinozaki, Shiro Minami, Hiroki Yamaguchi, Satoshi Asai, Yasuo Takahashi, Ken Yamaji, Kazuhisa Takahashi, Tomoaki Fujioka, Ryo Takata, Hideki Yanai, Akihide Masumoto, Yukihiro Koretsune, Hiromu Kutsumi, Masahiko Higashiyama, Shigeo Murayama, Naoko Minegishi, Kichiya Suzuki, Kozo Tanno, Atsushi Shimizu, Taiki Yamaji, Motoki Iwasaki, Norie Sawada, Hirokazu Uemura, Keitaro Tanaka, Mariko Naito, Makoto Sasaki, Kenji Wakai, Shoichiro Tsugane, Masayuki Yamamoto, Kazuhiko Yamamoto, Yoshinori Murakami, Yusuke Nakamura, Soumya Raychaudhuri, Johji Inazawa, Toshimasa Yamauchi, Takashi Kadowaki, Michiaki Kubo, Yoichiro Kamatani

Nature genetics, 52(7), 669-679, Jul, 2020, doi: 10.1038/s41588-020-0640-3

Genome-wide association meta-analysis identifies GP2 gene risk variants for pancreatic cancer.

Yingsong Lin, Masahiro Nakatochi, Yasuyuki Hosono, Hidemi Ito, Yoichiro Kamatani, Akihito Inoko, Hiromi Sakamoto, Fumie Kinoshita, Yumiko Kobayashi, Hiroshi Ishii, Masato Ozaka, Takashi Sasaki, Masato Matsuyama, Naoki Sasahira, Manabu Morimoto, Satoshi Kobayashi, Taito Fukushima, Makoto Ueno, Shinichi Ohkawa, Naoto Egawa, Sawako Kuruma, Mitsuru Mori, Haruhisa Nakao, Yasushi Adachi, Masumi Okuda, Takako Osaki, Shigeru Kamiya, Chaochen Wang, Kazuo Hara, Yasuhiro Shimizu, Tatsuo Miyamoto, Yuko Hayashi, Hiromichi Ebi, Tomohiro Kohmoto, Issei Imoto, Yumiko Kasugai, Yoshinori Murakami, Masato Akiyama, Kazuyoshi Ishigaki, Koichi Matsuda, Makoto Hirata, Kazuaki Shimada, Takuji Okusaka, Takahisa Kawaguchi, Meiko Takahashi, Yoshiyuki Watanabe, Kiyonori Kuriki, Aya Kadota, Rieko Okada, Haruo Mikami, Toshiro Takezaki, Sadao Suzuki, Taiki Yamaji, Motoki Iwasaki, Norie Sawada, Atsushi Goto, Kengo Kinoshita, Nobuo Fuse, Fumiki Katsuoka, Atsushi Shimizu, Satoshi S Nishizuka, Kozo Tanno, Ken Suzuki, Yukinori Okada, Momoko Horikoshi, Toshimasa Yamauchi, Takashi Kadowaki, Herbert Yu, Jun Zhong, Laufey T Amundadottir, Yuichiro Doki, Hideshi Ishii, Hidetoshi Eguchi, David Bogumil, Christopher A Haiman, Loic Le Marchand, Masaki Mori, Harvey Risch, Veronica W Setiawan, Shoichiro Tsugane, Kenji Wakai, Teruhiko Yoshida, Fumihiko Matsuda, Michiaki Kubo, Shogo Kikuchi, Keitaro Matsuo

Nature communications, 11(1), 3175, Jun 24, 2020, doi: 10.1038/s41467-020-16711-w

Identification of type 2 diabetes loci in 433,540 East Asian individuals

Cassandra N. Spracklen, Momoko Horikoshi, Young Jin Kim, Kuang Lin, Fiona Bragg, Sanghoon Moon, Ken Suzuki, Claudia H. T. Tam, Yasuharu Tabara, Soo-Heon Kwak, Fumihiko Takeuchi, Jirong Long, Victor J. Y. Lim, Jin-Fang Chai, Chien-Hsiun Chen, Masahiro Nakatochi, Jie Yao, Hyeok Sun Choi, Apoorva K. Iyengar, Hannah J. Perrin, Sarah M. Brotman, Martijn van de Bunt, Anna L. Gloyn, Jennifer E. Below, Michael Boehnke, Donald W. Bowden, John C. Chambers, Anubha Mahajan, Mark I. McCarthy, Maggie C. Y. Ng, Lauren E. Petty, Weihua Zhang, Andrew P. Morris, Linda S. Adair, Masato Akiyama, Zheng Bian, Juliana C. N. Chan, Li-Ching Chang, Miao-Li Chee, Yii-Der Ida Chen, Yuan-Tsong Chen, Zhengming Chen, Lee-Ming Chuang, Shufa Du, Penny Gordon-Larsen, Myron Gross, Xiuqing Guo, Yu Guo, Sohee Han, Annie-Green Howard, Wei Huang, Yi-Jen Hung, Mi Yeong Hwang, Chii-Min Hwu, Sahoko Ichihara, Masato Isono, Hye-Mi Jang, Guozhi Jiang, Jost B. Jonas, Yoichiro Kamatani, Tomohiro Katsuya, Takahisa Kawaguchi, Chiea-Chuen Khor, Katsuhiko Kohara, Myung-Shik Lee, Nanette R. Lee, Liming Li, Jianjun Liu, Andrea O. Luk, Jun Lv, Yukinori Okada, Mark A. Pereira, Charumathi Sabanayagam, Jinxiu Shi, Dong Mun Shin, Wing Yee So, Atsushi Takahashi, Brian Tomlinson, Fuu-Jen Tsai, Rob M. van Dam, Yong-Bing Xiang, Ken Yamamoto, Toshimasa Yamauchi, Kyungheon Yoon, Canqing Yu, Jian-Min Yuan, Liang Zhang, Wei Zheng, Michiya Igase, Yoon Shin Cho, Jerome I. Rotter, Ya-Xing Wang, Wayne H. H. Sheu, Mitsuhiro Yokota, Jer-Yuarn Wu, Ching-Yu Cheng, Tien-Yin Wong, Xiao-Ou Shu, Norihiro Kato, Kyong-Soo Park, E-Shyong Tai, Fumihiko Matsuda, Woon-Puay Koh, Ronald C. W. Ma, Shiro Maeda, Iona Y. Millwood, Juyoung Lee, Takashi Kadowaki, Robin G. Walters, Bong-Jo Kim, Karen L. Mohlke, Xueling Sim

Nature, 582(7811), 240-245, Jun, 2020, doi: 10.1038/s41586-020-2263-3

Transethnic Meta-Analysis of Genome-Wide Association Studies Identifies Three New Loci and Characterizes Population-Specific Differences for Coronary Artery Disease.

Hiroshi Matsunaga, Kaoru Ito, Masato Akiyama, Atsushi Takahashi, Satoshi Koyama, Seitaro Nomura, Hirotaka Ieki, Kouichi Ozaki, Yoshihiro Onouchi, Saori Sakaue, Shinichiro Suna, Soichi Ogishima, Masayuki Yamamoto, Atsushi Hozawa, Mamoru Satoh, Makoto Sasaki, Taiki Yamaji, Norie Sawada, Motoki Iwasaki, Shoichiro Tsugane, Keitaro Tanaka, Kokichi Arisawa, Hiroaki Ikezaki, Naoyuki Takashima, Mariko Naito, Kenji Wakai, Hideo Tanaka, Yasuhiko Sakata, Hiroyuki Morita, Yasushi Sakata, Koichi Matsuda, Yoshinori Murakami, Hiroshi Akazawa, Michiaki Kubo, Yoichiro Kamatani, Issei Komuro

Circulation. Genomic and precision medicine, 13(3), e002670, Jun, 2020, doi: 10.1161/CIRCGEN.119.002670

Genome-Wide Natural Selection Signatures Are Linked to Genetic Risk of Modern Phenotypes in the Japanese Population

Yoshiaki Yasumizu, Saori Sakaue, Takahiro Konuma, Ken Suzuki, Koichi Matsuda, Yoshinori Murakami, Michiaki Kubo, Pier Francesco Palamara, Yoichiro Kamatani, Yukinori Okada

Molecular Biology and Evolution, 37(5), 1306-1316, May 1, 2020, doi: 10.1093/molbev/msaa005

Subtype-specific gout susceptibility loci and enrichment of selection pressure on ABCG2 and ALDH2 identified by subtype genome-wide meta-analyses of clinically defined gout patients.

Akiyoshi Nakayama, Masahiro Nakatochi, Yusuke Kawamura, Ken Yamamoto, Hirofumi Nakaoka, Seiko Shimizu, Toshihide Higashino, Teruhide Koyama, Asahi Hishida, Kiyonori Kuriki, Miki Watanabe, Toru Shimizu, Keiko Ooyama, Hiroshi Ooyama, Mitsuo Nagase, Yuji Hidaka, Daisuke Matsui, Takashi Tamura, Takeshi Nishiyama, Chisato Shimanoe, Sakurako Katsuura-Kamano, Naoyuki Takashima, Yuya Shirai, Makoto Kawaguchi, Mikiya Takao, Ryo Sugiyama, Yuzo Takada, Takahiro Nakamura, Hiroshi Nakashima, Masashi Tsunoda, Inaho Danjoh, Atsushi Hozawa, Kazuyoshi Hosomichi, Yu Toyoda, Yu Kubota, Tappei Takada, Hiroshi Suzuki, Blanka Stiburkova, Tanya J Major, Tony R Merriman, Nagato Kuriyama, Haruo Mikami, Toshiro Takezaki, Keitaro Matsuo, Sadao Suzuki, Tatsuo Hosoya, Yoichiro Kamatani, Michiaki Kubo, Kimiyoshi Ichida, Kenji Wakai, Ituro Inoue, Yukinori Okada, Nariyoshi Shinomiya, Hirotaka Matsuo

Annals of the rheumatic diseases, 79(5), 657-665, May, 2020, doi: 10.1136/annrheumdis-2019-216644

A common variant of LDL receptor related protein 2 (LRP2) gene is associated with gout susceptibility: a meta-analysis in a Japanese population.

Airi Akashi, Akiyoshi Nakayama, Yoichiro Kamatani, Toshihide Higashino, Seiko Shimizu, Yusuke Kawamura, Misaki Imoto, Mariko Naito, Asahi Hishida, Makoto Kawaguchi, Mikiya Takao, Michinori Matsuo, Tappei Takada, Kimiyoshi Ichida, Hiroshi Ooyama, Nariyoshi Shinomiya, Hirotaka Matsuo

Human cell, 33(2), 303-307, Apr, 2020, doi: 10.1007/s13577-019-00318-5

Variants encoding a restricted carboxy-terminal domain of SLC12A2 cause hereditary hearing loss in humans.

Hideki Mutai, Koichiro Wasano, Yukihide Momozawa, Yoichiro Kamatani, Fuyuki Miya, Sawako Masuda, Noriko Morimoto, Kiyomitsu Nara, Satoe Takahashi, Tatsuhiko Tsunoda, Kazuaki Homma, Michiaki Kubo, Tatsuo Matsunaga

PLoS genetics, 16(4), e1008643, Apr, 2020, doi: 10.1371/journal.pgen.1008643

Predicting cell-type-specific non-coding RNA transcription from genome sequence

Masaru Koido, Chung-Chau Hon, Satoshi Koyama, Hideya Kawaji, Yasuhiro Murakawa, Kazuyoshi Ishigaki, Kaoru Ito, Jun Sese, Yoichiro Kamatani, Piero Carninci, Chikashi Terao

Mar 30, 2020, doi: 10.1101/2020.03.29.011205

Claudin-2 deficiency associates with hypercalciuria in mice and human kidney stone disease

Joshua N. Curry, Matthew Saurette, Masomeh Askari, Lei Pei, Michael B. Filla, Megan R. Beggs, Peter S.N. Rowe, Timothy Fields, Andre J. Sommer, Chizu Tanikawa, Yoichiro Kamatani, Andrew P. Evan, Mehdi Totonchi, R. Todd Alexander, Koichi Matsuda, Alan S.L. Yu

Journal of Clinical Investigation, 130(4), 1948-1960, Mar 9, 2020, doi: 10.1172/jci127750

GWAS of 165,084 Japanese individuals identified nine loci associated with dietary habits.

Nana Matoba, Masato Akiyama, Kazuyoshi Ishigaki, Masahiro Kanai, Atsushi Takahashi, Yukihide Momozawa, Shiro Ikegawa, Masashi Ikeda, Nakao Iwata, Makoto Hirata, Koichi Matsuda, Yoshinori Murakami, Michiaki Kubo, Yoichiro Kamatani, Yukinori Okada

Nature human behaviour, 4(3), 308-316, Mar, 2020, doi: 10.1038/s41562-019-0805-1

Functional variants in ADH1B and ALDH2 are non-additively associated with all-cause mortality in Japanese population.

Saori Sakaue, Masato Akiyama, Makoto Hirata, Koichi Matsuda, Yoshinori Murakami, Michiaki Kubo, Yoichiro Kamatani, Yukinori Okada

European journal of human genetics : EJHG, 28(3), 378-382, Mar, 2020, doi: 10.1038/s41431-019-0518-y

The Natural Metabolite 4-Cresol Improves Glucose Homeostasis and Enhances β-Cell Function.

Francois Brial, Fawaz Alzaid, Kazuhiro Sonomura, Yoichiro Kamatani, Kelly Meneyrol, Aurélie Le Lay, Noémie Péan, Lyamine Hedjazi, Taka-Aki Sato, Nicolas Venteclef, Christophe Magnan, Mark Lathrop, Marc-Emmanuel Dumas, Fumihiko Matsuda, Pierre Zalloua, Dominique Gauguier

Cell reports, 30(7), 2306-2320, Feb 18, 2020, doi: 10.1016/j.celrep.2020.01.066

Identification of Novel Loci and New Risk Variant in Known Loci for Colorectal Cancer Risk in East Asians

Yingchang Lu, Sun-Seog Kweon, Qiuyin Cai, Chizu Tanikawa, Xiao-Ou Shu, Wei-Hua Jia, Yong-Bing Xiang, Jeroen R. Huyghe, Tabitha A. Harrison, Jeongseon Kim, Aesun Shin, Dong-Hyun Kim, Keitaro Matsuo, Sun Ha Jee, Xingyi Guo, Wanqing Wen, Jiajun Shi, Bingshan Li, Nan Wang, Min-Ho Shin, Hong-Lan Li, Zefang Ren, Jae Hwan Oh, Isao Oze, Yoon-Ok Ahn, Keum Ji Jung, Jing Gao, Yu-Tang Gao, Zhi-Zhong Pan, Yoichiro Kamatani, Andrew T. Chan, Andrea Gsur, Jochen Hampe, Loic Le Marchand, Li Li, Annika Lindblom, Victor Moreno, Polly A. Newcomb, Kenneth Offit, Paul D.P. Pharoah, Franzel J.B. van Duijnhoven, Bethany Van Guelpen, Pavel Vodicka, Stephanie J. Weinstein, Alicja Wolk, Anna H. Wu, Li Hsu, Yi-Xin Zeng, Jirong Long, Ulrike Peters, Koichi Matsuda, Wei Zheng

Cancer Epidemiology Biomarkers & Prevention, 29(2), 477-486, Feb, 2020, doi: 10.1158/1055-9965.epi-19-0755

LDL receptor gene familyのひとつであるLRP2遺伝子の一塩基多型rs2544390は痛風発症と関連する 日本人男性におけるメタ解析

赤司 藍理, 中山 昌喜, 東野 俊英, 清水 聖子, 河村 優輔, 川口 真, 高尾 幹也, 高田 龍平, 市田 公美, 大山 博司, 四ノ宮 成祥, 松尾 洋孝, 鎌谷 洋一郎, 松尾 道憲, 井本 美咲, 内藤 真理子, 菱田 朝陽

日本痛風・核酸代謝学会総会プログラム抄録集, 53回, 67, Jan, 2020

Legacy Data Confound Genomics Studies.

Luke Anderson-Trocmé, Rick Farouni, Mathieu Bourgey, Yoichiro Kamatani, Koichiro Higasa, Jeong-Sun Seo, Changhoon Kim, Fumihiko Matsuda, Simon Gravel

Molecular biology and evolution, 37(1), 2-10, Jan 1, 2020, doi: 10.1093/molbev/msz201

GWAS of five gynecologic diseases and cross-trait analysis in Japanese.

Tatsuo Masuda, Siew-Kee Low, Masato Akiyama, Makoto Hirata, Yutaka Ueda, Koichi Matsuda, Tadashi Kimura, Yoshinori Murakami, Michiaki Kubo, Yoichiro Kamatani, Yukinori Okada

European journal of human genetics : EJHG, 28(1), 95-107, Jan, 2020, doi: 10.1038/s41431-019-0495-1

201964 papers

Associations of autozygosity with a broad range of human phenotypes

David W Clark, Yukinori Okada, Kristjan H S Moore, Dan Mason, Nicola Pirastu, Ilaria Gandin, Hannele Mattsson, Catriona L K Barnes, Kuang Lin, Jing Hua Zhao, Patrick Deelen, Rebecca Rohde, Claudia Schurmann, Xiuqing Guo, Franco Giulianini, Weihua Zhang, Carolina Medina-Gomez, Robert Karlsson, Yanchun Bao, Traci M Bartz, Clemens Baumbach, Ginevra Biino, Matthew J Bixley, Marco Brumat, Jin-Fang Chai, Tanguy Corre, Diana L Cousminer, Annelot M Dekker, David A Eccles, Kristel R van Eijk, Christian Fuchsberger, He Gao, Marine Germain, Scott D Gordon, Hugoline G de Haan, Sarah E Harris, Edith Hofer, Alicia Huerta-Chagoya, Catherine Igartua, Iris E Jansen, Yucheng Jia, Tim Kacprowski, Torgny Karlsson, Marcus E Kleber, Shengchao Alfred Li, Ruifang Li-Gao, Anubha Mahajan, Koichi Matsuda, Karina Meidtner, Weihua Meng, May E Montasser, Peter J van der Most, Matthias Munz, Teresa Nutile, Teemu Palviainen, Gauri Prasad, Rashmi B Prasad, Tallapragada Divya Sri Priyanka, Federica Rizzi, Erika Salvi, Bishwa R Sapkota, Daniel Shriner, Line Skotte, Melissa C Smart, Albert Vernon Smith, Ashley van der Spek, Cassandra N Spracklen, Rona J Strawbridge, Salman M Tajuddin, Stella Trompet, Constance Turman, Niek Verweij, Clara Viberti, Lihua Wang, Helen R Warren, Robyn E Wootton, Lisa R Yanek, Jie Yao, Noha A Yousri, Wei Zhao, Adebowale A Adeyemo, Saima Afaq, Carlos Alberto Aguilar-Salinas, Masato Akiyama, Matthew L Albert, Matthew A Allison, Maris Alver, Tin Aung, Fereidoun Azizi, Amy R Bentley, Heiner Boeing, Eric Boerwinkle, Judith B Borja, Gert J de Borst, Erwin P Bottinger, Linda Broer, Harry Campbell, Stephen Chanock, Miao-Li Chee, Guanjie Chen, Yii-Der I Chen, Zhengming Chen, Yen-Feng Chiu, Massimiliano Cocca, Francis S Collins, Maria Pina Concas, Janie Corley, Giovanni Cugliari, Rob M van Dam, Anna Damulina, Maryam S Daneshpour, Felix R Day, Graciela E Delgado, Klodian Dhana, Alexander S F Doney, Marcus Dörr, Ayo P Doumatey, Nduna Dzimiri, S Sunna Ebenesersdóttir, Joshua Elliott, 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Polderman, David J Porteous, Danielle Posthuma, Bruce M Psaty, John D Rioux, Fernando Rivadeneira, Charles Rotimi, Jerome I Rotter, Igor Rudan, Hester M Den Ruijter, Dharambir K Sanghera, Naveed Sattar, Reinhold Schmidt, Matthias B Schulze, Heribert Schunkert, Robert A Scott, Alan R Shuldiner, Xueling Sim, Neil Small, Jennifer A Smith, Nona Sotoodehnia, E-Shyong Tai, Alexander Teumer, Nicholas J Timpson, Daniela Toniolo, David-Alexandre Tregouet, Tiinamaija Tuomi, Peter Vollenweider, Carol A Wang, David R Weir, John B Whitfield, Cisca Wijmenga, Tien-Yin Wong, John Wright, Jingyun Yang, Lei Yu, Babette S Zemel, Alan B Zonderman, Markus Perola, Patrik K. E. Magnusson, André G Uitterlinden, Jaspal S Kooner, Daniel I Chasman, Ruth J. F. Loos, Nora Franceschini, Lude Franke, Chris S Haley, Caroline Hayward, Robin G Walters, John R. B. Perry, Tōnu Esko, Agnar Helgason, Kari Stefansson, Peter K Joshi, Michiaki Kubo, James F Wilson

Nature Communications, 10(1), Dec, 2019, doi: 10.1038/s41467-019-12283-6

Comparative genetic architectures of schizophrenia in East Asian and European populations.

Lam M, Chen CY, Li Z, Martin AR, Bryois J, Ma X, Gaspar H, Ikeda M, Benyamin B, Brown BC, Liu R, Zhou W, Guan L, Kamatani Y, Kim SW, Kubo M, Kusumawardhani AAAA, Liu CM, Ma H, Periyasamy S, Takahashi A, Xu Z, Yu H, Zhu F, Schizophrenia Working, Group of the, Psychiatric Genomics Consortium, Indonesia Schizophrenia Consortium, Genetic REsearch on schizophreniA neTwork-China, the Netherlands, GREAT-CN, Chen WJ, Faraone S, Glatt SJ, He L, Hyman SE, Hwu HG, McCarroll SA, Neale BM, Sklar P, Wildenauer DB, Yu X, Zhang D, Mowry BJ, Lee J, Holmans P, Xu S, Sullivan PF, Ripke S, O'Donovan MC, Daly MJ, Qin S, Sham P, Iwata N, Hong KS, Schwab SG, Yue W, Tsuang M, Liu J, Ma X, Kahn RS, Shi Y, Huang H

Nature genetics, 51(12), 1670-1678, Dec, 2019, doi: 10.1038/s41588-019-0512-x

A novel PAK3 pathogenic variant identified in two siblings from a Japanese family with X-linked intellectual disability: case report and review of the literature.

Aritoshi Iida, Kyoko Takano, Eri Takeshita, Chihiro Abe-Hatano, Shinichi Hirabayashi, Yuji Inaba, Shunichi Kosugi, Yoichiro Kamatani, Yukihide Momozawa, Michiaki Kubo, Eiji Nakagawa, Ken Inoue, Yu-Ichi Goto

Cold Spring Harbor molecular case studies, 5(6), Dec, 2019, doi: 10.1101/mcs.a003988

Genetic predisposition to mosaic Y chromosome loss in blood.

Deborah J Thompson, Giulio Genovese, Jonatan Halvardson, Jacob C Ulirsch, Daniel J Wright, Chikashi Terao, Olafur B Davidsson, Felix R Day, Patrick Sulem, Yunxuan Jiang, Marcus Danielsson, Hanna Davies, Joe Dennis, Malcolm G Dunlop, Douglas F Easton, Victoria A Fisher, Florian Zink, Richard S Houlston, Martin Ingelsson, Siddhartha Kar, Nicola D Kerrison, Ben Kinnersley, Ragnar P Kristjansson, Philip J Law, Rong Li, Chey Loveday, Jonas Mattisson, Steven A McCarroll, Yoshinori Murakami, Anna Murray, Pawel Olszewski, Edyta Rychlicka-Buniowska, Robert A Scott, Unnur Thorsteinsdottir, Ian Tomlinson, Behrooz Torabi Moghadam, Clare Turnbull, Nicholas J Wareham, Daniel F Gudbjartsson, Yoichiro Kamatani, Eva R Hoffmann, Steve P Jackson, Kari Stefansson, Adam Auton, Ken K Ong, Mitchell J Machiela, Po-Ru Loh, Jan P Dumanski, Stephen J Chanock, Lars A Forsberg, John R B Perry

Nature, 575(7784), 652-657, Nov, 2019, doi: 10.1038/s41586-019-1765-3

日本人のアテローム血栓性脳梗塞の強力な遺伝子多型RNF213 p.4810K

猪原 匡史, 岡崎 周平, 森本 貴昭, 鎌谷 洋一郎, 上村 鉄平, 原田 浩二, 冨田 努, 東山 綾, 高橋 淳, 中川原 譲二, 古賀 政利, 豊田 一則, 鷲田 和夫, 齊藤 聡, 望月 秀樹, 秦 淳, 二宮 利治, 吾郷 哲朗, 久保 充明, 小泉 昭夫

臨床神経学, 59(Suppl.), S233, Nov, 2019

Polygenic burden in focal and generalized epilepsies

Costin Leu, Remi Stevelink, Alexander W Smith, Slavina B Goleva, Masahiro Kanai, Lisa Ferguson, Ciaran Campbell, Yoichiro Kamatani, Yukinori Okada, Sanjay M Sisodiya, Gianpiero L Cavalleri, Bobby P C Koeleman, Holger Lerche, Lara Jehi, Lea K Davis, Imad M Najm, Aarno Palotie, Mark J Daly, Robyn M Busch, Liam E Abbott, Zaid Afawi, Danielle M Andrade, Grazia Annesi, Mutluay Arslan, Pauls Auce, Pia Auvinen, Andreas van Baalen, Melanie Bahlo, Simona Balestrini, Nina Barišic, Jürgen Bauer, Larry W Baum, Betül Baykan, Nerses Bebek, Felicitas Becker, Susannah T Bellows, Caitlin A Bennett, Samuel F Berkovic, Claudia Bianchini, Francesca Bisulli, Ilan Blatt, Ingo Borggräfe, Vera Braatz, Knut Brockmann, Russell J Buono, Rosemary Burgess, Hande S Caglayan, Laura Canafoglia, Christina Canavati, Barbara Castellotti, Gianpiero L Cavalleri, Felecia Cerrato, Stacey S Cherny, Seo-Kyung Chung, Claire Churchhouse, Valentina Ciullo, Patrick Cossette, Chris Cotsapas, Norman Delanty, Dieter Dennig, Chantal Depondt, Orrin Devinsky, Tracy Dixon-Salazar, Dennis J Dlugos, Viola Doccini, Colin P Doherty, Christian E Elger, Colin A Ellis, Hany El-Naggar, Yen-Chen Anne Feng, Thomas N Ferraro, Silvana Franceschetti, Jacqueline A French, Catharine Freyer, Monica Gagliardi, Sabina Gallati, Antonio Gambardella, Tommaso Gili, David B Goldstein, Tiziana Granata, Jurgita Grikiniene, Renzo Guerrini, Asli Gundogdu-Eken, Namrata Gupta, Hakon Hakonarson, Garen Haryanyan, Martin Häusler, Manu Hegde, Erin L Heinzen, Katherine L Helbig, Ingo Helbig, Christian Hengsbach, Daniel P Howrigan, Michele Iacomino, Yushi Inoue, Esther M C Johns, Michael R Johnson, Peter De Jonghe, Reetta Kälviäinen, Sitharthan Kamalakaran, Moien Kanaan, Bulent Kara, Yesim Kesim, Pouya Khankhanian, Chontelle King, Karl M Klein, Gerhard Kluger, Susanne Knake, Amos D Korczyn, Rudolf Korinthenberg, Ioanna Kousiappa, Roland Krause, Heinz Krestel, Ilona Krey, Wolfram S Kunz, Gerhard Kurlemann, Ruben I Kuzniecky, Patrick Kwan, Angelo Labate, Dennis Lal, Petra Laššuthová, Anna-Elina Lehesjoki, Johannes R Lemke, Holger Lerche, Costin Leu, Laura Licchetta, Tarja Linnankivi, Warren Lo, Daniel H Lowenstein, Colin H T Lui, Alexandra Macdonald, Rene Madeleyn, Francesca Madia, Ana F Maisch, Ruta Mameniskiene, Maria M Mancardi, Lorella Manna, Carla Marini, Anthony G Marson, Patrick May, Thomas Mayer, Mark McCormack, Kevin McKenna, Davide Mei, Raffaella Minardi, Kelly Mo, Martino Montomoli, Emily Mountier, Lorenzo Muccioli, Hiltrud Muhle, Karen Müller-Schlüter, Benjamin M Neale, Terence J O'Brien, Çigdem Özkara, Savvas S Papacostas, Elena Parrini, Manuela Pendziwiat, Slavé Petrovski, William O Pickrell, Tommaso Pippucci, Fabrizio Piras, Federica Piras, Annapurna Poduri, Robert Powell, Ruta Praninskiene, Michael Privitera, Annika Rademacher, Michael Rademacher, Sarah Rau, Mark I Rees, Brigid M Regan, Philipp S Reif, Felix Rosenow, Anni Saarela, Lynette G Sadleir, Tara R Sadoway, Baris Salman, Vincenzo Salpietro, Ruta Samaitiene, Steven Schachter, Christoph J Schankin, Ingrid E Scheffer, Natascha Schneider, Herbert Schreiber, Susanne Schubert-Bast, Andreas Schulze-Bonhage, Lucie Sedlácková, Catherine Shain, Pak C Sham, Beth R Sheidley, Hannah Shilling, Arif Shukralla, Graeme J Sills, Sanjay M Sisodiya, Gianfranco Spalletta, Michael R Sperling, Sarah von Spiczak, Hannah Stamberger, Bernhard J Steinhoff, Ulrich Stephani, Katalin Šterbová, Randy Stewart, Carlotta Stipa, Pasquale Striano, Toshimitsu Suzuki, George A Tanteles, Katherine Tashman, Paolo Tinuper, Marian Todaro, Pinar Topaloglu, Birute Tumiene, Dilsad Turkdogan, Sibel Ugur-Iseri, Algirdas Utkus, Maria Stella Vari, Annalisa Vetro, Markéta Vlcková, Yvonne G Weber, Dorien Weckhuysen, Sarah Weckhuysen, Stefan Wolking, Kazuhiro Yamakawa, Zuhal Yapici, Uluc Yis, Emrah Yücesan, Sara Zagaglia, Federico Zara, Gábor Zsurka, Dennis Lal

Brain, 142(11), 3473-3481, Nov 1, 2019, doi: 10.1093/brain/awz292

日本人のアテローム血栓性脳梗塞の強力な遺伝子多型RNF213 p.4810K

猪原 匡史, 岡崎 周平, 森本 貴昭, 鎌谷 洋一郎, 上村 鉄平, 原田 浩二, 冨田 努, 東山 綾, 高橋 淳, 中川原 譲二, 古賀 政利, 豊田 一則, 鷲田 和夫, 齊藤 聡, 望月 秀樹, 秦 淳, 二宮 利治, 吾郷 哲朗, 久保 充明, 小泉 昭夫

臨床神経学, 59(Suppl.), S233, Nov, 2019

Genome-wide association studies identify polygenic effects for completed suicide in the Japanese population.

Ikuo Otsuka, Masato Akiyama, Osamu Shirakawa, Satoshi Okazaki, Yukihide Momozawa, Yoichiro Kamatani, Takeshi Izumi, Shusuke Numata, Motonori Takahashi, Shuken Boku, Ichiro Sora, Ken Yamamoto, Yasuhiro Ueno, Tatsushi Toda, Michiaki Kubo, Akitoyo Hishimoto

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 44(12), 2119-2124, Nov, 2019, doi: 10.1038/s41386-019-0506-5

Identification of two novel breast cancer loci through large-scale genome-wide association study in the Japanese population.

Low SK, Chin YM, Ito H, Matsuo K, Tanikawa C, Matsuda K, Saito H, Sakurai-Yageta M, Nakaya N, Shimizu A, Nishizuka SS, Yamaji T, Sawada N, Iwasaki M, Tsugane S, Takezaki T, Suzuki S, Naito M, Wakai K, Kamatani Y, Momozawa Y, Murakami Y, Inazawa J, Nakamura Y, Kubo M, Katagiri T, Miki Y

Scientific reports, 9(1), 17332, Nov, 2019, doi: 10.1038/s41598-019-53654-9

HLA-DQ and RBFOX1 as susceptibility genes for an outbreak of hydrolyzed wheat allergy.

Emiko Noguchi, Masato Akiyama, Akiko Yagami, Tomomitsu Hirota, Yukinori Okada, Zenichiro Kato, Reiko Kishikawa, Yuma Fukutomi, Michihiro Hide, Eishin Morita, Michiko Aihara, Makiko Hiragun, Yuko Chinuki, Takahiro Okabe, Akiko Ito, Atsuko Adachi, Atsushi Fukunaga, Yumiko Kubota, Toshiyuki Aoki, Youko Aoki, Kazue Nishioka, Tetsuya Adachi, Nobuo Kanazawa, Hitoshi Miyazawa, Hiroyuki Sakai, Takehito Kozuka, Hideo Kitamura, Hideo Hashizume, Chiharu Kanegane, Koji Masuda, Kumiya Sugiyama, Reiko Tokuda, Junichi Furuta, Ikkou Higashimoto, Atsuko Kato, Mariko Seishima, Akihiko Tajiri, Atsuko Tomura, Hiroko Taniguchi, Hiroto Kojima, Hidenori Tanaka, Aiko Sakai, Wataru Morii, Masashi Nakamura, Yoichiro Kamatani, Atsushi Takahashi, Michiaki Kubo, Mayumi Tamari, Hirohisa Saito, Kayoko Matsunaga

The Journal of allergy and clinical immunology, 144(5), 1354-1363, Nov, 2019, doi: 10.1016/j.jaci.2019.06.034

Genetic variants of calcium and vitamin D metabolism in kidney stone disease.

Howles SA, Wiberg A, Goldsworthy M, Bayliss AL, Gluck AK, Ng M, Grout E, Tanikawa C, Kamatani Y, Terao C, Takahashi A, Kubo M, Matsuda K, Thakker RV, Turney BW, Furniss D

Nature communications, 10(1), 5175, Nov, 2019, doi: 10.1038/s41467-019-13145-x

Large scale genome-wide association study in a Japanese population identified 45 novel susceptibility loci for 22 diseases

Kazuyoshi Ishigaki, Masato Akiyama, Masahiro Kanai, Atsushi Takahashi, Eiryo Kawakami, Hiroki Sugishita, Saori Sakaue, Nana Matoba, Siew-Kee Low, Yukinori Okada, Chikashi Terao, Tiffany Amariuta, Steven Gazal, Yuta Kochi, Momoko Horikoshi, Ken Suzuki, Kaoru Ito, Yukihide Momozawa, Makoto Hirata, Koichi Matsuda, Masashi Ikeda, Nakao Iwata, Shiro Ikegawa, Ikuyo Kou, Toshihiro Tanaka, Hidewaki Nakagawa, Akari Suzuki, Tomomitsu Hirota, Mayumi Tamari, Kazuaki Chayama, Daiki Miki, Masaki Mori, Satoshi Nagayama, Yataro Daigo, Yoshio Miki, Toyomasa Katagiri, Osamu Ogawa, Wataru Obara, Hidemi Ito, Teruhiko Yoshida, Issei Imoto, Takashi Takahashi, Chizu Tanikawa, Takao Suzuki, Nobuaki Sinozaki, Shiro Minami, Hiroki Yamaguchi, Satoshi Asai, Yasuo Takahashi, Ken Yamaji, Kazuhisa Takahashi, Tomoaki Fujioka, Ryo Takata, Hideki Yanai, Akihide Masumoto, Yukihiro Koretsune, Hiromu Kutsumi, Masahiko Higashiyama, Shigeo Murayama, Naoko Minegishi, Kichiya Suzuki, Kozo Tanno, Atsushi Shimizu, Taiki Yamaji, Motoki Iwasaki, Norie Sawada, Hirokazu Uemura, Keitaro Tanaka, Mariko Naito, Makoto Sasaki, Kenji Wakai, Shoichiro Tsugane, Masayuki Yamamoto, Kazuhiko Yamamoto, Yoshinori Murakami, Yusuke Nakamura, Soumya Raychaudhuri, Johji Inazawa, Toshimasa Yamauchi, Takashi Kadowaki, Michiaki Kubo, Yoichiro Kamatani

Oct 8, 2019, doi: 10.1101/795948

Target genes, variants, tissues and transcriptional pathways influencing human serum urate levels

Adrienne Tin, Jonathan Marten, Victoria L. Halperin Kuhns, Yong Li, Matthias Wuttke, Holger Kirsten, Karsten B. Sieber, Chengxiang Qiu, Mathias Gorski, Zhi Yu, Ayush Giri, Gardar Sveinbjornsson, Man Li, Audrey Y. Chu, Anselm Hoppmann, Luke J. O’Connor, Bram Prins, Teresa Nutile, Damia Noce, Masato Akiyama, Massimiliano Cocca, Sahar Ghasemi, Peter J. van der Most, Katrin Horn, Yizhe Xu, Christian Fuchsberger, Sanaz Sedaghat, Saima Afaq, Najaf Amin, Johan Ärnlöv, Stephan J. L. Bakker, Nisha Bansal, Daniela Baptista, Sven Bergmann, Mary L. Biggs, Ginevra Biino, Eric Boerwinkle, Erwin P. Bottinger, Thibaud S. Boutin, Marco Brumat, Ralph Burkhardt, Eric Campana, Archie Campbell, Harry Campbell, Robert J. Carroll, Eulalia Catamo, John C. Chambers, Marina Ciullo, Maria Pina Concas, Josef Coresh, Tanguy Corre, Daniele Cusi, Sala Cinzia Felicita, Martin H. de Borst, Alessandro De Grandi, Renée de Mutsert, Aiko P. J. de Vries, Graciela Delgado, Ayşe Demirkan, Olivier Devuyst, Katalin Dittrich, Kai-Uwe Eckardt, Georg Ehret, Karlhans Endlich, Michele K. Evans, Ron T. Gansevoort, Paolo Gasparini, Vilmantas Giedraitis, Christian Gieger, Giorgia Girotto, Martin Gögele, Scott D. Gordon, Daniel F. Gudbjartsson, Vilmundur Gudnason, Toomas Haller, Pavel Hamet, Tamara B. Harris, Caroline Hayward, Andrew A. Hicks, Edith Hofer, Hilma Holm, Wei Huang, Nina Hutri-Kähönen, Shih-Jen Hwang, M. Arfan Ikram, Raychel M. Lewis, Erik Ingelsson, Johanna Jakobsdottir, Ingileif Jonsdottir, Helgi Jonsson, Peter K. Joshi, Navya Shilpa Josyula, Bettina Jung, Mika Kähönen, Yoichiro Kamatani, Masahiro Kanai, Shona M. Kerr, Wieland Kiess, Marcus E. Kleber, Wolfgang Koenig, Jaspal S. Kooner, Antje Körner, Peter Kovacs, Bernhard K. Krämer, Florian Kronenberg, Michiaki Kubo, Brigitte Kühnel, Martina La Bianca, Leslie A. Lange, Benjamin Lehne, Terho Lehtimäki, Jun Liu, Markus Loeffler, Ruth J. F. Loos, Leo-Pekka Lyytikäinen, Reedik Magi, Anubha Mahajan, Nicholas G. Martin, Winfried März, Deborah Mascalzoni, Koichi Matsuda, Christa Meisinger, Thomas Meitinger, Andres Metspalu, Yuri Milaneschi, Christopher J. O’Donnell, Otis D. Wilson, J. Michael Gaziano, Pashupati P. Mishra, Karen L. Mohlke, Nina Mononen, Grant W. Montgomery, Dennis O. Mook-Kanamori, Martina Müller-Nurasyid, Girish N. Nadkarni, Mike A. Nalls, Matthias Nauck, Kjell Nikus, Boting Ning, Ilja M. Nolte, Raymond Noordam, Jeffrey R. O’Connell, Isleifur Olafsson, Sandosh Padmanabhan, Brenda W. J. H. Penninx, Thomas Perls, Annette Peters, Mario Pirastu, Nicola Pirastu, Giorgio Pistis, Ozren Polasek, Belen Ponte, David J. Porteous, Tanja Poulain, Michael H. Preuss, Ton J. Rabelink, Laura M. Raffield, Olli T. Raitakari, Rainer Rettig, Myriam Rheinberger, Kenneth M. Rice, Federica Rizzi, Antonietta Robino, Igor Rudan, Alena Krajcoviechova, Renata Cifkova, Rico Rueedi, Daniela Ruggiero, Kathleen A. Ryan, Yasaman Saba, Erika Salvi, Helena Schmidt, Reinhold Schmidt, Christian M. Shaffer, Albert V. Smith, Blair H. Smith, Cassandra N. Spracklen, Konstantin Strauch, Michael Stumvoll, Patrick Sulem, Salman M. Tajuddin, Andrej Teren, Joachim Thiery, Chris H. L. Thio, Unnur Thorsteinsdottir, Daniela Toniolo, Anke Tönjes, Johanne Tremblay, André G. Uitterlinden, Simona Vaccargiu, Pim van der Harst, Cornelia M. van Duijn, Niek Verweij, Uwe Völker, Peter Vollenweider, Gerard Waeber, Melanie Waldenberger, John B. Whitfield, Sarah H. Wild, James F. Wilson, Qiong Yang, Weihua Zhang, Alan B. Zonderman, Murielle Bochud, James G. Wilson, Sarah A. Pendergrass, Kevin Ho, Afshin Parsa, Peter P. Pramstaller, Bruce M. Psaty, Carsten A. Böger, Harold Snieder, Adam S. Butterworth, Yukinori Okada, Todd L. Edwards, Kari Stefansson, Katalin Susztak, Markus Scholz, Iris M. Heid, Adriana M. Hung, Alexander Teumer, Cristian Pattaro, Owen M. Woodward, Veronique Vitart, Anna Köttgen

Nature Genetics, 51(10), 1459-1474, Oct, 2019, doi: 10.1038/s41588-019-0504-x

Comparison of effects of UGT1A1*6 and UGT1A1*28 on irinotecan-induced adverse reactions in the Japanese population: analysis of the Biobank Japan Project.

Hikino K, Ozeki T, Koido M, Terao C, Kamatani Y, Murakami Y, Kubo M, Mushiroda T

Journal of human genetics, 64(12), 1195-1202, Oct, 2019, doi: 10.1038/s10038-019-0677-2

HLA-B*51:01 and CYP2C9*3 are risk factors for phenytoin-induced eruption in the Japanese population: analysis of data from the Biobank Japan Project.

Hikino K, Ozeki T, Koido M, Terao C, Kamatani Y, Mizukawa Y, Shiohara T, Tohyama M, Azukizawa H, Aihara M, Nihara H, Morita E, Murakami Y, Kubo M, Mushiroda T

Clinical pharmacology and therapeutics, 107(5), 1170-1178, Oct, 2019, doi: 10.1002/cpt.1706

Genome-wide association study revealed novel loci which aggravate asymptomatic hyperuricaemia into gout.

Yusuke Kawamura, Hirofumi Nakaoka, Akiyoshi Nakayama, Yukinori Okada, Ken Yamamoto, Toshihide Higashino, Masayuki Sakiyama, Toru Shimizu, Hiroshi Ooyama, Keiko Ooyama, Mitsuo Nagase, Yuji Hidaka, Yuko Shirahama, Kazuyoshi Hosomichi, Yuichiro Nishida, Ippei Shimoshikiryo, Asahi Hishida, Sakurako Katsuura-Kamano, Seiko Shimizu, Makoto Kawaguchi, Hirokazu Uemura, Rie Ibusuki, Megumi Hara, Mariko Naito, Mikiya Takao, Mayuko Nakajima, Satoko Iwasawa, Hiroshi Nakashima, Keizo Ohnaka, Takahiro Nakamura, Blanka Stiburkova, Tony R Merriman, Masahiro Nakatochi, Sahoko Ichihara, Mitsuhiro Yokota, Tappei Takada, Tatsuya Saitoh, Yoichiro Kamatani, Atsushi Takahashi, Kokichi Arisawa, Toshiro Takezaki, Keitaro Tanaka, Kenji Wakai, Michiaki Kubo, Tatsuo Hosoya, Kimiyoshi Ichida, Ituro Inoue, Nariyoshi Shinomiya, Hirotaka Matsuo

Annals of the rheumatic diseases, 78(10), 1430-1437, Oct, 2019, doi: 10.1136/annrheumdis-2019-215521

GWAS of mosaic loss of chromosome Y highlights genetic effects on blood cell differentiation.

Terao C, Momozawa Y, Ishigaki K, Kawakami E, Akiyama M, Loh PR, Genovese G, Sugishita H, Ohta T, Hirata M, Perry JRB, Matsuda K, Murakami Y, Kubo M, Kamatani Y

Nature communications, 10(1), 4719, Oct, 2019, doi: 10.1038/s41467-019-12705-5

Association of Birth Weight With Type 2 Diabetes and Glycemic Traits: A Mendelian Randomization Study.

Tao Huang, Tiange Wang, Yan Zheng, Christina Ellervik, Xiang Li, Meng Gao, Zhe Fang, Jin-Fang Chai, Tarun Veer S Ahluwalia, Yujie Wang, Trudy Voortman, Raymond Noordam, Alexis Frazier-Wood, Markus Scholz, Emily Sonestedt, Masato Akiyama, Rajkumar Dorajoo, Ang Zhou, Tuomas O Kilpeläinen, Marcus E Kleber, Sarah R Crozier, Keith M Godfrey, Rozenn Lemaitre, Janine F Felix, Yuan Shi, Preeti Gupta, Chiea-Chuen Khor, Terho Lehtimäki, Carol A Wang, Carla M T Tiesler, Elisabeth Thiering, Marie Standl, Peter Rzehak, Eirini Marouli, Meian He, Cécile Lecoeur, Dolores Corella, Chao-Qiang Lai, Luis A Moreno, Niina Pitkänen, Colin A Boreham, Tao Zhang, Seang Mei Saw, Paul M Ridker, Mariaelisa Graff, Frank J A van Rooij, Andre G Uitterlinden, Albert Hofman, Diana van Heemst, Frits R Rosendaal, Renée de Mutsert, Ralph Burkhardt, Christina-Alexandra Schulz, Ulrika Ericson, Yoichiro Kamatani, Jian-Min Yuan, Chris Power, Torben Hansen, Thorkild I A Sørensen, Anne Tjønneland, Kim Overvad, Graciela Delgado, Cyrus Cooper, Luc Djousse, Fernando Rivadeneira, Karen Jameson, Wanting Zhao, Jianjun Liu, Nanette R Lee, Olli Raitakari, Mika Kähönen, Jorma Viikari, Veit Grote, Jean-Paul Langhendries, Berthold Koletzko, Joaquin Escribano, Elvira Verduci, George Dedoussis, Caizheng Yu, Yih Chung Tham, Blanche Lim, Sing Hui Lim, Philippe Froguel, Beverley Balkau, Nadia R Fink, Rebecca K Vinding, Astrid Sevelsted, Hans Bisgaard, Oscar Coltell, Jean Dallongeville, Frédéric Gottrand, Katja Pahkala, Harri Niinikoski, Elina Hyppönen, Oluf Pedersen, Winfried März, Hazel Inskip, Vincent W V Jaddoe, Elaine Dennison, Tien Yin Wong, Charumathi Sabanayagam, E-Shyong Tai, Karen L Mohlke, David A Mackey, Dariusz Gruszfeld, Panagiotis Deloukas, Katherine L Tucker, Frédéric Fumeron, Klaus Bønnelykke, Peter Rossing, Ramon Estruch, Jose M Ordovas, Donna K Arnett, Aline Meirhaeghe, Philippe Amouyel, Ching-Yu Cheng, Xueling Sim, Yik Ying Teo, Rob M van Dam, Woon-Puay Koh, Marju Orho-Melander, Markus Loeffler, Michiaki Kubo, Joachim Thiery, Dennis O Mook-Kanamori, Dariush Mozaffarian, Bruce M Psaty, Oscar H Franco, Tangchun Wu, Kari E North, George Davey Smith, Jorge E Chavarro, Daniel I Chasman, Lu Qi

JAMA network open, 2(9), e1910915, Sep 4, 2019, doi: 10.1001/jamanetworkopen.2019.10915

バイオバンキングが切り拓く新しいがん研究 わが国における骨髄性腫瘍およびクローン性造血に関するプレディスポジションの研究(Innovative cancer research based on biobanking Germline predisposition to myeloid neoplasms and clonal hematopoiesis of indeterminate potential in Japan)

牧島 秀樹, 吉里 哲一, 竹田 淳恵, 桃沢 幸秀, 南谷 泰仁, 熱田 由子, 鬼塚 真仁, 糸永 英弘, 宮崎 泰司, 眞田 昌, 鎌谷 洋一郎, 宮野 悟, 小川 誠司

日本癌学会総会記事, 78回, S11-5, Sep, 2019

IgG4-related disease in the Japanese population: a genome-wide association study

Chikashi Terao, Masao Ota, Takeshi Iwasaki, Masahiro Shiokawa, Shuji Kawaguchi, Katsutoshi Kuriyama, Takahisa Kawaguchi, Yuzo Kodama, Izumi Yamaguchi, Kazushige Uchida, Koichiro Higasa, Motohisa Yamamoto, Kensuke Kubota, Shujiro Yazumi, Kenji Hirano, Yasufumi Masaki, Hiroyuki Maguchi, Tomoki Origuchi, Shoko Matsui, Takahiro Nakazawa, Hideyuki Shiomi, Terumi Kamisawa, Osamu Hasebe, Eisuke Iwasaki, Kazuo Inui, Yoshiya Tanaka, Koh ichi Ohshima, Takashi Akamizu, Shigeo Nakamura, Seiji Nakamura, Takako Saeki, Hisanori Umehara, Tooru Shimosegawa, Nobumasa Mizuno, Mitsuhiro Kawano, Atsushi Azumi, Hiroki Takahashi, Tsuneyo Mimori, Yoichiro Kamatani, Kazuichi Okazaki, Tsutomu Chiba, Shigeyuki Kawa, Fumihiko Matsuda, Atsushi Kanno, Yoshihiro Okabe, Shinji Katsushima, Tetsuro Inokuma, Yukitaka Yamashita, Yoshitaka Nakai, Takayoshi Nishino, Kozo Kajimura, Mitsushige Shibatoge, Naoki Kanda, Akio Ido, Masaya Ohana, Ichiro Moriyama, Hiroshi Tatsuta, Kazuyoshi Matsumura, Keita Fujikawa, Norimoto Gotoh, Takanobu Tsutsumi, Masakazu Shimizu, Kazuya Setoh, Meiko Takahashi, Yasuharu Tabara, Jun Mimura, Takefumi Nakamura, Toshiyuki Kimura, Chiharu Kawanami

The Lancet Rheumatology, 1(1), e14-e22, Sep, 2019, doi: 10.1016/S2665-9913(19)30006-2

12 new susceptibility loci for prostate cancer identified by genome-wide association study in Japanese population.

Takata R, Takahashi A, Fujita M, Momozawa Y, Saunders EJ, Yamada H, Maejima K, Nakano K, Nishida Y, Hishida A, Matsuo K, Wakai K, Yamaji T, Sawada N, Iwasaki M, Tsugane S, Sasaki M, Shimizu A, Tanno K, Minegishi N, Suzuki K, Matsuda K, Kubo M, Inazawa J, Egawa S, Haiman CA, Ogawa O, Obara W, Kamatani Y, Akamatsu S, Nakagawa H

Nature communications, 10(1), 4422, Sep, 2019, doi: 10.1038/s41467-019-12267-6

Characterizing rare and low-frequency height-associated variants in the Japanese population.

Akiyama M, Ishigaki K, Sakaue S, Momozawa Y, Horikoshi M, Hirata M, Matsuda K, Ikegawa S, Takahashi A, Kanai M, Suzuki S, Matsui D, Naito M, Yamaji T, Iwasaki M, Sawada N, Tanno K, Sasaki M, Hozawa A, Minegishi N, Wakai K, Tsugane S, Shimizu A, Yamamoto M, Okada Y, Murakami Y, Kubo M, Kamatani Y

Nature communications, 10(1), 4393, Sep, 2019, doi: 10.1038/s41467-019-12276-5

Polygenic risk scores in schizophrenia with clinically significant copy number variants.

Taniguchi S, Ninomiya K, Kushima I, Saito T, Shimasaki A, Sakusabe T, Momozawa Y, Kubo M, Kamatani Y, Ozaki N, Ikeda M, Iwata N

Psychiatry and clinical neurosciences, 74(1), 35-39, Aug, 2019, doi: 10.1111/pcn.12926

The schizophrenia genetics knowledgebase: a comprehensive update of findings from candidate gene studies.

Liu C, Kanazawa T, Tian Y, Mohamed Saini S, Mancuso S, Mostaid MS, Takahashi A, Zhang D, Zhang F, Yu H, Doo Shin H, Sub Cheong H, Ikeda M, Kubo M, Iwata N, Woo SI, Yue W, Kamatani Y, Shi Y, Li Z, Everall I, Pantelis C, Bousman C

Translational psychiatry, 9(1), 205, Aug, 2019, doi: 10.1038/s41398-019-0532-4

Genome-wide association study identifies 14 previously unreported susceptibility loci for adolescent idiopathic scoliosis in Japanese.

Kou I, Otomo N, Takeda K, Momozawa Y, Lu HF, Kubo M, Kamatani Y, Ogura Y, Takahashi Y, Nakajima M, Minami S, Uno K, Kawakami N, Ito M, Yonezawa I, Watanabe K, Kaito T, Yanagida H, Taneichi H, Harimaya K, Taniguchi Y, Shigematsu H, Iida T, Demura S, Sugawara R, Fujita N, Yagi M, Okada E, Hosogane N, Kono K, Nakamura M, Chiba K, Kotani T, Sakuma T, Akazawa T, Suzuki T, Nishida K, Kakutani K, Tsuji T, Sudo H, Iwata A, Sato T, Inami S, Matsumoto M, Terao C, Watanabe K, Ikegawa S

Nature communications, 10(1), 3685, Aug, 2019, doi: 10.1038/s41467-019-11596-w

Publisher Correction: Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes

Rainer Malik, Ganesh Chauhan, Matthew Traylor, Muralidharan Sargurupremraj, Yukinori Okada, Aniket Mishra, Loes Rutten-Jacobs, Anne-Katrin Giese, Sander W. van der Laan, Solveig Gretarsdottir, Christopher D. Anderson, Michael Chong, Hieab H. H. Adams, Tetsuro Ago, Peter Almgren, Philippe Amouyel, Hakan Ay, Traci M. Bartz, Oscar R. Benavente, Steve Bevan, Giorgio B. Boncoraglio, Robert D. Brown, Adam S. Butterworth, Caty Carrera, Cara L. Carty, Daniel I. Chasman, Wei-Min Chen, John W. Cole, Adolfo Correa, Ioana Cotlarciuc, Carlos Cruchaga, John Danesh, Paul I. W. de Bakker, Anita L. DeStefano, Marcel den Hoed, Qing Duan, Stefan T. Engelter, Guido J. Falcone, Rebecca F. Gottesman, Raji P. Grewal, Vilmundur Gudnason, Stefan Gustafsson, Jeffrey Haessler, Tamara B. Harris, Ahamad Hassan, Aki S. Havulinna, Susan R. Heckbert, Elizabeth G. Holliday, George Howard, Fang-Chi Hsu, Hyacinth I. Hyacinth, M. Arfan Ikram, Erik Ingelsson, Marguerite R. Irvin, Xueqiu Jian, Jordi Jiménez-Conde, Julie A. Johnson, J. Wouter Jukema, Masahiro Kanai, Keith L. Keene, Brett M. Kissela, Dawn O. Kleindorfer, Charles Kooperberg, Michiaki Kubo, Leslie A. Lange, Carl D. Langefeld, Claudia Langenberg, Lenore J. Launer, Jin-Moo Lee, Robin Lemmens, Didier Leys, Cathryn M. Lewis, Wei-Yu Lin, Arne G. Lindgren, Erik Lorentzen, Patrik K. Magnusson, Jane Maguire, Ani Manichaikul, Patrick F. McArdle, James F. Meschia, Braxton D. Mitchell, Thomas H. Mosley, Michael A. Nalls, Toshiharu Ninomiya, Martin J. O’Donnell, Bruce M. Psaty, Sara L. Pulit, Kristiina Rannikmäe, Alexander P. Reiner, Kathryn M. Rexrode, Kenneth Rice, Stephen S. Rich, Paul M. Ridker, Natalia S. Rost, Peter M. Rothwell, Jerome I. Rotter, Tatjana Rundek, Ralph L. Sacco, Saori Sakaue, Michele M. Sale, Veikko Salomaa, Bishwa R. Sapkota, Reinhold Schmidt, Carsten O. Schmidt, Ulf Schminke, Pankaj Sharma, Agnieszka Slowik, Cathie L. M. Sudlow, Christian Tanislav, Turgut Tatlisumak, Kent D. Taylor, Vincent N. S. Thijs, Gudmar Thorleifsson, Unnur Thorsteinsdottir, Steffen Tiedt, Stella Trompet, Christophe Tzourio, Cornelia M. van Duijn, Matthew Walters, Nicholas J. Wareham, Sylvia Wassertheil-Smoller, James G. Wilson, Kerri L. Wiggins, Qiong Yang, Salim Yusuf, Joshua C. Bis, Tomi Pastinen, Arno Ruusalepp, Eric E. Schadt, Simon Koplev, Johan L. M. Björkegren, Veronica Codoni, Mete Civelek, Nicholas L. Smith, David A. Trégouët, Ingrid E. Christophersen, Carolina Roselli, Steven A. Lubitz, Patrick T. Ellinor, E. Shyong Tai, Jaspal S. Kooner, Norihiro Kato, Jiang He, Pim van der Harst, Paul Elliott, John C. Chambers, Fumihiko Takeuchi, Andrew D. Johnson, Dharambir K. Sanghera, Olle Melander, Christina Jern, Daniel Strbian, Israel Fernandez-Cadenas, W. T. Longstreth, Arndt Rolfs, Jun Hata, Daniel Woo, Jonathan Rosand, Guillaume Pare, Jemma C. Hopewell, Danish Saleheen, Kari Stefansson, Bradford B. Worrall, Steven J. Kittner, Sudha Seshadri, Myriam Fornage, Hugh S. Markus, Joanna M. M. Howson, Yoichiro Kamatani, Stephanie Debette, Martin Dichgans

Nature Genetics, 51(7), 1192-1193, Jul, 2019, doi: 10.1038/s41588-019-0449-0

無症候性高尿酸血症群と痛風症例群のゲノムワイド関連解析により痛風発症に関連する新規遺伝子座を同定した

河村 優輔, 松尾 洋孝, 中山 昌喜, 東野 俊英, 清水 徹, 大山 博司, 大山 恵子, 長瀬 満夫, 清水 聖子, 川口 真, 高尾 幹也, 高田 龍平, 細谷 龍男, 市田 公美, 四ノ宮 成祥, 中岡 博史, 岡田 随象, 山本 健, 崎山 真幸, 中村 好宏, 鎌谷 洋一郎, 久保 充明, 井ノ上 逸朗

痛風と尿酸・核酸, 43(1), 29-30, Jul, 2019

日本人121,745人を対象としたゲノムワイドメタ解析により血清尿酸値と関連する8つの新規遺伝子座を同定した

中杤 昌弘, 松尾 洋孝, 中山 昌喜, 河村 優輔, 清水 聖子, 川口 真, 高尾 幹也, 四ノ宮 成祥, 金井 仁弘, 菱田 朝陽, 中村 好宏, 久保 充明, 鎌谷 洋一郎, 横田 充弘, 若井 建志, 岡田 随象

痛風と尿酸・核酸, 43(1), 31, Jul, 2019

National platform for Rare Diseases Data Registry of Japan

Yoshihiko Furusawa, Izumi Yamaguchi, Naoko Yagishita, Kazumasa Tanzawa, Fumihiko Matsuda, Yoshihisa Yamano, Ryo Yamada, Yasuharu Tabara, Yoichiro Kamatani, Syuji Kawaguchi, Shinji Kosugi, Koichiro Higasa, Yoichi Matsubara, Naomichi Matsumoto, Yoshihiro Aasano, Ichizo Nishino, Harumasa Nakamura, Atsushi Takano, Motoi Iot, Shinya Sakai

LEARNING HEALTH SYSTEMS, 3(3), Jul, 2019, doi: 10.1002/lrh2.10080

Genome-wide analysis of dental caries and periodontitis combining clinical and self-reported data.

Dmitry Shungin, Simon Haworth, Kimon Divaris, Cary S Agler, Yoichiro Kamatani, Myoung Keun Lee, Kelsey Grinde, George Hindy, Viivi Alaraudanjoki, Paula Pesonen, Alexander Teumer, Birte Holtfreter, Saori Sakaue, Jun Hirata, Yau-Hua Yu, Paul M Ridker, Franco Giulianini, Daniel I Chasman, Patrik K E Magnusson, Takeaki Sudo, Yukinori Okada, Uwe Völker, Thomas Kocher, Vuokko Anttonen, Marja-Liisa Laitala, Marju Orho-Melander, Tamar Sofer, John R Shaffer, Alexandre Vieira, Mary L Marazita, Michiaki Kubo, Yasushi Furuichi, Kari E North, Steve Offenbacher, Erik Ingelsson, Paul W Franks, Nicholas J Timpson, Ingegerd Johansson

Nature communications, 10(1), 2773, Jun 24, 2019, doi: 10.1038/s41467-019-10630-1

Genome-Wide Association Study Detected Novel Susceptibility Genes for Schizophrenia and Shared Trans-Populations/Diseases Genetic Effect.

Masashi Ikeda, Atsushi Takahashi, Yoichiro Kamatani, Yukihide Momozawa, Takeo Saito, Kenji Kondo, Ayu Shimasaki, Kohei Kawase, Takaya Sakusabe, Yoshimi Iwayama, Tomoko Toyota, Tomoyasu Wakuda, Mitsuru Kikuchi, Nobuhisa Kanahara, Hidenaga Yamamori, Yuka Yasuda, Yuichiro Watanabe, Satoshi Hoya, Branko Aleksic, Itaru Kushima, Heii Arai, Manabu Takaki, Kotaro Hattori, Hiroshi Kunugi, Yuko Okahisa, Tohru Ohnuma, Norio Ozaki, Toshiyuki Someya, Ryota Hashimoto, Takeo Yoshikawa, Michiaki Kubo, Nakao Iwata

Schizophrenia bulletin, 45(4), 824-834, Jun 18, 2019, doi: 10.1093/schbul/sby140

Germline pathogenic variants in 7,636 Japanese patients with prostate cancer and 12,366 controls.

Momozawa Y, Iwasaki Y, Hirata M, Liu X, Kamatani Y, Takahashi A, Sugano K, Yoshida T, Murakami Y, Matsuda K, Nakagawa H, Spurdle AB, Kubo M

Journal of the National Cancer Institute, 112(4), 369-376, Jun, 2019, doi: 10.1093/jnci/djz124

Genetic characteristics of retinitis pigmentosa in 1204 Japanese patients.

Koyanagi Y, Akiyama M, Nishiguchi KM, Momozawa Y, Kamatani Y, Takata S, Inai C, Iwasaki Y, Kumano M, Murakami Y, Omodaka K, Abe T, Komori S, Gao D, Hirakata T, Kurata K, Hosono K, Ueno S, Hotta Y, Murakami A, Terasaki H, Wada Y, Nakazawa T, Ishibashi T, Ikeda Y, Kubo M, Sonoda KH

Journal of medical genetics, 56(10), 662-670, Jun, 2019, doi: 10.1136/jmedgenet-2018-105691

A frequent variant in the Japanese population determines quasi-Mendelian inheritance of rare retinal ciliopathy.

Nikopoulos K, Cisarova K, Quinodoz M, Koskiniemi-Kuendig H, Miyake N, Farinelli P, Rehman AU, Khan MI, Prunotto A, Akiyama M, Kamatani Y, Terao C, Miya F, Ikeda Y, Ueno S, Fuse N, Murakami A, Wada Y, Terasaki H, Sonoda KH, Ishibashi T, Kubo M, Cremers FPM, Kutalik Z, Matsumoto N, Nishiguchi KM, Nakazawa T, Rivolta C

Nat Commun., 10(1), 2884, Jun, 2019, doi: 10.1038/s41467-019-10746-4

Multiancestry Genome-Wide Association Study of Lipid Levels Incorporating Gene-Alcohol Interactions.

de Vries PS, Brown MR, Bentley AR, Sung YJ, Winkler TW, Ntalla I, Schwander K, Kraja AT, Guo X, Franceschini N, Cheng CY, Sim X, Vojinovic D, Huffman JE, Musani SK, Li C, Feitosa MF, Richard MA, Noordam R, Aschard H, Bartz TM, Bielak LF, Deng X, Dorajoo R, Lohman KK, Manning AK, Rankinen T, Smith AV, Tajuddin SM, Evangelou E, Graff M, Alver M, Boissel M, Chai JF, Chen X, Divers J, Gandin I, Gao C, Goel A, Hagemeijer Y, Harris SE, Hartwig FP, He M, Horimoto ARVR, Hsu FC, Jackson AU, Kasturiratne A, Komulainen P, Kühnel B, Laguzzi F, Lee JH, Luan J, Lyytikäinen LP, Matoba N, Nolte IM, Pietzner M, Riaz M, Said MA, Scott RA, Sofer T, Stančáková A, Takeuchi F, Tayo BO, van der Most PJ, Varga TV, Wang Y, Ware EB, Wen W, Yanek LR, Zhang W, Zhao JH, Afaq S, Amin N, Amini M, Arking DE, Aung T, Ballantyne C, Boerwinkle E, Broeckel U, Campbell A, Canouil M, Charumathi S, Chen YI, Connell JM, de Faire U, de Las Fuentes L, de Mutsert R, de Silva HJ, Ding J, Dominiczak AF, Duan Q, Eaton CB, Eppinga RN, Faul JD, Fisher V, Forrester T, Franco OH, Friedlander Y, Ghanbari M, Giulianini F, Grabe HJ, Grove ML, Gu CC, Harris TB, Heikkinen S, Heng CK, Hirata M, Hixson JE, Howard BV, Ikram MA, InterAct Consortium, Jacobs DR, Johnson C, Jonas JB, Kammerer CM, Katsuya T, Khor CC, Kilpeläinen TO, Koh WP, Koistinen HA, Kolcic I, Kooperberg C, Krieger JE, Kritchevsky SB, Kubo M, Kuusisto J, Lakka TA, Langefeld CD, Langenberg C, Launer LJ, Lehne B, Lemaitre RN, Li Y, Liang J, Liu J, Liu K, Loh M, Louie T, Mägi R, Manichaikul AW, McKenzie CA, Meitinger T, Metspalu A, Milaneschi Y, Milani L, Mohlke KL, Mosley TH, Mukamal KJ, Nalls MA, Nauck M, Nelson CP, Sotoodehnia N, O'Connell JR, Palmer ND, Pazoki R, Pedersen NL, Peters A, Peyser PA, Polasek O, Poulter N, Raffel LJ, Raitakari OT, Reiner AP, Rice TK, Rich SS, Robino A, Robinson JG, Rose LM, Rudan I, Schmidt CO, Schreiner PJ, Scott WR, Sever P, Shi Y, Sidney S, Sims M, Smith BH, Smith JA, Snieder H, Starr JM, Strauch K, Tan N, Taylor KD, Teo YY, Tham YC, Uitterlinden AG, van Heemst D, Vuckovic D, Waldenberger M, Wang L, Wang Y, Wang Z, Wei WB, Williams C, Wilson G, Wojczynski MK, Yao J, Yu B, Yu C, Yuan JM, Zhao W, Zonderman AB, Becker DM, Boehnke M, Bowden DW, Chambers JC, Deary IJ, Esko T, Farrall M, Franks PW, Freedman BI, Froguel P, Gasparini P, Gieger C, Horta BL, Kamatani Y, Kato N, Kooner JS, Laakso M, Leander K, Lehtimäki T, Lifelines Cohort, Groningen,The Netherlands (Lifelines Cohort Study, Magnusson PKE, Penninx B, Pereira AC, Rauramaa R, Samani NJ, Scott J, Shu XO, van der Harst P, Wagenknecht LE, Wang YX, Wareham NJ, Watkins H, Weir DR, Wickremasinghe AR, Zheng W, Elliott P, North KE, Bouchard C, Evans MK, Gudnason V, Liu CT, Liu Y, Psaty BM, Ridker PM, van Dam RM, Kardia SLR, Zhu X, Rotimi CN, Mook-Kanamori DO, Fornage M, Kelly TN, Fox ER, Hayward C, van Duijn CM, Tai ES, Wong TY, Liu J, Rotter JI, Gauderman WJ, Province MA, Munroe PB, Rice K, Chasman DI, Cupples LA, Rao DC, Morrison AC

American journal of epidemiology, 188(6), 1033-1054, Jun, 2019, doi: 10.1093/aje/kwz005

A catalog of genetic loci associated with kidney function from analyses of a million individuals.

Matthias Wuttke, Yong Li, Man Li, Karsten B Sieber, Mary F Feitosa, Mathias Gorski, Adrienne Tin, Lihua Wang, Audrey Y Chu, Anselm Hoppmann, Holger Kirsten, Ayush Giri, Jin-Fang Chai, Gardar Sveinbjornsson, Bamidele O Tayo, Teresa Nutile, Christian Fuchsberger, Jonathan Marten, Massimiliano Cocca, Sahar Ghasemi, Yizhe Xu, Katrin Horn, Damia Noce, Peter J van der Most, Sanaz Sedaghat, Zhi Yu, Masato Akiyama, Saima Afaq, Tarunveer S Ahluwalia, Peter Almgren, Najaf Amin, Johan Ärnlöv, Stephan J L Bakker, Nisha Bansal, Daniela Baptista, Sven Bergmann, Mary L Biggs, Ginevra Biino, Michael Boehnke, Eric Boerwinkle, Mathilde Boissel, Erwin P Bottinger, Thibaud S Boutin, Hermann Brenner, Marco Brumat, Ralph Burkhardt, Adam S Butterworth, Eric Campana, Archie Campbell, Harry Campbell, Mickaël Canouil, Robert J Carroll, Eulalia Catamo, John C Chambers, Miao-Ling Chee, Miao-Li Chee, Xu Chen, Ching-Yu Cheng, Yurong Cheng, Kaare Christensen, Renata Cifkova, Marina Ciullo, Maria Pina Concas, James P Cook, Josef Coresh, Tanguy Corre, Cinzia Felicita Sala, Daniele Cusi, John Danesh, E Warwick Daw, Martin H de Borst, Alessandro De Grandi, Renée de Mutsert, Aiko P J de Vries, Frauke Degenhardt, Graciela Delgado, Ayse Demirkan, Emanuele Di Angelantonio, Katalin Dittrich, Jasmin Divers, Rajkumar Dorajoo, Kai-Uwe Eckardt, Georg Ehret, Paul Elliott, Karlhans Endlich, Michele K Evans, Janine F Felix, Valencia Hui Xian Foo, Oscar H Franco, Andre Franke, Barry I Freedman, Sandra Freitag-Wolf, Yechiel Friedlander, Philippe Froguel, Ron T Gansevoort, He Gao, Paolo Gasparini, J Michael Gaziano, Vilmantas Giedraitis, Christian Gieger, Giorgia Girotto, Franco Giulianini, Martin Gögele, Scott D Gordon, Daniel F Gudbjartsson, Vilmundur Gudnason, Toomas Haller, Pavel Hamet, Tamara B Harris, Catharina A Hartman, Caroline Hayward, Jacklyn N Hellwege, Chew-Kiat Heng, Andrew A Hicks, Edith Hofer, Wei Huang, Nina Hutri-Kähönen, Shih-Jen Hwang, M Arfan Ikram, Olafur S Indridason, Erik Ingelsson, Marcus Ising, Vincent W V Jaddoe, Johanna Jakobsdottir, Jost B Jonas, Peter K Joshi, Navya Shilpa Josyula, Bettina Jung, Mika Kähönen, Yoichiro Kamatani, Candace M Kammerer, Masahiro Kanai, Mika Kastarinen, Shona M Kerr, Chiea-Chuen Khor, Wieland Kiess, Marcus E Kleber, Wolfgang Koenig, Jaspal S Kooner, Antje Körner, Peter Kovacs, Aldi T Kraja, Alena Krajcoviechova, Holly Kramer, Bernhard K Krämer, Florian Kronenberg, Michiaki Kubo, Brigitte Kühnel, Mikko Kuokkanen, Johanna Kuusisto, Martina La Bianca, Markku Laakso, Leslie A Lange, Carl D Langefeld, Jeannette Jen-Mai Lee, Benjamin Lehne, Terho Lehtimäki, Wolfgang Lieb, Su-Chi Lim, Lars Lind, Cecilia M Lindgren, Jun Liu, Jianjun Liu, Markus Loeffler, Ruth J F Loos, Susanne Lucae, Mary Ann Lukas, Leo-Pekka Lyytikäinen, Reedik Mägi, Patrik K E Magnusson, Anubha Mahajan, Nicholas G Martin, Jade Martins, Winfried März, Deborah Mascalzoni, Koichi Matsuda, Christa Meisinger, Thomas Meitinger, Olle Melander, Andres Metspalu, Evgenia K Mikaelsdottir, Yuri Milaneschi, Kozeta Miliku, Pashupati P Mishra, Karen L Mohlke, Nina Mononen, Grant W Montgomery, Dennis O Mook-Kanamori, Josyf C Mychaleckyj, Girish N Nadkarni, Mike A Nalls, Matthias Nauck, Kjell Nikus, Boting Ning, Ilja M Nolte, Raymond Noordam, Jeffrey O'Connell, Michelle L O'Donoghue, Isleifur Olafsson, Albertine J Oldehinkel, Marju Orho-Melander, Willem H Ouwehand, Sandosh Padmanabhan, Nicholette D Palmer, Runolfur Palsson, Brenda W J H Penninx, Thomas Perls, Markus Perola, Mario Pirastu, Nicola Pirastu, Giorgio Pistis, Anna I Podgornaia, Ozren Polasek, Belen Ponte, David J Porteous, Tanja Poulain, Peter P Pramstaller, Michael H Preuss, Bram P Prins, Michael A Province, Ton J Rabelink, Laura M Raffield, Olli T Raitakari, Dermot F Reilly, Rainer Rettig, Myriam Rheinberger, Kenneth M Rice, Paul M Ridker, Fernando Rivadeneira, Federica Rizzi, David J Roberts, Antonietta Robino, Peter Rossing, Igor Rudan, Rico Rueedi, Daniela Ruggiero, Kathleen A Ryan, Yasaman Saba, Charumathi Sabanayagam, Veikko Salomaa, Erika Salvi, Kai-Uwe Saum, Helena Schmidt, Reinhold Schmidt, Ben Schöttker, Christina-Alexandra Schulz, Nicole Schupf, Christian M Shaffer, Yuan Shi, Albert V Smith, Blair H Smith, Nicole Soranzo, Cassandra N Spracklen, Konstantin Strauch, Heather M Stringham, Michael Stumvoll, Per O Svensson, Silke Szymczak, E-Shyong Tai, Salman M Tajuddin, Nicholas Y Q Tan, Kent D Taylor, Andrej Teren, Yih-Chung Tham, Joachim Thiery, Chris H L Thio, Hauke Thomsen, Gudmar Thorleifsson, Daniela Toniolo, Anke Tönjes, Johanne Tremblay, Ioanna Tzoulaki, André G Uitterlinden, Simona Vaccargiu, Rob M van Dam, Pim van der Harst, Cornelia M van Duijn, Digna R Velez Edward, Niek Verweij, Suzanne Vogelezang, Uwe Völker, Peter Vollenweider, Gerard Waeber, Melanie Waldenberger, Lars Wallentin, Ya Xing Wang, Chaolong Wang, Dawn M Waterworth, Wen Bin Wei, Harvey White, John B Whitfield, Sarah H Wild, James F Wilson, Mary K Wojczynski, Charlene Wong, Tien-Yin Wong, Liang Xu, Qiong Yang, Masayuki Yasuda, Laura M Yerges-Armstrong, Weihua Zhang, Alan B Zonderman, Jerome I Rotter, Murielle Bochud, Bruce M Psaty, Veronique Vitart, James G Wilson, Abbas Dehghan, Afshin Parsa, Daniel I Chasman, Kevin Ho, Andrew P Morris, Olivier Devuyst, Shreeram Akilesh, Sarah A Pendergrass, Xueling Sim, Carsten A Böger, Yukinori Okada, Todd L Edwards, Harold Snieder, Kari Stefansson, Adriana M Hung, Iris M Heid, Markus Scholz, Alexander Teumer, Anna Köttgen, Cristian Pattaro

Nature genetics, 51(6), 957-972, Jun, 2019, doi: 10.1038/s41588-019-0407-x

Comprehensive evaluation of structural variation detection algorithms for whole genome sequencing.

Kosugi S, Momozawa Y, Liu X, Terao C, Kubo M, Kamatani Y

Genome biology, 20(1), 117, Jun, 2019, doi: 10.1186/s13059-019-1720-5

Novel Risk Loci Identified in a Genome-Wide Association Study of Urolithiasis in a Japanese Population.

Tanikawa C, Kamatani Y, Terao C, Usami M, Takahashi A, Momozawa Y, Suzuki K, Ogishima S, Shimizu A, Satoh M, Matsuo K, Mikami H, Naito M, Wakai K, Yamaji T, Sawada N, Iwasaki M, Tsugane S, Kohri K, Yu ASL, Yasui T, Murakami Y, Kubo M, Matsuda K

Journal of the American Society of Nephrology : JASN, 30(5), 855-864, May, 2019, doi: 10.1681/ASN.2018090942

GWAS of smoking behaviour in 165,436 Japanese people reveals seven new loci and shared genetic architecture.

Matoba N, Akiyama M, Ishigaki K, Kanai M, Takahashi A, Momozawa Y, Ikegawa S, Ikeda M, Iwata N, Hirata M, Matsuda K, Kubo M, Okada Y, Kamatani Y

Nature human behaviour, 3(5), 471-477, May, 2019, doi: 10.1038/s41562-019-0557-y

大規模ゲノム解析による28の新規2型糖尿病感受性領域および日本人と欧米人に特徴的な2型糖尿病の生物学的パスウェイの同定

鈴木 顕, 秋山 雅人, 石垣 和慶, 金井 仁弘, 細江 隼, 庄嶋 伸浩, 久保 充明, 岡田 随象, 鎌谷 洋一郎, 堀越 桃子, 山内 敏正, 門脇 孝

日本臨床分子医学会学術総会プログラム・抄録集, 56回, 46, Apr, 2019

大規模ゲノム解析による28の新規2型糖尿病感受性領域および日本人と欧米人に特徴的な2型糖尿病の生物学的パスウェイの同定

鈴木 顕, 秋山 雅人, 石垣 和慶, 金井 仁弘, 細江 隼, 庄嶋 伸浩, 岩田 仲生, 池田 匡志, 池川 志郎, 前田 士郎, 村上 善則, 若井 建志, 津金 昌一郎, 佐々木 真理, 山本 雅之, 岡田 随象, 久保 充明, 鎌谷 洋一郎, 堀越 桃子, 山内 敏正, 門脇 孝

糖尿病, 62(Suppl.1), S-108, Apr, 2019

Large-Scale Genome-Wide Association Study of East Asians Identifies Loci Associated With Risk for Colorectal Cancer.

Lu Y, Kweon SS, Tanikawa C, Jia WH, Xiang YB, Cai Q, Zeng C, Schmit SL, Shin A, Matsuo K, Jee SH, Kim DH, Kim J, Wen W, Shi J, Guo X, Li B, Wang N, Zhang B, Li X, Shin MH, Li HL, Ren Z, Oh JH, Oze I, Ahn YO, Jung KJ, Conti DV, Schumacher FR, Rennert G, Jenkins MA, Campbell PT, Hoffmeister M, Casey G, Gruber SB, Gao J, Gao YT, Pan ZZ, Kamatani Y, Zeng YX, Shu XO, Long J, Matsuda K, Zheng W

Gastroenterology, 156(5), 1455-1466, Apr, 2019, doi: 10.1053/j.gastro.2018.11.066

PLD4 is a genetic determinant to systemic lupus erythematosus and involved in murine autoimmune phenotypes.

Shuji Akizuki, Kazuyoshi Ishigaki, Yuta Kochi, Sze-Ming Law, Keitaro Matsuo, Koichiro Ohmura, Akari Suzuki, Manabu Nakayama, Yusuke Iizuka, Haruhiko Koseki, Osamu Ohara, Jun Hirata, Yoichiro Kamatani, Fumihiko Matsuda, Takayuki Sumida, Kazuhiko Yamamoto, Yukinori Okada, Tsuneyo Mimori, Chikashi Terao

Annals of the rheumatic diseases, 78(4), 509-518, Apr, 2019, doi: 10.1136/annrheumdis-2018-214116

Clinical use of current polygenic risk scores may exacerbate health disparities.

Martin AR, Kanai M, Kamatani Y, Okada Y, Neale BM, Daly MJ

Nature genetics, 51(4), 584-591, Apr, 2019, doi: 10.1038/s41588-019-0379-x

Multi-ancestry genome-wide gene-smoking interaction study of 387,272 individuals identifies new loci associated with serum lipids.

Bentley AR, Sung YJ, Brown MR, Winkler TW, Kraja AT, Ntalla I, Schwander K, Chasman DI, Lim E, Deng X, Guo X, Liu J, Lu Y, Cheng CY, Sim X, Vojinovic D, Huffman JE, Musani SK, Li C, Feitosa MF, Richard MA, Noordam R, Baker J, Chen G, Aschard H, Bartz TM, Ding J, Dorajoo R, Manning AK, Rankinen T, Smith AV, Tajuddin SM, Zhao W, Graff M, Alver M, Boissel M, Chai JF, Chen X, Divers J, Evangelou E, Gao C, Goel A, Hagemeijer Y, Harris SE, Hartwig FP, He M, Horimoto ARVR, Hsu FC, Hung YJ, Jackson AU, Kasturiratne A, Komulainen P, Kühnel B, Leander K, Lin KH, Luan J, Lyytikäinen LP, Matoba N, Nolte IM, Pietzner M, Prins B, Riaz M, Robino A, Said MA, Schupf N, Scott RA, Sofer T, Stancáková A, Takeuchi F, Tayo BO, van der Most PJ, Varga TV, Wang TD, Wang Y, Ware EB, Wen W, Xiang YB, Yanek LR, Zhang W, Zhao JH, Adeyemo A, Afaq S, Amin N, Amini M, Arking DE, Arzumanyan Z, Aung T, Ballantyne C, Barr RG, Bielak LF, Boerwinkle E, Bottinger EP, Broeckel U, Brown M, Cade BE, Campbell A, Canouil M, Charumathi S, Chen YI, Christensen K, COGENT-Kidney Consortium, Concas MP, Connell JM, de Las Fuentes L, de Silva HJ, de Vries PS, Doumatey A, Duan Q, Eaton CB, Eppinga RN, Faul JD, Floyd JS, Forouhi NG, Forrester T, Friedlander Y, Gandin I, Gao H, Ghanbari M, Gharib SA, Gigante B, Giulianini F, Grabe HJ, Gu CC, Harris TB, Heikkinen S, Heng CK, Hirata M, Hixson JE, Ikram MA, EPIC-InterAct Consortium, Jia Y, Joehanes R, Johnson C, Jonas JB, Justice AE, Katsuya T, Khor CC, Kilpeläinen TO, Koh WP, Kolcic I, Kooperberg C, Krieger JE, Kritchevsky SB, Kubo M, Kuusisto J, Lakka TA, Langefeld CD, Langenberg C, Launer LJ, Lehne B, Lewis CE, Li Y, Liang J, Lin S, Liu CT, Liu J, Liu K, Loh M, Lohman KK, Louie T, Luzzi A, Mägi R, Mahajan A, Manichaikul AW, McKenzie CA, Meitinger T, Metspalu A, Milaneschi Y, Milani L, Mohlke KL, Momozawa Y, Morris AP, Murray AD, Nalls MA, Nauck M, Nelson CP, North KE, O'Connell JR, Palmer ND, Papanicolau GJ, Pedersen NL, Peters A, Peyser PA, Polasek O, Poulter N, Raitakari OT, Reiner AP, Renström F, Rice TK, Rich SS, Robinson JG, Rose LM, Rosendaal FR, Rudan I, Schmidt CO, Schreiner PJ, Scott WR, Sever P, Shi Y, Sidney S, Sims M, Smith JA, Snieder H, Starr JM, Strauch K, Stringham HM, Tan NYQ, Tang H, Taylor KD, Teo YY, Tham YC, Tiemeier H, Turner ST, Uitterlinden AG, Understanding Society Scientific Group, van Heemst D, Waldenberger M, Wang H, Wang L, Wang L, Wei WB, Williams CA, Wilson G Sr, Wojczynski MK, Yao J, Young K, Yu C, Yuan JM, Zhou J, Zonderman AB, Becker DM, Boehnke M, Bowden DW, Chambers JC, Cooper RS, de Faire U, Deary IJ, Elliott P, Esko T, Farrall M, Franks PW, Freedman BI, Froguel P, Gasparini P, Gieger C, Horta BL, Juang JJ, Kamatani Y, Kammerer CM, Kato N, Kooner JS, Laakso M, Laurie CC, Lee IT, Lehtimäki T, Lifelines Cohort, Magnusson PKE, Oldehinkel AJ, Penninx BWJH, Pereira AC, Rauramaa R, Redline S, Samani NJ, Scott J, Shu XO, van der Harst P, Wagenknecht LE, Wang JS, Wang YX, Wareham NJ, Watkins H, Weir DR, Wickremasinghe AR, Wu T, Zeggini E, Zheng W, Bouchard C, Evans MK, Gudnason V, Kardia SLR, Liu Y, Psaty BM, Ridker PM, van Dam RM, Mook-Kanamori DO, Fornage M, Province MA, Kelly TN, Fox ER, Hayward C, van Duijn CM, Tai ES, Wong TY, Loos RJF, Franceschini N, Rotter JI, Zhu X, Bierut LJ, Gauderman WJ, Rice K, Munroe PB, Morrison AC, Rao DC, Rotimi CN, Cupples LA

Nature genetics, 51(4), 636-648, Apr, 2019, doi: 10.1038/s41588-019-0378-y

A multi-ancestry genome-wide study incorporating gene-smoking interactions identifies multiple new loci for pulse pressure and mean arterial pressure.

Sung YJ, de Las Fuentes L, Winkler TW, Chasman DI, Bentley AR, Kraja AT, Ntalla I, Warren HR, Guo X, Schwander K, Manning AK, Brown MR, Aschard H, Feitosa MF, Franceschini N, Lu Y, Cheng CY, Sim X, Vojinovic D, Marten J, Musani SK, Kilpeläinen TO, Richard MA, Aslibekyan S, Bartz TM, Dorajoo R, Li C, Liu Y, Rankinen T, Smith AV, Tajuddin SM, Tayo BO, Zhao W, Zhou Y, Matoba N, Sofer T, Alver M, Amini M, Boissel M, Chai JF, Chen X, Divers J, Gandin I, Gao C, Giulianini F, Goel A, Harris SE, Hartwig FP, He M, Horimoto ARVR, Hsu FC, Jackson AU, Kammerer CM, Kasturiratne A, Komulainen P, Kühnel B, Leander K, Lee WJ, Lin KH, Luan J, Lyytikäinen LP, McKenzie CA, Nelson CP, Noordam R, Scott RA, Sheu WHH, Stančáková A, Takeuchi F, van der Most PJ, Varga TV, Waken RJ, Wang H, Wang Y, Ware EB, Weiss S, Wen W, Yanek LR, Zhang W, Zhao JH, Afaq S, Alfred T, Amin N, Arking DE, Aung T, Barr RG, Bielak LF, Boerwinkle E, Bottinger EP, Braund PS, Brody JA, Broeckel U, Cade B, Campbell A, Canouil M, Chakravarti A, Cocca M, Collins FS, Connell JM, de Mutsert R, de Silva HJ, Dörr M, Duan Q, Eaton CB, Ehret G, Evangelou E, Faul JD, Forouhi NG, Franco OH, Friedlander Y, Gao H, Gigante B, Gu CC, Gupta P, Hagenaars SP, Harris TB, He J, Heikkinen S, Heng CK, Hofman A, Howard BV, Hunt SC, Irvin MR, Jia Y, Katsuya T, Kaufman J, Kerrison ND, Khor CC, Koh WP, Koistinen HA, Kooperberg CB, Krieger JE, Kubo M, Kutalik Z, Kuusisto J, Lakka TA, Langefeld CD, Langenberg C, Launer LJ, Lee JH, Lehne B, Levy D, Lewis CE, Li Y, Lifelines Cohort Study, Lim SH, Liu CT, Liu J, Liu J, Liu Y, Loh M, Lohman KK, Louie T, Mägi R, Matsuda K, Meitinger T, Metspalu A, Milani L, Momozawa Y, Mosley TH Jr, Nalls MA, Nasri U, O'Connell JR, Ogunniyi A, Palmas WR, Palmer ND, Pankow JS, Pedersen NL, Peters A, Peyser PA, Polasek O, Porteous D, Raitakari OT, Renström F, Rice TK, Ridker PM, Robino A, Robinson JG, Rose LM, Rudan I, Sabanayagam C, Salako BL, Sandow K, Schmidt CO, Schreiner PJ, Scott WR, Sever P, Sims M, Sitlani CM, Smith BH, Smith JA, Snieder H, Starr JM, Strauch K, Tang H, Taylor KD, Teo YY, Tham YC, Uitterlinden AG, Waldenberger M, Wang L, Wang YX, Wei WB, Wilson G, Wojczynski MK, Xiang YB, Yao J, Yuan JM, Zonderman AB, Becker DM, Boehnke M, Bowden DW, Chambers JC, Chen YI, Weir DR, de Faire U, Deary IJ, Esko T, Farrall M, Forrester T, Freedman BI, Froguel P, Gasparini P, Gieger C, Horta BL, Hung YJ, Jonas JB, Kato N, Kooner JS, Laakso M, Lehtimäki T, Liang KW, Magnusson PKE, Oldehinkel AJ, Pereira AC, Perls T, Rauramaa R, Redline S, Rettig R, Samani NJ, Scott J, Shu XO, van der Harst P, Wagenknecht LE, Wareham NJ, Watkins H, Wickremasinghe AR, Wu T, Kamatani Y, Laurie CC, Bouchard C, Cooper RS, Evans MK, Gudnason V, Hixson J, Kardia SLR, Kritchevsky SB, Psaty BM, van Dam RM, Arnett DK, Mook-Kanamori DO, Fornage M, Fox ER, Hayward C, van Duijn CM, Tai ES, Wong TY, Loos RJF, Reiner AP, Rotimi CN, Bierut LJ, Zhu X, Cupples LA, Province MA, Rotter JI, Franks PW, Rice K, Elliott P, Caulfield MJ, Gauderman WJ, Munroe PB, Rao DC, Morrison AC

Human molecular genetics, 28(15), 2615-2633, Apr, 2019, doi: 10.1093/hmg/ddz070

Genetic and phenotypic landscape of the major histocompatibilty complex region in the Japanese population.

Jun Hirata, Kazuyoshi Hosomichi, Saori Sakaue, Masahiro Kanai, Hirofumi Nakaoka, Kazuyoshi Ishigaki, Ken Suzuki, Masato Akiyama, Toshihiro Kishikawa, Kotaro Ogawa, Tatsuo Masuda, Kenichi Yamamoto, Makoto Hirata, Koichi Matsuda, Yukihide Momozawa, Ituro Inoue, Michiaki Kubo, Yoichiro Kamatani, Yukinori Okada

Nature genetics, 51(3), 470-480, Mar, 2019, doi: 10.1038/s41588-018-0336-0

Identification of 28 new susceptibility loci for type 2 diabetes in the Japanese population.

Suzuki K, Akiyama M, Ishigaki K, Kanai M, Hosoe J, Shojima N, Hozawa A, Kadota A, Kuriki K, Naito M, Tanno K, Ishigaki Y, Hirata M, Matsuda K, Iwata N, Ikeda M, Sawada N, Yamaji T, Iwasaki M, Ikegawa S, Maeda S, Murakami Y, Wakai K, Tsugane S, Sasaki M, Yamamoto M, Okada Y, Kubo M, Kamatani Y, Horikoshi M, Yamauchi T, Kadowaki T

Nature genetics, 51(3), 379-386, Mar, 2019, doi: 10.1038/s41588-018-0332-4

Association between genetic risk and development of type 2 diabetes in a general Japanese population: The Hisayama Study.

Inaishi J, Hirakawa Y, Horikoshi M, Akiyama M, Higashioka M, Yoshinari M, Hata J, Mukai N, Kamatani Y, Momozawa Y, Kubo M, Ninomiya T

The Journal of clinical endocrinology and metabolism, 104(8), 3213-3222, Mar, 2019, doi: 10.1210/jc.2018-01782

Genome-Wide Association and Functional Studies Reveal Novel Pharmacological Mechanisms for Allopurinol.

Brackman DJ, Yee SW, Enogieru OJ, Shaffer C, Ranatunga D, Denny JC, Wei WQ, Kamatani Y, Kubo M, Roden DM, Jorgenson E, Giacomini KM

Clinical pharmacology and therapeutics, Mar, 2019, doi: 10.1002/cpt.1439

Diabetes and cancer risk: A Mendelian randomization study.

Goto A, Yamaji T, Sawada N, Momozawa Y, Kamatani Y, Kubo M, Shimazu T, Inoue M, Noda M, Tsugane S, Iwasaki M

International journal of cancer, 146(3), 712-719, Mar, 2019, doi: 10.1002/ijc.32310

Hidden 'risk' in polygenic scores: clinical use today could exacerbate health disparities.

Martin AR, Kanai M, Kamatani Y, Okada Y, Neale BM, Daly MJ

Nature genetics, In Press, Feb, 2019

Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use.

Liu M, Jiang Y, Wedow R, Li Y, Brazel DM, Chen F, Datta G, Davila-Velderrain J, McGuire D, Tian C, Zhan X, ndMe Research Team, HUNT All-In Psychiatry, Choquet H, Docherty AR, Faul JD, Foerster JR, Fritsche LG, Gabrielsen ME, Gordon SD, Haessler J, Hottenga JJ, Huang H, Jang SK, Jansen PR, Ling Y, Mägi R, Matoba N, McMahon G, Mulas A, Orrù V, Palviainen T, Pandit A, Reginsson GW, Skogholt AH, Smith JA, Taylor AE, Turman C, Willemsen G, Young H, Young KA, Zajac GJM, Zhao W, Zhou W, Bjornsdottir G, Boardman JD, Boehnke M, Boomsma DI, Chen C, Cucca F, Davies GE, Eaton CB, Ehringer MA, Esko T, Fiorillo E, Gillespie NA, Gudbjartsson DF, Haller T, Harris KM, Heath AC, Hewitt JK, Hickie IB, Hokanson JE, Hopfer CJ, Hunter DJ, Iacono WG, Johnson EO, Kamatani Y, Kardia SLR, Keller MC, Kellis M, Kooperberg C, Kraft P, Krauter KS, Laakso M, Lind PA, Loukola A, Lutz SM, Madden PAF, Martin NG, McGue M, McQueen MB, Medland SE, Metspalu A, Mohlke KL, Nielsen JB, Okada Y, Peters U, Polderman TJC, Posthuma D, Reiner AP, Rice JP, Rimm E, Rose RJ, Runarsdottir V, Stallings MC, Stančáková A, Stefansson H, Thai KK, Tindle HA, Tyrfingsson T, Wall TL, Weir DR, Weisner C, Whitfield JB, Winsvold BS, Yin J, Zuccolo L, Bierut LJ, Hveem K, Lee JJ, Munafò MR, Saccone NL, Willer CJ, Cornelis MC, David SP, Hinds DA, Jorgenson E, Kaprio J, Stitzel JA, Stefansson K, Thorgeirsson TE, Abecasis G, Liu DJ, Vrieze S

Nature genetics, 51(2), 237-244, Feb, 2019, doi: 10.1038/s41588-018-0307-5

Empirical evaluation of variant calling accuracy using ultra-deep whole-genome sequencing data.

Kishikawa T, Momozawa Y, Ozeki T, Mushiroda T, Inohara H, Kamatani Y, Kubo M, Okada Y

Scientific reports, 9(1), 1784, Feb, 2019, doi: 10.1038/s41598-018-38346-0

Genome-wide association study of cervical cancer suggests a role for ARRDC3 gene in human papillomavirus infection.

Fumihiko Takeuchi, Iwao Kukimoto, Zhiqiang Li, Shuang Li, Ni Li, Zhibin Hu, Atsushi Takahashi, Shusaku Inoue, Sana Yokoi, Jianhua Chen, Dong Hang, Makoto Kuroda, Fumihiko Matsuda, Mika Mizuno, Seiichiro Mori, Peng Wu, Naotake Tanaka, Keitaro Matsuo, Yoichiro Kamatani, Michiaki Kubo, Ding Ma, Yongyong Shi

Human molecular genetics, 28(2), 341-348, Jan 15, 2019, doi: 10.1093/hmg/ddy390

GWAS identifies nine nephrolithiasis susceptibility loci related with metabolic metabolic and crystallization pathways

Chizu Tanikawa, Yoichiro Kamatani, Chikashi Terao, Masayuki Usami, Atsushi Takahashi, Yukihide Momozawa, Kichiya Suzuki, Soichi Ogishima, Atsushi Shimizu, Mamoru Satoh, Keitaro Matsuo, Haruo Mikami, Mariko Naito, Kenji Wakai, Taiki Yamaji, Norie Sawada, Motoki Iwasaki, Shoichiro Tsugane, Kenjiro Kohri, Takahiro Yasui, Yoshinori Murakami, Michiaki Kubo, Koichi Matsuda

Jan 13, 2019, doi: 10.1101/519553

Moyamoya Disease Susceptibility Variant RNF213 p.R4810K Increases the Risk of Ischemic Stroke Attributable to Large-Artery Atherosclerosis.

Shuhei Okazaki, Takaaki Morimoto, Yoichiro Kamatani, Teppei Kamimura, Hatasu Kobayashi, Kouji Harada, Tsutomu Tomita, Aya Higashiyama, Jun C Takahashi, Jyoji Nakagawara, Masatoshi Koga, Kazunori Toyoda, Kazuo Washida, Satoshi Saito, Atsushi Takahashi, Makoto Hirata, Koichi Matsuda, Hideki Mochizuki, Michael Chong, Guillaume Paré, Martin O'Donnell, Tetsuro Ago, Jun Hata, Toshiharu Ninomiya, Martin Dichgans, Stéphanie Debette, Michiaki Kubo, Akio Koizumi, Masafumi Ihara

Circulation, 139(2), 295-298, Jan 8, 2019, doi: 10.1161/CIRCULATIONAHA.118.038439

無症候性高尿酸血症群と痛風症例群のゲノムワイド関連解析により痛風発症に関連する新規遺伝子座を同定した

河村 優輔, 松尾 洋孝, 中山 昌喜, 東野 俊英, 清水 徹, 大山 博司, 大山 恵子, 長瀬 満夫, 清水 聖子, 川口 真, 高尾 幹也, 高田 龍平, 細谷 龍男, 市田 公美, 四ノ宮 成祥, 中岡 博史, 岡田 随象, 山本 健, 崎山 真幸, 中村 好宏, 鎌谷 洋一郎, 久保 充明, 井ノ上 逸朗

日本痛風・核酸代謝学会総会プログラム抄録集, 52回, 74, Jan, 2019

日本人121,745人を対象としたゲノムワイドメタ解析により血清尿酸値と関連する8つの新規遺伝子座を同定した

中杤 昌弘, 松尾 洋孝, 中山 昌喜, 河村 優輔, 清水 聖子, 川口 真, 高尾 幹也, 四ノ宮 成祥, 金井 仁弘, 菱田 朝陽, 中村 好宏, 久保 充明, 鎌谷 洋一郎, 横田 充弘, 若井 建志, 岡田 随象

日本痛風・核酸代謝学会総会プログラム抄録集, 52回, 75, Jan, 2019

日本人の臨床検査値に影響する遺伝的背景の解明 58の量的形質における大規模ゲノムワイド関連解析

金井 仁弘, 岡田 随象, 鎌谷 洋一郎

臨床免疫・アレルギー科, 71(1), 78-85, Jan, 2019

A novel intragenic deletion in OPHN1 in a Japanese patient with Dandy-Walker malformation.

Aritoshi Iida, Eri Takeshita, Shunichi Kosugi, Yoichiro Kamatani, Yukihide Momozawa, Michiaki Kubo, Eiji Nakagawa, Kenji Kurosawa, Ken Inoue, Yu-Ichi Goto

Human genome variation, 6, 1, 2019, doi: 10.1038/s41439-018-0032-8

Genetically Determined Levels of Circulating Cytokines and Risk of Stroke.

Georgakis MK, Gill D, Rannikmäe K, Traylor M, Anderson CD, Lee JM, Kamatani Y, Hopewell JC, Worrall BB, Bernhagen J, Sudlow CLM, Malik R, Dichgans M

Circulation, 139(2), 256-268, Jan, 2019, doi: 10.1161/CIRCULATIONAHA.118.035905

Trans-ethnic kidney function association study reveals putative causal genes and effects on kidney-specific disease aetiologies.

Morris AP, Le TH, Wu H, Akbarov A, van der Most PJ, Hemani G, Smith GD, Mahajan A, Gaulton KJ, Nadkarni GN, Valladares-Salgado A, Wacher-Rodarte N, Mychaleckyj JC, Dueker ND, Guo X, Hai Y, Haessler J, Kamatani Y, Stilp AM, Zhu G, Cook JP, Ärnlöv J, Blanton SH, de Borst MH, Bottinger EP, Buchanan TA, Cechova S, Charchar FJ, Chu PL, Damman J, Eales J, Gharavi AG, Giedraitis V, Heath AC, Ipp E, Kiryluk K, Kramer HJ, Kubo M, Larsson A, Lindgren CM, Lu Y, Madden PAF, Montgomery GW, Papanicolaou GJ, Raffel LJ, Sacco RL, Sanchez E, Stark H, Sundstrom J, Taylor KD, Xiang AH, Zivkovic A, Lind L, Ingelsson E, Martin NG, Whitfield JB, Cai J, Laurie CC, Okada Y, Matsuda K, Kooperberg C, Chen YI, Rundek T, Rich SS, Loos RJF, Parra EJ, Cruz M, Rotter JI, Snieder H, Tomaszewski M, Humphreys BD, Franceschini N

Nature communications, 10(1), 29, Jan, 2019, doi: 10.1038/s41467-018-07867-7

Genome-wide meta-analysis identifies multiple novel loci associated with serum uric acid levels in Japanese individuals.

Nakatochi M, Kanai M, Nakayama A, Hishida A, Kawamura Y, Ichihara S, Akiyama M, Ikezaki H, Furusyo N, Shimizu S, Yamamoto K, Hirata M, Okada R, Kawai S, Kawaguchi M, Nishida Y, Shimanoe C, Ibusuki R, Takezaki T, Nakajima M, Takao M, Ozaki E, Matsui D, Nishiyama T, Suzuki S, Takashima N, Kita Y, Endoh K, Kuriki K, Uemura H, Arisawa K, Oze I, Matsuo K, Nakamura Y, Mikami H, Tamura T, Nakashima H, Nakamura T, Kato N, Matsuda K, Murakami Y, Matsubara T, Naito M, Kubo M, Kamatani Y, Shinomiya N, Yokota M, Wakai K, Okada Y, Matsuo H

Communications biology, 2(1), 115, 2019, doi: 10.1038/s42003-019-0339-0

201832 papers

Integration of genetics and miRNA-target gene network identified disease biology implicated in tissue specificity.

Saori Sakaue, Jun Hirata, Yuichi Maeda, Eiryo Kawakami, Takuro Nii, Toshihiro Kishikawa, Kazuyoshi Ishigaki, Chikashi Terao, Ken Suzuki, Masato Akiyama, Naomasa Suita, Tatsuo Masuda, Kotaro Ogawa, Kenichi Yamamoto, Yukihiko Saeki, Masato Matsushita, Maiko Yoshimura, Hidetoshi Matsuoka, Katsunori Ikari, Atsuo Taniguchi, Hisashi Yamanaka, Hideya Kawaji, Timo Lassmann, Masayoshi Itoh, Hiroyuki Yoshitomi, Hiromu Ito, Koichiro Ohmura, Alistair R R Forrest, Yoshihide Hayashizaki, Piero Carninci, Atsushi Kumanogoh, Yoichiro Kamatani, Michiel de Hoon, Kazuhiko Yamamoto, Yukinori Okada

Nucleic acids research, 46(22), 11898-11909, Dec 14, 2018, doi: 10.1093/nar/gky1066

GWAS and colocalization analyses implicate carotid intima-media thickness and carotid plaque loci in cardiovascular outcomes

Nora Franceschini, Claudia Giambartolomei, Paul S. de Vries, Chris Finan, Joshua C. Bis, Rachael P. Huntley, Ruth C. Lovering, Salman M. Tajuddin, Thomas W. Winkler, Misa Graff, Maryam Kavousi, Caroline Dale, Albert V. Smith, Edith Hofer, Elisabeth M. van Leeuwen, Ilja M. Nolte, Lingyi Lu, Markus Scholz, Muralidharan Sargurupremraj, Niina Pitkänen, Oscar Franzén, Peter K. Joshi, Raymond Noordam, Riccardo E. Marioni, Shih-Jen Hwang, Solomon K. Musani, Ulf Schminke, Walter Palmas, Aaron Isaacs, Adolfo Correa, Alan B. Zonderman, Albert Hofman, Alexander Teumer, Amanda J. Cox, André G. Uitterlinden, Andrew Wong, Andries J. Smit, Anne B. Newman, Annie Britton, Arno Ruusalepp, Bengt Sennblad, Bo Hedblad, Bogdan Pasaniuc, Brenda W. Penninx, Carl D. Langefeld, Christina L. Wassel, Christophe Tzourio, Cristiano Fava, Damiano Baldassarre, Daniel H. O’Leary, Daniel Teupser, Diana Kuh, Elena Tremoli, Elmo Mannarino, Enzo Grossi, Eric Boerwinkle, Eric E. Schadt, Erik Ingelsson, Fabrizio Veglia, Fernando Rivadeneira, Frank Beutner, Ganesh Chauhan, Gerardo Heiss, Harold Snieder, Harry Campbell, Henry Völzke, Hugh S. Markus, Ian J. Deary, J. Wouter Jukema, Jacqueline de Graaf, Jacqueline Price, Janne Pott, Jemma C. Hopewell, Jingjing Liang, Joachim Thiery, Jorgen Engmann, Karl Gertow, Kenneth Rice, Kent D. Taylor, Klodian Dhana, Lambertus A. L. M. Kiemeney, Lars Lind, Laura M. Raffield, Lenore J. Launer, Lesca M. Holdt, Marcus Dörr, Martin Dichgans, Matthew Traylor, Matthias Sitzer, Meena Kumari, Mika Kivimaki, Mike A. Nalls, Olle Melander, Olli Raitakari, Oscar H. Franco, Oscar L. Rueda-Ochoa, Panos Roussos, Peter H. Whincup, Philippe Amouyel, Philippe Giral, Pramod Anugu, Quenna Wong, Rainer Malik, Rainer Rauramaa, Ralph Burkhardt, Rebecca Hardy, Reinhold Schmidt, Renée de Mutsert, Richard W. Morris, Rona J. Strawbridge, S. Goya Wannamethee, Sara Hägg, Sonia Shah, Stela McLachlan, Stella Trompet, Sudha Seshadri, Sudhir Kurl, Susan R. Heckbert, Susan Ring, Tamara B. Harris, Terho Lehtimäki, Tessel E. Galesloot, Tina Shah, Ulf de Faire, Vincent Plagnol, Wayne D. Rosamond, Wendy Post, Xiaofeng Zhu, Xiaoling Zhang, Xiuqing Guo, Yasaman Saba, Yukinori Okada, Aniket Mishra, Loes Rutten-Jacobs, Anne-Katrin Giese, Sander W. van der Laan, Solveig Gretarsdottir, Christopher D. Anderson, Michael Chong, Hieab H. H. Adams, Tetsuro Ago, Peter Almgren, Hakan Ay, Traci M. Bartz, Oscar R. Benavente, Steve Bevan, Giorgio B. Boncoraglio, Robert D. Brown, Adam S. Butterworth, Caty Carrera, Cara L. Carty, Daniel I. Chasman, Wei-Min Chen, John W. Cole, Ioana Cotlarciuc, Carlos Cruchaga, John Danesh, Paul I. W. de Bakker, Anita L. DeStefano, Marcel den Hoed, Qing Duan, Stefan T. Engelter, Guido J. Falcone, Rebecca F. Gottesman, Raji P. Grewal, Stefan Gustafsson, Jeffrey Haessler, Tamara B. Harris, Ahamad Hassan, Aki S. Havulinna, Elizabeth G. Holliday, George Howard, Fang-Chi Hsu, Hyacinth I. Hyacinth, M. Arfan Ikram, Marguerite R. Irvin, Xueqiu Jian, Jordi Jiménez-Conde, Julie A. Johnson, Masahiro Kanai, Keith L. Keene, Brett M. Kissela, Dawn O. Kleindorfer, Charles Kooperberg, Michiaki Kubo, Leslie Lange, Claudia Langenberg, Jin-Moo Lee, Robin Lemmens, Didier Leys, Cathryn M. Lewis, Wei-Yu Lin, Arne G. Lindgren, Erik Lorentzen, Patrik K. Magnusson, Jane Maguire, Ani Manichaikul, Patrick F. McArdle, James F. Meschia, Thomas H. Mosley, Toshiharu Ninomiya, Martin J. O’Donnell, Sara L. Pulit, Kristiina Rannikmäe, Alexander P. Reiner, Kathryn M. Rexrode, Stephen S. Rich, Paul M. Ridker, Natalia S. Rost, Peter M. Rothwell, Tatjana Rundek, Ralph L. Sacco, Saori Sakaue, Michele M. Sale, Veikko Salomaa, Bishwa R. Sapkota, Reinhold Schmidt, Carsten O. Schmidt, Pankaj Sharma, Agnieszka Slowik, Cathie L. M. Sudlow, Christian Tanislav, Turgut Tatlisumak, Vincent N. S. Thijs, Gudmar Thorleifsson, Unnur Thorsteinsdottir, Steffen Tiedt, Matthew Walters, Nicholas J. Wareham, Sylvia Wassertheil-Smoller, Kerri L. 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Nature Communications, 9(1), Dec 1, 2018, doi: 10.1038/s41467-018-07340-5

日本人における尿酸値のGWASメタ解析による8個の新規遺伝子座の同定

中嶌 真由子, 中杤 昌弘, 金井 仁弘, 中山 昌喜, 菱田 朝陽, 河村 優輔, 青柳 有香, 久保 充明, 鎌谷 洋一郎, 横田 充弘, 若井 建志, 岡田 随象, 四ノ宮 成祥, 松尾 洋孝

防衛衛生, 66(別冊), 44, Dec, 2018

Genome-wide association study identifies gastric cancer susceptibility loci at 12q24.11-12 and 20q11.21

Tanikawa, Chizu, Kamatani, Yoichiro, Toyoshima, Osamu, Sakamoto, Hiromi, Ito, Hidemi, Takahashi, Atsushi, Momozawa, Yukihide, Hirata, Makoto, Fuse, Nobuo, Takai-Igarashi, Takako, Shimizu, Atsushi, Sasaki, Makoto, Yamaji, Taiki, Sawada, Norie, Iwasaki, Mot

CANCER SCIENCE, 109(12), 4015-4024, Dec, 2018, doi: 10.1111/cas.13815

Deep whole-genome sequencing reveals recent selection signatures linked to evolution and disease risk of Japanese

Yukinori Okada, Yukihide Momozawa, Saori Sakaue, Masahiro Kanai, Kazuyoshi Ishigaki, Masato Akiyama, Toshihiro Kishikawa, Yasumichi Arai, Takashi Sasaki, Kenjiro Kosaki, Makoto Suematsu, Koichi Matsuda, Kazuhiko Yamamoto, Michiaki Kubo, Nobuyoshi Hirose, Yoichiro Kamatani

Nature Communications, 9(1), 1631, Dec 1, 2018, doi: 10.1038/s41467-018-03274-0

Elucidating the genetic architecture of reproductive ageing in the Japanese population

Momoko Horikoshi, Felix R. Day, Masato Akiyama, Makoto Hirata, Yoichiro Kamatani, Koichi Matsuda, Kazuyoshi Ishigaki, Masahiro Kanai, Hollis Wright, Carlos A. Toro, Sergio R. Ojeda, Alejandro Lomniczi, Michiaki Kubo, Ken K. Ong, John R.B. Perry

Nature Communications, 9(1), 1977, Dec 1, 2018, doi: 10.1038/s41467-018-04398-z

Genome-wide association study identifies gastric cancer susceptibility loci at 12q24.11-12 and 20q11.21.

Tanikawa C, Kamatani Y, Toyoshima O, Sakamoto H, Ito H, Takahashi A, Momozawa Y, Hirata M, Fuse N, Takai-Igarashi T, Shimizu A, Sasaki M, Yamaji T, Sawada N, Iwasaki M, Tsugane S, Naito M, Hishida A, Wakai K, Furusyo N, Murakami Y, Nakamura Y, Imoto I, Inazawa J, Oze I, Sato N, Tanioka F, Sugimura H, Hirose H, Yoshida T, Matsuo K, Kubo M, Matsuda K

Cancer science, 109(12), 4015-4024, Dec, 2018, doi: 10.1111/cas.13815

Analysis of Genomic Predispositions to Sporadic Myeloid Neoplasms Mediated By DDX41 in Japan

Takeda June, Yoshida Kenichi, Yoshizato Tetsuichi, Shiraishi Yuichi, Okuno Yusuke, Kon Ayana, Kataoka Keisuke, Chiba Kenichi, Tanaka Hiroko, Sanada Masashi, Ishiyama Ken, Chiba Shigeru, Asou Norio, Miyazaki Yasushi, Naoe Tomoki, Usuki Kensuke, Miyawaki Shuichi, Kamatani Yoichiro, Momozawa Yukihide, Nagasaki Masao, Miyano Satoru, Kubo Michiaki, Makishima Hideki, Ogawa Seishi

BLOOD, 132, Nov 29, 2018, doi: 10.1182/blood-2018-99-117664

Interethnic analyses of blood pressure loci in populations of East Asian and European descent.

Fumihiko Takeuchi, Masato Akiyama, Nana Matoba, Tomohiro Katsuya, Masahiro Nakatochi, Yasuharu Tabara, Akira Narita, Woei-Yuh Saw, Sanghoon Moon, Cassandra N Spracklen, Jin-Fang Chai, Young-Jin Kim, Liang Zhang, Chaolong Wang, Huaixing Li, Honglan Li, Jer-Yuarn Wu, Rajkumar Dorajoo, Jovia L Nierenberg, Ya Xing Wang, Jing He, Derrick A Bennett, Atsushi Takahashi, Yukihide Momozawa, Makoto Hirata, Koichi Matsuda, Hiromi Rakugi, Eitaro Nakashima, Masato Isono, Matsuyuki Shirota, Atsushi Hozawa, Sahoko Ichihara, Tatsuaki Matsubara, Ken Yamamoto, Katsuhiko Kohara, Michiya Igase, Sohee Han, Penny Gordon-Larsen, Wei Huang, Nanette R Lee, Linda S Adair, Mi Yeong Hwang, Juyoung Lee, Miao Li Chee, Charumathi Sabanayagam, Wanting Zhao, Jianjun Liu, Dermot F Reilly, Liang Sun, Shaofeng Huo, Todd L Edwards, Jirong Long, Li-Ching Chang, Chien-Hsiun Chen, Jian-Min Yuan, Woon-Puay Koh, Yechiel Friedlander, Tanika N Kelly, Wen Bin Wei, Liang Xu, Hui Cai, Yong-Bing Xiang, Kuang Lin, Robert Clarke, Robin G Walters, Iona Y Millwood, Liming Li, John C Chambers, Jaspal S Kooner, Paul Elliott, Pim van der Harst, Zhengming Chen, Makoto Sasaki, Xiao-Ou Shu, Jost B Jonas, Jiang He, Chew-Kiat Heng, Yuan-Tsong Chen, Wei Zheng, Xu Lin, Yik-Ying Teo, E-Shyong Tai, Ching-Yu Cheng, Tien Yin Wong, Xueling Sim, Karen L Mohlke, Masayuki Yamamoto, Bong-Jo Kim, Tetsuro Miki, Toru Nabika, Mitsuhiro Yokota, Yoichiro Kamatani, Michiaki Kubo, Norihiro Kato

Nature communications, 9(1), 5052, Nov 28, 2018, doi: 10.1038/s41467-018-07345-0

Amino acid position 37 of HLA-DRβ1 affects susceptibility to Crohn's disease in Asians.

Han B, Akiyama M, Kim KK, Oh H, Choi H, Lee CH, Jung S, Lee HS, Kim EE, Cook S, Haritunians T, Yamazaki K, Park SH, Ye BD, McGovern DPB, Esaki M, Kawaguchi T, Khor SS, Taylor KD, Rotter JI, Suzuki Y, Matsui T, Motoya S, Bang SY, Kim TH, Momozawa Y, Kamatani Y, Tokunaga K, Kubo M, Okada Y, Yang SK, Song K

Human molecular genetics, 27(22), 3901-3910, Nov, 2018, doi: 10.1093/hmg/ddy285

Germline pathogenic variants of 11 breast cancer genes in 7,051 Japanese patients and 11,241 controls.

Momozawa Y, Iwasaki Y, Parsons MT, Kamatani Y, Takahashi A, Tamura C, Katagiri T, Yoshida T, Nakamura S, Sugano K, Miki Y, Hirata M, Matsuda K, Spurdle AB, Kubo M

Nature communications, 9(1), 4083, Oct, 2018, doi: 10.1038/s41467-018-06581-8

Genome-wide analyses identify a role for SLC17A4 and AADAT in thyroid hormone regulation.

Teumer A, Chaker L, Groeneweg S, Li Y, Di Munno C, Barbieri C, Schultheiss UT, Traglia M, Ahluwalia TS, Akiyama M, Appel EVR, Arking DE, Arnold A, Astrup A, Beekman M, Beilby JP, Bekaert S, Boerwinkle E, Brown SJ, De Buyzere M, Campbell PJ, Ceresini G, Cerqueira C, Cucca F, Deary IJ, Deelen J, Eckardt KU, Ekici AB, Eriksson JG, Ferrrucci L, Fiers T, Fiorillo E, Ford I, Fox CS, Fuchsberger C, Galesloot TE, Gieger C, Gögele M, De Grandi A, Grarup N, Greiser KH, Haljas K, Hansen T, Harris SE, van Heemst D, den Heijer M, Hicks AA, den Hollander W, Homuth G, Hui J, Ikram MA, Ittermann T, Jensen RA, Jing J, Jukema JW, Kajantie E, Kamatani Y, Kasbohm E, Kaufman JM, Kiemeney LA, Kloppenburg M, Kronenberg F, Kubo M, Lahti J, Lapauw B, Li S, Liewald DCM, Lifelines Cohort Study, Lim EM, Linneberg A, Marina M, Mascalzoni D, Matsuda K, Medenwald D, Meisinger C, Meulenbelt I, De Meyer T, Meyer Zu Schwabedissen HE, Mikolajczyk R, Moed M, Netea-Maier RT, Nolte IM, Okada Y, Pala M, Pattaro C, Pedersen O, Petersmann A, Porcu E, Postmus I, Pramstaller PP, Psaty BM, Ramos YFM, Rawal R, Redmond P, Richards JB, Rietzschel ER, Rivadeneira F, Roef G, Rotter JI, Sala CF, Schlessinger D, Selvin E, Slagboom PE, Soranzo N, Sørensen TIA, Spector TD, Starr JM, Stott DJ, Taes Y, Taliun D, Tanaka T, Thuesen B, Tiller D, Toniolo D, Uitterlinden AG, Visser WE, Walsh JP, Wilson SG, Wolffenbuttel BHR, Yang Q, Zheng HF, Cappola A, Peeters RP, Naitza S, Völzke H, Sanna S, Köttgen A, Visser TJ, Medici M

Nature communications, 9(1), 4455, Oct, 2018, doi: 10.1038/s41467-018-06356-1

A locus at 7p14.3 predisposes to refractory celiac disease progression from celiac disease.

Hrdlickova B, Mulder CJ, Malamut G, Meresse B, Platteel M, Kamatani Y, Ricaño-Ponce I, van Wanrooij RLJ, Zorro MM, Jan Bonder M, Gutierrez-Achury J, Cellier C, Zhernakova A, Nijeboer P, Galan P, Withoff S, Lathrop M, Bouma G, Xavier RJ, Jabri B, Bensussan NC, Wijmenga C, Kumar V

European journal of gastroenterology & hepatology, 30(8), 828-837, Aug, 2018, doi: 10.1097/MEG.0000000000001168

Re-evaluating classical body type theories: genetic correlation between psychiatric disorders and body mass index.

Ikeda M, Tanaka S, Saito T, Ozaki N, Kamatani Y, Iwata N

Psychological medicine, 48(10), 1745-1748, Jul, 2018, doi: 10.1017/S0033291718000685

Multi-ethnic genome-wide association study for atrial fibrillation

Carolina Roselli, Mark D. Chaffin, Lu-Chen Weng, Stefanie Aeschbacher, Gustav Ahlberg, Christine M. Albert, Peter Almgren, Alvaro Alonso, Christopher D. Anderson, Krishna G. Aragam, Dan E. Arking, John Barnard, Traci M. Bartz, Emelia J. Benjamin, Nathan A. Bihlmeyer, Joshua C. Bis, Heather L. Bloom, Eric Boerwinkle, Erwin B. Bottinger, Jennifer A. Brody, Hugh Calkins, Archie Campbell, Thomas P. Cappola, John Carlquist, Daniel I. Chasman, Lin Y. Chen, Yii-Der Ida Chen, Eue-Keun Choi, Seung Hoan Choi, Ingrid E. Christophersen, Mina K. Chung, John W. Cole, David Conen, James Cook, Harry J. Crijns, Michael J. Cutler, Scott M. Damrauer, Brian R. Daniels, Dawood Darbar, Graciela Delgado, Joshua C. Denny, Martin Dichgans, Marcus Dörr, Elton A. Dudink, Samuel C. Dudley, Nada Esa, Tonu Esko, Markku Eskola, Diane Fatkin, Stephan B. Felix, Ian Ford, Oscar H. Franco, Bastiaan Geelhoed, Raji P. Grewal, Vilmundur Gudnason, Xiuqing Guo, Namrata Gupta, Stefan Gustafsson, Rebecca Gutmann, Anders Hamsten, Tamara B. Harris, Caroline Hayward, Susan R. Heckbert, Jussi Hernesniemi, Lynne J. Hocking, Albert Hofman, Andrea R. V. R. Horimoto, Jie Huang, Paul L. Huang, Jennifer Huffman, Erik Ingelsson, Esra Gucuk Ipek, Kaoru Ito, Jordi Jimenez-Conde, Renee Johnson, J. Wouter Jukema, Stefan Kääb, Mika Kähönen, Yoichiro Kamatani, John P. Kane, Adnan Kastrati, Sekar Kathiresan, Petra Katschnig-Winter, Maryam Kavousi, Thorsten Kessler, Bas L. Kietselaer, Paulus Kirchhof, Marcus E. Kleber, Stacey Knight, Jose E. Krieger, Michiaki Kubo, Lenore J. Launer, Jari Laurikka, Terho Lehtimäki, Kirsten Leineweber, Rozenn N. Lemaitre, Man Li, Hong Euy Lim, Henry J. Lin, Honghuang Lin, Lars Lind, Cecilia M. Lindgren, Marja-Liisa Lokki, Barry London, Ruth J. F. Loos, Siew-Kee Low, Yingchang Lu, Leo-Pekka Lyytikäinen, Peter W. Macfarlane, Patrik K. Magnusson, Anubha Mahajan, Rainer Malik, Alfredo J. Mansur, Gregory M. Marcus, Lauren Margolin, Kenneth B. Margulies, Winfried März, David D. McManus, Olle Melander, Sanghamitra Mohanty, Jay A. Montgomery, Michael P. Morley, Andrew P. Morris, Martina Müller-Nurasyid, Andrea Natale, Saman Nazarian, Benjamin Neumann, Christopher Newton-Cheh, Maartje N. Niemeijer, Kjell Nikus, Peter Nilsson, Raymond Noordam, Heidi Oellers, Morten S. Olesen, Marju Orho-Melander, Sandosh Padmanabhan, Hui-Nam Pak, Guillaume Paré, Nancy L. Pedersen, Joanna Pera, Alexandre Pereira, David Porteous, Bruce M. Psaty, Sara L. Pulit, Clive R. Pullinger, Daniel J. Rader, Lena Refsgaard, Marta Ribasés, Paul M. Ridker, Michiel Rienstra, Lorenz Risch, Dan M. Roden, Jonathan Rosand, Michael A. Rosenberg, Natalia Rost, Jerome I. Rotter, Samir Saba, Roopinder K. Sandhu, Renate B. Schnabel, Katharina Schramm, Heribert Schunkert, Claudia Schurman, Stuart A. Scott, Ilkka Seppälä, Christian Shaffer, Svati Shah, Alaa A. Shalaby, Jaemin Shim, M. Benjamin Shoemaker, Joylene E. Siland, Juha Sinisalo, Moritz F. Sinner, Agnieszka Slowik, Albert V. Smith, Blair H. Smith, J. Gustav Smith, Jonathan D. Smith, Nicholas L. Smith, Elsayed Z. Soliman, Nona Sotoodehnia, Bruno H. Stricker, Albert Sun, Han Sun, Jesper H. Svendsen, Toshihiro Tanaka, Kahraman Tanriverdi, Kent D. Taylor, Maris Teder-Laving, Alexander Teumer, Sébastien Thériault, Stella Trompet, Nathan R. Tucker, Arnljot Tveit, Andre G. Uitterlinden, Pim van der Harst, Isabelle C. van Gelder, David R. van Wagoner, Niek Verweij, Efthymia Vlachopoulou, Uwe Völker, Biqi Wang, Peter E. Weeke, Bob Weijs, Raul Weiss, Stefan Weiss, Quinn S. Wells, Kerri L. Wiggins, Jorge A. Wong, Daniel Woo, Bradford B. Worrall, Pil-Sung Yang, Jie Yao, Zachary T. Yoneda, Tanja Zeller, Lingyao Zeng, Steven A. Lubitz, Kathryn L. Lunetta, Patrick T. Ellinor

Nature Genetics, 50(9), 1-9, Jun 11, 2018, doi: 10.1038/s41588-018-0133-9

Genome-Wide Association Study of Renal Function Traits: Results from the Japan Multi-Institutional Collaborative Cohort Study

Asahi Hishida, Masahiro Nakatochi, Masato Akiyama, Yoichiro Kamatani, Takeshi Nishiyama, Hidemi Ito, Isao Oze, Yuichiro Nishida, Megumi Hara, Naoyuki Takashima, Tanvir Chowdhury Turin, Miki Watanabe, Sadao Suzuki, Rie Ibusuki, Ippei Shimoshikiryo, Yohko Nakamura, Haruo Mikami, Hiroaki Ikezaki, Norihiro Furusyo, Kiyonori Kuriki, Kaori Endoh, Teruhide Koyama, Daisuke Matsui, Hirokazu Uemura, Kokichi Arisawa, Tae Sasakabe, Rieko Okada, Sayo Kawai, Mariko Naito, Yukihide Momozawa, Michiaki Kubo, Kenji Wakai

American Journal of Nephrology, 47(5), 304-316, Jun 1, 2018, doi: 10.1159/000488946

Analysis of shared heritability in common disorders of the brain.

Brainstorm Consortium, Anttila V, Bulik-Sullivan B, Finucane HK, Walters RK, Bras J, Duncan L, Escott-Price V, Falcone GJ, Gormley P, Malik R, Patsopoulos NA, Ripke S, Wei Z, Yu D, Lee PH, Turley P, Grenier-Boley B, Chouraki V, Kamatani Y, Berr C, Letenneur L, Hannequin D, Amouyel P, Boland A, Deleuze JF, Duron E, Vardarajan BN, Reitz C, Goate AM, Huentelman MJ, Kamboh MI, Larson EB, Rogaeva E, St George-Hyslop P, Hakonarson H, Kukull WA, Farrer LA, Barnes LL, Beach TG, Demirci FY, Head E, Hulette CM, Jicha GA, Kauwe JSK, Kaye JA, Leverenz JB, Levey AI, Lieberman AP, Pankratz VS, Poon WW, Quinn JF, Saykin AJ, Schneider LS, Smith AG, Sonnen JA, Stern RA, Van Deerlin VM, Van Eldik LJ, Harold D, Russo G, Rubinsztein DC, Bayer A, Tsolaki M, Proitsi P, Fox NC, Hampel H, Owen MJ, Mead S, Passmore P, Morgan K, Nöthen MM, Rossor M, Lupton MK, Hoffmann P, Kornhuber J, Lawlor B, McQuillin A, Al-Chalabi A, Bis JC, Ruiz A, Boada M, Seshadri S, Beiser A, Rice K, van der Lee SJ, De Jager PL, 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Science (New York, N.Y.), 360(6395), Jun, 2018, doi: 10.1126/science.aap8757

Identification of LEF1 as a Susceptibility Locus for Kawasaki Disease in Patients Younger than 6 Months of Age.

Hea-Ji Kim, Sin Weon Yun, Jeong Jin Yu, Kyung Lim Yoon, Kyung-Yil Lee, Hong-Ryang Kil, Gi Beom Kim, Myung-Ki Han, Min Seob Song, Hyoung Doo Lee, Kee Soo Ha, Sejung Sohn, Ryota Ebata, Hiromichi Hamada, Hiroyuki Suzuki, Yoichiro Kamatani, Michiaki Kubo, Kaoru Ito, Yoshihiro Onouchi, Young Mi Hong, Gi Young Jang, Jong-Keuk Lee

Genomics & informatics, 16(2), 36-41, Jun, 2018, doi: 10.5808/GI.2018.16.2.36

GWAS identifies two novel colorectal cancer loci at 16q24.1 and 20q13.12.

Tanikawa C, Kamatani Y, Takahashi A, Momozawa Y, Leveque K, Nagayama S, Mimori K, Mori M, Ishii H, Inazawa J, Yasuda J, Tsuboi A, Shimizu A, Sasaki M, Yamaji T, Sawada N, Iwasaki M, Tsugane S, Naito M, Wakai K, Koyama T, Takezaki T, Yuji K, Murakami Y, Nakamura Y, Kubo M, Matsuda K

Carcinogenesis, 39(5), 652-660, May, 2018, doi: 10.1093/carcin/bgy026

Genome-wide association study identifies seven novel susceptibility loci for primary open-angle glaucoma

Yukihiro Shiga, Japan Glaucoma Society Omics Group (JGS-OG), Masato Akiyama, Koji M. Nishiguchi, Kota Sato, Nobuhiro Shimozawa, Atsushi Takahashi, Yukihide Momozawa, Makoto Hirata, Koichi Matsuda, Taiki Yamaji, Motoki Iwasaki, Shoichiro Tsugane, Isao Oze, Haruo Mikami, Mariko Naito, Kenji Wakai, Munemitsu Yoshikawa, Masahiro Miyake, Kenji Yamashiro, Kenji Kashiwagi, Takeshi Iwata, Fumihiko Mabuchi, Mitsuko Takamoto, Mineo Ozaki, Kazuhide Kawase, Makoto Aihara, Makoto Araie, Tetsuya Yamamoto, Yoshiaki Kiuchi, Makoto Nakamura, Yasuhiro Ikeda, Koh-Hei Sonoda, Tatsuro Ishibashi, Koji Nitta, Aiko Iwase, Shiroaki Shirato, Yoshitaka Oka, Mamoru Satoh, Makoto Sasaki, Nobuo Fuse, Yoichi Suzuki, Ching-Yu Cheng, Chiea Chuen Khor, Mani Baskaran, Shamira Perera, Tin Aung, Eranga N. Vithana, Jessica N. Cooke Bailey, Jae H. Kang, Louis R. Pasquale, Jonathan L. Haines, Janey L. Wiggs, Kathryn P. Burdon, Puya Gharahkhani, Alex W. Hewitt, David A. Mackey, Stuart MacGregor, Jamie E. Craig, R. Rand Allingham, Micheal Hauser, Adeyinka Ashaye, Donald L. Budenz, Stephan Akafo, Susan E.I. Williams, Yoichiro Kamatani, Toru Nakazawa, Michiaki Kubo

Human Molecular Genetics, 27(8), 1486-1496, Apr 15, 2018, doi: 10.1093/hmg/ddy053

Re-evaluating classical body type theories: Genetic correlation between psychiatric disorders and body mass index

Ikeda, M, Tanaka, S, Saito, T, Ozaki, N, Kamatani, Y, Iwata, N

Psychological Medicine, 1-4, Apr 13, 2018, doi: 10.1017/S0033291718000685

Splicing variant of WDFY4 augments MDA5 signalling and the risk of clinically amyopathic dermatomyositis.

Yuta Kochi, Yoichiro Kamatani, Yuya Kondo, Akari Suzuki, Eiryo Kawakami, Ryosuke Hiwa, Yukihide Momozawa, Manabu Fujimoto, Masatoshi Jinnin, Yoshiya Tanaka, Takashi Kanda, Robert G Cooper, Hector Chinoy, Simon Rothwell, Janine A Lamb, Jiří Vencovský, Heřman Mann, Koichiro Ohmura, Keiko Myouzen, Kazuyoshi Ishigaki, Ran Nakashima, Yuji Hosono, Hiroto Tsuboi, Hidenaga Kawasumi, Yukiko Iwasaki, Hiroshi Kajiyama, Tetsuya Horita, Mariko Ogawa-Momohara, Akito Takamura, Shinichiro Tsunoda, Jun Shimizu, Keishi Fujio, Hirofumi Amano, Akio Mimori, Atsushi Kawakami, Hisanori Umehara, Tsutomu Takeuchi, Hajime Sano, Yoshinao Muro, Tatsuya Atsumi, Toshihide Mimura, Yasushi Kawaguchi, Tsuneyo Mimori, Atsushi Takahashi, Michiaki Kubo, Hitoshi Kohsaka, Takayuki Sumida, Kazuhiko Yamamoto

Annals of the rheumatic diseases, 77(4), 602-611, Apr, 2018, doi: 10.1136/annrheumdis-2017-212149

Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes

Rainer Malik, Ganesh Chauhan, Matthew Traylor, Muralidharan Sargurupremraj, Yukinori Okada, Aniket Mishra, Loes Rutten-Jacobs, Anne-Katrin Giese, Sander W. Van Der Laan, Solveig Gretarsdottir, Christopher D. Anderson, Michael Chong, Hieab H. H. Adams, Tetsuro Ago, Peter Almgren, Philippe Amouyel, Hakan Ay, Traci M. Bartz, Oscar R. Benavente, Steve Bevan, Giorgio B. Boncoraglio, Robert D. Brown, Adam S. Butterworth, Caty Carrera, Cara L. Carty, Daniel I. Chasman, Wei-Min Chen, John W. Cole, Adolfo Correa, Ioana Cotlarciuc, Carlos Cruchaga, John Danesh, Paul I. W. De Bakker, Anita L. Destefano, Marcel Den Hoed, Qing Duan, Stefan T. Engelter, Guido J. Falcone, Rebecca F. Gottesman, Raji P. Grewal, Vilmundur Gudnason, Stefan Gustafsson, Jeffrey Haessler, Tamara B. Harris, Ahamad Hassan, Aki S. Havulinna, Susan R. Heckbert, Elizabeth G. Holliday, George Howard, Fang-Chi Hsu, Hyacinth I. Hyacinth, M. Arfan Ikram, Erik Ingelsson, Marguerite R. Irvin, Xueqiu Jian, Jordi Jiménez-Conde, Julie A. Johnson, J. Wouter Jukema, Masahiro Kanai, Keith L. Keene, Brett M. Kissela, Dawn O. Kleindorfer, Charles Kooperberg, Michiaki Kubo, Leslie A. Lange, Carl D. Langefeld, Claudia Langenberg, Lenore J. Launer, Jin-Moo Lee, Robin Lemmens, Didier Leys, Cathryn M. Lewis, Wei-Yu Lin, Arne G. Lindgren, Erik Lorentzen, Patrik K. Magnusson, Jane Maguire, Ani Manichaikul, Patrick F. McArdle, James F. Meschia, Braxton D. Mitchell, Thomas H. Mosley, Michael A. Nalls, Toshiharu Ninomiya, Martin J. O'Donnell, Bruce M. Psaty, Sara L. Pulit, Kristiina Rannikmäe, Alexander P. Reiner, Kathryn M. Rexrode, Kenneth Rice, Stephen S. Rich, Paul M. Ridker, Natalia S. Rost, Peter M. Rothwell, Jerome I. Rotter, Tatjana Rundek, Ralph L. Sacco, Saori Sakaue, Michele M. Sale, Veikko Salomaa, Bishwa R. Sapkota, Reinhold Schmidt, Carsten O. Schmidt, Ulf Schminke, Pankaj Sharma, Agnieszka Slowik, Cathie L. M. Sudlow, Christian Tanislav, Turgut Tatlisumak, Kent D. Taylor, Vincent N. S. Thijs, Gudmar Thorleifsson, Unnur Thorsteinsdottir, Steffen Tiedt, Stella Trompet, Christophe Tzourio, Cornelia M. Van Duijn, Matthew Walters, Nicholas J. Wareham, Sylvia Wassertheil-Smoller, James G. Wilson, Kerri L. Wiggins, Qiong Yang, Salim Yusuf, Joshua C. Bis, Tomi Pastinen, Arno Ruusalepp, Eric E. Schadt, Simon Koplev, Johan L. M. Björkegren, Veronica Codoni, Mete Civelek, Nicholas L. Smith, David A. Trégouët, Ingrid E. Christophersen, Carolina Roselli, Steven A. Lubitz, Patrick T. Ellinor, E. Shyong Tai, Jaspal S. Kooner, Norihiro Kato, Jiang He, Pim Van Der Harst, Paul Elliott, John C. Chambers, Fumihiko Takeuchi, Andrew D. Johnson, Dharambir K. Sanghera, Olle Melander, Christina Jern, Daniel Strbian, Israel Fernandez-Cadenas, W. T. Longstreth, Arndt Rolfs, Jun Hata, Daniel Woo, Jonathan Rosand, Guillaume Pare, Jemma C. Hopewell, Danish Saleheen, Kari Stefansson, Bradford B. Worrall, Steven J. Kittner, Sudha Seshadri, Myriam Fornage, Hugh S. Markus, Joanna M. M. Howson, Yoichiro Kamatani, Stephanie Debette, Martin Dichgans, Najaf Amin, Hugo S. Aparicio, Donna K. Arnett, John Attia, Alexa S. Beiser, Claudine Berr, Julie E. Buring, Mariana Bustamante, Valeria Caso, Yu-Ching Cheng, Seung Hoan Choi, Ayesha Chowhan, Natalia Cullell, Jean-François Dartigues, Hossein Delavaran, Pilar Delgado, Marcus Dörr, Gunnar Engström, Ian Ford, Wander S. Gurpreet, Anders Hamsten, Laura Heitsch, Atsushi Hozawa, Laura Ibanez, Andreea Ilinca, Martin Ingelsson, Motoki Iwasaki, Rebecca D. Jackson, Katarina Jood, Pekka Jousilahti, Sara Kaffashian, Lalit Kalra, Masahiro Kamouchi, Takanari Kitazono, Olafur Kjartansson, Manja Kloss, Peter J. Koudstaal, Jerzy Krupinski, Daniel L. Labovitz, Cathy C. Laurie, Christopher R. Levi, Linxin Li, Lars Lind, Cecilia M. Lindgren, Vasileios Lioutas, Yong Mei Liu, Oscar L. Lopez, Hirata Makoto, Nicolas Martinez-Majander, Koichi Matsuda, Naoko Minegishi, Joan Montaner, Andrew P. Morris, Elena Muiño, Martina Müller-Nurasyid, Bo Norrving, Soichi Ogishima, Eugenio A. Parati, Leema Reddy Peddareddygari, Nancy L. Pedersen, Joanna Pera, Markus Perola, Alessandro Pezzini, Silvana Pileggi, Raquel Rabionet, Iolanda Riba-Llena, Marta Ribasés, Jose R. Romero, Jaume Roquer, Anthony G. Rudd, Antti-Pekka Sarin, Ralhan Sarju, Chloe Sarnowski, Makoto Sasaki, Claudia L. Satizabal, Mamoru Satoh, Naveed Sattar, Norie Sawada, Gerli Sibolt, Ásgeir Sigurdsson, Albert Smith, Kenji Sobue, Carolina Soriano-Tárraga, Tara Stanne, O. Colin Stine, David J. Stott, Konstantin Strauch, Takako Takai, Hideo Tanaka, Kozo Tanno, Alexander Teumer, Liisa Tomppo, Nuria P. Torres-Aguila, Emmanuel Touze, Shoichiro Tsugane, Andre G. Uitterlinden, Einar M. Valdimarsson, Sven J. Van Der Lee, Henry Völzke, Kenji Wakai, David Weir, Stephen R. Williams, Charles D. A. Wolfe, Quenna Wong, Huichun Xu, Taiki Yamaji, AFGen Consortium

Nature Genetics, 50(4), 524-537, Apr 1, 2018, doi: 10.1038/s41588-018-0058-3

A genome-wide association study identifies two novel susceptibility loci and trans population polygenicity associated with bipolar disorder

M. Ikeda, A. Takahashi, Y. Kamatani, Y. Okahisa, H. Kunugi, N. Mori, T. Sasaki, T. Ohmori, Y. Okamoto, H. Kawasaki, S. Shimodera, T. Kato, H. Yoneda, R. Yoshimura, M. Iyo, K. Matsuda, M. Akiyama, K. Ashikawa, K. Kashiwase, K. Tokunaga, K. Kondo, T. Saito, A. Shimasaki, K. Kawase, T. Kitajima, K. Matsuo, M. Itokawa, T. Someya, T. Inada, R. Hashimoto, T. Inoue, K. Akiyama, H. Tanii, H. Arai, S. Kanba, N. Ozaki, I. Kusumi, T. Yoshikawa, M. Kubo, N. Iwata, Advanced Collaborative Study of Mood Disorder (COSMO) team

Molecular Psychiatry, 23(3), 639-647, Mar 1, 2018, doi: 10.1038/mp.2016.259

Genetic analysis of quantitative traits in the Japanese population links cell types to complex human diseases

Masahiro Kanai, Masato Akiyama, Atsushi Takahashi, Nana Matoba, Yukihide Momozawa, Masashi Ikeda, Nakao Iwata, Shiro Ikegawa, Makoto Hirata, Koichi Matsuda, Michiaki Kubo, Yukinori Okada, Yoichiro Kamatani

Nature Genetics, 50(3), 390-400, Mar 1, 2018, doi: 10.1038/s41588-018-0047-6

A Large-Scale Multi-ancestry Genome-wide Study Accounting for Smoking Behavior Identifies Multiple Significant Loci for Blood Pressure

Yun J. Sung, The CHARGE Neurology Working Group, Thomas W. Winkler, Lisa de las Fuentes, Amy R. Bentley, Michael R. Brown, Aldi T. Kraja, Karen Schwander, Ioanna Ntalla, Xiuqing Guo, Nora Franceschini, Yingchang Lu, Ching-Yu Cheng, Xueling Sim, Dina Vojinovic, Jonathan Marten, Solomon K. Musani, Changwei Li, Mary F. Feitosa, Tuomas O. Kilpeläinen, Melissa A. Richard, Raymond Noordam, Stella Aslibekyan, Hugues Aschard, Traci M. Bartz, Rajkumar Dorajoo, Yongmei Liu, Alisa K. Manning, Tuomo Rankinen, Albert Vernon Smith, Salman M. Tajuddin, Bamidele O. Tayo, Helen R. Warren, Wei Zhao, Yanhua Zhou, Nana Matoba, Tamar Sofer, Maris Alver, Marzyeh Amini, Mathilde Boissel, Jin Fang Chai, Xu Chen, Jasmin Divers, Ilaria Gandin, Chuan Gao, Franco Giulianini, Anuj Goel, Sarah E. Harris, Fernando Pires Hartwig, Andrea R.V.R. Horimoto, Fang-Chi Hsu, Anne U. Jackson, Mika Kähönen, Anuradhani Kasturiratne, Brigitte Kühnel, Karin Leander, Wen-Jane Lee, Keng-Hung Lin, Jian ’an Luan, Colin A. McKenzie, He Meian, Christopher P. Nelson, Rainer Rauramaa, Nicole Schupf, Robert A. Scott, Wayne H.H. Sheu, Alena Stančáková, Fumihiko Takeuchi, Peter J. van der Most, Tibor V. Varga, Heming Wang, Yajuan Wang, Erin B. Ware, Stefan Weiss, Wanqing Wen, Lisa R. Yanek, Weihua Zhang, Jing Hua Zhao, Saima Afaq, Tamuno Alfred, Najaf Amin, Dan Arking, Tin Aung, R. Graham Barr, Lawrence F. Bielak, Eric Boerwinkle, Erwin P. Bottinger, Peter S. Braund, Jennifer A. Brody, Ulrich Broeckel, Claudia P. Cabrera, Brian Cade, Yu Caizheng, Archie Campbell, Mickaël Canouil, Aravinda Chakravarti, Ganesh Chauhan, Kaare Christensen, Massimiliano Cocca, Francis S. Collins, John M. Connell, Renée de Mutsert, H. Janaka de Silva, Stephanie Debette, Marcus Dörr, Qing Duan, Charles B. Eaton, Georg Ehret, Evangelos Evangelou, Jessica D. Faul, Virginia A. Fisher, Nita G. Forouhi, Oscar H. Franco, Yechiel Friedlander, He Gao, Bruna Gigante, Misa Graff, C. Charles Gu, Dongfeng Gu, Preeti Gupta, Saskia P. Hagenaars, Tamara B. Harris, Jiang He, Sami Heikkinen, Chew-Kiat Heng, Makoto Hirata, Albert Hofman, Barbara V. Howard, Steven Hunt, Marguerite R. Irvin, Yucheng Jia, Roby Joehanes, Anne E. Justice, Tomohiro Katsuya, Joel Kaufman, Nicola D. Kerrison, Chiea Chuen Khor, Woon-Puay Koh, Heikki A. Koistinen, Pirjo Komulainen, Charles Kooperberg, Jose E. Krieger, Michiaki Kubo, Johanna Kuusisto, Carl D. Langefeld, Claudia Langenberg, Lenore J. Launer, Benjamin Lehne, Cora E. Lewis, Yize Li, Sing Hui Lim, Shiow Lin, Ching-Ti Liu, Jianjun Liu, Jingmin Liu, Kiang Liu, Yeheng Liu, Marie Loh, Kurt K. Lohman, Jirong Long, Tin Louie, Reedik Mägi, Anubha Mahajan, Thomas Meitinger, Andres Metspalu, Lili Milani, Yukihide Momozawa, Andrew P. Morris, Thomas H. Mosley, Peter Munson, Alison D. Murray, Mike A. Nalls, Ubaydah Nasri, Jill M. Norris, Kari North, Adesola Ogunniyi, Sandosh Padmanabhan, Walter R. Palmas, Nicholette D. Palmer, James S. Pankow, Nancy L. Pedersen, Annette Peters, Patricia A. Peyser, Ozren Polasek, Olli T. Raitakari, Frida Renström, Treva K. Rice, Paul M. Ridker, Antonietta Robino, Jennifer G. Robinson, Lynda M. Rose, Igor Rudan, Charumathi Sabanayagam, Babatunde L. Salako, Kevin Sandow, Carsten O. Schmidt, Pamela J. Schreiner, William R. Scott, Sudha Seshadri, Peter Sever, Colleen M. Sitlani, Jennifer A. Smith, Harold Snieder, John M. Starr, Konstantin Strauch, Hua Tang, Kent D. Taylor, Yik Ying Teo, Yih Chung Tham, André G. Uitterlinden, Melanie Waldenberger, Lihua Wang, Ya X. Wang, Wen Bin Wei, Christine Williams, Gregory Wilson, Mary K. Wojczynski, Jie Yao, Jian-Min Yuan, Alan B. Zonderman, Diane M. Becker, Michael Boehnke, Donald W. Bowden, John C. Chambers, Yii-Der Ida Chen, Ulf de Faire, Ian J. Deary, Tõnu Esko, Martin Farrall, Terrence Forrester, Paul W. Franks, Barry I. Freedman, Philippe Froguel, Paolo Gasparini, Christian Gieger, Bernardo Lessa Horta, Yi-Jen Hung, Jost B. Jonas, Norihiro Kato, Jaspal S. Kooner, Markku Laakso, Terho Lehtimäki, Kae-Woei Liang, Patrik K.E. Magnusson, Anne B. Newman, Albertine J. Oldehinkel, Alexandre C. Pereira, Susan Redline, Rainer Rettig, Nilesh J. Samani, James Scott, Xiao-Ou Shu, Pim van der Harst, Lynne E. Wagenknecht, Nicholas J. Wareham, Hugh Watkins, David R. Weir, Ananda R. Wickremasinghe, Tangchun Wu, Wei Zheng, Yoichiro Kamatani, Cathy C. Laurie, Claude Bouchard, Richard S. Cooper, Michele K. Evans, Vilmundur Gudnason, Sharon L.R. Kardia, Stephen B. Kritchevsky, Daniel Levy, Jeff R. O'Connell, Bruce M. Psaty, Rob M. van Dam, Mario Sims, Donna K. Arnett, Dennis O. Mook-Kanamori, Tanika N. Kelly, Ervin R. Fox, Caroline Hayward, Myriam Fornage, Charles N. Rotimi, Michael A. Province, Cornelia M. van Duijn, E. Shyong Tai, Tien Yin Wong, Ruth J.F. Loos, Alex P. Reiner, Jerome I. Rotter, Xiaofeng Zhu, Laura J. Bierut, W. James Gauderman, Mark J. Caulfield, Paul Elliott, Kenneth Rice, Patricia B. Munroe, Alanna C. Morrison, L. Adrienne Cupples, Dabeeru C. Rao, Daniel I. Chasman

American Journal of Human Genetics, 102(3), 375-400, Mar 1, 2018, doi: 10.1016/j.ajhg.2018.01.015

Citrullination of RGG Motifs in FET Proteins by PAD4 Regulates Protein Aggregation and ALS Susceptibility.

Chizu Tanikawa, Koji Ueda, Akari Suzuki, Aritoshi Iida, Ryoichi Nakamura, Naoki Atsuta, Genki Tohnai, Gen Sobue, Naomi Saichi, Yukihide Momozawa, Yoichiro Kamatani, Michiaki Kubo, Kazuhiko Yamamoto, Yusuke Nakamura, Koichi Matsuda

Cell reports, 22(6), 1473-1483, Feb 6, 2018, doi: 10.1016/j.celrep.2018.01.031

A GWAS identifies gastric cancer susceptibility loci at 12q24.11-12 and 20q11.21.

Tanikawa C, Kamatani Y, Toyoshima O, Sakamoto H, Ito H, Takahashi A, Momozawa Y, Hirata M, Fuse N, Takai-Igarashi T, Shimizu A, Sasaki M, Yamaji T, Sawada N, Iwasaki M, Tsugane S, Naito M, Hishida A, Wakai K, Furusyo N, Murakami Y, Nakamura Y, Imoto I, Inazawa J, Oze I, Sato N, Tanioka F, Sugimura H, Hirose H, Yoshida T, Matsuo K, Michiaki K, Matsuda K

Cancer Sci., 2018

Novel genetic associations for blood pressure identified via gene-alcohol interaction in up to 570K individuals across multiple ancestries.

Feitosa MF, Kraja AT, Chasman DI, Sung YJ, Winkler TW, Ntalla I, Guo X, Franceschini N, Cheng CY, Sim X, Vojinovic D, Marten J, Musani SK, Li C, Bentley AR, Brown MR, Schwander K, Richard MA, Noordam R, Aschard H, Bartz TM, Bielak LF, Dorajoo R, Fisher V, Hartwig FP, Horimoto ARVR, Lohman KK, Manning AK, Rankinen T, Smith AV, Tajuddin SM, Wojczynski MK, Alver M, Boissel M, Cai Q, Campbell A, Chai JF, Chen X, Divers J, Gao C, Goel A, Hagemeijer Y, Harris SE, He M, Hsu FC, Jackson AU, Kähönen M, Kasturiratne A, Komulainen P, Kühnel B, Laguzzi F, Luan J, Matoba N, Nolte IM, Padmanabhan S, Riaz M, Rueedi R, Robino A, Said MA, Scott RA, Sofer T, Stančáková A, Takeuchi F, Tayo BO, van der Most PJ, Varga TV, Vitart V, Wang Y, Ware EB, Warren HR, Weiss S, Wen W, Yanek LR, Zhang W, Zhao JH, Afaq S, Amin N, Amini M, Arking DE, Aung T, Boerwinkle E, Borecki I, Broeckel U, Brown M, Brumat M, Burke GL, Canouil M, Chakravarti A, Charumathi S, Ida Chen YD, Connell JM, Correa A, de Las Fuentes L, de Mutsert R, de Silva HJ, Deng X, Ding J, Duan Q, Eaton CB, Ehret G, Eppinga RN, Evangelou E, Faul JD, Felix SB, Forouhi NG, Forrester T, Franco OH, Friedlander Y, Gandin I, Gao H, Ghanbari M, Gigante B, Gu CC, Gu D, Hagenaars SP, Hallmans G, Harris TB, He J, Heikkinen S, Heng CK, Hirata M, Howard BV, Ikram MA, InterAct Consortium, John U, Katsuya T, Khor CC, Kilpeläinen TO, Koh WP, Krieger JE, Kritchevsky SB, Kubo M, Kuusisto J, Lakka TA, Langefeld CD, Langenberg C, Launer LJ, Lehne B, Lewis CE, Li Y, Lin S, Liu J, Liu J, Loh M, Louie T, Mägi R, McKenzie CA, Meitinger T, Metspalu A, Milaneschi Y, Milani L, Mohlke KL, Momozawa Y, Nalls MA, Nelson CP, Sotoodehnia N, Norris JM, O'Connell JR, Palmer ND, Perls T, Pedersen NL, Peters A, Peyser PA, Poulter N, Raffel LJ, Raitakari OT, Roll K, Rose LM, Rosendaal FR, Rotter JI, Schmidt CO, Schreiner PJ, Schupf N, Scott WR, Sever PS, Shi Y, Sidney S, Sims M, Sitlani CM, Smith JA, Snieder H, Starr JM, Strauch K, Stringham HM, Tan NYQ, Tang H, Taylor KD, Teo YY, Tham YC, Turner ST, Uitterlinden AG, Vollenweider P, Waldenberger M, Wang L, Wang YX, Wei WB, Williams C, Yao J, Yu C, Yuan JM, Zhao W, Zonderman AB, Becker DM, Boehnke M, Bowden DW, Chambers JC, Deary IJ, Esko T, Farrall M, Franks PW, Freedman BI, Froguel P, Gasparini P, Gieger C, Jonas JB, Kamatani Y, Kato N, Kooner JS, Kutalik Z, Laakso M, Laurie CC, Leander K, Lehtimäki T, Study LC, Magnusson PKE, Oldehinkel AJ, Penninx BWJH, Polasek O, Porteous DJ, Rauramaa R, Samani NJ, Scott J, Shu XO, van der Harst P, Wagenknecht LE, Wareham NJ, Watkins H, Weir DR, Wickremasinghe AR, Wu T, Zheng W, Bouchard C, Christensen K, Evans MK, Gudnason V, Horta BL, Kardia SLR, Liu Y, Pereira AC, Psaty BM, Ridker PM, van Dam RM, Gauderman WJ, Zhu X, Mook-Kanamori DO, Fornage M, Rotimi CN, Cupples LA, Kelly TN, Fox ER, Hayward C, van Duijn CM, Tai ES, Wong TY, Kooperberg C, Palmas W, Rice K, Morrison AC, Elliott P, Caulfield MJ, Munroe PB, Rao DC, Province MA, Levy D

PloS one, 13(6), e0198166, 2018, doi: 10.1371/journal.pone.0198166

Genetics of the thrombomodulin-endothelial cell protein C receptor system and the risk of early-onset ischemic stroke.

Cole JW, Xu H, Ryan K, Jaworek T, Dueker N, McArdle P, Gaynor B, Cheng YC, O'Connell J, Bevan S, Malik R, Ahmed NU, Amouyel P, Anjum S, Bis JC, Crosslin D, Danesh J, Engelter ST, Fornage M, Frossard P, Gieger C, Giese AK, Grond-Ginsbach C, Ho WK, Holliday E, Hopewell J, Hussain M, Iqbal W, Jabeen S, Jannes J, Kamal A, Kamatani Y, Kanse S, Kloss M, Lathrop M, Leys D, Lindgren A, Longstreth WT Jr, Mahmood K, Meisinger C, Metso TM, Mosley T Jr, Müller-Nurasyid M, Norrving B, Parati E, Peters A, Pezzini A, Quereshi I, Rasheed A, Rauf A, Salam T, Shen J, Słowik A, Stanne T, Strauch K, Tatlisumak T, Thijs VN, Tiedt S, Traylor M, Waldenberger M, Walters M, Zhao W, Boncoraglio G, Debette S, Jern C, Levi C, Markus H, Meschia J, Rolfs A, Rothwell P, Saleheen D, Seshadri S, Sharma P, Sudlow C, Worrall B, METASTROKE Consortium of, the ISGC, WTCCC, Consortium, Stine OC, Kittner SJ, Mitchell BD

PloS one, 13(11), e0206554, 2018, doi: 10.1371/journal.pone.0206554

Genome-wide association study (GWAS) of ovarian cancer in Japanese predicted regulatory variants in 22q13.1.

Yodsurang V, Tang Y, Takahashi Y, Tanikawa C, Kamatani Y, Takahashi A, Momozawa Y, Fuse N, Sugawara J, Shimizu A, Fukushima A, Hishida A, Furusyo N, Naito M, Wakai K, Yamaji T, Sawada N, Iwasaki M, Tsugane S, Hirata M, Murakami Y, Kubo M, Matsuda K

PloS one, 13(12), e0209096, 2018, doi: 10.1371/journal.pone.0209096

A variant within the FTO confers susceptibility to diabetic nephropathy in Japanese patients with type 2 diabetes.

Makiko Taira, Minako Imamura, Atsushi Takahashi, Yoichiro Kamatani, Toshimasa Yamauchi, Shin-Ichi Araki, Nobue Tanaka, Natalie R van Zuydam, Emma Ahlqvist, Masao Toyoda, Tomoya Umezono, Koichi Kawai, Masahito Imanishi, Hirotaka Watada, Daisuke Suzuki, Hiroshi Maegawa, Tetsuya Babazono, Kohei Kaku, Ryuzo Kawamori, Leif C Groop, Mark I McCarthy, Takashi Kadowaki, Shiro Maeda

PloS one, 13(12), e0208654, 2018, doi: 10.1371/journal.pone.0208654

201737 papers

Genetic landscape of interactive effects of HLA-DRB1 alleles on susceptibility to ACPA(+) rheumatoid arthritis and ACPA levels in Japanese population

Chikashi Terao, Yukinori Okada, Katsunori Ikari, Yuta Kochi, Akari Suzuki, Koichiro Ohmura, Keitaro Matsuo, Atsuo Taniguchi, Michiaki Kubo, Soumya Raychaudhuri, Kazuhiko Yamamoto, Hisashi Yamanaka, Yoichiro Kamatani, Tsuneyo Mimori, Fumihiko Matsuda

JOURNAL OF MEDICAL GENETICS, 54(12), 853-858, Dec, 2017, doi: 10.1136/jmedgenet-2017-104779

Common variants at 2q11.2, 8q21.3, and 11q13.2 are associated with major mood disorders

Xiao Xiao, Lu Wang, Chuang Wang, Ti-Fei Yuan, Dongsheng Zhou, Fanfan Zheng, Lingyi Li, Maria Grigoroiu-Serbanescu, Masashi Ikeda, Nakao Iwata, Atsushi Takahashi, Yoichiro Kamatani, Michiaki Kubo, Martin Preisig, Zoltan Kutalik, Enrique Castelao, Giorgio Pistis, Najaf Amin, Cornelia M. van Duijn, Andreas J. Forstner, Jana Strohmaier, Julian Hecker, Thomas G. Schulze, Bertram Mueller-Myhsok, Andreas Reif, Philip B. Mitchell, Nicholas G. Martin, Peter R. Schofield, Sven Cichon, Markus M. Noethen, Hong Chang, Xiong-Jian Luo, Yiru Fang, Yong-Gang Yao, Chen Zhang, Marcella Rietschel, Ming Li

TRANSLATIONAL PSYCHIATRY, 7(12), 1273, Dec, 2017, doi: 10.1038/s41398-017-0019-0

Genome-wide Association Study of Idiopathic Osteonecrosis of the Femoral Head

Yuma Sakamoto, Takuaki Yamamoto, Nobuhiko Sugano, Daisuke Takahashi, Toshiyuki Watanabe, Takashi Atsumi, Junichi Nakamura, Yukiharu Hasegawa, Koichi Akashi, Ichiei Narita, Takeshi Miyamoto, Tsutomu Takeuchi, Katsunori Ikari, Koichi Amano, Atsuhiro Fujie, Toshikazu Kubo, Yoshifumi Tada, Ayumi Kaneuji, Hiroaki Nakamura, Tomoya Miyamura, Tamon Kabata, Ken Yamaji, Takahiro Okawa, Akihiro Sudo, Kenji Ohzono, Yoshiya Tanaka, Yuji Yasunaga, Shuichi Matsuda, Yuuki Imai, Masato Akiyama, Michiaki Kubo, Yoichiro Kamatani, Yukihide Iwamoto, Shiro Ikegawa

SCIENTIFIC REPORTS, 7(1), 15035, Nov, 2017, doi: 10.1038/s41598-017-14778-y

Genome-wide association study identifies 112 new loci for body mass index in the Japanese population

Masato Akiyama, Yukinori Okada, Masahiro Kanai, Atsushi Takahashi, Yukihide Momozawa, Masashi Ikeda, Nakao Iwata, Shiro Ikegawa, Makoto Hirata, Koichi Matsuda, Motoki Iwasaki, Taiki Yamaji, Norie Sawada, Tsuyoshi Hachiya, Kozo Tanno, Atsushi Shimizu, Atsushi Hozawa, Naoko Minegishi, Shoichiro Tsugane, Masayuki Yamamoto, Michiaki Kubo, Yoichiro Kamatani

NATURE GENETICS, 49(10), 1458-+, Oct, 2017, doi: 10.1038/ng.3951

A functional variant in MIR4300HG, the host gene of microRNA MIR4300 is associated with progression of adolescent idiopathic scoliosis

Yoji Ogura, Ikuyo Kou, Yohei Takahashi, Kazuki Takeda, Shohei Minami, Noriaki Kawakami, Koki Uno, Manabu Ito, Ikuho Yonezawa, Takashi Kaito, Haruhisa Yanagida, Kei Watanabe, Hiroshi Taneichi, Katsumi Harimaya, Yuki Taniguchi, Toshiaki Kotani, Taichi Tsuji, Teppei Suzuki, Hideki Sudo, Nobuyuki Fujita, Mitsuru Yagi, Kazuhiro Chiba, Michiaki Kubo, Yoichiro Kamatani, Masaya Nakamura, Morio Matsumoto, Kota Watanabe, Shiro Ikegawa

HUMAN MOLECULAR GENETICS, 26(20), 4086-4092, Oct, 2017, doi: 10.1093/hmg/ddx291

Large-scale analyses of common and rare variants identify 12 new loci associated with atrial fibrillation (vol 49, pg 946, 2017)

Ingrid E. Christophersen, Michiel Rienstra, Carolina Roselli, Xiaoyan Yin, Bastiaan Geelhoed, John Barnard, Honghuang Lin, Dan E. Arking, Albert V. Smith, Christine M. Albert, Mark Chaffin, Nathan R. Tucker, Molong Li, Derek Klarin, Nathan A. Bihlmeyer, Siew-Kee Low, Peter E. Weeke, Martina Mueller-Nurasyid, J. Gustav Smith, Jennifer A. Brody, Maartje N. Niemeijer, Marcus Dorr, Stella Trompet, Jennifer Huffman, Stefan Gustafsson, Claudia Schurmann, Marcus E. Kleber, Leo-Pekka Lyytikainen, Ilkka Seppala, Rainer Malik, Andrea R. V. R. Horimoto, Marco Perez, Juha Sinisalo, Stefanie Aeschbacher, Sebastien Theriault, Jie Yao, Farid Radmanesh, Stefan Weiss, Alexander Teumer, Seung Hoan Choi, Lu-Chen Weng, Sebastian Clauss, Rajat Deo, Daniel J. Rader, Svati H. Shah, Albert Sun, Jemma C. Hopewell, Stephanie Debette, Ganesh Chauhan, Qiong Yang, Bradford B. Worrall, Guillaume Pare, Yoichiro Kamatani, Yanick P. Hagemeijer, Niek Verweij, Joylene E. Siland, Michiaki Kubo, Jonathan D. Smith, David R. Van Wagoner, Joshua C. Bis, Siegfried Perz, Bruce M. Psaty, Paul M. Ridker, Jared W. Magnani, Tamara B. Harris, Lenore J. Launer, M. Benjamin Shoemaker, Sandosh Padmanabhan, Jeffrey Haessler, Traci M. Bartz, Melanie Waldenberger, Peter Lichtner, Marina Arendt, Jose E. Krieger, Mika Kahonen, Lorenz Risch, Alfredo J. Mansur, Annette Peters, Blair H. Smith, Lars Lind, Stuart A. Scott, Yingchang Lu, Erwin B. Bottinger, Jussi Hernesniemi, Cecilia M. Lindgren, Jorge A. Wong, Jie Huang, Markku Eskola, Andrew P. Morris, Ian Ford, Alex P. Reiner, Graciela Delgado, Lin Y. Chen, Yii-Der Ida Chen, Roopinder K. Sandhu, Man Li, Eric Boerwinkle, Lewin Eisele, Lars Lannfelt, Natalia Rost, Christopher D. Anderson, Kent D. Taylor, Archie Campbell, Patrik K. Magnusson, David Porteous, Lynne J. Hocking, Efthymia Vlachopoulou, Nancy L. Pedersen, Kjell Nikus, Marju Orho-Melander, Anders Hamsten, Jan Heeringa, Joshua C. Denny, Jennifer Kriebel, Dawood Darbar, Christopher Newton-Cheh, Christian Shaffer, Peter W. Macfarlane, Stefanie Heilmann-Heimbach, Peter Almgren, Paul L. Huang, Nona Sotoodehnia, Elsayed Z. Soliman, Andre G. Uitterlinden, Albert Hofman, Oscar H. Franco, Uwe Volker, Karl-Heinz Jockel, Moritz F. Sinner, Henry J. Lin, Xiuqing Guo, Martin Dichgans, Erik Ingelsson, Charles Kooperberg, Olle Melander, Ruth J. F. Loos, Jari Laurikka, David Conen, Jonathan Rosand, Pim van der Harst, Marja-Liisa Lokki, Sekar Kathiresan, Alexandre Pereira, J. Wouter Jukema, Caroline Hayward, Jerome I. Rotter, Winfried Mrz, Terho Lehtimaki, Bruno H. Stricker, Mina K. Chung, Stephan B. Felix, Vilmundur Gudnason, Alvaro Alonso, Dan M. Roden, Stefan Kaab, Daniel I. Chasman, Susan R. Heckbert, Emelia J. Benjamin, Toshihiro Tanaka, Kathryn L. Lunetta, Steven A. Lubitz, Patrick T. Ellinor

NATURE GENETICS, 49(8), 1286, Aug, 2017, doi: 10.1038/ng0817-1286c

Erratum to "Characteristics and prognosis of Japanese colorectal cancer patients: The BioBank Japan Project" [J Epidemiol 27(3S) (2017) S36-S42].

Tamakoshi A, Nakamura K, Ukawa S, Okada E, Hirata M, Nagai A, Matsuda K, Kamatani Y, Muto K, Kiyohara Y, Yamagata Z, Ninomiya T, Kubo M, Nakamura Y, BioBank Japan, Coope, a, i, Hospital Grou

Journal of epidemiology, 27(8), 398-399, Aug, 2017, doi: 10.1016/j.je.2017.04.001

Polygenic burdens on cell-specific pathways underlie the risk of rheumatoid arthritis

Kazuyoshi Ishigaki, Yuta Kochi, Akari Suzuki, Yumi Tsuchida, Haruka Tsuchiya, Shuji Sumitomo, Kensuke Yamaguchi, Yasuo Nagafuchi, Shinichiro Nakachi, Rika Kato, Keiichi Sakurai, Hirofumi Shoda, Katsunori Ikari, Atsuo Taniguchi, Hisashi Yamanaka, Fuyuki Miya, Tatsuhiko Tsunoda, Yukinori Okada, Yukihide Momozawa, Yoichiro Kamatani, Ryo Yamada, Michiaki Kubo, Keishi Fujio, Kazuhiko Yamamoto

NATURE GENETICS, 49(7), 1120-+, Jul, 2017, doi: 10.1038/ng.3885

Large-scale analyses of common and rare variants identify 12 new loci associated with atrial fibrillation

Ingrid E. Christophersen, Michiel Rienstra, Carolina Roselli, Xiaoyan Yin, Bastiaan Geelhoed, John Barnard, Honghuang Lin, Dan E. Arking, Albert V. Smith, Christine M. Albert, Mark Chaffin, Nathan R. Tucker, Molong Li, Derek Klarin, Nathan A. Bihlmeyer, Siew-Kee Low, Peter E. Weeke, Martina Mueller-Nurasyid, J. Gustav Smith, Jennifer A. Brody, Maartje N. Niemeijer, Marcus Doerr, Stella Trompet, Jennifer Huffman, Stefan Gustafsson, Claudia Schurmann, Marcus E. Kleber, Leo-Pekka Lyytikainen, Ilkka Seppala, Rainer Malik, Andrea R. V. R. Horimoto, Marco Perez, Juha Sinisalo, Stefanie Aeschbacher, Sebastien Theriault, Jie Yao, Farid Radmanesh, Stefan Weiss, Alexander Teumer, Seung Hoan Choi, Lu-Chen Weng, Sebastian Clauss, Rajat Deo, Daniel J. Rader, Svati H. Shah, Albert Sun, Jemma C. Hopewell, Stephanie Debette, Ganesh Chauhan, Qiong Yang, Bradford B. Worrall, Guillaume Pare, Yoichiro Kamatani, Yanick P. Hagemeijer, Niek Verweij, Joylene E. Siland, Michiaki Kubo, Jonathan D. Smith, David R. Van Wagoner, Joshua C. Bis, Siegfried Perz, Bruce M. Psaty, Paul M. Ridker, Jared W. Magnani, Tamara B. Harris, Lenore J. Launer, M. Benjamin Shoemaker, Sandosh Padmanabhan, Jeffrey Haessler, Traci M. Bartz, Melanie Waldenberger, Peter Lichtner, Marina Arendt, Jose E. Krieger, Mika Kahonen, Lorenz Risch, Alfredo J. Mansur, Annette Peters, Blair H. Smith, Lars Lind, Stuart A. Scott, Yingchang Lu, Erwin B. Bottinger, Jussi Hernesniemi, Cecilia M. Lindgren, Jorge A. Wong, Jie Huang, Markku Eskola, Andrew P. Morris, Ian Ford, Alex P. Reiner, Graciela Delgado, Lin Y. Chen, Yii-Der Ida Chen, Roopinder K. Sandhu, Man Li, Eric Boerwinkle, Lewin Eisele, Lars Lannfelt, Natalia Rost, Christopher D. Anderson, Kent D. Taylor, Archie Campbell, Patrik K. Magnusson, David Porteous, Lynne J. Hocking, Efthymia Vlachopoulou, Nancy L. Pedersen, Kjell Nikus, Marju Orho-Melander, Anders Hamsten, Jan Heeringa, Joshua C. Denny, Jennifer Kriebel, Dawood Darbar, Christopher Newton-Cheh, Christian Shaffer, Peter W. Macfarlane, Stefanie Heilmann-Heimbach, Peter Almgren, Paul L. Huang, Nona Sotoodehnia, Elsayed Z. Soliman, Andre G. Uitterlinden, Albert Hofman, Oscar H. Franco, Uwe Voelker, Karl-Heinz Joeckel, Moritz F. Sinner, Henry J. Lin, Xiuqing Guo, Martin Dichgans, Erik Ingelsson, Charles Kooperberg, Olle Melander, Ruth J. F. Loos, Jari Laurikka, David Conen, Jonathan Rosand, Pim van der Harst, Marja-Liisa Lokki, Sekar Kathiresan, Alexandre Pereira, J. Wouter Jukema, Caroline Hayward, Jerome I. Rotter, Winfried Maerz, Terho Lehtimaki, Bruno H. Stricker, Mina K. Chung, Stephan B. Felix, Vilmundur Gudnason, Alvaro Alonso, Dan M. Roden, Stefan Kaeaeb, Daniel I. Chasman, Susan R. Heckbert, Emelia J. Benjamin, Toshihiro Tanaka, Kathryn L. Lunetta, Steven A. Lubitz, Patrick T. Ellinor

NATURE GENETICS, 49(6), 946-+, Jun, 2017, doi: 10.1038/ng.3843

Large-scale analyses of common and rare variants identify 12 new loci associated with atrial fibrillation (vol 49, pg 946, 2017)

Ingrid E. Christophersen, Michiel Rienstra, Carolina Roselli, Xiaoyan Yin, Bastiaan Geelhoed, John Barnard, Honghuang Lin, Dan E. Arking, Albert V. Smith, Christine M. Albert, Mark Chaffin, Nathan R. Tucker, Molong Li, Derek Klarin, Nathan A. Bihlmeyer, Siew-Kee Low, Peter E. Weeke, Martina Muller-Nurasyid, J. Gustav Smith, Jennifer A. Brody, Maartje N. Niemeijer, Marcus Dorr, Stella Trompet, Jennifer Huffman, Stefan Gustafsson, Claudia Schurmann, Marcus E. Kleber, Leo-Pekka Lyytikainen, Ilkka Seppala, Rainer Malik, Andrea R. V. R. Horimoto, Marco Perez, Juha Sinisalo, Stefanie Aeschbacher, Sebastien Theriault, Jie Yao, Farid Radmanesh, Stefan Weiss, Alexander Teumer, Seung Hoan Choi, Lu-Chen Weng, Sebastian Clauss, Rajat Deo, Daniel J. Rader, Svati H. Shah, Albert Sun, Jemma C. Hopewell, Stephanie Debette, Ganesh Chauhan, Qiong Yang, Bradford B. Worrall, Guillaume Pare, Yoichiro Kamatani, Yanick P. Hagemeijer, Niek Verweij, Joylene E. Siland, Michiaki Kubo, Jonathan D. Smith, David R. Van Wagoner, Joshua C. Bis, Siegfried Perz, Bruce M. Psaty, Paul M. Ridker, Jared W. Magnani, Tamara B. Harris, Lenore J. Launer, M. Benjamin Shoemaker, Sandosh Padmanabhan, Jeffrey Haessler, Traci M. Bartz, Melanie Waldenberger, Peter Lichtner, Marina Arendt, Jose E. Krieger, Mika Kahonen, Lorenz Risch, Alfredo J. Mansur, Annette Peters, Blair H. Smith, Lars Lind, Stuart A. Scott, Yingchang Lu, Erwin B. Bottinger, Jussi Hernesniemi, Cecilia M. Lindgren, Jorge A. Wong, Jie Huang, Markku Eskola, Andrew P. Morris, Ian Ford, Alex P. Reiner, Graciela Delgado, Lin Y. Chen, Yii-Der Ida Chen, Roopinder K. Sandhu, Man Li, Eric Boerwinkle, Lewin Eisele, Lars Lannfelt, Natalia Rost, Christopher D. Anderson, Kent D. Taylor, Archie Campbell, Patrik K. Magnusson, David Porteous, Lynne J. Hocking, Efthymia Vlachopoulou, Nancy L. Pedersen, Kjell Nikus, Marju Orho-Melander, Anders Hamsten, Jan Heeringa, Joshua C. Denny, Jennifer Kriebel, Dawood Darbar, Christopher Newton-Cheh, Christian Shaffer, Peter W. Macfarlane, Stefanie Heilmann-Heimbach, Peter Almgren, Paul L. Huang, Nona Sotoodehnia, Elsayed Z. Soliman, Andre G. Uitterlinden, Albert Hofman, Oscar H. Franco, Uwe Volker, Karl-Heinz Jockel, Moritz F. Sinner, Henry J. Lin, Xiuqing Guo, Martin Dichgans, Erik Ingelsson, Charles Kooperberg, Olle Melander, Ruth J. F. Loos, Jari Laurikka, David Conen, Jonathan Rosand, Pim van der Harst, Marja-Liisa Lokki, Sekar Kathiresan, Alexandre Pereira, J. Wouter Jukema, Caroline Hayward, Jerome I. Rotter, Winfried Marz, Terho Lehtimaki, Bruno H. Stricker, Mina K. Chung, Stephan B. Felix, Vilmundur Gudnason, Alvaro Alonso, Dan M. Roden, Stefan Kaab, Daniel I. Chasman, Susan R. Heckbert, Emelia J. Benjamin, Toshihiro Tanaka, Kathryn L. Lunetta, Steven A. Lubitz, Patrick T. Ellinor

NATURE GENETICS, 49(6), 946-952, Jun, 2017, doi: 10.1038/ng.3843

Identification of six new genetic loci associated with atrial fibrillation in the Japanese population

Siew-Kee Low, Atsushi Takahashi, Yusuke Ebana, Kouichi Ozaki, Ingrid E. Christophersen-, Patrick T. Ellinor, Soichi Ogishima, Masayuki Yamamoto, Mamoru Satoh, Makoto Sasaki, Taiki Yamaji, Motoki Iwasaki, Shoichiro Tsugane, Keitaro Tanaka, Mariko Naito, Kenji Wakai, Hideo Tanaka, Tetsushi Furukawa, Michiaki Kubo, Kaoru Ito, Yoichiro Kamatani, Toshihiro Tanaka

NATURE GENETICS, 49(6), 953-+, Jun, 2017, doi: 10.1038/ng.3842

Association of variations in HLA-class II and other loci with susceptibility to EGFR-mutated lung adenocarcinoma

Kouya Shiraishi, Yukinori Okada, Atsushi Takahashi, Yoichiro Kamatani, Kyota Ashikawa, Yukihide Momozawa, Hideo Kunitoh, Shingo Matsumoto, Atsushi Takano, Kimihiro Shimizu, Akiteru Goto, Koji Tsuta, Shun-ichi Watanabe, Yuichiro Ohe, Yukio Watanabe, Yasishi Goto, Hiroshi Nokihara, Koh Furuta, Akihiko Yoshida, Koichi Goto, Tomoyuki Hishida, Masahiro Tsuboi, Katsuya Tsuchihara, Yohei Miyagi, Haruhiko Nakamura, Tomoyuki Yokose, Katsuya Tanaka, Toshiteru Nagashima, Yoichi Ohtaki, Daichi Maeda, Kazuhiro Imai, Yoshihiro Minamiya, Hiromi Sakamoto, Akira Saito, Yoko Shimada, Kuniko Sunami, Motonobu Saito, Teruhiko Yoshida, Jun Yokota, Fumihiko Matsuda, Keitaro Matsuo, Yataro Daigo, Michiaki Kubo, Takashi Kohno

CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION, 26(5), May, 2017, doi: 10.1158/1538-7755.CARISK16-B25

GWAS of clinically defined gout and subtypes identifies multiple susceptibility loci that include urate transporter genes.

Akiyoshi Nakayama, Hirofumi Nakaoka, Ken Yamamoto, Masayuki Sakiyama, Amara Shaukat, Yu Toyoda, Yukinori Okada, Yoichiro Kamatani, Takahiro Nakamura, Tappei Takada, Katsuhisa Inoue, Tomoya Yasujima, Hiroaki Yuasa, Yuko Shirahama, Hiroshi Nakashima, Seiko Shimizu, Toshihide Higashino, Yusuke Kawamura, Hiraku Ogata, Makoto Kawaguchi, Yasuyuki Ohkawa, Inaho Danjoh, Atsumi Tokumasu, Keiko Ooyama, Toshimitsu Ito, Takaaki Kondo, Kenji Wakai, Blanka Stiburkova, Karel Pavelka, Lisa K Stamp, Nicola Dalbeth, Yutaka Sakurai, Hiroshi Suzuki, Makoto Hosoyamada, Shin Fujimori, Takashi Yokoo, Tatsuo Hosoya, Ituro Inoue, Atsushi Takahashi, Michiaki Kubo, Hiroshi Ooyama, Toru Shimizu, Kimiyoshi Ichida, Nariyoshi Shinomiya, Tony R Merriman, Hirotaka Matsuo

Annals of the rheumatic diseases, 76(5), 869-877, May, 2017, doi: 10.1136/annrheumdis-2016-209632

GWAS of clinically defined gout and subtypes identifies multiple susceptibility loci that include urate transporter genes

Akiyoshi Nakayama, Hirofumi Nakaoka, Ken Yamamoto, Masayuki Sakiyama, Amara Shaukat, Yu Toyoda, Yukinori Okada, Yoichiro Kamatani, Takahiro Nakamura, Tappei Takada, Katsuhisa Inoue, Tomoya Yasujima, Hiroaki Yuasa, Yuko Shirahama, Hiroshi Nakashima, Seiko Shimizu, Toshihide Higashino, Yusuke Kawamura, Hiraku Ogata, Makoto Kawaguchi, Yasuyuki Ohkawa, Inaho Danjoh, Atsumi Tokumasu, Keiko Ooyama, Toshimitsu Ito, Takaaki Kondo, Kenji Wakai, Blanka Stiburkova, Karel Pavelka, Lisa K. Stamp, Nicola Dalbeth, Eurogout Consortium, Yutaka Sakurai, Hiroshi Suzuki, Makoto Hosoyamada, Shin Fujimori, Takashi Yokoo, Tatsuo Hosoya, Ituro Inoue, Atsushi Takahashi, Michiaki Kubo, Hiroshi Ooyama, Toru Shimizu, Kimiyoshi Ichida, Nariyoshi Shinomiya, Tony R. Merriman, Hirotaka Matsuo

ANNALS OF THE RHEUMATIC DISEASES, 76(5), 869-877, May, 2017, doi: 10.1136/annrheumdis-2016-209632

Meta-analysis identifies five novel loci associated with endometriosis highlighting key genes involved in hormone metabolism

Yadav Sapkota, Valgerdur Steinthorsdottir, Andrew P. Morris, Amelie Fassbender, Nilufer Rahmioglu, Immaculata De Vivo, Julie E. Buring, Futao Zhang, Todd L. Edwards, Sarah Jones, O. Dorien, Danielle Peterse, Kathryn M. Rexrode, Paul M. Ridker, Andrew J. Schork, Stuart MacGregor, Nicholas G. Martin, Christian M. Becker, Sosuke Adachi, Kosuke Yoshihara, Takayuki Enomoto, Atsushi Takahashi, Yoichiro Kamatani, Koichi Matsuda, Michiaki Kubo, Gudmar Thorleifsson, Reynir T. Geirsson, Unnur Thorsteinsdottir, Leanne M. Wallace, Jian Yang, Digna R. Velez Edwards, Mette Nyegaard, Siew-Kee Low, Krina T. Zondervan, Stacey A. Missmer, Thomas D'Hooghe, Grant W. Montgomery, Daniel I. Chasman, Kari Stefansson, Joyce Y. Tung, Dale R. Nyholt

NATURE COMMUNICATIONS, 8, 15539, May, 2017, doi: 10.1038/ncomms15539

日本人2型糖尿病集団における糖尿病網膜症のゲノムワイド関連解析

今村 美菜子, 平良 摩紀子, 堀越 桃子, 高橋 篤, 鎌谷 洋一郎, 久保 充明, 前田 士郎

糖尿病, 60(Suppl.1), S-281, Apr, 2017

次世代シークエンサーによる加齢黄斑変性症感受性多型の同定

秋山 雅人, 桃沢 幸秀, 鎌谷 洋一郎, 荒川 聡, 安田 美穂, 吉田 茂生, 大島 裕司, 森 隆三郎, 田中 公二, 森 圭介, 井上 聡, 寺崎 浩子, 安間 哲宏, 本田 茂, 三木 明子, 井上 麻衣子, 藤澤 公彦, 高橋 寛二, 安川 力, 柳 靖雄, 門之園 一明, 園田 康平, 石橋 達朗, 高橋 篤, 久保 充明

日本眼科学会雑誌, 121(臨増), 241, Mar, 2017

Risk prediction models for mortality in patients with cardiovascular disease: The BioBank Japan project

Jun Hata, Akiko Nagai, Makoto Hirata, Yoichiro Kamatani, Akiko Tamakoshi, Zentaro Yamagata, Kaori Muto, Koichi Matsuda, Michiaki Kubo, Yusuke Nakamura, Yutaka Kiyohara, Toshiharu Ninomiya

JOURNAL OF EPIDEMIOLOGY, 27(3), S71-S76, Mar, 2017, doi: 10.1016/j.je.2016.10.007

Serum glucose, cholesterol and blood pressure levels in Japanese type 1 and 2 diabetic patients: BioBank Japan

Hiroshi Yokomichi, Akiko Nagai, Makoto Hirata, Yutaka Kiyohara, Kaori Muto, Toshiharu Ninomiya, Koichi Matsuda, Yoichiro Kamatani, Akiko Tamakoshi, Michiaki Kubo, Yusuke Nakamura, Zentaro Yamagata

JOURNAL OF EPIDEMIOLOGY, 27(3), S92-S97, Mar, 2017, doi: 10.1016/j.je.2016.12.013

Overview of the BioBank Japan Project: Study design and profile

Akiko Nagai, Makoto Hirata, Yoichiro Kamatani, Kaori Muto, Koichi Matsuda, Yutaka Kiyohara, Toshiharu Ninomiya, Akiko Tamakoshi, Zentaro Yamagata, Taisei Mushiroda, Yoshinori Murakami, Koichiro Yuji, Yoichi Furukawa, Hitoshi Zembutsu, Toshihiro Tanaka, Yozo Ohnishi, Yusuke Nakamura, Michiaki Kubo

JOURNAL OF EPIDEMIOLOGY, 27(3), S2-S8, Mar, 2017, doi: 10.1016/j.je.2016.12.005

Cross-sectional analysis of BioBank Japan clinical data: A large cohort of 200,000 patients with 47 common diseases

Makoto Hirata, Yoichiro Kamatani, Akiko Nagai, Yutaka Kiyohara, Toshiharu Ninomiya, Akiko Tamakoshi, Zentaro Yamagata, Michiaki Kubo, Kaori Muto, Taisei Mushiroda, Yoshinori Murakami, Koichiro Yuji, Yoichi Furukawa, Hitoshi Zembutsu, Toshihiro Tanaka, Yozo Ohnishi, Yusuke Nakamura, Koichi Matsuda

JOURNAL OF EPIDEMIOLOGY, 27(3), S9-S21, Mar, 2017, doi: 10.1016/j.je.2016.12.003

Demographic and lifestyle factors and survival among patients with esophageal and gastric cancer: The Biobank Japan Project

Emiko Okada, Shigekazu Ukawa, Koshi Nakamura, Makoto Hirata, Akiko Nagai, Koichi Matsuda, Toshiharu Ninomiya, Yutaka Kiyohara, Kaori Muto, Yoichiro Kamatani, Zentaro Yamagata, Michiaki Kubo, Yusuke Nakamura, Akiko Tamakoshi

JOURNAL OF EPIDEMIOLOGY, 27(3), S29-S35, Mar, 2017, doi: 10.1016/j.je.2016.12.002

Overview of BioBank Japan follow-up data in 32 diseases

Makoto Hirata, Akiko Nagai, Yoichiro Kamatani, Toshiharu Ninomiya, Akiko Tamakoshi, Zentaro Yamagata, Michiaki Kubo, Kaori Muto, Yutaka Kiyohara, Taisei Mushiroda, Yoshinori Murakami, Koichiro Yuji, Yoichi Furukawa, Hitoshi Zembutsu, Toshihiro Tanaka, Yozo Ohnishi, Yusuke Nakamura, Koichi Matsuda

JOURNAL OF EPIDEMIOLOGY, 27(3), S22-S28, Mar, 2017, doi: 10.1016/j.je.2016.12.006

Statin use and all-cause and cancer mortality: BioBank Japan cohort

Hiroshi Yokomichi, Akiko Nagai, Makoto Hirata, Akiko Tamakoshi, Yutaka Kiyohara, Yoichiro Kamatani, Kaori Muto, Toshiharu Ninomiya, Koichi Matsuda, Michiaki Kubo, Yusuke Nakamura, Zentaro Yamagata

JOURNAL OF EPIDEMIOLOGY, 27(3), S84-S91, Mar, 2017, doi: 10.1016/j.je.2016.12.011

Cholesterol levels of Japanese dyslipidaemic patients with various comorbidities: BioBank Japan

Hiroshi Yokomichi, Hokuto Noda, Akiko Nagai, Makoto Hirata, Akiko Tamakoshi, Yoichiro Kamatani, Yutaka Kiyohara, Koichi Matsuda, Kaori Muto, Toshiharu Ninomiya, Michiaki Kubo, Yusuke Nakamura, Zentaro Yamagata

JOURNAL OF EPIDEMIOLOGY, 27(3), S77-S83, Mar, 2017, doi: 10.1016/j.je.2016.12.014

Characteristics and prognosis of Japanese male and female lung cancer patients: The BioBank Japan Project

Koshi Nakamura, Shigekazu Ukawa, Emiko Okada, Makoto Hirata, Akiko Nagai, Zentaro Yamagata, Toshiharu Ninomiya, Kaori Muto, Yutaka Kiyohara, Koichi Matsuda, Yoichiro Kamatani, Michiaki Kubo, Yusuke Nakamura, Akiko Tamakoshi

JOURNAL OF EPIDEMIOLOGY, 27(3), S49-S57, Mar, 2017, doi: 10.1016/j.je.2016.12.010

Survival of macrovascular disease, chronic kidney disease, chronic respiratory disease, cancer and smoking in patients with type 2 diabetes: BioBank Japan cohort

Hiroshi Yokomichi, Akiko Nagai, Makoto Hirata, Yutaka Kiyohara, Kaori Muto, Toshiharu Ninomiya, Koichi Matsuda, Yoichiro Kamatani, Akiko Tamakoshi, Michiaki Kubo, Yusuke Nakamura, Zentaro Yamagata

JOURNAL OF EPIDEMIOLOGY, 27(3), S98-S106, Mar, 2017, doi: 10.1016/j.je.2016.12.012

Characteristics of patients with liver cancer in the BioBank Japan project

Shigekazu Ukawa, Emiko Okada, Koshi Nakamura, Makoto Hirata, Akiko Nagai, Koichi Matsuda, Zentaro Yamagata, Yoichiro Kamatani, Toshiharu Ninomiya, Yutaka Kiyohara, Kaori Muto, Michiaki Kubo, Yusuke Nakamura, Akiko Tamakoshi

JOURNAL OF EPIDEMIOLOGY, 27(3), S43-S48, Mar, 2017, doi: 10.1016/j.je.2016.12.007

Characteristics and prognosis of Japanese colorectal cancer patients: The BioBank Japan Project

Akiko Tamakoshi, Koshi Nakamura, Shigekazu Ukawa, Emiko Okada, Makoto Hirata, Akiko Nagai, Koichi Matsuda, Yoichiro Kamatani, Kaori Muto, Yutaka Kiyohara, Zentaro Yamagata, Toshiharu Ninomiya, Michiaki Kubo, Yusuke Nakamura

JOURNAL OF EPIDEMIOLOGY, 27(3), S36-S42, Mar, 2017, doi: 10.1016/j.je.2016.12.004

Clinical and histopathological characteristics of patients with prostate cancer in the BioBank Japan project

Shigekazu Ukawa, Koshi Nakamura, Emiko Okada, Makoto Hirata, Akiko Nagai, Zentaro Yamagata, Kaori Muto, Koichi Matsuda, Toshiharu Ninomiya, Yutaka Kiyohara, Yoichiro Kamatani, Michiaki Kubo, Yusuke Nakamura, Akiko Tamakoshi

JOURNAL OF EPIDEMIOLOGY, 27(3), S65-S70, Mar, 2017, doi: 10.1016/j.je.2016.12.008

Characteristics and prognosis of Japanese female breast cancer patients: The BioBank Japan

Koshi Nakamura, Emiko Okada, Shigekazu Ukawa, Makoto Hirata, Akiko Nagai, Zentaro Yamagata, Yutaka Kiyohara, Kaori Muto, Yoichiro Kamatani, Toshiharu Ninomiya, Koichi Matsuda, Michiaki Kubo, Yusuke Nakamura, Akiko Tamakoshi

JOURNAL OF EPIDEMIOLOGY, 27(3), S58-S64, Mar, 2017, doi: 10.1016/j.je.2016.12.009

Genetic Predisposition to Ischemic Stroke: A Polygenic Risk Score

Tsuyoshi Hachiya, Yoichiro Kamatani, Atsushi Takahashi, Jun Hata, Ryohei Furukawa, Yuh Shiwa, Taiki Yamaji, Megumi Hara, Kozo Tanno, Hideki Ohmomo, Kanako Ono, Naoyuki Takashima, Koichi Matsuda, Kenji Wakai, Norie Sawada, Motoki Iwasaki, Kazumasa Yamagishi, Tetsuro Ago, Toshiharu Ninomiya, Akimune Fukushima, Atsushi Hozawa, Naoko Minegishi, Mamoru Satoh, Ryujin Endo, Makoto Sasaki, Kiyomi Sakata, Seiichiro Kobayashi, Kuniaki Ogasawara, Motoyuki Nakamura, Jiro Hitomi, Yoshikuni Kita, Keitaro Tanaka, Hiroyasu Iso, Takanari Kitazono, Michiaki Kubo, Hideo Tanaka, Shoichiro Tsugane, Yutaka Kiyohara, Masayuki Yamamoto, Kenji Sobue, Atsushi Shimizu

STROKE, 48(2), 253-258, Feb, 2017, doi: 10.1161/STROKEAHA.116.014506

Using spatio-temporal surveillance data to test the infectious environment of children before type 1 diabetes diagnosis

Pierre Bougneres, Sophie Le Fur, Sophie Valtat, Yoichiro Kamatani, Mark Lathrop, Alain-Jacques Valleron

PLOS ONE, 12(2), e0170658, Feb, 2017, doi: 10.1371/journal.pone.0170658

Association of Variations in HLA-Class II and Other Loci with Susceptibility to EGFR-Mutated Lung Adenocarcinonna

Kouya Shiraishi, Yukinori Okada, Atsushi Takahashi, Yoichiro Kamatani, Kyota Ashikawa, Yukihide Momozawa, Hideo Kunitoh, Shingo Matsumoto, Atsushi Takano, Kimihiro Shimizu, Akiteru Goto, Koji Tsuta, Shun-Ichi Watanabe, Yuichiro Ohe, Yukio Watanabe, Yasishi Goto, Hiroshi Nokihara, Koh Furuta, Akihiko Yoshida, Koichi Goto, Tomoyuki Hishida, Masahiro Tsuboi, Katsuya Tsuchihara, Yohei Miyagi, Haruhiko Nakamura, Tomoyuki Yokose, Katsuya Tanaka, Toshiteru Nagashima, Yoichi Ohtaki, Daichi Maeda, Kazuhiro Imai, Yoshihiro Minamiya, Yoko Shimada, Kuniko Sunami, Motonobu Saito, Jun Yokota, Fumihiko Matsuda, Keitaro Matsuo, Yataro Daigo, Michiaki Kubo, Takashi Kohno

JOURNAL OF THORACIC ONCOLOGY, 12(1), S280-S281, Jan, 2017

Hierarchical Maximum Likelihood Clustering Approach

Alok Sharma, Keith A. Boroevich, Daichi Shigemizu, Yoichiro Kamatani, Michiaki Kubo, Tatsuhiko Tsunoda

IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING, 64(1), 112-122, Jan, 2017, doi: 10.1109/TBME.2016.2542212

Genome-wide Trans-ethnic Meta-analysis Identifies Seven Genetic Loci Influencing Erythrocyte Traits and a Role for RBPMS in Erythropoiesis

Frank J. A. van Rooij, Rehan Qayyum, Albert V. Smith, Yi Zhou, Stella Trompet, Toshiko Tanaka, Margaux F. Keller, Li-Ching Chang, Helena Schmidt, Min-Lee Yang, Ming-Huei Chen, James Hayes, Andrew D. Johnson, Lisa R. Yanek, Christian Mueller, Leslie Lange, James S. Floyd, Mohsen Ghanbari, Alan B. Zonderman, J. Wouter Jukema, Albert Hofman, Cornelia M. van Duijn, Karl C. Desch, Yasaman Saba, Ayse B. Ozel, Beverly M. Snively, Jer-Yuarn Wu, Reinhold Schmidt, Myriam Fornage, Robert J. Klein, Caroline S. Fox, Koichi Matsuda, Naoyuki Kamatani, Philipp S. Wild, David J. Stott, Ian Ford, P. Eline Slagboom, Jaden Yang, Audrey Y. Chu, Amy J. Lambert, Andre G. Uitterlinden, Oscar H. Franco, Edith Hofer, David Ginsburg, Bella Hu, Brendan Keating, Ursula M. Schick, Jennifer A. Brody, Jun Z. Li, Zhao Chen, Tanja Zeller, Jack M. Guralnik, Daniel I. Chasman, Luanne L. Peters, Michiaki Kubo, Diane M. Becker, Jin Li, Gudny Eiriksdottir, Jerome I. Rotter, Daniel Levy, Vera Grossmann, Kushang V. Patel, Chien-Hsiun Chen, Paul M. Ridker, Hua Tang, Lenore J. Launer, Kenneth M. Rice, Ruifang Li-Gao, Luigi Ferrucci, Michelle K. Evans, Avik Choudhuri, Eirini Trompouki, Brian J. Abraham, Song Yang, Atsushi Takahashi, Yoichiro Kamatani, Charles Kooperberg, Tamara B. Harris, Sun Ha Jee, Josef Coresh, Fuu-Jen Tsai, Dan L. Longo, Yuan-Tsong Chen, Janine F. Felix, Qiong Yang, Bruce M. Psaty, Eric Boerwinkle, Lewis C. Becker, Dennis O. Mook-Kanamori, James G. Wilson, Vilmundur Gudnason, Christopher J. O'Donnell, Abbas Dehghan, L. Adrienne Cupples, Michael A. Nalls, Andrew P. Morris, Yukinori Okada, Alexander P. Reiner, Leonard I. Zon, Santhi K. Ganesh

AMERICAN JOURNAL OF HUMAN GENETICS, 100(1), 51-63, Jan, 2017, doi: 10.1016/j.ajhg.2016.11.016

Association between GWAS-identified lung adenocarcinoma susceptibility loci and EGFR mutations in never-smoking Asian women, and comparison with findings from Western populations

Wei Jie Seow, Keitaro Matsuo, Chao Agnes Hsiung, Kouya Shiraishi, Minsun Song, Hee Nam Kim, Maria Pik Wong, Yun-Chul Hong, H. Dean Hosgood, Zhaoming Wang, I-Shou Chang, Jiu-Cun Wang, Nilanjan Chatterjee, Margaret Tucker, Hu Wei, Tetsuya Mitsudomi, Wei Zheng, Jin Hee Kim, Baosen Zhou, Neil E. Caporaso, Demetrius Albanes, Min-Ho Shin, Lap Ping Chung, She-Juan An, Ping Wang, Hong Zheng, Yasushi Yatabe, Xu-Chao Zhang, Young Tae Kim, Xiao-Ou Shu, Young-Chul Kim, Bryan A. Bassig, Jiang Chang, James Chung Man Ho, Bu-Tian Ji, Michiaki Kubo, Yataro Daigo, Hidemi Ito, Yukihide Momozawa, Kyota Ashikawa, Yoichiro Kamatani, Takayuki Honda, Hiromi Sakamoto, Hideo Kunitoh, Koji Tsuta, Shun-Ichi Watanabe, Hiroshi Nokihara, Yohei Miyagi, Haruhiko Nakayama, Shingo Matsumoto, Masahiro Tsuboi, Koichi Goto, Zhihua Yin, Jianxin Shi, Atsushi Takahashi, Akiteru Goto, Yoshihiro Minamiya, Kimihiro Shimizu, Kazumi Tanaka, Tangchun Wu, Fusheng Wei, Jason Y. Y. Wong, Fumihiko Matsuda, Jian Su, Yeul Hong Kim, In-Jae Oh, Fengju Song, Victor Ho Fun Lee, Wu-Chou Su, Yuh-Min Chen, Gee-Chen Chang, Kuan-Yu Chen, Ming-Shyan Huang, Pan-Chyr Yang, Hsien-Chih Lin, Yong-Bing Xiang, Adeline Seow, Jae Yong Park, Sun-Seog Kweon, Chien-Jen Chen, Haixin Li, Yu-Tang Gao, Chen Wu, Biyun Qian, Daru Lu, Jianjun Liu, Hyo-Sung Jeon, Chin-Fu Hsiao, Jae Sook Sung, Ying-Huang Tsai, Yoo Jin Jung, Huan Guo, Zhibin Hu, Wen-Chang Wang, Charles C. Chung, Charles Lawrence, Laurie Burdett, Meredith Yeager, Kevin B. Jacobs, Amy Hutchinson, Sonja I. Berndt, Xingzhou He, Wei Wu, Junwen Wang, Yuqing Li, Jin Eun Choi, Kyong Hwa Park, Sook Whan Sung, Li Liu, Chang Hyun Kang, Lingmin Hu, Chung-Hsing Chen, Tsung-Ying Yang, Jun Xu, Peng Guan, Wen Tan, Chih-Liang Wang, Alan Dart Loon Sihoe, Ying Chen, Yi Young Choi, Jen-Yu Hung, Jun Suk Kim, Ho-Il Yoon, Qiuyin Cai, Chien-Chung Lin, In Kyu Park, Ping Xu, Jing Dong, Christopher Kim, Qincheng He, Reury-Perng Perng, Chih-Yi Chen, Roel Vermeulen, Junjie Wu, Wei-Yen Lim, Kun-Chieh Chen, John K. C. Chan, Minjie Chu, Yao-Jen Li, Jihua Li, Hongyan Chen, Chong-Jen Yu, Li Jin, Yen-Li Lo, Ying-Hsiang Chen, Joseph F. Fraumeni, Jie Liu, Taiki Yamaji, Yang Yang, Belynda Hicks, Kathleen Wyatt, Shengchao A. Li, Juncheng Dai, Hongxia Ma, Guangfu Jin, Bao Song, Zhehai Wang, Sensen Cheng, Xuelian Li, Yangwu Ren, Ping Cui, Motoki Iwasaki, Taichi Shimazu, Shoichiro Tsugane, Junjie Zhu, Gening Jiang, Ke Fei, Guoping Wu, Li-Hsin Chien, Hui-Ling Chen, Yu-Chun Su, Fang-Yu Tsai, Yi-Song Chen, Jinming Yu, Victoria L. Stevens, Ite A. Laird-Offringa, Crystal N. Marconett, Dongxin Lin, Kexin Chen, Yi-Long Wu, Maria Teresa Landi, Hongbing Shen, Nathaniel Rothman, Takashi Kohno, Stephen J. Chanock, Qing Lan

HUMAN MOLECULAR GENETICS, 26(2), 454-465, Jan, 2017, doi: 10.1093/hmg/ddw414

201618 papers

Genomewide Association Studies in Pharmacogenomics: Meeting Report of the NIH Pharmacogenomics Research Network-RIKEN (PGRN-RIKEN) Collaboration

S. W. Yee, Y. Momozawa, Y. Kamatani, R. F. Tyndale, R. M. Weinshilboum, M. J. Ratain, K. M. Giacomini, M. Kubo

CLINICAL PHARMACOLOGY & THERAPEUTICS, 100(5), 423-426, Nov, 2016, doi: 10.1002/cpt.405

Risk factors and clinical characteristics of the depressive state induced by pegylated interferon therapy in patients with hepatitis C virus infection: A prospective study

Kohei Kawase, Kenji Kondo, Takeo Saito, Ayu Shimasaki, Atsushi Takahashi, Yoichiro Kamatani, Naoto Kawabe, Senju Hashimoto, Masashi Ikeda, Michiaki Kubo, Kentaro Yoshioka, Nakao Iwata

PSYCHIATRY AND CLINICAL NEUROSCIENCES, 70(11), 489-497, Nov, 2016, doi: 10.1111/pcn.12424

Low-frequency coding variants in CETP and CFB are associated with susceptibility of exudative age-related macular degeneration in the Japanese population

Yukihide Momozawa, Masato Akiyama, Yoichiro Kamatani, Satoshi Arakawa, Miho Yasuda, Shigeo Yoshida, Yuji Oshima, Ryusaburo Mori, Koji Tanaka, Keisuke Mori, Satoshi Inoue, Hiroko Terasaki, Tetsuhiro Yasuma, Shigeru Honda, Akiko Miki, Maiko Inoue, Kimihiko Fujisawa, Kanji Takahashi, Tsutomu Yasukawa, Yasuo Yanagi, Kazuaki Kadonosono, Koh-Hei Sonoda, Tatsuro Ishibashi, Atsushi Takahashi, Michiaki Kubo

HUMAN MOLECULAR GENETICS, 25(22), 5027-5034, Nov, 2016, doi: 10.1093/hmg/ddw335

Low-frequency coding variants in CETP and CFB are associated with susceptibility of exudative age-related macular degeneration in the Japanese population.

Momozawa Y, Akiyama M, Kamatani Y, Arakawa S, Yasuda M, Yoshida S, Oshima Y, Mori R, Tanaka K, Mori K, Inoue S, Terasaki H, Yasuma T, Honda S, Miki A, Inoue M, Fujisawa K, Takahashi K, Yasukawa T, Yanagi Y, Kadonosono K, Sonoda KH, Ishibashi T, Takahashi A, Kubo M

Hum Mol Genet, Oct 3, 2016

バイオバンクジャパン 13悪性腫瘍における追跡調査

平田 真, 鎌谷 洋一郎, 玉腰 暁子, 山縣 然太朗, 清原 裕, 古川 洋一, 村上 善則, 中村 祐輔, 久保 充明, 松田 浩一

日本癌学会総会記事, 75回, E-3078, Oct, 2016

ゲノムワイド関連解析による新規子宮筋腫感受性遺伝子の同定

坂井 健良, 平田 真, 谷川 千津, 鎌谷 洋一郎, 久保 充明, 平沢 晃, 松田 浩一

日本癌学会総会記事, 75回, P-3366, Oct, 2016

Dosage Contribution of a Non-Classical HLA Gene, HLA-Doa, to the Risk of Rheumatoid Arthritis

Yukinori Okada, Akari Suzuki, Katsunori Ikari, Chikashi Terao, Yuta Kochi, Koichiro Ohmura, Koichiro Higasa, Masato Akiyama, Kyoto Ashikawa, Masahiro Kanai, Jun Hirata, Naomasa Suita, Yik-Ying Teo, Huji Xu, Sang-Cheol Bae, Yukihide Momozawa, Koichi Matsuda, Shigeki Momohara, Atsuo Taniguchi, Ryo Yamada, Tsuneyo Mimori, Michiaki Kubo, Matthew A. Brown, Soumya Raychaudhuri, Fumihiko Matsuda, Hisashi Yamanaka, Yoichiro Kamatani, Kazuhiko Yamamoto

ARTHRITIS & RHEUMATOLOGY, 68, Oct, 2016, doi: 10.1016/j.ajhg.2016.06.019

Pharmacogenomic Study of Clozapine-Induced Agranulocytosis/Granulocytopenia in a Japanese Population

Takeo Saito, Masashi Ikeda, Taisei Mushiroda, Takeshi Ozeki, Kenji Kondo, Ayu Shimasaki, Kohei Kawase, Shuji Hashimoto, Hidenaga Yamamori, Yuka Yasuda, Michiko Fujimoto, Kazutaka Ohi, Masatoshi Takeda, Yoichiro Kamatani, Shusuke Numata, Tetsuro Ohmori, Shu-ichi Ueno, Manabu Makinodan, Yosuke Nishihata, Masaharu Kubota, Takemi Kimura, Nobuhisa Kanahara, Naoki Hashimoto, Kiyoshi Fujita, Kiyotaka Nemoto, Taku Fukao, Taro Suwa, Tetsuro Noda, Yuji Yada, Manabu Takaki, Naoya Kida, Taku Otsuru, Masaru Murakami, Atsushi Takahashi, Michiaki Kubo, Ryota Hashimoto, Nakao Iwata

BIOLOGICAL PSYCHIATRY, 80(8), 636-642, Oct, 2016, doi: 10.1016/j.biopsych.2015.12.006

Trans-ethnic Fine Mapping Highlights Kidney-Function Genes Linked to Salt Sensitivity

Anubha Mahajan, Aylin R. Rodan, Thu H. Le, Kyle J. Gaulton, Jeffrey Haessler, Adrienne M. Stilp, Yoichiro Kamatani, Gu Zhu, Tamar Sofer, Sanjana Puri, Jeffrey N. Schellinger, Pei-Lun Chu, Sylvia Cechova, Natalie van Zuydam, Johan Arnlov, Michael F. Flessner, Vilmantas Giedraitis, Andrew C. Heath, Michiaki Kubo, Anders Larsson, Cecilia M. Lindgren, Pamela A. F. Madden, Grant W. Montgomery, George J. Papanicolaou, Alex P. Reiner, Johan Sundstrom, Timothy A. Thornton, Lars Lind, Erik Ingelsson, Jianwen Cai, Nicholas G. Martin, Charles Kooperberg, Koichi Matsuda, John B. Whitfield, Yukinori Okada, Cathy C. Laurie, Andrew P. Morris, Nora Franceschini

AMERICAN JOURNAL OF HUMAN GENETICS, 99(3), 636-646, Sep, 2016, doi: 10.1016/j.ajhg.2016.07.012

Contribution of a Non-classical HLA Gene, HLA-DOA, to the Risk of Rheumatoid Arthritis

Yukinori Okada, Akari Suzuki, Katsunori Ikari, Chikashi Terao, Yuta Kochi, Koichiro Ohmura, Koichiro Higasa, Masato Akiyama, Kyota Ashikawa, Masahiro Kanai, Jun Hirata, Naomasa Suita, Yik-Ying Teo, Huji Xu, Sang-Cheol Bae, Atsushi Takahashi, Yukihide Momozawa, Koichi Matsuda, Shigeki Momohara, Atsuo Taniguchi, Ryo Yamada, Tsuneyo Mimori, Michiaki Kubo, Matthew A. Brown, Soumya Raychaudhuri, Fumihiko Matsuda, Hisashi Yamanaka, Yoichiro Kamatani, Kazuhiko Yamamoto

AMERICAN JOURNAL OF HUMAN GENETICS, 99(2), 366-374, Aug, 2016, doi: 10.1016/j.ajhg.2016.06.019

Association of variations in HLA class II and other loci with susceptibility to EGFR-mutated lung adenocarcinoma

Kouya Shiraishi, Yukinori Okada, Atsushi Takahashi, Yoichiro Kamatani, Yukihide Momozawa, Kyota Ashikawa, Hideo Kunitoh, Shingo Matsumoto, Atsushi Takano, Kimihiro Shimizu, Akiteru Goto, Koji Tsuta, Shun-ichi Watanabe, Yuichiro Ohe, Yukio Watanabe, Yasushi Goto, Hiroshi Nokihara, Koh Furuta, Akihiko Yoshida, Koichi Goto, Tomoyuki Hishida, Masahiro Tsuboi, Katsuya Tsuchihara, Yohei Miyagi, Haruhiko Nakayama, Tomoyuki Yokose, Kazumi Tanaka, Toshiteru Nagashima, Yoichi Ohtaki, Daichi Maeda, Kazuhiro Imai, Yoshihiro Minamiya, Hiromi Sakamoto, Akira Saito, Yoko Shimada, Kuniko Sunami, Motonobu Saito, Johji Inazawa, Yusuke Nakamura, Teruhiko Yoshida, Jun Yokota, Fumihiko Matsuda, Keitaro Matsuo, Yataro Daigo, Michiaki Kubo, Takashi Kohno

Nature Communications, 7, 12451, Aug, 2016, doi: 10.1038/ncomms12451

Stepwise iterative maximum likelihood clustering approach

Alok Sharma, Daichi Shigemizu, Keith A. Boroevich, Yosvany Lopez, Yoichiro Kamatani, Michiaki Kubo, Tatsuhiko Tsunoda

BMC BIOINFORMATICS, 17(1), 319, Aug, 2016, doi: 10.1186/s12859-016-1184-5

Identification of additional risk loci for stroke and small vessel disease: a meta-analysis of genome-wide association studies

Ganesh Chauhan, Corey R. Arnold, Audrey Y. Chu, Myriam Fornage, Azadeh Reyahi, Joshua C. Bis, Ald S. Havulinna, Muralidharan Sargurupremraj, Albert Vernon Smith, Hieab H. H. Adams, Seung Hoan Choi, Sara L. Pulit, Stella Trompet, Melissa E. Garcia, Ani Manichaikul, Alexander Teumer, Stefan Gustafsson, Traci M. Bartz, Celine Bellenguez, Jean Sebastien Vidal, Xueqiu Jian, Olafur Kjartansson, Kerni L. Wiggins, Claudia L. Satizabal, Flora Xue, Samuli Ripatti, Yongmei Liu, Joris Deelen, Marcel den Hoed, Steve Bevan, Jemma C. Hopewell, Rainer Malik, Susan R. Heckbert, Kenneth Rice, Nicholas L. Smith, Christopher Levi, Pankaj Sharma, Cathie L. M. Sudlow, Ali Moussavi Nik, John W. Cole, Reinhold Schmidt, James Meschia, Vincent Thijs, Arne Lindgren, Olle Melander, Raji P. Grewal, Ralph L. Sacco, Tatjana Rundek, Peter M. Rothwell, Donna K. Arnett, Christina Jern, Julie A. Johnson, Oscar R. Benavente, Sylvia Wassertheil-Smoller, Jin-Moo Lee, Quenna Wong, Hugo J. Aparicio, Stefan T. Engelter, Manja Kloss, Didier Leys, Alessandro Pezzini, Julie E. Buring, Paul M. Ridker, Claudine Berr, Jean-Francois Dartigues, Anders Hamsten, Patrik K. Magnusson, Matthew Traylor, Nancy L. Pedersen, Lars Lannfelt, Lars Lind, Cecilia M. Lindgren, Andrew P. Morris, Jordi Jimenez-Conde, Joan Montaner, Farid Radmanesh, Agnieszka Slowik, Daniel Woo, Albert Hofman, Peter J. Koudstaal, Marileen L. P. Portegies, Andre G. Uitterlinden, Anton J. M. de Craen, Ian Ford, J. Wouter Jukema, David J. Stott, Norrina B. Allen, Michele M. Sale, Andrew D. Johnson, David A. Bennett, Philip L. De Jager, Charles C. White, Hans Jorgen Grabe, Marcell Ricardo Paulista Markus, Ulf Schminke, Giorgio B. Boncoraglio, Robert Clarke, Yoichiro Kamatani, Jean Dallongeville, Oscar L. Lopez, Jerome I. Rotter, Michael A. Nails, Rebecca F. Gottesman, Michael E. Griswold, David S. Knopman, B. Gwen Windham, Alexa Beiser, Hugh S. Markus, Erkki Vartiainen, Curtis R. French, Martin Dichgans, Tomi Pastinen, Mark Lathrop, Vilmundur Gudnason, Tobias Kurth, Bruce M. Psaty, Tamara B. Harris, Stephen S. Rich, Anita L. deStefano, Carsten Oliver Schmidt, Bradford B. Worrall, Jonathan Rosand, Veikko Salomaa, Thomas H. Mosley, Erik Ingelsson, Cornelia M. van Duijn, Christophe Tzourio, Kathryn M. Rexrode, Ordan J. Lehmann, Lenore J. Launer, M. Arfan Ikram, Peter Carlsson, Daniel I. Chasman, Sarah J. Childs, William T. Longstreth Junior, Sudha Seshadri, Stephanie Debette

LANCET NEUROLOGY, 15(7), 695-707, Jun, 2016, doi: 10.1016/s1474-4422(16)00102-2

Genome-wide imputation study identifies novel HLA locus for pulmonary fibrosis and potential role for auto-immunity in fibrotic idiopathic interstitial pneumonia

Tasha E. Fingerlin, Weiming Zhang, Ivana V. Yang, Hannah C. Ainsworth, Pamela H. Russell, Rachel Z. Blumhagen, Marvin I. Schwarz, Kevin K. Brown, Mark P. Steele, James E. Loyd, Gregory P. Cosgrove, David A. Lynch, Steve Groshong, Harold R. Collard, Paul J. Wolters, Williamson Z. Bradford, Karl Kossen, Scott D. Seiwert, Roland M. du Bois, Christine Kim Garcia, Megan S. Devine, Gunnar Gudmundsson, Helgi J. Isaksson, Naftali Kaminski, Yingze Zhang, Kevin F. Gibson, Lisa H. Lancaster, Toby M. Maher, Philip L. Molyneaux, Athol U. Wells, Miriam F. Moffatt, Moises Selman, Annie Pardo, Dong Soon Kim, James D. Crapo, Barry J. Make, Elizabeth A. Regan, Dinesha S. Walek, Jerry J. Daniel, Yoichiro Kamatani, Diana Zelenika, Elissa Murphy, Keith Smith, David McKean, Brent S. Pedersen, Janet Talbert, Julia Powers, Cheryl R. Markin, Kenneth B. Beckman, Mark Lathrop, Brian Freed, Carl D. Langefeld, David A. Schwartz

BMC GENETICS, 17(1), 74, Jun, 2016, doi: 10.1186/s12863-016-0377-2

Search for new loci and low-frequency variants influencing glioma risk by exome-array analysis

Ben Kinnersley, Yoichiro Kamatani, Marianne Labussiere, Yufei Wang, Pilar Galan, Karima Mokhtari, Jean-Yves Delattre, Konstantinos Gousias, Johannes Schramm, Minouk J. Schoemaker, Anthony Swerdlow, Sarah J. Fleming, Stefan Herms, Stefanie Heilmann, Markus M. Noethen, Matthias Simon, Marc Sanson, Mark Lathrop, Richard S. Houlston

EUROPEAN JOURNAL OF HUMAN GENETICS, 24(5), 717-724, May, 2016, doi: 10.1038/ejhg.2015.170

[Genome Wide Association Study:its theory and methodological review].

Kamatani Y

Clinical calcium, 26(4), 525-535, Apr, 2016

Genome-Wide Association Analysis of Young-Onset Stroke Identifies a Locus on Chromosome 10q25 Near HABP2

Yu-Ching Cheng, Tara M. Stanne, Anne-Katrin Giese, Weang Kee Ho, Matthew Traylor, Philippe Amouyel, Elizabeth G. Holliday, Rainer Malik, Huichun Xu, Steven J. Kittner, John W. Cole, Jeffrey R. O'Connell, John Danesh, Asif Rasheed, Wei Zhao, Stefan Engelter, Caspar Grond-Ginsbach, Yoichiro Kamatani, Mark Lathrop, Didier Leys, Vincent Thijs, Tiina M. Metso, Turgut Tatlisumak, Alessandro Pezzini, Eugenio A. Parati, Bo Norrving, Steve Bevan, Peter M. Rothwell, Cathie Sudlow, Agnieszka Slowik, Arne Lindgren, Matthew R. Walters, Jim Jannes, Jess Shen, David Crosslin, Kimberly Doheny, Cathy C. Laurie, Sandip M. Kanse, Joshua C. Bis, Myriam Fornage, Thomas H. Mosley, Jemma C. Hopewell, Konstantin Strauch, Martina Mueller-Nurasyid, Christian Gieger, Melanie Waldenberger, Annette Peters, Christine Meisinger, M. Arfan Ikram, W. T. Longstreth, James F. Meschia, Sudha Seshadri, Pankaj Sharma, Bradford Worrall, Christina Jern, Christopher Levi, Martin Dichgans, Giorgio B. Boncoraglio, Hugh S. Markus, Stephanie Debette, Arndt Rolfs, Danish Saleheen, Braxton D. Mitchell

STROKE, 47(2), 307-+, Feb, 2016, doi: 10.1161/STROKEAHA.115.011328

A novel Alzheimer disease locus located near the gene encoding tau protein

G. Jun, C. A. Ibrahim-Verbaas, M. Vronskaya, J-C Lambert, J. Chung, A. C. Naj, B. W. Kunkle, L-S Wang, J. C. Bis, C. Bellenguez, D. Harold, K. L. Lunetta, A. L. Destefano, B. Grenier-Boley, R. Sims, G. W. Beecham, A. V. Smith, V. Chouraki, K. L. Hamilton-Nelson, M. A. Ikram, N. Fievet, N. Denning, E. R. Martin, H. Schmidt, Y. Kamatani, M. L. Dunstan, O. Valladares, A. R. Laza, D. Zelenika, A. Ramirez, T. M. Foroud, S-H Choi, A. Boland, T. Becker, W. A. Kukull, S. J. van der Lee, F. Pasquier, C. Cruchaga, D. Beekly, A. L. Fitzpatrick, O. Hanon, M. Gill, R. Barber, V. Gudnason, D. Campion, S. Love, D. A. Bennett, N. Amin, C. Berr, Magda Tsolaki, J. D. Buxbaum, O. L. Lopez, V. Deramecourt, N. C. Fox, L. B. Cantwell, L. Tarraga, C. Dufouil, J. Hardy, P. K. Crane, G. Eiriksdottir, D. Hannequin, R. Clarke, D. Evans, T. H. Mosley, L. Letenneur, C. Brayne, W. Maier, P. De Jager, V. Emilsson, J-F Dartigues, H. Hampel, M. I. Kamboh, R. F. A. G. de Bruijn, C. Tzourio, P. Pastor, E. B. Larson, J. I. Rotter, M. C. O'Donovan, T. J. Montine, M. A. Nalls, S. Mead, E. M. Reiman, P. V. Jonsson, C. Holmes, P. H. St George-Hyslop, M. Boada, P. Passmore, J. R. Wendland, R. Schmidt, K. Morgan, A. R. Winslow, J. F. Powell, M. Carasquillo, S. G. Younkin, J. Jakobsdottir, J. S. K. Kauwe, K. C. Wilhelmsen, D. Rujescu, M. M. Noethen, A. Hofman, L. Jones, J. L. Haines, B. M. Psaty, C. Van Broeckhoven, P. Holmans, L. J. Launer, R. Mayeux, M. Lathrop, A. M. Goate, V. Escott-Price, S. Seshadri, M. A. Pericak-Vance, P. Amouyel, J. Williams, C. M. van Duijn, G. D. Schellenberg, L. A. Farrer

MOLECULAR PSYCHIATRY, 21(1), 108-117, Jan, 2016, doi: 10.1038/mp.2015.23

20158 papers

バイオバンクジャパンコホートプロファイル 47疾患20万人の大規模コホートデータ

平田 真, 山内 麻衣, 鎌谷 洋一郎, 玉腰 暁子, 山縣 然太朗, 清原 裕, 古川 洋一, 村上 善則, 中村 祐輔, 久保 充明, 松田 浩一

日本癌学会総会記事, 74回, J-1342, Oct, 2015

Imputation of KIR Types from SNP Variation Data

Damjan Vukcevic, James A. Traherne, Sigrid Naess, Eva Ellinghaus, Yoichiro Kamatani, Alexander Dilthey, Mark Lathrop, Tom H. Karlsen, Andre Franke, Miriam Moffatt, William Cookson, John Trowsdale, Gil McVean, Stephen Sawcer, Stephen Leslie

AMERICAN JOURNAL OF HUMAN GENETICS, 97(4), 593-607, Oct, 2015, doi: 10.1016/j.ajhg.2015.09.005

A Functional SNP in BNC2 Is Associated with Adolescent Idiopathic Scoliosis

Yoji Ogura, Ikuyo Kou, Shigenori Miura, Atsushi Takahashi, Leilei Xu, Kazuki Takeda, Yohei Takahashi, Katsuki Kono, Noriaki Kawakami, Koki Uno, Manabu Ito, Shohei Minami, Ikuho Yonezawa, Haruhisa Yanagida, Hiroshi Taneichi, Zezhang Zhu, Taichi Tsuji, Teppei Suzuki, Hideki Sudo, Toshiaki Kotani, Kota Watanabe, Naobumi Hosogane, Eijiro Okada, Aritoshi Iida, Masahiro Nakajima, Akihiro Sudo, Kazuhiro Chiba, Yuji Hiraki, Yoshiaki Toyama, Yong Qiu, Chisa Shukunami, Yoichiro Kamatani, Michiaki Kubo, Mono Matsumoto, Shiro Ikegawal

AMERICAN JOURNAL OF HUMAN GENETICS, 97(2), 337-342, Aug, 2015, doi: 10.1016/j.ajhg.2015.06.012

Construction of a population-specific HLA imputation reference panel and its application to Graves' disease risk in Japanese

Yukinori Okada, Yukihide Momozawa, Kyota Ashikawa, Masahiro Kanai, Koichi Matsuda, Yoichiro Kamatani, Atsushi Takahashi, Michiaki Kubo

NATURE GENETICS, 47(7), 798-+, Jul, 2015, doi: 10.1038/ng.3310

Directional dominance on stature and cognition in diverse human populations

Peter K. Joshi, Tonu Esko, Hannele Mattsson, Niina Eklund, Ilaria Gandin, Teresa Nutile, Anne U. Jackson, Claudia Schurmann, Albert V. Smith, Weihua Zhang, Yukinori Okada, Alena Stancakova, Jessica D. Faul, Wei Zhao, Traci M. Bartz, Maria Pina Concas, Nora Franceschini, Stefan Enroth, Veronique Vitart, Stella Trompet, Xiuqing Guo, Daniel I. Chasman, Jeffrey R. O'Connel, Tanguy Corre, Suraj S. Nongmaithem, Yuning Chen, Massimo Mangino, Daniela Ruggiero, Michela Traglia, Aliki-Eleni Farmaki, Tim Kacprowski, Andrew Bjonnes, Ashley van der Spek, Ying Wu, Anil K. Giri, Lisa R. Yanek, Lihua Wang, Edith Hofer, Cornelius A. Rietveld, Olga McLeod, Marilyn C. Cornelis, Cristian Pattaro, Niek Verweij, Clemens Baumbach, Abdel Abdellaoui, Helen R. Warren, Dragana Vuckovic, Hao Mei, Claude Bouchard, John R. B. Perry, Stefania Cappellani, Saira S. Mirza, Miles C. Benton, Ulrich Broeckel, Sarah E. Medland, PenelopeA. Lind, Giovanni Malerba, Alexander Drong, Loic Yengo, Lawrence F. Bielak, Degui Zhi, Peter J. van der Most, Daniel Shriner, Reedik Maegi, Gibran Hemani, Tugce Karaderi, Zhaoming Wang, Tian Liu, Ilja Demuth, Jing Hua Zhao, Weihua Meng, Lazaros Lataniotis, Sander W. van der Laan, Jonathan P. Bradfield, Andrew R. Wood, Amelie Bonnefond, Tarunveer S. Ahluwalia, LeanneM. Hall, Erika Salvi, Seyhan Yazar, Lisbeth Carstensen, Hugoline G. de Haan, Mark Abney, Uzma Afzal, Matthew A. Allison, Najaf Amin, Folkert W. Asselbergs, Stephan J. L. Bakker, R. Graham Barr, Sebastian E. Baumeister, Daniel J. Benjamin, Sven Bergmann, Eric Boerwinkle, Erwin P. Bottinger, Archie Campbell, Aravinda Chakravarti, Yingleong Chan, Stephen J. Chanock, Constance Chen, Y. -D. Ida Chen, Francis S. Collins, John Connell, Adolfo Correa, L. Adrienne Cupples, George Davey Smith, Gail Davies, Marcus Doerr, Georg Ehret, Stephen B. Ellis, Bjarke Feenstra, Mary F. Feitosa, Ian Ford, Caroline S. Fox, Timothy M. Frayling, Nele Friedrich, Frank Geller, Generation Scotland, Irina Gillham-Nasenya, Omri Gottesman, Misa Graff, Francine Grodstein, Charles Gu, Chris Haley, Christopher J. Hammond, Sarah E. Harris, Tamara B. Harris, Nicholas D. Hastie, Nancy L. Heard-Costa, Kauko Heikkila, Lynne J. Hocking, Georg Homuth, Jouke-Jan Hottenga, Jinyan Huang, Jennifer E. Huffman, Pirro G. Hysi, M. Arfan Ikram, Erik Ingelsson, Anni Joensuu, Asa Johansson, Pekka Jousilahti, J. Wouter Jukema, Mika Kahonen, Yoichiro Kamatani, Stavroula Kanoni, Shona M. Kerr, Nazir M. Khan, Philipp Koellinger, Heikki A. Koistinen, Manraj K. Kooner, Michiaki Kubo, Johanna Kuusisto, Jari Lahti, Lenore J. Launer, Rodney A. Lea, Benjamin Lehne, Terho Lehtimaki, David C. M. Liewald, Lars Lind, Marie Loh, Marja-Liisa Lokki, Stephanie J. London, Stephanie J. Loomis, Anu Loukola, Yingchang Lu, Thomas Lumley, Annamari Lundqvist, Satu Mannisto, Pedro Marques-Vidal, Corrado Masciullo, Angela Matchan, Rasika A. Mathias, Koichi Matsuda, James B. Meigs, Christa Meisinger, Thomas Meitinger, Cristina Menni, Frank D. Mentch, Evelin Mihailov, Lili Milani, May E. Montasser, GrantW. Montgomery, Alanna Morrison, Richard H. Myers, Rajiv Nadukuru, Pau Navarro, Mari Nelis, Markku S. Nieminen, Ilja M. Nolte, George T. O'Connor, Adesola Ogunniyi, Sandosh Padmanabhan, Walter R. Palmas, James S. Pankow, Inga Patarcic, Francesca Pavani, Patricia A. Peyser, Kirsi Pietilainen, Neil Poulter, Inga Prokopenko, Sarju Ralhan, Paul Redmond, Stephen S. Rich, Harri Rissanen, Antonietta Robino, Lynda M. Rose, Richard Rose, Cinzia Sala, Babatunde Salako, Veikko Salomaa, Antti-Pekka Sarin, Richa Saxena, Helena Schmidt, Laura J. Scott, William R. Scott, Bengt Sennblad, Sudha Seshadri, Peter Sever, Smeeta Shrestha, Blair H. Smith, Jennifer A. Smith, Nicole Soranzo, Nona Sotoodehnia, Lorraine Southam, Alice V. Stanton, Maria G. Stathopoulou, Konstantin Strauch, Rona J. Strawbridge, Matthew J. Suderman, Nikhil Tandon, Sian-Tsun Tang, Kent D. Taylor, Bamidele O. Tayo, Anna Maria Toeglhofer, Maciej Tomaszewski, Natalia Tsernikova, Jaakko Tuomilehto, Andre G. Uitterlinden, Dhananjay Vaidya, Astrid van Hylckama Vlieg, Jessica van Setten, Tuula Vasankari, Sailaja Vedantam, Efthymia Vlachopoulou, Diego Vozzi, Eero Vuoksimaa, Melanie Waldenberger, Erin B. Ware, William Wentworth-Shields, John B. Whitfield, Sarah Wild, Gonneke Willemsen, Chittaranjan S. Yajnik, Jie Yao, Gianluigi Zaza, Xiaofeng Zhu, Rany M. Salem, Mads Melbye, Hans Bisgaard, Nilesh J. Samani, Daniele Cusi, David A. Mackey, Richard S. Cooper, Philippe Froguel, Gerard Pasterkamp, Struan F. A. Grant, Hakon Hakonarson, Luigi Ferrucci, Robert A. Scott, Andrew D. Morris, Colin N. A. Palmer, George Dedoussis, Panos Deloukas, Lars Bertram, Ulman Lindenberger, Sonja I. Berndt, Cecilia M. Lindgren, Nicholas J. Timpson, Anke Toenjes, Patricia B. Munroe, Thorkild I. A. Sorensen, Charles N. Rotimi, Donna K. Arnett, Albertine J. Oldehinkel, Sharon L. R. Kardia, Beverley Balkau, Giovanni Gambaro, Andrew P. Morris, Johan G. Eriksson, Margie J. Wright, Nicholas G. Martin, Steven C. Hunt, John M. Starr, Ian J. Deary, Lyn R. Griffiths, Henning Tiemeier, Nicola Pirastu, Jaakko Kaprio, Nicholas J. Wareham, Louis Perusse, James G. Wilson, Giorgia Girotto, Mark J. Caulfield, Olli Raitakari, Dorret I. Boomsma, Christian Gieger, Pim van der Harst, Andrew A. Hicks, Peter Kraft, Juha Sinisalo, Paul Knekt, Magnus Johannesson, Patrik K. E. Magnusson, Anders Hamsten, Reinhold Schmidt, Ingrid B. Borecki, Erkki Vartiainen, Diane M. Becker, Dwaipayan Bharadwaj, Karen L. Mohlke, Michael Boehnke, Cornelia M. van Duijn, Dharambir K. Sanghera, Alexander Teumer, Eleftheria Zeggini, Andres Metspalu, Paolo Gasparini, Sheila Ulivi, Carole Ober, Daniela Toniolo, Igor Rudan, David J. Porteous, Marina Ciullo, Tim D. Spector, Caroline Hayward, Josee Dupuis, Ruth J. F. Loos, Alan F. Wright, Giriraj R. Chandak, Peter Vollenweider, Alan R. Shuldiner, Paul M. Ridker, Jerome I. Rotter, Naveed Sattar, Ulf Gyllensten, Kari E. North, Mario Pirastu, Bruce M. Psaty, David R. Weir, Markku Laakso, Vilmundur Gudnason, Atsushi Takahashi, John C. Chambers, Jaspal S. Kooner, David P. Strachan, Harry Campbell, Joel N. Hirschhorn, Markus Perola, Ozren Polasek, James F. Wilson

NATURE, 523(7561), 459-U176, Jul, 2015, doi: 10.1038/nature14618

Convergent genetic and expression data implicate immunity in Alzheimer's disease

Lesley Jones, Jean-Charles Lambert, Li-San Wang, Seung-Hoan Choi, Denise Harold, Alexey Vedernikov, Valentina Escott-Price, Timothy Stone, Alexander Richards, Celine Bellenguez, Carla A. Ibrahim-Verbaas, Adam C. Naj, Rebecca Sims, Amy Gerrish, Gyungah Jun, Anita L. DeStefano, Joshua C. Bis, Gary W. Beecham, Benjamin Grenier-Boley, Giancarlo Russo, Tricia A. Thornton-Wells, Nicola Jones, Albert V. Smith, Vincent Chouraki, Charlene Thomas, M. Arfan Ikram, Diana Zelenika, Badri N. Vardarajan, Yoichiro Kamatani, Chiao-Feng Lin, Helena Schmidt, Brian W. Kunkle, Melanie L. Dunstan, Agustin Ruiz, Marie-Therese Bihoreau, Christiane Reitz, Florence Pasquier, Paul Hollingworth, Olivier Hanon, Annette L. Fitzpatrick, Joseph D. Buxbaum, Dominique Campion, Paul K. Crane, Tim Becker, Vilmundur Gudnason, Carlos Cruchaga, David Craig, Najaf Amin, Claudine Berr, Oscar L. Lopez, Philip L. De Jager, Vincent Deramecourt, Janet A. Johnston, Denis Evans, Simon Lovestone, Luc Letteneur, Johanes Kornhuber, Lluis Tarraga, David C. Rubinsztein, Gudny Eiriksdottir, Kristel Sleegers, Alison M. Goate, Nathalie Fievet, Matthew J. Huentelman, Michael Gill, Valur Emilsson, Kristelle Brown, M. Ilyas Kamboh, Lina Keller, Pascale Barberger-Gateau, Bernadette McGuinness, Eric B. Larson, Amanda J. Myers, Carole Dufouil, Stephen Todd, David Wallon, Seth Love, Pat Kehoe, Ekaterina Rogaeva, John Gallacher, Peter St George-Hyslop, Jordi Clarimon, Alberti Lleo, Anthony Bayer, Debby W. Tsuang, Lei Yu, Magda Tsolaki, Paola Bossu, Gianfranco Spalletta, Petra Proitsi, John Collinge, Sandro Sorbi, Fiorentino Sanchez Garcia, Nick Fox, John Hardy, Maria Candida Deniz Naranjo, Cristina Razquin, Paola Bosco, Robert Clarke, Carol Brayne, Daniela Galimberti, Michelangelo Mancuso, Susanne Moebus, Patrizia Mecocci, Maria del Zompo, Wolfgang Maier, Harald Hampel, Alberto Pilotto, Maria Bullido, Francesco Panza, Paolo Caffarra, Benedetta Nacmias, John R. Gilbert, Manuel Mayhaus, Frank Jessen, Martin Dichgans, Lars Lannfelt, Hakon Hakonarson, Sabrina Pichler, Minerva M. Carrasquillo, Martin Ingelsson, Duane Beekly, Victoria Alavarez, Fanggeng Zou, Otto Valladares, Steven G. Younkin, Eliecer Coto, Kara L. Hamilton-Nelson, Ignacio Mateo, Michael J. Owen, Kelley M. Faber, Palmi V. Jonsson, Onofre Combarros, Michael C. O'Donovan, Laura B. Cantwell, Hilkka Soininen, Deborah Blacker, Simon Mead, Thomas H. Mosley, David A. Bennett, Tamara B. Harris, Laura Fratiglioni, Clive Holmes, Renee F. A. G. de Bruijn, Peter Passmore, Thomas J. Montine, Karolien Bettens, Jerome I. Rotter, Alexis Brice, Kevin Morgan, Tatiana M. Foroud, Walter A. Kukull, Didier Hannequin, John F. Powell, Michael A. Nails, Karen Ritchie, Kathryn L. Lunetta, John S. K. Kauwe, Eric Boerwinkle, Matthias Riemenschneider, Merce Boada, Mikko Hiltunen, Eden R. Martin, Pau Pastor, Reinhold Schmidt, Dan Rujescu, Jean-Francois Dartigues, Richard Mayeux, Christophe Tzourio, Albert Hofman, Markus M. Noethen, Caroline Graff, Bruce M. Psaty, Jonathan L. Haines, Mark Lathrop, Margaret A. Pericak-Vance, Lenore J. Launer, Lindsay A. Farrer, Cornelia M. van Duijn, Christine Van Broeckhoven, Alfredo Ramirez, Gerard D. Schellenberg, Sudha Seshadri, Philippe Amouyel, Julie Williams, Peter A. Holmans

ALZHEIMERS & DEMENTIA, 11(6), 658-671, Jun, 2015, doi: 10.1016/j.jalz.2014.05.1757

Circulating lipid levels and risk of coronary artery disease in a large group of patients undergoing coronary angiography

Daniel E. Platt, Michella Ghassibe-Sabbagh, Sonia Youhanna, Joerg Hager, Jean-Baptiste Cazier, Yoichiro Kamatani, Angelique K. Salloum, Marc Haber, Jihane Romanos, Bouchra Doueihy, Francis Mouzaya, Samer Kibbani, Hana Sbeite, Mary E. Deeb, Elie Chammas, Hamid el Bayeh, Georges Khazen, Dominique Gauguier, Pierre A. Zalloua, Antoine B. Abchee

JOURNAL OF THROMBOSIS AND THROMBOLYSIS, 39(1), 15-22, Jan, 2015, doi: 10.1007/s11239-014-1069-2

Common variation in PHACTR1 is associated with susceptibility to cervical artery dissection

Stephanie Debette, Yoichiro Kamatani, Tiina M. Metso, Manja Kloss, Ganesh Chauhan, Stefan T. Engelter, Alessandro Pezzini, Vincent Thijs, Hugh S. Markus, Martin Dichgans, Christiane Wolf, Ralf Dittrich, Emmanuel Touze, Andrew M. Southerland, Yves Samson, Sherine Abboud, Yannick Bejot, Valeria Caso, Anna Bersano, Andreas Gschwendtner, Maria Sessa, John Cole, Chantal Lamy, Elisabeth Medeiros, Simone Beretta, Leo H. Bonati, Armin J. Grau, Patrik Michel, Jennifer J. Majersik, Pankaj Sharma, Ludmila Kalashnikova, Maria Nazarova, Larisa Dobrynina, Eva Bartels, Benoit Guillon, Evita G. van den Herik, Israel Fernandez-Cadenas, Katarina Jood, Michael A. Nalls, Frank-Erik De Leeuw, Christina Jern, Yu-Ching Cheng, Inge Werner, Antti J. Metso, Christoph Lichy, Philippe A. Lyrer, Tobias Brandt, Giorgio B. Boncoraglio, Heinz-Erich Wichmann, Christian Gieger, Andrew D. Johnson, Thomas Bottcher, Maurizio Castellano, Dominique Arveiler, M. Arfan Ikram, Monique M. B. Breteler, Alessandro Padovani, James F. Meschia, Gregor Kuhlenbaumer, Arndt Rolfs, Bradford B. Worrall, Erich-Bernd Ringelstein, Diana Zelenika, Turgut Tatlisumak, Mark Lathrop, Didier Leys, Philippe Amouyel, Jean Dallongeville, R. Lemmens, M. Pandolfo, M. Bodenant, F. Louillet, J. L. Mas, S. Deltour, S. Leder, A. Leger, S. Canaple, O. Godefroy, M. Giroud, A. Jacquin, T. Moulin, F. Vullier, C. Tzourio, M. Dos Santos, R. Malik, I. Hausser, C. Thomas-Feles, R. Weber, C. Grond-Ginsbach, W. Hacke, A. Giossi, I. Volonghi, P. Costa, E. del Zotto, A. Morotti, L. Poli, M. Lorenza Muiesan, M. Salvetti, E. Agabiti Rosei, S. Lanfranconi, P. Baron, C. Ferrarese, E. Susani, M. Bicocca, G. Giacalone, S. Paolucci, R. Palmirotta, Fiorella Guadagni, M. Paciaroni, E. Ballabio, E. A. Parati, E. Ciusani, F. Fluri, F. Hatz, D. Gisler, M. Amort, S. Bevan, T. James, S. Olsson, L. Holmegaard, A. Altintas, J. J. Martin, S. Kittner, B. MItchell, C. Stine, J. O'Connell, N. Dueker, P. J. Koudstaal, L. M. de Lau, A. Hofman, B. F. Verhaaren, A. G. Uitterlinden, J. Montaner, M. Mendioroz, S. Yadav, M. S. Khan, M. Wilder, E. van Dijk, N. Maaijwee, L. Rutten-Jacobs, J. Kramer, S. Malik, R. D. Brown, A. Singleton, J. Hardy, S. S. Rich, C. Tanislav, J. Jungehuelsing

NATURE GENETICS, 47(1), 78-+, Jan, 2015, doi: 10.1038/ng.3154

20146 papers

Trans-ethnic meta-analysis of white blood cell phenotypes

Margaux F. Keller, Alexander P. Reiner, Yukinori Okada, Frank J. A. van Rooij, Andrew D. Johnson, Ming-Huei Chen, Albert V. Smith, Andrew P. Morris, Toshiko Tanaka, Luigi Ferrucci, Alan B. Zonderman, Guillaume Lettre, Tamara Harris, Melissa Garcia, Stefania Bandinelli, Rehan Qayyum, Lisa R. Yanek, Diane M. Becker, Lewis C. Becker, Charles Kooperberg, Brendan Keating, Jared Reis, Hua Tang, Eric Boerwinkle, Yoichiro Kamatani, Koichi Matsuda, Naoyuki Kamatani, Yusuke Nakamura, Michiaki Kubo, Simin Liu, Abbas Dehghan, Janine F. Felix, Albert Hofman, Andre G. Uitterlinden, Cornelia M. van Duijn, Oscar H. Franco, Dan L. Longo, Andrew B. Singleton, Bruce M. Psaty, Michelle K. Evans, L. Adrienne Cupples, Jerome I. Rotter, Christopher J. O'Donnell, Atsushi Takahashi, James G. Wilson, Santhi K. Ganesh, Mike A. Nalls

HUMAN MOLECULAR GENETICS, 23(25), 6944-6960, Dec, 2014, doi: 10.1093/hmg/ddu401

Rare and common variants in extracellular matrix gene Fibrillin 2 (FBN2) are associated with macular degeneration

Rinki Ratnapriya, Xiaowei Zhan, Robert N. Fariss, Kari E. Branham, David Zipprer, Christina F. Chakarova, Yuri V. Sergeev, Maria M. Campos, Mohammad Othman, James S. Friedman, Arvydas Maminishkis, Naushin H. Waseem, Matthew Brooks, Harsha K. Rajasimha, Albert O. Edwards, Andrew Lotery, Barbara E. Klein, Barbara J. Truitt, Bingshan Li, Debra A. Schaumberg, Denise J. Morgan, Margaux A. Morrison, Eric Souied, Evangelia E. Tsironi, Felix Grassmann, Gerald A. Fishman, Giuliana Silvestri, Hendrik P. N. Scholl, Ivana K. Kim, Jacqueline Ramke, Jingsheng Tuo, Joanna E. Merriam, John C. Merriam, Kyu Hyung Park, Lana M. Olson, Lindsay A. Farrer, Matthew P. Johnson, Neal S. Peachey, Mark Lathrop, Robert V. Baron, Robert P. Igo, Ronald Klein, Stephanie A. Hagstrom, Yoichiro Kamatani, Tammy M. Martin, Yingda Jiang, Yvette Conley, Jose-Alan Sahel, Donald J. Zack, Chi-Chao Chan, Margaret A. Pericak-Vance, Samuel G. Jacobson, Michael B. Gorin, Michael L. Klein, Rando Allikmets, Sudha K. Iyengar, Bernhard H. Weber, Jonathan L. Haines, Thierry Leveillard, Margaret M. Deangelis, Dwight Stambolian, Daniel E. Weeks, Shomi S. Bhattacharya, Emily Y. Chew, John R. Heckenlively, Goncalo R. Abecasis, Anand Swaroop

HUMAN MOLECULAR GENETICS, 23(21), 5827-5837, Nov, 2014, doi: 10.1093/hmg/ddu276

Genome-wide association meta-analysis of human longevity identifies a novel locus conferring survival beyond 90 years of age

Joris Deelen, Marian Beekman, Hae-Won Uh, Linda Broer, Kristin L. Ayers, Qihua Tan, Yoichiro Kamatani, Anna M. Bennet, Riin Tamm, Stella Trompet, Daniel F. Guobjartsson, Friederike Flachsbart, Giuseppina Rose, Alexander Viktorin, Krista Fischer, Marianne Nygaard, Heather J. Cordell, Paolina Crocco, Erik B. Van den Akker, Stefan Bohringer, Quinta Helmer, Christopher P. Nelson, Gary I. Saunders, Maris Alver, Karen Andersen-Ranberg, Marie E. Breen, Ruud van der Breggen, Amke Caliebe, Miriam Capri, Elisa Cevenini, Joanna C. Collerton, Serena Dato, Karen Davies, Ian Ford, Jutta Gampe, Paolo Garagnani, Eco J. C. de Geus, Jennifer Harrow, Diana van Heemst, Bastiaan T. Heijmans, Femke-Anouska Heinsen, Jouke-Jan Hottenga, Albert Hofman, Bernard Jeune, Palmi V. Jonsson, Mark Lathrop, Doris Lechner, Carmen Martin-Ruiz, Susan E. Mcnerlan, Evelin Mihailov, Alberto Montesanto, Simon P. Mooijaart, Anne Murphy, Ellen A. Nohr, Lavinia Paternoster, Iris Postmus, Fernando Rivadeneira, Owen A. Ross, Stefano Salvioli, Naveed Sattar, Stefan Schreiber, Hreinn Stefansson, David J. Stott, Henning Tiemeier, Andre G. Uitterlinden, Rudi G. J. Westendorp, Gonneke Willemsen, Nilesh J. Samani, Pilar Galan, Thorkild I. A. Sorensen, Dorret I. Boomsma, J. Wouter Jukema, Irene Maeve Rea, Giuseppe Passarino, Anton J. M. de Craen, Kaare Christensen, Almut Nebel, Kari Stefansson, Andres Metspalu, Patrik Magnusson, Helene Blanche, Lene Christiansen, Thomas B. L. Kirkwood, Cornelia M. van Duijn, Claudio Franceschi, Jeanine J. Houwing-Duistermaat, P. Eline Slagboom

HUMAN MOLECULAR GENETICS, 23(16), 4420-4432, Aug, 2014, doi: 10.1093/hmg/ddu139

Gene-Wide Analysis Detects Two New Susceptibility Genes for Alzheimer's Disease

Valentina Escott-Price, Celine Bellenguez, Li-San Wang, Seung-Hoan Choi, Denise Harold, Lesley Jones, Peter Holmans, Amy Gerrish, Alexey Vedernikov, Alexander Richards, Anita L. DeStefano, Jean-Charles Lambert, Carla A. Ibrahim-Verbaas, Adam C. Naj, Rebecca Sims, Gyungah Jun, Joshua C. Bis, Gary W. Beecham, Benjamin Grenier-Boley, Giancarlo Russo, Tricia A. Thornton-Wells, Nicola Denning, Albert V. Smith, Vincent Chouraki, Charlene Thomas, M. Arfan Ikram, Diana Zelenika, Badri N. Vardarajan, Yoichiro Kamatani, Chiao-Feng Lin, Helena Schmidt, Brian Kunkle, Melanie L. Dunstan, Maria Vronskaya, Andrew D. Johnson, Agustin Ruiz, Marie-Therese Bihoreau, Christiane Reitz, Florence Pasquier, Paul Hollingworth, Olivier Hanon, Annette L. Fitzpatrick, Joseph D. Buxbaum, Dominique Campion, Paul K. Crane, Clinton Baldwin, Tim Becker, Vilmundur Gudnason, Carlos Cruchaga, David Craig, Najaf Amin, Claudine Berr, Oscar L. Lopez, Philip L. De Jager, Vincent Deramecourt, Janet A. Johnston, Denis Evans, Simon Lovestone, Luc Letenneur, Isabel Hernandez, David C. Rubinsztein, Gudny Eiriksdottir, Kristel Sleegers, Alison M. Goate, Nathalie Fievet, Matthew J. Huentelman, Michael Gill, Kristelle Brown, M. Ilyas Kamboh, Lina Keller, Pascale Barberger-Gateau, Bernadette McGuinness, Eric B. Larson, Amanda J. Myers, Carole Dufouil, Stephen Todd, David Wallon, Seth Love, Ekaterina Rogaeva, John Gallacher, Peter St George-Hyslop, Jordi Clarimon, Alberto Lleo, Anthony Bayer, Debby W. Tsuang, Lei Yu, Magda Tsolaki, Paola Bossu, Gianfranco Spalletta, Petra Proitsi, John Collinge, Sandro Sorbi, Florentino Sanchez Garcia, Nick C. Fox, John Hardy, Maria Candida Deniz Naranjo, Paolo Bosco, Robert Clarke, Carol Brayne, Daniela Galimberti, Elio Scarpini, Ubaldo Bonuccelli, Michelangelo Mancuso, Gabriele Siciliano, Susanne Moebus, Patrizia Mecocci, Maria Del Zompo, Wolfgang Maier, Harald Hampel, Alberto Pilotto, Ana Frank-Garcia, Francesco Panza, Vincenzo Solfrizzi, Paolo Caffarra, Benedetta Nacmias, William Perry, Manuel Mayhaus, Lars Lannfelt, Hakon Hakonarson, Sabrina Pichler, Minerva M. Carrasquillo, Martin Ingelsson, Duane Beekly, Victoria Alvarez, Fanggeng Zou, Otto Valladares, Steven G. Younkin, Eliecer Coto, Kara L. Hamilton-Nelson, Wei Gu, Cristina Razquin, Pau Pastor, Ignacio Mateo, Michael J. Owen, Kelley M. Faber, Palmi V. Jonsson, Onofre Combarros, Michael C. O'Donovan, Laura B. Cantwell, Hilkka Soininen, Deborah Blacker, Simon Mead, Thomas H. Mosley, David A. Bennett, Tamara B. Harris, Laura Fratiglioni, Clive Holmes, Renee F. A. G. de Bruijn, Peter Passmore, Thomas J. Montine, Karolien Bettens, Jerome I. Rotter, Alexis Brice, Kevin Morgan, Tatiana M. Foroud, Walter A. Kukull, Didier Hannequin, John F. Powell, Michael A. Nalls, Karen Ritchie, Kathryn L. Lunetta, John S. K. Kauwe, Eric Boerwinkle, Matthias Riemenschneider, Merce Boada, Mikko Hiltunen, Eden R. Martin, Reinhold Schmidt, Dan Rujescu, Jean-Francois Dartigues, Richard Mayeux, Christophe Tzourio, Albert Hofman, Markus M. Noethen, Caroline Graff, Bruce M. Psaty, Jonathan L. Haines, Mark Lathrop, Margaret A. Pericak-Vance, Lenore J. Launer, Christine Van Broeckhoven, Lindsay A. Farrer, Cornelia M. van Duijn, Alfredo Ramirez, Sudha Seshadri, Gerard D. Schellenberg, Philippe Amouyel, Julie Williams

PLOS ONE, 9(6), e94661, Jun, 2014, doi: 10.1371/journal.pone.0094661

Genetics of rheumatoid arthritis contributes to biology and drug discovery

Yukinori Okada, Di Wu, Gosia Trynka, Towfique Raj, Chikashi Terao, Katsunori Ikari, Yuta Kochi, Koichiro Ohmura, Akari Suzuki, Shinji Yoshida, Robert R. Graham, Arun Manoharan, Ward Ortmann, Tushar Bhangale, Joshua C. Denny, Robert J. Carroll, Anne E. Eyler, Jeffrey D. Greenberg, Joel M. Kremer, Dimitrios A. Pappas, Lei Jiang, Jian Yin, Lingying Ye, Ding-Feng Su, Jian Yang, Gang Xie, Ed Keystone, Harm-Jan Westra, Tonu Esko, Andres Metspalu, Xuezhong Zhou, Namrata Gupta, Daniel Mirel, Eli A. Stahl, Dorothee Diogo, Jing Cui, Katherine Liao, Michael H. Guo, Keiko Myouzen, Takahisa Kawaguchi, Marieke J. H. Coenen, Piet L. C. M. van Riel, Mart A. F. J. van de laar, Henk-Jan Guchelaar, Tom W. J. Huizinga, Philippe Dieude, Xavier Mariette, S. Louis Bridges, Alexandra Zhernakova, Rene E. M. Toes, Paul P. Tak, Corinne Miceli-Richard, So-Young Bang, Hye-Soon Lee, Javier Martin, Miguel A. Gonzalez-Gay, Luis Rodriguez-Rodriguez, Solbritt Rantapaa-Dahlqvist, Lisbeth Arlestig, Hyon K. Choi, Yoichiro Kamatani, Pilar Galan, Mark Lathrop, Steve Eyre, John Bowes, Anne Barton, Niek de Vries, Larry W. Moreland, Lindsey A. Criswell, Elizabeth W. Karlson, Atsuo Taniguchi, Ryo Yamada, Michiaki Kubo, Jun S. Liu, Sang-Cheol Bae, Jane Worthington, Leonid Padyukov, Lars Klareskog, Peter K. Gregersen, Soumya Raychaudhuri, Barbara E. Stranger, Philip L. De Jager, Lude Franke, Peter M. Visscher, Matthew A. Brown, Hisashi Yamanaka, Tsuneyo Mimori, Atsushi Takahashi, Huji Xu, Timothy W. Behrens, Katherine A. Siminovitch, Shigeki Momohara, Fumihiko Matsuda, Kazuhiko Yamamoto, Robert M. Plenge

NATURE, 506(7488), 376-+, Feb, 2014, doi: 10.1038/nature12873

Integration of Sequence Data from a Consanguineous Family with Genetic Data from an Outbred Population Identifies PLB1 as a Candidate Rheumatoid Arthritis Risk Gene

Yukinori Okada, Dorothee Diogo, Jeffrey D. Greenberg, Faten Mouassess, Walid A. L. Achkar, Robert S. Fulton, Joshua C. Denny, Namrata Gupta, Daniel Mirel, Stacy Gabriel, Gang Li, Joel M. Kremer, Dimitrios A. Pappas, Robert J. Carroll, Anne E. Eyler, Gosia Trynka, Eli A. Stahl, Jing Cui, Richa Saxena, Marieke J. H. Coenen, Henk-Jan Guchelaar, Tom W. J. Huizinga, Philippe Dieude, Xavier Mariette, Anne Barton, Helena Canhao, Joao E. Fonseca, Niek de Vries, Paul P. Tak, Larry W. Moreland, S. Louis Bridges, Corinne Miceli-Richard, Hyon K. Choi, Yoichiro Kamatani, Pilar Galan, Mark Lathrop, Towfique Raj, Philip L. De Jager, Soumya Raychaudhuri, Jane Worthington, Leonid Padyukov, Lars Klareskog, Katherine A. Siminovitch, Peter K. Gregersen, Elaine R. Mardis, Thurayya Arayssi, Layla A. Kazkaz, Robert M. Plenge

PLOS ONE, 9(2), e87645, Feb, 2014, doi: 10.1371/journal.pone.0087645

20136 papers

Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease

Jean-Charles Lambert, Carla A. Ibrahim-Verbaas, Denise Harold, Adam C. Naj, Rebecca Sims, Celine Bellenguez, Gyungah Jun, Anita L. DeStefano, Joshua C. Bis, Gary W. Beecham, Benjamin Grenier-Boley, Giancarlo Russo, Tricia A. Thornton-Wells, Nicola Jones, Albert V. Smith, Vincent Chouraki, Charlene Thomas, M. Arfan Ikram, Diana Zelenika, Badri N. Vardarajan, Yoichiro Kamatani, Chiao-Feng Lin, Amy Gerrish, Helena Schmidt, Brian Kunkle, Melanie L. Dunstan, Agustin Ruiz, Marie-Therese Bihoreau, Seung-Hoan Choi, Christiane Reitz, Florence Pasquier, Paul Hollingworth, Alfredo Ramirez, Olivier Hanon, Annette L. Fitzpatrick, Joseph D. Buxbaum, Dominique Campion, Paul K. Crane, Clinton Baldwin, Tim Becker, Vilmundur Gudnason, Carlos Cruchaga, David Craig, Najaf Amin, Claudine Berr, Oscar L. Lopez, Philip L. De Jager, Vincent Deramecourt, Janet A. Johnston, Denis Evans, Simon Lovestone, Luc Letenneur, Francisco J. Moron, David C. Rubinsztein, Gudny Eiriksdottir, Kristel Sleegers, Alison M. Goate, Nathalie Fievet, Matthew J. Huentelman, Michael Gill, Kristelle Brown, M. Ilyas Kamboh, Lina Keller, Pascale Barberger-Gateau, Bernadette McGuinness, Eric B. Larson, Robert Green, Amanda J. Myers, Carole Dufouil, Stephen Todd, David Wallon, Seth Love, Ekaterina Rogaeva, John Gallacher, Peter St George-Hyslop, Jordi Clarimon, Alberto Lleo, Anthony Bayer, Debby W. Tsuang, Lei Yu, Magda Tsolaki, Paola Bossu, Gianfranco Spalletta, Petroula Proitsi, John Collinge, Sandro Sorbi, Florentino Sanchez-Garcia, Nick C. Fox, John Hardy, Maria Candida Deniz Naranjo, Paolo Bosco, Robert Clarke, Carol Brayne, Daniela Galimberti, Michelangelo Mancuso, Fiona Matthews, Susanne Moebus, Patrizia Mecocci, Maria Del Zompo, Wolfgang Maier, Harald Hampel, Alberto Pilotto, Maria Bullido, Francesco Panza, Paolo Caffarra, Benedetta Nacmias, John R. Gilbert, Manuel Mayhaus, Lars Lannfelt, Hakon Hakonarson, Sabrina Pichler, Minerva M. Carrasquillo, Martin Ingelsson, Duane Beekly, Victoria Alvarez, Fanggeng Zou, Otto Valladares, Steven G. Younkin, Eliecer Coto, Kara L. Hamilton-Nelson, Wei Gu, Cristina Razquin, Pau Pastor, Ignacio Mateo, Michael J. Owen, Kelley M. Faber, Palmi V. Jonsson, Onofre Combarros, Michael C. O'Donovan, Laura B. Cantwell, Hilkka Soininen, Deborah Blacker, Simon Mead, Thomas H. Mosley, David A. Bennett, Tamara B. Harris, Laura Fratiglioni, Clive Holmes, Renee F. A. G. de Bruijn, Peter Passmore, Thomas J. Montine, Karolien Bettens, Jerome I. Rotter, Alexis Brice, Kevin Morgan, Tatiana M. Foroud, Walter A. Kukull, Didier Hannequin, John F. Powell, Michael A. Nalls, Karen Ritchie, Kathryn L. Lunetta, John S. K. Kauwe, Eric Boerwinkle, Matthias Riemenschneider, Merce Boada, Mikko Hiltunen, Eden R. Martin, Reinhold Schmidt, Dan Rujescu, Li-San Wang, Jean-Francois Dartigues, Richard Mayeux, Christophe Tzourio, Albert Hofman, Markus M. Noethen, Caroline Graff, Bruce M. Psaty, Lesley Jones, Jonathan L. Haines, Peter A. Holmans, Mark Lathrop, Margaret A. Pericak-Vance, Lenore J. Launer, Lindsay A. Farrer, Cornelia M. van Duijn, Christine Van Broeckhoven, Valentina Moskvina, Sudha Seshadri, Julie Williams, Gerard D. Schellenberg, Philippe Amouyel

NATURE GENETICS, 45(12), 1452-U206, Dec, 2013, doi: 10.1038/ng.2802

A genome-wide association study of atopic dermatitis identifies loci with overlapping effects on asthma and psoriasis

Stephan Weidinger, Saffron A. G. Willis-Owen, Yoichiro Kamatani, Hansjoerg Baurecht, Nilesh Morar, Liming Liang, Pauline Edser, Teresa Street, Elke Rodriguez, Grainne M. O'Regan, Paula Beattie, Regina Foelster-Holst, Andre Franke, Natalija Novak, Caoimhe M. Fahy, Marten C. G. Winge, Michael Kabesch, Thomas Illig, Simon Heath, Cilla Soderhall, Erik Melen, Goran Pershagen, Juha Kere, Maria Bradley, Agne Lieden, Magnus Nordenskjold, John I. Harper, W. H. Irwin Mclean, Sara J. Brown, William O. C. Cookson, G. Mark Lathrop, Alan D. Irvine, Miriam F. Moffatt

HUMAN MOLECULAR GENETICS, 22(23), 4841-4856, Dec, 2013, doi: 10.1093/hmg/ddt317

Genome-wide association study in breast cancer survivors reveals SNPs associated with gene expression of genes belonging to MHC class I and II

Hege Landmark-Hoyvik, Vanessa Dumeaux, Daniel Nebdal, Eiliv Lund, Joerg Tost, Yoichiro Kamatani, Victor Renault, Anne-Lise Borresen-Dale, Vessela Kristensen, Hege Edvardsen

GENOMICS, 102(4), 278-287, Oct, 2013, doi: 10.1016/j.ygeno.2013.07.006

Genome-wide association study identifies multiple susceptibility loci for pulmonary fibrosis.

Fingerlin TE, Murphy E, Zhang W, Peljto AL, Brown KK, Steele MP, Loyd JE, Cosgrove GP, Lynch D, Groshong S, Collard HR, Wolters PJ, Bradford WZ, Kossen K, Seiwert SD, du Bois RM, Garcia CK, Devine MS, Gudmundsson G, Isaksson HJ, Kaminski N, Zhang Y, Gibson KF, Lancaster LH, Cogan JD, Mason WR, Maher TM, Molyneaux PL, Wells AU, Moffatt MF, Selman M, Pardo A, Kim DS, Crapo JD, Make BJ, Regan EA, Walek DS, Daniel JJ, Kamatani Y, Zelenika D, Smith K, McKean D, Pedersen BS, Talbert J, Kidd RN, Markin CR, Beckman KB, Lathrop M, Schwarz MI, Schwartz DA

Nature genetics, 45(6), 613-620, Jun, 2013, doi: 10.1038/ng.2609

Genome-wide haplotype association study identifies the FRMD4A gene as a risk locus for Alzheimer's disease

J-C Lambert, B. Grenier-Boley, D. Harold, D. Zelenika, V. Chouraki, Y. Kamatani, K. Sleegers, M. A. Ikram, M. Hiltunen, C. Reitz, I. Mateo, T. Feulner, M. Bullido, D. Galimberti, L. Concari, V. Alvarez, R. Sims, A. Gerrish, J. Chapman, C. Deniz-Naranjo, V. Solfrizzi, S. Sorbi, B. Arosio, G. Spalletta, G. Siciliano, J. Epelbaum, D. Hannequin, J-F Dartigues, C. Tzourio, C. Berr, E. M. C. Schrijvers, R. Rogers, G. Tosto, F. Pasquier, K. Bettens, C. Van Cauwenberghe, L. Fratiglioni, C. Graff, M. Delepine, R. Ferri, C. A. Reynolds, L. Lannfelt, M. Ingelsson, J. A. Prince, C. Chillotti, A. Pilotto, D. Seripa, A. Boland, M. Mancuso, P. Bossu, G. Annoni, B. Nacmias, P. Bosco, F. Panza, F. Sanchez-Garcia, M. Del Zompo, E. Coto, M. Owen, M. O'Donovan, F. Valdivieso, P. Caffara, E. Scarpini, O. Combarros, L. Buee, D. Campion, H. Soininen, M. Breteler, M. Riemenschneider, C. Van Broeckhoven, A. Alperovitch, M. Lathrop, D-A Tregouet, J. Williams, P. Amouyel

MOLECULAR PSYCHIATRY, 18(4), 461-470, Apr, 2013, doi: 10.1038/mp.2012.14

Seven new loci associated with age-related macular degeneration

Lars G. Fritsche, Wei Chen, Matthew Schu, Brian L. Yaspan, Yi Yu, Gudmar Thorleifsson, Donald J. Zack, Satoshi Arakawa, Valentina Cipriani, Stephan Ripke, Robert P. Igo, Gabrielle H. S. Buitendijk, Xueling Sim, Daniel E. Weeks, Robyn H. Guymer, Joanna E. Merriam, Peter J. Francis, Gregory Hannum, Anita Agarwal, Ana Maria Armbrecht, Isabelle Audo, Tin Aung, Gaetano R. Barile, Mustapha Benchaboune, Alan C. Bird, Paul N. Bishop, Kari E. Branham, Matthew Brooks, Alexander J. Brucker, William H. Cade, Melinda S. Cain, Peter A. Campochiaroll, Chi-Chao Chan, Ching-Yu Cheng, Emily Y. Chew, Kimberly A. Chin, Itay Chowers, David G. Clayton, Radu Cojocaru, Yvette P. Conley, Belinda K. Cornes, Mark J. Daly, Baljean Dhillon, Albert Edwards, Evangelos Evangelou, Jesen Fagemess, Henry A. Ferreyra, James S. Friedman, Asbjorg Geirsdottir, Ronnie J. George, Christian Gieger, Neel Gupta, Stephanie A. Hagstrom, Simon P. Harding, Christos Haritoglou, John R. Heckenlively, Frank G. Hoz, Guy Hughes, John P. A. Ioannidis, Tatsuro Ishibashi, Peronne Joseph, Gyungah Jun, Yoichiro Kamatani, Nicholas Katsanis, Claudia N. Keilhauer, Jane C. Khan, Ivana K. Kim, Yutaka Kiyohara, Barbara E. K. Klein, Ronald Klein, Jaclyn L. Kovach, Igor Kozak, Clara J. Lee, Kristine E. Lee, Peter Lichtner, Andrew J. Lotery, Thomas Meitinger, Paul Mitchell, Saddek Mohand-Saied, Anthony T. Moore, Denise J. Morgan, Margaux A. Morrison, Chelsea E. Myers, Adam C. Naj, Yusuke Nakamura, Yukinori Okada, Anton Orlin, M. Carolina Ortube, Mohammad I. Othman, Chris Pappas, Kyu Hyung Park, Gayle J. T. Pauer, Neal S. Peachey, Olivier Poch, Rinki Ratna Priya, Robyn Reynolds, Andrea J. Richardson, Raymond Ripp, Guenther Rudolph, Euijung Ryu, Jose-Alain Sahel, Debra A. Schaumberg, Hendrik P. N. Scholl, Stephen G. Schwartz, William K. Scott, Humma Shahid, Haraldur Sigurdsson, Giuliana Silvestri, Theru A. Sivakumaran, R. Theodore Smith, Lucia Sobrin, Eric H. Souied, Dwight E. Stambolian, Hreinn Stefansson, Gwen M. Sturgill-Short, Atsushi Takahashi, Nirubol Tosakulwong, Barbara J. Truitt, Evangelia E. Tsironi, Andre G. Uitterlinden, Cornelia M. van Duijn, Lingam Vijaya, Johannes R. Vingerling, Eranga N. Vithana, Andrew R. Webster, H-Erich Wichmann, Thomas W. Winkler, Tien Y. Wong, Alan F. Wright, Diana Zelenika, Ming Zhang, Ling Zhao, Kang Zhang, Michael L. Klein, Gregory S. Hageman, G. Mark Lathrop, Kari Stefansson, Rando Allikmets, Paul N. Baird, Michael B. Gorin, Jie Jin Wang, Caroline C. W. Klaver, Johanna M. Seddon, Margaret A. Pericak-Vance, Sudha K. Iyengar, John R. W. Yates, Anand Swaroop, Bernhard H. F. Weber, Michiaki Kubo, Margaret M. DeAngelis, Thierry Leveillard, Unnur Thorsteinsdottir, Jonathan L. Haines, Lindsay A. Farrer, Iris M. Heid, Goncalo R. Abecasis

NATURE GENETICS, 45(4), 433-439, Apr, 2013, doi: 10.1038/ng.2578

20127 papers

TFAP2B Influences the Effect of Dietary Fat on Weight Loss under Energy Restriction

Tanja Stocks, Lars Angquist, Karina Banasik, Marie N. Harder, Moira A. Taylor, Joerg Hager, Peter Arner, Jean-Michel Oppert, J. Alfredo Martinez, Jan Polak, Francis Rousseau, Dominique Langin, Stephan Rossner, Claus Holst, Ian A. MacDonald, Yoichiro Kamatani, Andreas F. H. Pfeiffer, Marie Kunesova, Wim H. M. Saris, Torben Hansen, Oluf Pedersen, Arne Astrup, Thorkild I. A. Sorensen

PLOS ONE, 7(8), e43212, Aug, 2012, doi: 10.1371/journal.pone.0043212

Genome-Wide Association Study in a Lebanese Cohort Confirms PHACTR1 as a Major Determinant of Coronary Artery Stenosis

Joerg Hager, Yoichiro Kamatani, Jean-Baptiste Cazier, Sonia Youhanna, Michella Ghassibe-Sabbagh, Daniel E. Platt, Antoine B. Abchee, Jihane Romanos, Georges Khazen, Raed Othman, Danielle A. Badro, Marc Haber, Angelique K. Salloum, Bouchra Douaihy, Nabil Shasha, Samer Kabbani, Hana Sbeite, Elie Chammas, Hamid el Bayeh, Francis Rousseau, Diana Zelenika, Ivo Gut, Mark Lathrop, Martin Farrall, Dominique Gauguier, Pierre A. Zalloua

PLOS ONE, 7(6), e38663, Jun, 2012, doi: 10.1371/journal.pone.0038663

Genetic and environmental influences on total plasma homocysteine and its role in coronary artery disease risk

Michella Ghassibe-Sabbagh, Daniel E. Platt, Sonia Youhanna, Antoine B. Abchee, Krista Stewart, Danielle A. Badro, Marc Haber, Angelique K. Salloum, Bouchra Douaihy, Hamid el Bayeh, Raed Othman, Nabil Shasha, Samer Kibbani, Elie Chammas, Aline Milane, Rita Nemr, Yoichiro Kamatani, Joerg Hager, Jean-Baptiste Cazier, Dominique Gauguier, Pierre A. Zalloua

ATHEROSCLEROSIS, 222(1), 180-186, May, 2012, doi: 10.1016/j.atherosclerosis.2012.02.035

Association of Common Variants in TNFRSF13B, TNFSF13, and ANXA3 with Serum Levels of Non-Albumin Protein and Immunoglobulin Isotypes in Japanese

Wael Osman, Yukinori Okada, Yoichiro Kamatani, Michiaki Kubo, Koichi Matsuda, Yusuke Nakamura

PLOS ONE, 7(4), e32683, Apr, 2012, doi: 10.1371/journal.pone.0032683

Common genetic factors for hematological traits in Humans

Yukinori Okada, Yoichiro Kamatani

JOURNAL OF HUMAN GENETICS, 57(3), 161-169, Mar, 2012, doi: 10.1038/jhg.2012.2

Genome-Wide Association Study of Classical Hodgkin Lymphoma and Epstein-Barr Virus Status-Defined Subgroups

Kevin Y. Urayama, Ruth F. Jarrett, Henrik Hjalgrim, Arjan Diepstra, Yoichiro Kamatani, Amelie Chabrier, Valerie Gaborieau, Anne Boland, Alexandra Nieters, Nikolaus Becker, Lenka Foretova, Yolanda Benavente, Marc Maynadie, Anthony Staines, Lesley Shield, Annette Lake, Dorothy Montgomery, Malcolm Taylor, Karin Ekstrom Smedby, Rose-Marie Amini, Hans-Olov Adami, Bengt Glimelius, Bjarke Feenstra, Ilja M. Nolte, Lydia Visser, Gustaaf W. van Imhoff, Tracy Lightfoot, Pierluigi Cocco, Lambertus Kiemeney, Sita H. Vermeulen, Ivana Holcatova, Lars Vatten, Gary J. Macfarlane, Peter Thomson, David I. Conway, Simone Benhamou, Antonio Agudo, Claire M. Healy, Kim Overvad, Anne Tjonneland, Beatrice Melin, Federico Canzian, Kay-Tee Khaw, Ruth C. Travis, Petra H. M. Peeters, Carlos A. Gonzalez, Jose Ramon Quiros, Maria-Jose Sanchez, Jose Maria Huerta, Eva Ardanaz, Miren Dorronsoro, Francoise Clavel-Chapelon, H. Bas Bueno-de-Mesquita, Elio Riboli, Eve Roman, Paolo Boffetta, Silvia de Sanjose, Diana Zelenika, Mads Melbye, Anke van den Berg, Mark Lathrop, Paul Brennan, James D. McKay

JOURNAL OF THE NATIONAL CANCER INSTITUTE, 104(3), 240-253, Feb, 2012, doi: 10.1093/jnci/djr516

Functional Variants in NFKBIE and RTKN2 Involved in Activation of the NF-κB Pathway Are Associated with Rheumatoid Arthritis in Japanese

K. Myouzen, Y. Kochi, Y. Okada, C. Terao, A. Suzuki, K. Ikari, T. Tsunoda, A. Takahashi, M. Kubo, A. Taniguchi, F. Matsuda, K. Ohmura, S. Momohara, T. Mimori, H. Yamanaka, N. Kamatani, R. Yamada, Y. Nakamura, K. Yamamoto

PLoS Genetics, 8(9), 2012, doi: 10.1371/journal.pgen.1002949

20118 papers

Large Scale Association Analysis Identifies Three Susceptibility Loci for Coronary Artery Disease

Stephanie Saade, Jean-Baptiste Cazier, Michella Ghassibe-Sabbagh, Sonia Youhanna, Danielle A. Badro, Yoichiro Kamatani, Joerg Hager, Joumana S. Yeretzian, Georges El-Khazen, Marc Haber, Angelique K. Salloum, Bouchra Douaihy, Raed Othman, Nabil Shasha, Samer Kabbani, Hamid El Bayeh, Elie Chammas, Martin Farrall, Dominique Gauguier, Daniel E. Platt, Pierre A. Zalloua

PLOS ONE, 6(12), e29427, Dec, 2011, doi: 10.1371/journal.pone.0029427

Genome-wide association study on bipolar disorder in the Bulgarian population

A. Yosifova, T. Mushiroda, M. Kubo, A. Takahashi, Y. Kamatani, N. Kamatani, D. Stoianov, R. Vazharova, S. Karachanak, I. Zaharieva, I. Dimova, S. Hadjidekova, V. Milanova, N. Madjirova, I. Gerdjikov, T. Tolev, N. Poryazova, M. C. O'Donovan, M. J. Owen, G. Kirov, D. Toncheva, Y. Nakamura

GENES BRAIN AND BEHAVIOR, 10(7), 789-797, Oct, 2011, doi: 10.1111/j.1601-183X.2011.00721.x

A genome-wide association study of chronic hepatitis B identified novel risk locus in a Japanese population

Hamdi Mbarek, Hidenori Ochi, Yuji Urabe, Vinod Kumar, Michiaki Kubo, Naoya Hosono, Atsushi Takahashi, Yoichiro Kamatani, Daiki Miki, Hiromi Abe, Tatsuhiko Tsunoda, Naoyuki Kamatani, Kazuaki Chayama, Yusuke Nakamura, Koichi Matsuda

HUMAN MOLECULAR GENETICS, 20(19), 3884-3892, Oct, 2011, doi: 10.1093/hmg/ddr301

Family-based designs for genome-wide association studies

Jurg Ott, Yoichiro Kamatani, Mark Lathrop

NATURE REVIEWS GENETICS, 12(7), 465-474, Jul, 2011, doi: 10.1038/nrg2989

Common variant in 6q26-q27 is associated with distal colon cancer in an Asian population

R. Cui, Y. Okada, S. G. Jang, J. L. Ku, J. G. Park, Y. Kamatani, N. Hosono, T. Tsunoda, V. Kumar, C. Tanikawa, N. Kamatani, R. Yamada, M. Kubo, Y. Nakamura, Koichi Matsuda

Gut, 60(6), 799-805, Jun, 2011, doi: 10.1136/gut.2010.215947

Identification of Nine Novel Loci Associated with White Blood Cell Subtypes in a Japanese Population

Yukinori Okada, Tomomitsu Hirota, Yoichiro Kamatani, Atsushi Takahashi, Hiroko Ohmiya, Natsuhiko Kumasaka, Koichiro Higasa, Yumi Yamaguchi-Kabata, Naoya Hosono, Michael A. Nalls, Ming Huei Chen, Frank J. A. van Rooij, Albert V. Smith, Toshiko Tanaka, David J. Couper, Neil A. Zakai, Luigi Ferrucci, Dan L. Longo, Dena G. Hernandez, Jacqueline C. M. Witteman, Tamara B. Harris, Christopher J. O'Donnell, Santhi K. Ganesh, Koichi Matsuda, Tatsuhiko Tsunoda, Toshihiro Tanaka, Michiaki Kubo, Yusuke Nakamura, Mayumi Tamari, Kazuhiko Yamamoto, Naoyuki Kamatani

PLOS GENETICS, 7(6), e1002067, Jun, 2011, doi: 10.1371/journal.pgen.1002067

Multiple Loci Are Associated with White Blood Cell Phenotypes

Michael A. Nalls, David J. Couper, Toshiko Tanaka, Frank J. A. van Rooij, Ming-Huei Chen, Albert V. Smith, Daniela Toniolo, Neil A. Zakai, Qiong Yang, Andreas Greinacher, Andrew R. Wood, Melissa Garcia, Paolo Gasparini, Yongmei Liu, Thomas Lumley, Aaron R. Folsom, Alex P. Reiner, Christian Gieger, Vasiliki Lagou, Janine F. Felix, Henry Voelzke, Natalia A. Gouskova, Alessandro Biffi, Angela Doering, Uwe Voelker, Sean Chong, Kerri L. Wiggins, Augusto Rendon, Abbas Dehghan, Matt Moore, Kent Taylor, James G. Wilson, Guillaume Lettre, Albert Hofman, Joshua C. Bis, Nicola Pirastu, Caroline S. Fox, Christa Meisinger, Jennifer Sambrook, Sampath Arepalli, Matthias Nauck, Holger Prokisch, Jonathan Stephens, Nicole L. Glazer, L. Adrienne Cupples, Yukinori Okada, Atsushi Takahashi, Yoichiro Kamatani, Koichi Matsuda, Tatsuhiko Tsunoda, Toshihiro Tanaka, Michiaki Kubo, Yusuke Nakamura, Kazuhiko Yamamoto, Naoyuki Kamatani, Michael Stumvoll, Anke Toenjes, Inga Prokopenko, Thomas Illig, Kushang V. Patel, Stephen F. Garner, Brigitte Kuhnel, Massimo Mangino, Ben A. Oostra, Swee Lay Thein, Josef Coresh, H. -Erich Wichmann, Stephan Menzel, JingPing Lin, Giorgio Pistis, Andre G. Uitterlinden, Tim D. Spector, Alexander Teumer, Gudny Eiriksdottir, Vilmundur Gudnason, Stefania Bandinelli, Timothy M. Frayling, Aravinda Chakravarti, Cornelia M. van Duijn, David Melzer, Willem H. Ouwehand, Daniel Levy, Eric Boerwinkle, Andrew B. Singleton, Dena G. Hernandez, Dan L. Longo, Nicole Soranzo, Jacqueline C. M. Witteman, Bruce M. Psaty, Luigi Ferrucci, Tamara B. Harris, Christopher J. O'Donnell, Santhi K. Ganesh

PLOS GENETICS, 7(6), e1002113, Jun, 2011, doi: 10.1371/journal.pgen.1002113

Genome-wide association study for C-reactive protein levels identified pleiotropic associations in the IL6 locus

Yukinori Okada, Atsushi Takahashi, Hiroko Ohmiya, Natsuhiko Kumasaka, Yoichiro Kamatani, Naoya Hosono, Tatsuhiko Tsunoda, Koichi Matsuda, Toshihiro Tanaka, Michiaki Kubo, Yusuke Nakamura, Kazuhiko Yamamoto, Naoyuki Kamatani

HUMAN MOLECULAR GENETICS, 20(6), 1224-1231, Mar, 2011, doi: 10.1093/hmg/ddq551

20104 papers

A Large-Scale, Consortium-Based Genomewide Association Study of Asthma

Miriam F. Moffatt, Ivo G. Gut, Florence Demenais, David P. Strachan, Emmanuelle Bouzigon, Simon Heath, Erika von Mutius, Martin Farrall, Mark Lathrop, William O. C. M. Cookson, Ashish Kumar, Peter Burney, Debbie Jarvis, Matthias Wjst, Manolis Kogevinas, Rain Jogi, Christer Janson, Karl A. Franklin, Ernst Omenaas, Benedicte Leynaert, Isabelle Pin, Joachim Heinrich, Nicole M. Probst-Hensch, Josep M. Anto, Jordi Sunyer, Jose-Antonio Maldonado, Jesus Martinez-Moratalla, Isabel Urrutia, Felix Payo, Francine Kauffmann, Marie-Helene Dizier, Valerie Siroux, Andrzej Boznanski, Charlotte Braun-Fahrlaender, Jon Genuneit, Juergen Glas, Elisabeth Horak, Michael Kabesch, Sreekumar G. Pillai, Peter J. Helms, Karin Carlsen, Kai-Hakon Carlsen, Jorrit Gerritsen, Michael Silverman, Peter Sly, John Tsanakas, Andrea Von Berg, Moira Whyte, Malcolm Blumenthal, Medea Imboden, Thierry Rochat, Gian Andri Thun, Margaret W. Gerbase, Ivan Curjuric, Jean-Michel Gaspoz, Lee-Jane S. Liu, Inge M. Wouters, Torben Sigsgaard, Dick Heederik, Ioannis Basinas, Vivi Schlunssen, Oyvind Omland, Paul Cullinan, Roel Vermeulen, John Henderson, Raquel Granell, Wendy L. McArdle, George Davey Smith, Alan L. James, Jennie Hui, Lyle J. Palmer, John Beilby, A. William Musk, Catherine Laprise, Thomas J. Hudson, Mathieu Lemire, Denise Daley, Allan Becker, Moira Chan-Yeung, Andrew Sandford, Anita L. Kozyrskyj, Peter Pare, Alexander Ferguson, Helen Dimich-Ward, Wade T. Watson, Maxim B. Freidin, Elena Iu. Bragina, Ivan A. Deev, Eugenia V. Deeva, Olga S. Kobyakova, Valery P. Puzyrev, Ludmila M. Ogorodova, Elza K. Khusnutdinova, Alexandra S. Karunas, Yuliya Y. Fedorova, Ian P. Hall, Ian Sayers, Martin D. Tobin, Yize I. Wan, Liam G. Heaney, Basima A. H. Al-Momani, Adel H. Mansur, Sarah Manney, Neil C. Thomson, Rekha Chaudhuri, Christopher E. Brightling, Mona Bafadhel, Amisha Singapuri, Robert Niven, Angela Simpson, John W. Holloway, Peter H. Howarth, Alexey V. Polonikov, Vladimir P. Ivanov, Maria A. Solodilova, Erik Melen, Goeran Pershagen, Anna Bergstroem, Inger Kull, Fredrik Nyberg, Magnus Wickman, Cilla Soderhall, Juha Kere, Dirkje S. Postma, Marjan Kerkhof, Bert Brunekreef, Henriette A. Smit, Johan C. de Jongste, Alet Wijga, R. C. Aalberse, Maarten O. Hoekstra, Gerard H. Koppelman, Aristea Binia, Kian Fan Chung, Pankaj Bhavsar, Florence Chow, Patricia Macedo, Andrew Menzies-Gow, Nicole van Stiphout, Andrew Bush, Young-Ae Lee, Jorge Esparza-Gordillo, Renate Nickel, Ulrich Wahn, Susanne Lau, Ingo Marenholz, Tari Haahtela, Leena von Hertzen, Pekka Jousilahti, Tiina Laatikainen, Mika J. Makela, Erkki Vartiainen, Tarja Laitinen, David J. Balding, John F. Peden, Eve Corda, Doris Lechner, Celine Besse, Diana Zelenika, Anne Boland, Delphine Bacq, Stephanie Demonchy, Helene Blanche, Yoichiro Kamatani, Erika von Mutius, Martin Farrall, Mark Lathrop, William O. C. M. Cookson

NEW ENGLAND JOURNAL OF MEDICINE, 363(13), 1211-1221, Sep, 2010

A genome-wide association study in 19 633 Japanese subjects identified LHX3-QSOX2 and IGF1 as adult height loci

Yukinori Okada, Yoichiro Kamatani, Atsushi Takahashi, Koichi Matsuda, Naoya Hosono, Hiroko Ohmiya, Yataro Daigo, Kazuhiko Yamamoto, Michiaki Kubo, Yusuke Nakamura, Naoyuki Kamatani

HUMAN MOLECULAR GENETICS, 19(11), 2303-2312, Jun, 2010, doi: 10.1093/hmg/ddq091

Common variations in PSMD3-CSF3 and PLCB4 are associated with neutrophil count

Yukinori Okada, Yoichiro Kamatani, Atsushi Takahashi, Koichi Matsuda, Naoya Hosono, Hiroko Ohmiya, Yataro Daigo, Kazuhiko Yamamoto, Michiaki Kubo, Yusuke Nakamura, Naoyuki Kamatani

HUMAN MOLECULAR GENETICS, 19(10), 2079-2085, May, 2010, doi: 10.1093/hmg/ddq080

Genome-wide association study of hematological and biochemical traits in a Japanese population

Yoichiro Kamatani, Koichi Matsuda, Yukinori Okada, Michiaki Kubo, Naoya Hosono, Yataro Daigo, Yusuke Nakamura, Naoyuki Kamatani

NATURE GENETICS, 42(3), 210-U25, Mar, 2010, doi: 10.1038/ng.531

20093 papers

Functional Variants in ADH1B and ALDH2 Coupled With Alcohol and Smoking Synergistically Enhance Esophageal Cancer Risk

Ri Cui, Yoichiro Kamatani, Atsushi Takahashi, Masayuki Usami, Naoya Hosono, Takahisa Kawaguchi, Tatsuhiko Tsunoda, Naoyuki Kamatani, Michiaki Kubo, Yusuke Nakamura, Koichi Matsuda

GASTROENTEROLOGY, 137(5), 1768-1775, Nov, 2009, doi: 10.1053/j.gastro.2009.07.070

A genome-wide association study identifies variants in the HLA-DP locus associated with chronic hepatitis B in Asians

Yoichiro Kamatani, Sukanya Wattanapokayakit, Hidenori Ochi, Takahisa Kawaguchi, Atsushi Takahashi, Naoya Hosono, Michiaki Kubo, Tatsuhiko Tsunoda, Naoyuki Kamatani, Hiromitsu Kumada, Aekkachai Puseenam, Thanyachai Sura, Yataro Daigo, Kazuaki Chayama, Wasun Chantratita, Yusuke Nakamura, Koichi Matsuda

NATURE GENETICS, 41(5), 591-595, May, 2009, doi: 10.1038/ng.348

Evaluation of imputation-based association in and around the integrin-alpha-M (ITGAM) gene and replication of robust association between a non-synonymous functional variant within ITGAM and systemic lupus erythematosus (SLE)

Shizhong Han, Xana Kim-Howard, Harshal Deshmukh, Yoichiro Kamatani, Parvathi Viswanathan, Joel M. Guthridge, Kenaz Thomas, Kenneth M. Kaufman, Joshua Ojwang, Adriana Rojas-Villarraga, Vicente Baca, Lorena Orozco, Benjamin Rhodes, Chan-Bum Choi, Peter K. Gregersen, Joan T. Merrill, Judith A. James, Patrick M. Gaffney, Kathy L. Moser, Chaim O. Jacob, Robert P. Kimberly, John B. Harley, Sang-Choel Bae, Juan-Manuel Anaya, Marta E. Alarcon-Riquelme, Koichi Matsuda, Timothy J. Vyse, Swapan K. Nath

HUMAN MOLECULAR GENETICS, 18(6), 1171-1180, Mar, 2009, doi: 10.1093/hmg/ddp007

20083 papers

Functional SNPs in CD244 increase the risk of rheumatoid arthritis in a Japanese population

Akari Suzuki, Ryo Yamada, Yuta Kochi, Tetsuji Sawada, Yukinori Okada, Koichi Matsuda, Yoichiro Kamatani, Mikako Mori, Kenichi Shimane, Yasuhiko Hirabayashi, Atsushi Takahashi, Tatsuhiko Tsunoda, Akihiko Miyatake, Michiaki Kubo, Naoyuki Kamatani, Yusuke Nakamura, Kazuhiko Yamamoto

NATURE GENETICS, 40(10), 1224-1229, Oct, 2008, doi: 10.1038/ng.205

A functional SNP in the NKX2.5-binding site of ITPR3 promoter is associated with susceptibility to systemic lupus erythematosus in Japanese population

Tetsuya Oishi, Aritoshi Iida, Shigeru Otsubo, Yoichiro Kamatani, Masayuki Usami, Takashi Takei, Keiko Uchida, Ken Tsuchiya, Susumu Saito, Yozo Ohnisi, Katsushi Tokunaga, Kosaku Nitta, Yasushi Kawaguchi, Naoyuki Kamatani, Yuta Kochi, Kenichi Shimane, Kazuhiko Yamamoto, Yusuke Nakamura, Wako Yumura, Koichi Matsuda

JOURNAL OF HUMAN GENETICS, 53(2), 151-162, Feb, 2008, doi: 10.1007/s10038-007-0233-3

Identification of a significant association of a single nucleotide polymorphism in TNXB with systemic lupus erythematosus in a Japanese population

Yoichiro Kamatani, Koichi Matsuda, Tetsuya Ohishi, Shigeru Ohtsubo, Keiko Yamazaki, Aritoshi Iida, Naoya Hosono, Michiaki Kubo, Wako Yumura, Kosaku Nitta, Toyomasa Katagiri, Yasushi Kawaguchi, Naoyuki Kamatani, Yusuke Nakamura

JOURNAL OF HUMAN GENETICS, 53(1), 64-73, Jan, 2008, doi: 10.1007/s10038-007-0219-1

20041 papers

[Clinical management of metabolic syndrome: discussion].

Saito Y, Kamatani Y, Egusa G, Oikwa S, Hayashi Y

Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine, 93(4), 740-755, Apr, 2004

Publications synced from researchmap (Prof. Yoichiro Kamatani).